| Compound ID |
Compound Name |
Compound Formula |
|
CP0053887
|
4-[(3S,3aS,4S)-4-hydroxy-3-methoxy-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl]-2-chloro-3-methylbenzonitrile
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C15H16ClN3O2
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
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CP0902637
|
4-[(1S,2S,6R,7R)-9-(3-Methanesulfonyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
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|
C25H22F3N3O5S
|
1
|
| 1 |
IC50 = 7.4 nM
|
|
|
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CP0906735
|
3-[(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-9-yl]-benzamide
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|
C25H21F3N4O4
|
1
|
| 1 |
IC50 = 7.4 nM
|
|
|
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CP0844856
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid propyl ester
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|
C22H22F3N3O5
|
1
|
| 1 |
IC50 = 9.3 nM
|
|
|
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CP0844858
|
4-[(1S,2S,6R,7R)-9-(6-Chloro-pyrimidin-4-yl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
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|
C22H17ClF3N5O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0844851
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid isopropyl ester
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|
C22H22F3N3O5
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0871744
|
4-((1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-9-propyl-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C21H22F3N3O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
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CP0902636
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid phenylamide
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|
C25H21F3N4O4
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0867205
|
4-((1S,2S,6R,7R)-9-Methoxy-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C19H18F3N3O4
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0859770
|
4-((1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-9-pyrimidin-2-yl-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C22H18F3N5O3
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0904024
|
4-((1S,2S,6R,7R)-9-Isopropyl-1,7-dimethyl-3,5,8,10-tetraoxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C21H18F3N3O5
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0860897
|
3-[(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-9-yl]-benzenesulfonamide
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|
C24H21F3N4O5S
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0859768
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid(4-fluoro-phenyl)-amide
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|
C25H20F4N4O4
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0845618
|
4-[(1S,2S,6R,7R)-9-(4-Fluoro-benzenesulfonyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
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|
C24H19F4N3O5S
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
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CP0914809
|
4-((1S,2S,6R,7R)-9-Benzoyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C25H20F3N3O4
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
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CP0844848
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid ethyl ester
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|
C21H20F3N3O5
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
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CP0859765
|
4-((1S,2S,6R,7R)-9-Cyclopropanecarbonyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C22H20F3N3O4
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0913170
|
4-((1S,2S,6R,7R)-9-Ethanesulfonyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C20H20F3N3O5S
|
1
|
| 1 |
IC50 = 85 nM
|
|
|
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CP0916497
|
4-[(1R,2R,6S,7S)-3,5-dioxo-9-(phenylsulfonyl)-11-oxa-4,9-diazatricyclo[5.3.1.0 2,6]undec-4-yl]-2-(trifluoromethyl)benzonitrile
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|
C24H20F3N3O5S
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0859766
|
4-((1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C18H16F3N3O3
|
1
|
| 1 |
IC50 = 128 nM
|
|
|
|
CP0902635
|
4-[(1R,2R,6S,7S)-3,5-dioxo-9-propionyl-11-oxa-4,9-diazatricyclo[5.3.1.02,6]undec-4-yl]-2-(trifluoromethyl)benzonitrile
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|
C21H20F3N3O4
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
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CP0844849
|
4-[(1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-9-(pyridine-2-sulfonyl)-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
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|
C23H19F3N4O5S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0146696
|
Bicalutamide
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|
C18H14F4N2O4S
|
1
|
| 1 |
IC50 = 173 nM
|
|
|
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CP0906734
|
4-((1S,2S,6R,7R)-9-Hydroxy-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C18H16F3N3O4
|
1
|
| 1 |
IC50 = 182 nM
|
|
|
|
CP0860898
|
4-((1S,2S,6R,7R)-9-Methanesulfonyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C19H18F3N3O5S
|
1
|
| 1 |
IC50 = 205 nM
|
|
|
|
CP0844854
|
4-((1S,2S,6R,7R)-9-Isobutyryl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C22H22F3N3O4
|
1
|
| 1 |
IC50 = 215 nM
|
|
|
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CP0860896
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid ethylamide
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|
C21H21F3N4O4
|
1
|
| 1 |
IC50 = 313 nM
|
|
|
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CP0859767
|
4-((1S,2S,6R,7R)-9-Cyclopropylmethyl-1,7-dimethyl-3,5,8,10-tetraoxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C22H18F3N3O5
|
1
|
| 1 |
IC50 = 873 nM
|
|
|
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CP0858358
|
(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid isopropylamide
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|
C22H23F3N4O4
|
1
|
| 1 |
IC50 = 876 nM
|
|
|
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CP0844850
|
2-Trifluoromethyl-4-((1S,2S,6R,7R)-1,7,9-trimethyl-3,5,8,10-tetraoxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-benzonitrile
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|
C19H14F3N3O5
|
1
|
| 1 |
IC50 = 2144 nM
|
|
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CP0859764
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4-((1S,2S,6R,7R)-9-Isopropyl-1,7-dimethyl-3,5,8,10-tetraoxo-9-oxy-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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|
C21H18F3N3O6
|
1
|
| 1 |
IC50 = 3900 nM
|
|
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