Brief Information of the Compound and Protein
Compound Name
3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
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PubChem ID
CID: 11477970
SID: 16578762
Canonical SMILES
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NCc2ccccc2)c1=O
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Compound Formula C29H28F3N3O3
Compound Structure
Protein Name
Gonadotropin-releasing hormone receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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GnRH receptor
Uniprot ID
P30968
Gene Name
GNRHR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 25 nM
   TI
   LI
   LO
   TS
2
Ki = 51 nM
   TI
   LI
   LO
   TS
CL000194 RBL-1 Rattus norvegicus (Rat)  1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS