General Information of the Compound
Compound ID
CP0440478
Compound Name
8-Cyano-1-cyclopropylmethyl-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
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Structure
Formula
C31H33N5O4
Molecular Weight
539.636
Canonical SMILES
CCOC(=O)c1cn(CC2CC2)c2c(C#N)c(c(CN(C)CCc3ccccn3)n2c1=O)-c1ccc(OC)cc1
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InChI
InChI=1S/C31H33N5O4/c1-4-40-31(38)26-19-35(18-21-8-9-21)29-25(17-32)28(22-10-12-24(39-3)13-11-22)27(36(29)30(26)37)20-34(2)16-14-23-7-5-6-15-33-23/h5-7,10-13,15,19,21H,4,8-9,14,16,18,20H2,1-3H3
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InChIKey
GCDCEDCLHWYOML-UHFFFAOYSA-N
Physicochemical Property
logP
4.30448
Rotatable Bonds
11
Heavy Atom Count
40
Polar Areas
101.86
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44352975
ChEMBL ID
CHEMBL334816
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01836, Gonadotropin-releasing hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 50000 nM
   TI
   LI
   LO
   TS