Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

Bicalutamide

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PubChem ID

CID: 2375

SID: 12014029

Canonical SMILES	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F Show/Hide
Compound Formula	C18H14F4N2O4S

Compound Structure

Protein Name

Protein Info

Androgen receptor

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 3

Nuclear hormone receptor subfamily 3 group C

Nuclear hormone receptor subfamily 3 group C member 4

Uniprot ID

P10275

Gene Name

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000237	22Rv1 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 4600 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 200 nM	TI LI LO TS
CL000880	COS Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	IC50 = 117 nM	TI LI LO TS
2	Ki = 82 nM	TI LI LO TS
CL000109	COS-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	IC50 = 86.9 nM	TI LI LO TS
2	Ki = 117 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	6
1	EC50 = 180 nM	TI LI LO TS
2	EC50 > 10000 nM	TI LI LO TS
3	IC50 = 330 nM	TI LI LO TS
4	IC50 = 470 nM	TI LI LO TS
5	IC50 > 10000 nM	TI LI LO TS
6	Ki = 151 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	7
1	EC50 = 157 nM	TI LI LO TS
2	EC50 > 10000 nM	TI LI LO TS
3	IC50 = 157 nM	TI LI LO TS
4	IC50 = 162 nM	TI LI LO TS
5	IC50 = 300 nM	TI LI LO TS
6	IC50 = 338 nM	TI LI LO TS
7	Ki = 151 nM	TI LI LO TS
CL000742	FreeStyle 293-F Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 54 nM	TI LI LO TS
2	IC50 = 120 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	3
1	IC50 = 54 nM	TI LI LO TS
2	IC50 = 120 nM	TI LI LO TS
3	IC50 = 248 nM	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 140 nM	TI LI LO TS
2	IC50 = 200 nM	TI LI LO TS
CL000141	LNCaP Cell Line Info	Homo sapiens (Human)	9
1	IC50 = 270 nM	TI LI LO TS
2	IC50 = 400 nM	TI LI LO TS
3	IC50 = 550 nM	TI LI LO TS
4	IC50 = 600 nM	TI LI LO TS
5	IC50 = 889 nM	TI LI LO TS
6	IC50 = 940 nM	TI LI LO TS
7	IC50 = 44260 nM	TI LI LO TS
8	IC50 > 100000 nM	TI LI LO TS
9	Ki = 35 nM	TI LI LO TS
CL000888	LNCaP-hr Cell Line Info	Homo sapiens (Human)	1
1	EC50 > 10000 nM	TI LI LO TS
CL000112	MDA-MB-435 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 173 nM	TI LI LO TS
CL000284	MDA-MB-453 Cell Line Info	Homo sapiens (Human)	5
1	IC50 = 170 nM	TI LI LO TS
2	IC50 = 173 nM	TI LI LO TS
3	Ki = 64 nM	TI LI LO TS
4	Ki = 65 nM	TI LI LO TS
5	Ki = 151 nM	TI LI LO TS
CL000807	MDA-PCa-2b Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 725 nM	TI LI LO TS
CL000099	SaOS-2 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 232 nM	TI LI LO TS

Biochemical Assays

1	IC50 = 1300 nM
2	Ki = 11 nM
3	Ki = 19 nM
4	Ki = 160.2 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han