General Information of the Compound
Compound ID
CP0432211
Compound Name
5-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-1-(2,6-difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
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Structure
Formula
C29H26F4N4O4
Molecular Weight
570.543
Canonical SMILES
CN(CCc1ccccn1)CCn1c(=O)c(-c2ccc3OC(F)(F)Oc3c2)c(C)n(Cc2c(F)cccc2F)c1=O
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InChI
InChI=1S/C29H26F4N4O4/c1-18-26(19-9-10-24-25(16-19)41-29(32,33)40-24)27(38)36(15-14-35(2)13-11-20-6-3-4-12-34-20)28(39)37(18)17-21-22(30)7-5-8-23(21)31/h3-10,12,16H,11,13-15,17H2,1-2H3
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InChIKey
GTKRATWSXSFSLO-UHFFFAOYSA-N
Physicochemical Property
logP
4.20292
Rotatable Bonds
9
Heavy Atom Count
41
Polar Areas
78.59
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11238459
SID: 16322428
ChEMBL ID
CHEMBL23737
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01836, Gonadotropin-releasing hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 470 nM
   TI
   LI
   LO
   TS