General Information of the Compound
Compound ID
CP0174047
Compound Name
8-Cyano-7-(4-cyclopentyloxy-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid cyclopentyl ester
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Structure
Formula
C41H42FN5O4
Molecular Weight
687.816
Canonical SMILES
CN(CCc1ccccn1)Cc1c(c(C#N)c2n(Cc3ccccc3F)cc(C(=O)OC3CCCC3)c(=O)n12)-c1ccc(OC2CCCC2)cc1
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InChI
InChI=1S/C41H42FN5O4/c1-45(23-21-30-11-8-9-22-44-30)27-37-38(28-17-19-33(20-18-28)50-31-12-3-4-13-31)34(24-43)39-46(25-29-10-2-7-16-36(29)42)26-35(40(48)47(37)39)41(49)51-32-14-5-6-15-32/h2,7-11,16-20,22,26,31-32H,3-6,12-15,21,23,25,27H2,1H3
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InChIKey
BJIUDYSNIPRIDK-UHFFFAOYSA-N
Physicochemical Property
logP
7.31738
Rotatable Bonds
12
Heavy Atom Count
51
Polar Areas
101.86
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
51

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44352657
ChEMBL ID
CHEMBL131665
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01836, Gonadotropin-releasing hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 33 nM
   TI
   LI
   LO
   TS