General Information of the Compound
Compound ID
CP0410510
Compound Name
7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-[(methyl-phenethyl-amino)-methyl]-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
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Structure
Formula
C40H45FN4O4
Molecular Weight
664.822
Canonical SMILES
CCCC(=O)Nc1ccc(cc1)-c1cc2n(Cc3ccccc3F)cc(C(=O)OC(CC)CC)c(=O)n2c1CN(C)CCc1ccccc1
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InChI
InChI=1S/C40H45FN4O4/c1-5-13-37(46)42-31-20-18-29(19-21-31)33-24-38-44(25-30-16-11-12-17-35(30)41)26-34(40(48)49-32(6-2)7-3)39(47)45(38)36(33)27-43(4)23-22-28-14-9-8-10-15-28/h8-12,14-21,24,26,32H,5-7,13,22-23,25,27H2,1-4H3,(H,42,46)
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InChIKey
MALCCJMOWDULCW-UHFFFAOYSA-N
Physicochemical Property
logP
7.7139
Rotatable Bonds
15
Heavy Atom Count
49
Polar Areas
85.05
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
49

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44353262
ChEMBL ID
CHEMBL337919
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01836, Gonadotropin-releasing hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 2.1 nM
   TI
   LI
   LO
   TS