General Information of the Protein
Protein ID
PT06068
Protein Name
Tumor necrosis factor ligand superfamily member 10
Secondarily
Protein Name
Apo-2 ligand
TNF-related apoptosis-inducing ligand
Gene Name
TNFSF10
Secondarily
Gene Name
APO2L
TRAIL
Sequence
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
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Organism
Homo sapiens, Human
Protein Classification
Secreted protein
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
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Uniprot ID
Primary ID:
P50591

Secondarily ID:
A1Y9B3
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Ensembl ID
ENSG00000121858
HGNC ID
HGNC:11925
Subcellular Location
Cell membrane
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000112 , MDA-MB-435
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0439199
 Compound Info 
2-(dichloromethyl)-4-(methylthio)-6-(4-nitrophenyl)-1,3,5-triazine
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C11H8Cl2N4O2S
  1
1
IC50 = 806 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0395081
 Compound Info 
2-(methylthio)-4-phenyl-6-propan-2-yl-1,3,5-triazine
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C13H15N3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0395082
 Compound Info 
2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-1-pyrrolidin-1-yl-propan-1-one
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C18H18F3N3OS
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0402427
 Compound Info 
4-methoxy-6-phenyl-1H-pyrimidine-2-thione
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C11H10N2OS
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0425353
 Compound Info 
MLS-0390927.0001
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C18H15N3O2S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0439232
 Compound Info 
2-(4-chlorophenyl)-4-(ethylthio)-6-(1-pyrrolidinyl)pyrimidine
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C16H18ClN3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0496287
 Compound Info 
2-(methylthio)-4,6-diphenyl-1,3,5-triazine
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C16H13N3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0498877
 Compound Info 
2-(ethylthio)-6-phenyl-1H-pyrimidin-4-one
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C12H12N2OS
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000590 , PPC-1
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( TNF related apoptosis inducing ligand (TNFSF10) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Metastatic colorectal cancer [ICD-11: 2B91]
Discontinued Drug(s) 1 Discontinued Drug  1
1 Nimesulide
 Drug Info 
Terminated
Metastatic colorectal cancer