General Information of the Cell Line
Cell Line ID
CL000112
Cell Line Name
MDA-MB-435
Synonyms
MDA-MB435
MDAMB435
MDA.MB.435
MDA-435
MDA 435
MDA435
MD Anderson-Metastatic Breast-435
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0417
Tissue Information
Hypodermis
Disease
Amelanotic melanoma (NCIt: C3802)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01786, Autotaxin
Compound ID Compound Name Compound Formula
CP0227783
2-(4-((3,5-dichlorophenyl)carbamothioyl)piperazin-1-yl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
   Show/Hide
C21H20Cl2N6O3S
 2
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
2
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0281260
2-(4-((9H-xanthene-9-carbonyl)carbamothioyl)piperazin-1-yl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
   Show/Hide
C29H26N6O5S
 2
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
2
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0281261
4-(2-(3-ethyl-4-oxo-3,4,6,7,8,9-hexahydropyrimido[4,5-b]quinolin-2-ylthio)acetamido)benzoic acid
   Show/Hide
C22H22N4O4S
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0301794
4-(4-(2-(naphthalen-1-yl)-1,3-dioxoisoindoline-5-carbonyl)phenoxy)benzoic acid
   Show/Hide
C32H19NO6
 1
1
IC50 = 6800 nM
   TI
   LI
   LO
   TS
CP0265597
4,4'-(5,5'-carbonylbis(1,3-dioxoisoindoline-5,2-diyl))bis(methylene)dibenzoic acid
   Show/Hide
C33H20N2O9
 1
1
IC50 = 12800 nM
   TI
   LI
   LO
   TS
CP0265598
3-(1,3-dioxo-2-(4-(phenyldiazenyl)phenyl)isoindoline-5-carboxamido)benzoic acid
   Show/Hide
C28H18N4O5
 1
1
IC50 = 12800 nM
   TI
   LI
   LO
   TS
CP0160898
3-(6-chloro-2-methyl-1-phenylindol-3-yl)sulfanylbenzoic acid
   Show/Hide
C22H16ClNO2S
 1
1
IC50 < 300 nM
   TI
   LI
   LO
   TS
CP0169882
6-[6-chloro-2-methyl-1-(1-methylpyrazol-4-yl)indol-3-yl]sulfanylpyridine-2-carboxylic acid
   Show/Hide
C19H15ClN4O2S
 1
1
IC50 < 300 nM
   TI
   LI
   LO
   TS
CP0436386
3-[6-chloro-2-methyl-1-(1-methylpyrazol-4-yl)indol-3-yl]sulfanylbenzoic acid
   Show/Hide
C20H16ClN3O2S
 1
1
IC50 < 300 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003433
(Arylindolyl)maleimide deriv. 27
   Show/Hide
C21H16N4O2  1
1
GI50 = 648 nM
   TI
   LI
   LO
   TS
CP0007711
(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-N'-propylprop-2-enehydrazide;2,2,2-trifluoroacetic acid
   Show/Hide
C26H31F3N4O3  1
1
LC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0034470
(-)-combretastatin
   Show/Hide
C18H20O5  1
1
IC50 = 3.4 nM
   TI
   LI
   LO
   TS
CP0055838
3-[2-(4-amino-1-ethylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C30H31F3N8O  1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0091315
US9422297, AAG145-136
   Show/Hide
C17H13ClN4  1
1
GI50 = 554 nM
   TI
   LI
   LO
   TS
CP0212776
5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-N-phenethyl-benzamide
   Show/Hide
C22H22N2O4  1
1
GI50 = 19000 nM
   TI
   LI
   LO
   TS
CP0268441
5-(2,5-Dihydroxy-benzylamino)-N-[2-(4-fluoro-phenyl)-ethyl]-2-hydroxy-benzamide
   Show/Hide
C22H21FN2O4  1
1
GI50 = 13000 nM
   TI
   LI
   LO
   TS
CP0270683
5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-N-(3-phenyl-propyl)-benzamide
   Show/Hide
C23H24N2O4  1
1
GI50 = 18000 nM
   TI
   LI
   LO
   TS
CP0337077
4-(2,5-Dihydroxy-benzylamino)-N-(3-phenyl-propyl)-benzamide
   Show/Hide
C23H24N2O3  1
1
GI50 = 5800 nM
   TI
   LI
   LO
   TS
CP0358636
N-[2-(4-chlorophenyl)ethyl]-5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzamide
   Show/Hide
C22H21ClN2O4  1
1
GI50 = 20000 nM
   TI
   LI
   LO
   TS
CP0383276
N-(4-methoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C16H17N3O2  1
1
IC50 = 17.1 nM
   TI
   LI
   LO
   TS
CP0388586
N-(2,4-dimethoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C17H19N3O3  1
1
IC50 = 139.5 nM
   TI
   LI
   LO
   TS
CP0399064
N-butyl-N-(4-methoxyphenyl)-2,6-dimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C19H23N3O2  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0415601
1-N,4-N-dimethyl-4-N-(5-methylfuro[2,3-d]pyrimidin-4-yl)benzene-1,4-diamine
   Show/Hide
C15H16N4O  1
1
IC50 = 74 nM
   TI
   LI
   LO
   TS
CP0426689
(2,6-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-(4-methoxyphenyl)-methylazanium;chloride
   Show/Hide
C17H22ClN3O  1
1
GI50 < 10 nM
   TI
   LI
   LO
   TS
CP0432230
N-(2,3-dihydro-1-benzofuran-5-yl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C17H17N3O2  2
1
GI50 = 14 nM
   TI
   LI
   LO
   TS
2
IC50 = 96.2 nM
   TI
   LI
   LO
   TS
CP0447221
N-(4-methoxyphenyl)-2,6-dimethyl-N-propan-2-ylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C18H21N3O2  1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0492215
N-benzyl-4-[(2,5-dihydroxyphenyl)methylamino]benzamide
   Show/Hide
C21H20N2O3  1
1
GI50 = 12000 nM
   TI
   LI
   LO
   TS
CP0492803
N-[3-[2-[4-amino-1-[(2S)-3-hydroxy-2-methylpropyl]pyrazolo[3,4-d]pyrimidin-3-yl]ethynyl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C26H23F3N6O2  1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0504741
N-(4-ethoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C17H19N3O2  1
1
IC50 = 13.4 nM
   TI
   LI
   LO
   TS
CP0510836
N-(4-methoxyphenyl)-2,6-dimethyl-N-propylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C18H21N3O2  1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0516902
N-(5-methoxynaphthalen-2-yl)-N,2-dimethylquinazolin-4-amine
   Show/Hide
C21H19N3O  1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0526577
N-ethyl-N-(4-methoxyphenyl)-2,6-dimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
C17H19N3O2  1
1
IC50 = 136.6 nM
   TI
   LI
   LO
   TS
CP0563709
US10266537, Compound 31
   Show/Hide
C28H26F3N7O  1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0858674
N-(4-Methoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine hydrochloride
   Show/Hide
C16H18ClN3O2  2
1
IC50 = 47 nM
   TI
   LI
   LO
   TS
2
IC50 = 53 nM
   TI
   LI
   LO
   TS
CP0897293
1-(7-Benzyl-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline hydrochloride
   Show/Hide
C24H25ClN4O  1
1
GI50 = 341 nM
   TI
   LI
   LO
   TS
CP0906523
7-Benzyl-N-(4-methoxyphenyl)-N,2,5-trimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride
   Show/Hide
C23H25ClN4O  1
1
GI50 = 21.4 nM
   TI
   LI
   LO
   TS
CP0911977
N-(4-Methoxyphenyl)-N,2-dimethyl-6,7-dihydro-5H-cyclopenta-[d]pyrimidin-4-aminium Chloride
   Show/Hide
C16H20ClN3O  1
1
GI50 < 10 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Hypodermis)
Cell Line Name Organism Disease
MDA435/LCC6MDR1 Homo sapiens (Human) Amelanotic melanoma
M14 Homo sapiens (Human) Amelanotic melanoma
ChaGo-K-1 Homo sapiens (Human) Bronchogenic carcinoma
NCI-H125 Homo sapiens (Human) Lung adenosquamous carcinoma
HT-144 Homo sapiens (Human) Melanoma