General Information of the Compound
Compound ID
CP0384181
Compound Name
8-Cyano-1-(2-methoxy-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
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Structure
Formula
C35H35N5O5
Molecular Weight
605.695
Canonical SMILES
CCOC(=O)c1cn(Cc2ccccc2OC)c2c(C#N)c(c(CN(C)CCc3ccccn3)n2c1=O)-c1ccc(OC)cc1
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InChI
InChI=1S/C35H35N5O5/c1-5-45-35(42)29-22-39(21-25-10-6-7-12-31(25)44-4)33-28(20-36)32(24-13-15-27(43-3)16-14-24)30(40(33)34(29)41)23-38(2)19-17-26-11-8-9-18-37-26/h6-16,18,22H,5,17,19,21,23H2,1-4H3
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InChIKey
PSMWETCHLLHYKZ-UHFFFAOYSA-N
Physicochemical Property
logP
4.95138
Rotatable Bonds
12
Heavy Atom Count
45
Polar Areas
111.09
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44352641
ChEMBL ID
CHEMBL340856
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01836, Gonadotropin-releasing hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 6600 nM
   TI
   LI
   LO
   TS