Protein Information

General Information of the Protein

Protein ID	PT01534
Protein Name	Prostaglandin E2 receptor EP4 subtype
Secondarily Protein Name	Prostanoid EP4 receptor
Gene Name	PTGER4
Secondarily Gene Name	PTGER2
Sequence	MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Lipid-like ligand receptor (family A GPCR) > Prostanoid receptor
Function	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Show/Hide
Uniprot ID	Primary ID: P35408 Secondarily ID: Q3MJ87 Show/Hide
Ensembl ID	ENSG00000171522
HGNC ID	HGNC:9596
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0387603 Compound Info	2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22N2O4S2	1
1	EC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0200701 Compound Info	7-{(R)-2-[(E)-3-(4'-Chloro-2'-methyl-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C27H32ClNO4	1
1	EC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0108468 Compound Info	(E)-7-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-hept-5-enoic acid Show/Hide	C19H31NO5	1
1	EC50 = 6.1 nM Bioactivity Info	TI LI LO TS
CP0055947 Compound Info	(15S)-prostaglandin E2 Show/Hide	C20H32O5	1
1	EC50 = 7.5 nM Bioactivity Info	TI LI LO TS
CP0189820 Compound Info	7-{(R)-2-[(E)-(S)-3-Hydroxy-4-(3-trifluoromethyl-phenyl)-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C22H28F3NO4	1
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0178463 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(4'-hydroxy-2'-methyl-biphenyl-3-yl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C27H33NO5	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0189821 Compound Info	7-{(S)-2-[(R)-3-Hydroxy-3-(4'-hydroxy-2'-methyl-biphenyl-3-yl)-propyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C27H35NO5	1
1	EC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0183758 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-4-(3-trifluoromethyl-phenyl)-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C22H28F3NO4	1
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0415590 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H29NO4S2	1
1	EC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0847317 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C22H25NO6S	1
1	EC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0049080 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(5-trifluoromethyl-furan-2-yl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C19H24F3NO5	1
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0193925 Compound Info	7-{(R)-2-[(E)-3-(2'-Chloro-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C26H30ClNO4	1
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0108373 Compound Info	7-{(R)-2-[(E)-3-(4'-Chloro-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C26H30ClNO4	1
1	EC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0144553 Compound Info	7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C19H33NO4	1
1	EC50 = 56 nM Bioactivity Info	TI LI LO TS
CP0164857 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(3-phenoxy-phenyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C26H31NO5	1
1	EC50 = 85 nM Bioactivity Info	TI LI LO TS
CP0415587 Compound Info	2-[2-[(1R,2R)-2-[(E)-4-hydroxy-4-methylnon-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H31NO4S2	1
1	EC50 = 91 nM Bioactivity Info	TI LI LO TS
CP0203647 Compound Info	7-[(R)-2-((E)-(S)-4-Cyclohexyl-3-hydroxy-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C21H35NO4	1
1	EC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0450782 Compound Info	2-[2-[(1R,5R)-2-oxo-5-[(E,4S)-7,7,7-trifluoro-4-hydroxy-4-methylhept-1-enyl]cyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H24F3NO4S2	1
1	EC50 = 127 nM Bioactivity Info	TI LI LO TS
CP0097984 Compound Info	7-{(S)-2-[(R)-3-Hydroxy-3-(3-trifluoromethyl-phenyl)-propyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C21H28F3NO4	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0257412 Compound Info	7-[(R)-2-((E)-3-Hydroxy-4-phenyl-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C21H29NO4	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0523517 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-4-hydroxy-4-methylnon-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H31NO4S2	1
1	EC50 = 146 nM Bioactivity Info	TI LI LO TS
CP0189604 Compound Info	7-{(R)-2-[(E)-3-(3'-Chloro-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C26H30ClNO4	1
1	EC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0084755 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C23H31NO4	1
1	EC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0186519 Compound Info	7-[(R)-2-((E)-(S)-4-Cyclobutyl-3-hydroxy-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C19H31NO4	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0182637 Compound Info	2-[2-[(4S)-4-[(E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxyprop-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H27FN2O5S2	1
1	EC50 = 339 nM Bioactivity Info	TI LI LO TS
CP0214479 Compound Info	7-[(R)-2-((E)-3-Biphenyl-3-yl-3-hydroxy-propenyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C26H31NO4	1
1	EC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0039941 Compound Info	7-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)heptanoic acid Show/Hide	C22H30F3NO4	1
1	EC50 = 460 nM Bioactivity Info	TI LI LO TS
CP0041448 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(3-trifluoromethyl-phenyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C21H26F3NO4	1
1	EC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0415589 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-8-fluoro-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H28FNO4S2	1
1	EC50 = 578 nM Bioactivity Info	TI LI LO TS
CP0862926 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-4-phenoxy-1-buten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C22H25NO5S	1
1	EC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0396047 Compound Info	2-[2-[(1R,2R)-2-[(E,4R)-4-hydroxy-4-methylnon-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H31NO4S2	1
1	EC50 = 2540 nM Bioactivity Info	TI LI LO TS
CP0415586 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-5-cyclopentyl-4-hydroxy-4-methylpent-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H31NO4S2	1
1	EC50 = 2636 nM Bioactivity Info	TI LI LO TS
CP0482357 Compound Info	2-[2-[(4S)-4-[(E)-4-hydroxy-4-methylnon-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H28N2O5S2	1
1	EC50 = 3380 nM Bioactivity Info	TI LI LO TS
CP0858586 Compound Info	4-((2S,4aR,5R,6R,7aS)-6-hydroxy-5-((R,E)-3-hydroxy-4-phenoxybut-1-enyl)octahydrocyclopenta[b]pyran-2-yl)butanoic acid Show/Hide	C22H30O6	1
1	EC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0429273 Compound Info	7-[(R)-2-((E)-(R)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C19H33NO4	1
1	EC50 = 6100 nM Bioactivity Info	TI LI LO TS
CP0114360 Compound Info	7-{(S)-2-Oxo-5-[3-oxo-3-(3-trifluoromethyl-phenyl)-propyl]-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C21H26F3NO4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0183258 Compound Info	7-[(R)-2-((E)-3-Hydroxy-3-phenyl-propenyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C20H27NO4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0391092 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-oxazole-4-carboxylic acid Show/Hide	C20H22ClNO6	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0391098 Compound Info	4-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]thiophene-2-carboxylic acid Show/Hide	C21H23ClO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0401698 Compound Info	2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-methoxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H24ClNO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0401699 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22ClNO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0401700 Compound Info	2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22ClNO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0401702 Compound Info	2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-fluoro-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H21ClFNO4S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0407410 Compound Info	4-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]furan-2-carboxylic acid Show/Hide	C21H23ClO6	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0434444 Compound Info	5-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]furan-2-carboxylic acid Show/Hide	C21H23ClO6	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0380278 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-(phenoxymethyl)-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H21NO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0847318 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-3-phenoxy-1-propen-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C21H23NO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0847320 Compound Info	2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-(2-phenoxyethyl)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H23NO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0847322 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-5-phenoxy-1-penten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C23H27NO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0870958 Compound Info	2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-(3-phenoxypropyl)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H25NO5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0407876 Compound Info	2-[2-[(4S,5S)-4-[(E)-5-cyclohexyl-4-hydroxy-4-methylpent-1-enyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H32N2O5S2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0407877 Compound Info	2-[2-[(1R,2R)-2-[(E,4R)-5-cyclopentyl-4-hydroxy-4-methylpent-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H31NO4S2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0407879 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-4-hydroxy-4,7,7-trimethyloct-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H33NO4S2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0415588 Compound Info	2-[2-[(4S)-4-[(E)-5-cyclohexyl-4-hydroxy-4-methylpent-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H30N2O5S2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0309929 Compound Info	7-[(R)-2-((E)-3-Biphenyl-2-yl-3-hydroxy-propenyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C26H31NO4	1
1	EC50 = 42000 nM Bioactivity Info	TI LI LO TS
CP0451221 Compound Info	7-[(S)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C19H33NO4	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0438577 Compound Info	4-[(1S)-1-[[5-phenyl-3-[2-[3-(trifluoromethyl)phenoxy]ethyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C27H23F3N4O4	1
1	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0569215 Compound Info	4-[[[2-[(4-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]methyl]benzoic acid Show/Hide	C23H20FNO4S	1
1	IC50 = 2.7 nM Bioactivity Info	TI LI LO TS
CP0477511 Compound Info	4-[(1S)-1-[[3-[2-(4-fluorophenoxy)ethyl]-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H23FN4O4	1
1	IC50 = 3.1 nM Bioactivity Info	TI LI LO TS
CP0473341 Compound Info	4-[(1S)-1-[[5-(5-methylthiophen-2-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H21F3N4O3S	1
1	IC50 = 4.6 nM Bioactivity Info	TI LI LO TS
CP0473344 Compound Info	4-[(1S)-1-[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H21F3N4O3	1
1	IC50 = 6.1 nM Bioactivity Info	TI LI LO TS
CP0435681 Compound Info	US8686018, 107 Show/Hide	C22H18F5N3O4	1
1	IC50 = 7.5 nM Bioactivity Info	TI LI LO TS
CP0427396 Compound Info	4-[(1S)-1-[[5-phenyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H21F3N4O3	1
1	IC50 = 8.5 nM Bioactivity Info	TI LI LO TS
CP0477478 Compound Info	4-[(1S)-1-[[3-[(4-methoxyphenyl)methyl]-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H24N4O4	1
1	IC50 = 9.3 nM Bioactivity Info	TI LI LO TS
CP0423189 Compound Info	4-[[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]methyl]benzoic acid Show/Hide	C22H19F3N4O3	1
1	IC50 = 10.5 nM Bioactivity Info	TI LI LO TS
CP0473342 Compound Info	4-[(1S)-1-[[5-thiophen-3-yl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C24H19F3N4O3S	1
1	IC50 = 12.9 nM Bioactivity Info	TI LI LO TS
CP0533199 Compound Info	4-[[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]methyl]cyclohexane-1-carboxylic acid Show/Hide	C22H25F3N4O3	1
1	IC50 = 13.9 nM Bioactivity Info	TI LI LO TS
CP0533261 Compound Info	4-[1-[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]cyclopropyl]benzoic acid Show/Hide	C24H21F3N4O3	1
1	IC50 = 13.9 nM Bioactivity Info	TI LI LO TS
CP0435682 Compound Info	4-[(1S)-1-[[5-phenyl-3-[[3-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H21F3N4O3	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0427397 Compound Info	4-[(1S)-1-[[5-(cyclopenten-1-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H23F3N4O3	1
1	IC50 = 27.9 nM Bioactivity Info	TI LI LO TS
CP0438578 Compound Info	4-[(1S)-1-[[3-[(3-fluoro-4-methoxyphenyl)methyl]-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H23FN4O4	1
1	IC50 = 29.8 nM Bioactivity Info	TI LI LO TS
CP0477510 Compound Info	4-[(1S)-1-[[5-prop-1-ynyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H19F3N4O3	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0438580 Compound Info	4-[(1S)-1-[[5-(furan-3-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C24H19F3N4O4	1
1	IC50 = 45.6 nM Bioactivity Info	TI LI LO TS
CP0533271 Compound Info	4-[(1S)-1-[[5-phenyl-3-[2-[4-(trifluoromethyl)phenoxy]ethyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C27H23F3N4O4	1
1	IC50 = 49.1 nM Bioactivity Info	TI LI LO TS
CP0477507 Compound Info	4-[(1S)-1-[[5-cyclopropyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H21F3N4O3	1
1	IC50 = 52.1 nM Bioactivity Info	TI LI LO TS
CP0567498 Compound Info	4-[(1S)-1-[[5-(4-fluorophenyl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H20F4N4O3	1
1	IC50 = 57.9 nM Bioactivity Info	TI LI LO TS
CP0538484 Compound Info	4-[(1S)-1-[[5-cyclopentyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H25F3N4O3	1
1	IC50 = 65.1 nM Bioactivity Info	TI LI LO TS
CP0562867 Compound Info	4-[(1S)-1-[[5-propyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H23F3N4O3	1
1	IC50 = 68.8 nM Bioactivity Info	TI LI LO TS
CP0435683 Compound Info	4-[(1S)-1-[[5-cyclobutyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C24H23F3N4O3	1
1	IC50 = 75.3 nM Bioactivity Info	TI LI LO TS
CP0520122 Compound Info	4-[(1S)-1-[[3-[(3-methoxyphenyl)methyl]-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H24N4O4	1
1	IC50 = 96.8 nM Bioactivity Info	TI LI LO TS
CP0477508 Compound Info	4-[(1S)-1-[[5-(3,6-dihydro-2H-pyran-4-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H23F3N4O4	1
1	IC50 = 118.8 nM Bioactivity Info	TI LI LO TS
CP0543972 Compound Info	4-[(1S)-1-[[3-[(3,4-dimethoxyphenyl)methyl]-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C27H26N4O5	1
1	IC50 = 119.4 nM Bioactivity Info	TI LI LO TS
CP0438576 Compound Info	4-[(1S)-1-[[3-[(3,4-difluorophenyl)methyl]-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H20F2N4O3	1
1	IC50 = 147.5 nM Bioactivity Info	TI LI LO TS
CP0493958 Compound Info	4-[(1S)-1-[[5-cyclohexyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H27F3N4O3	1
1	IC50 = 161.3 nM Bioactivity Info	TI LI LO TS
CP0435684 Compound Info	4-[(1S)-1-[[5-(cyclohexen-1-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H25F3N4O3	1
1	IC50 = 183 nM Bioactivity Info	TI LI LO TS
CP0435680 Compound Info	4-[(1S)-1-[[5-(trifluoromethyl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H16F6N4O3	1
1	IC50 = 224.8 nM Bioactivity Info	TI LI LO TS
CP0455821 Compound Info	4-[(1S)-1-[[3-[2-(4-fluorophenoxy)ethyl]-5-(trifluoromethyl)triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H18F4N4O4	1
1	IC50 = 275.5 nM Bioactivity Info	TI LI LO TS
CP0534118 Compound Info	4-[(1S)-1-[[3-[(4-fluorophenyl)methyl]-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H21FN4O3	1
1	IC50 = 330.2 nM Bioactivity Info	TI LI LO TS
CP0477482 Compound Info	4-[(1S)-1-[(3-benzyl-5-phenyltriazole-4-carbonyl)amino]ethyl]benzoic acid Show/Hide	C25H22N4O3	1
1	IC50 = 646.6 nM Bioactivity Info	TI LI LO TS
CP0475475 Compound Info	4-[(1S)-1-[[5-(trifluoromethyl)-3-[[3-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H16F6N4O3	1
1	IC50 = 1970 nM Bioactivity Info	TI LI LO TS
CP0567499 Compound Info	4-[(1S)-1-[[3-[(4-fluorophenyl)methyl]-5-(trifluoromethyl)triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C20H16F4N4O3	1
1	IC50 = 2315.7 nM Bioactivity Info	TI LI LO TS
CP0095751 Compound Info	(5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid Show/Hide	C20H34O5	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0295469 Compound Info	(Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl}-hept-5-enoic acid Show/Hide	C22H29ClO6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0372737 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-m-tolylsulfanyl-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C23H36O5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0374214 Compound Info	7-{2-[4-(3-Chloro-phenylsulfanyl)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid Show/Hide	C22H33ClO5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0377752 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenylamino-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C22H35NO5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0395236 Compound Info	7-{2-[4-(3-Fluoro-phenylsulfanyl)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid Show/Hide	C22H33FO5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0402541 Compound Info	7-{(1R,2R,3R,5S)-2-[(R)-4-(3-Chloro-phenoxy)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid Show/Hide	C22H33ClO6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0402565 Compound Info	7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-5-phenyl-pentyl)-cyclopentyl]-heptanoic acid Show/Hide	C23H36O5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0432809 Compound Info	7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((S)-3-hydroxy-octyl)-cyclopentyl]-heptanoic acid Show/Hide	C20H38O5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0432810 Compound Info	7-{3,5-Dihydroxy-2-[3-hydroxy-4-(thiazol-2-ylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid Show/Hide	C19H31NO5S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0433187 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenylsulfanyl-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C22H34O5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0438269 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenoxy-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C22H34O6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0445340 Compound Info	7-{3,5-Dihydroxy-2-[3-hydroxy-4-(thiophen-2-ylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid Show/Hide	C20H32O5S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0448266 Compound Info	7-{3,5-Dihydroxy-2-[3-hydroxy-4-(3-trifluoromethyl-phenylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid Show/Hide	C23H33F3O5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0427395 Compound Info	4-[(1S)-1-[[3-(cyclohexylmethyl)-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H28N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0438574 Compound Info	4-[(1S)-1-[[5-methyl-1-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H19F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0477476 Compound Info	4-[(1S)-1-[[5-(trifluoromethyl)-1-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H16F6N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0477477 Compound Info	4-[(1S)-1-[[5-ethyl-1-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C22H21F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0477479 Compound Info	4-[(1S)-1-[[5-(trifluoromethyl)-1-[[3-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H16F6N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0477480 Compound Info	4-[(1S)-1-[[5-phenyl-1-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H21F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0477481 Compound Info	4-[(1S)-1-[[3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C20H17F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0493957 Compound Info	4-[(1S)-1-[[3-[2-(4-fluorophenyl)ethyl]-5-(trifluoromethyl)triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H18F4N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0533200 Compound Info	4-[(1S)-1-[[1-[2-(4-fluorophenoxy)ethyl]-5-(trifluoromethyl)triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H18F4N4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0533260 Compound Info	4-[(1S)-1-[[3-(oxan-4-ylmethyl)-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C24H26N4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0533578 Compound Info	4-[(1S)-1-[[5-methyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H19F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0534117 Compound Info	4-[(1S)-1-[[5-propyl-1-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H23F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0538483 Compound Info	4-[(1S)-1-[[5-ethyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C22H21F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0538485 Compound Info	4-[(1S)-1-[[1-[(4-fluorophenyl)methyl]-5-(trifluoromethyl)triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C20H16F4N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0538486 Compound Info	4-[(1S)-1-[[1-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C20H17F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0561571 Compound Info	4-[(1S)-1-[[1-[2-(4-fluorophenyl)ethyl]-5-(trifluoromethyl)triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C21H18F4N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0383448 Compound Info	5-[2-[5-chloro-2-[(4-fluorophenyl)methoxy]phenyl]-5-methylpyrrol-1-yl]-2-methylbenzoic acid Show/Hide	C26H21ClFNO3	3
1	IC50 = 15848.93 nM Bioactivity Info	TI LI LO TS
2	Ki = 6309.57 nM Bioactivity Info	TI LI LO TS
3	Ki = 7943.28 nM Bioactivity Info	TI LI LO TS
CP0438579 Compound Info	4-[(1R)-1-[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H21F3N4O3	1
1	IC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0477509 Compound Info	4-[(1S)-1-[[5-prop-2-enyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H21F3N4O3	1
1	IC50 > 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000064 , Chem-1

Cell Line Info

Cell Line ID: CL000076 , CHO/Galpha16

Cell Line Info

Cell Line ID: CL000516 , ECV-304

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000314 , HEK293T/17

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0182637 Compound Info	2-[2-[(4S)-4-[(E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxyprop-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H27FN2O5S2	1
1	EC50 = 195 nM
CP0055947 Compound Info	(15S)-prostaglandin E2 Show/Hide	C20H32O5	7
1	IC50 = 0.45 nM
2	IC50 = 3.8 nM
3	IC50 = 9.9 nM
4	Ki = 0.17 nM
5	Ki = 0.79 nM
6	Ki = 1.9 nM
7	Ki = 3.1 nM
CP0718063 Compound Info	(2R)-2-((S)-1-(4-carboxyphenyl)ethylcarbamoyl)-1-(2-(4-fluorophenoxy)ethyl)piperidinium chloride Show/Hide	C23H28ClFN2O4	1
1	IC50 = 121 nM
CP0663915 Compound Info	4-((S)-1-((R)-1-(2-phenoxyethyl)piperidine-2-carboxamido)ethyl)benzoic acid hydrochloride Show/Hide	C23H29ClN2O4	2
1	IC50 = 123 nM
2	IC50 = 126 nM
CP0852327 Compound Info	(2R)-2-((S)-1-(4-carboxyphenyl)propylcarbamoyl)-1-(2-phenoxyethyl)piperidinium chloride Show/Hide	C24H31ClN2O4	1
1	IC50 = 291 nM
CP0801377 Compound Info	(2R)-2-(1-(4-carboxyphenyl)cyclopropylcarbamoyl)-1-(2-phenoxyethyl)piperidinium chloride Show/Hide	C24H29ClN2O4	1
1	IC50 = 586 nM
CP0719709 Compound Info	(2R)-2-(4-carboxybenzylcarbamoyl)-1-(2-phenoxyethyl)piperidinium chloride Show/Hide	C22H27ClN2O4	1
1	IC50 = 899 nM
CP0801376 Compound Info	(2R)-2-((S)-1-(4-carboxyphenyl)ethylcarbamoyl)-1-(2-(4-cyanophenoxy)ethyl)piperidinium chloride Show/Hide	C24H28ClN3O4	1
1	IC50 = 1209 nM
CP0065814 Compound Info	AAT-007 Show/Hide	C26H29N5O3S	2
1	IC50 = 1614 nM
2	Ki = 448 nM
CP0095751 Compound Info	(5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid Show/Hide	C20H34O5	1
1	IC50 = 4200 nM
CP0070143 Compound Info	2-(2-benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acid Show/Hide	C20H18N2O3	1
1	IC50 > 10000 nM
CP0117207 Compound Info	3-(4-(2-(2-(2-methoxyphenyl)acetamido)ethyl)phenyl)-N,N,5,7-tetramethylbenzo[b]thiophene-2-carboxamide Show/Hide	C30H32N2O3S	3
1	Ki = 0.2 nM
2	Ki = 3.4 nM
3	Ki = 17 nM
CP0035303 Compound Info	N,N,5,7-tetramethyl-3-[4-[2-[(4-methylphenyl)sulfonylcarbamoylamino]ethyl]phenyl]-1-benzothiophene-2-carboxamide Show/Hide	C29H31N3O4S2	3
1	Ki = 0.54 nM
2	Ki = 1.4 nM
3	Ki = 2.6 nM
CP0108468 Compound Info	(E)-7-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-hept-5-enoic acid Show/Hide	C19H31NO5	1
1	Ki = 0.8 nM
CP0080235 Compound Info	4-(2-((R)-2-((S)-3-hydroxyhept-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoate Show/Hide	C20H27NO4	1
1	Ki = 1 nM
CP0189820 Compound Info	7-{(R)-2-[(E)-(S)-3-Hydroxy-4-(3-trifluoromethyl-phenyl)-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C22H28F3NO4	1
1	Ki = 1.6 nM
CP0198309 Compound Info	3-[[3-[3-(hydroxymethyl)phenyl]naphthalene-1-carbonyl]amino]-2,4-dimethylbenzoic acid Show/Hide	C27H23NO4	1
1	Ki = 1.98 nM
CP0200701 Compound Info	7-{(R)-2-[(E)-3-(4'-Chloro-2'-methyl-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C27H32ClNO4	1
1	Ki = 3.1 nM
CP0048416 Compound Info	3-[[3-(3-chlorophenyl)naphthalene-1-carbonyl]amino]-2,4-dimethylbenzoic acid Show/Hide	C26H20ClNO3	1
1	Ki = 3.49 nM
CP0048414 Compound Info	4-[[3-[3-(hydroxymethyl)phenyl]naphthalene-1-carbonyl]amino]-3,5-dimethylbenzoic acid Show/Hide	C27H23NO4	1
1	Ki = 3.54 nM
CP0186519 Compound Info	7-[(R)-2-((E)-(S)-4-Cyclobutyl-3-hydroxy-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C19H31NO4	1
1	Ki = 4.2 nM
CP0144553 Compound Info	7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C19H33NO4	1
1	Ki = 4.5 nM
CP0178463 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(4'-hydroxy-2'-methyl-biphenyl-3-yl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C27H33NO5	1
1	Ki = 4.9 nM
CP0257412 Compound Info	7-[(R)-2-((E)-3-Hydroxy-4-phenyl-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C21H29NO4	1
1	Ki = 6.1 nM
CP0193925 Compound Info	7-{(R)-2-[(E)-3-(2'-Chloro-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C26H30ClNO4	1
1	Ki = 6.2 nM
CP0233548 Compound Info	2,4-dimethyl-3-[(3-phenylnaphthalene-1-carbonyl)amino]benzoic acid Show/Hide	C26H21NO3	1
1	Ki = 6.72 nM
CP0097984 Compound Info	7-{(S)-2-[(R)-3-Hydroxy-3-(3-trifluoromethyl-phenyl)-propyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C21H28F3NO4	1
1	Ki = 7.4 nM
CP0203647 Compound Info	7-[(R)-2-((E)-(S)-4-Cyclohexyl-3-hydroxy-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C21H35NO4	1
1	Ki = 7.5 nM
CP0198225 Compound Info	3,5-dimethyl-4-[(3-phenylnaphthalene-1-carbonyl)amino]benzoic acid Show/Hide	C26H21NO3	1
1	Ki = 8.04 nM
CP0189821 Compound Info	7-{(S)-2-[(R)-3-Hydroxy-3-(4'-hydroxy-2'-methyl-biphenyl-3-yl)-propyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C27H35NO5	1
1	Ki = 8.2 nM
CP0049080 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(5-trifluoromethyl-furan-2-yl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C19H24F3NO5	1
1	Ki = 10 nM
CP0084755 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C23H31NO4	1
1	Ki = 12 nM
CP0039941 Compound Info	7-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)heptanoic acid Show/Hide	C22H30F3NO4	1
1	Ki = 16 nM
CP0198224 Compound Info	3-[[2-[3-(hydroxymethyl)phenyl]quinoline-4-carbonyl]amino]-2,4-dimethylbenzoic acid Show/Hide	C26H22N2O4	1
1	Ki = 17 nM
CP0164857 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(3-phenoxy-phenyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C26H31NO5	1
1	Ki = 32 nM
CP0572549 Compound Info	3,5-dimethyl-4-[(2-phenylquinoline-4-carbonyl)amino]benzoic acid Show/Hide	C25H20N2O3	1
1	Ki = 39.2 nM
CP0048413 Compound Info	4-[[2-[3-(hydroxymethyl)phenyl]quinoline-4-carbonyl]amino]-3,5-dimethylbenzoic acid Show/Hide	C26H22N2O4	1
1	Ki = 52.3 nM
CP0045193 Compound Info	US8933098, 1 Show/Hide	C21H25N3O4	1
1	Ki = 58 nM
CP0041448 Compound Info	7-{(R)-2-[(E)-3-Hydroxy-3-(3-trifluoromethyl-phenyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C21H26F3NO4	1
1	Ki = 140 nM
CP0214479 Compound Info	7-[(R)-2-((E)-3-Biphenyl-3-yl-3-hydroxy-propenyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C26H31NO4	1
1	Ki = 360 nM
CP0108373 Compound Info	7-{(R)-2-[(E)-3-(4'-Chloro-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C26H30ClNO4	1
1	Ki = 390 nM
CP0189604 Compound Info	7-{(R)-2-[(E)-3-(3'-Chloro-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid Show/Hide	C26H30ClNO4	1
1	Ki = 420 nM
CP0061222 Compound Info	N-(2,6-dimethylphenyl)-2-phenylquinoline-4-carboxamide Show/Hide	C24H20N2O	1
1	Ki = 512 nM
CP0179414 Compound Info	3-(2-((E)-3-(4-(benzyloxy)-3-methoxyphenyl)prop-1-enyl)phenyl)-N-(thiophen-2-ylsulfonyl)acrylamide Show/Hide	C30H27NO5S2	1
1	Ki = 840 nM
CP0277044 Compound Info	(E)-3-{2-[(E)-3-(2-Benzyloxy-3-methyl-phenyl)-allyl]-phenyl}-acrylic acid Show/Hide	C26H24O3	1
1	Ki = 1900 nM
CP0183258 Compound Info	7-[(R)-2-((E)-3-Hydroxy-3-phenyl-propenyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C20H27NO4	1
1	Ki = 2300 nM
CP0160939 Compound Info	(E)-3-[2-(3,4-dichlorophenyl)phenyl]-N-thiophen-2-ylsulfonylprop-2-enamide Show/Hide	C19H13Cl2NO3S2	1
1	Ki = 3700 nM
CP0041889 Compound Info	2-((R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid Show/Hide	C23H24ClNO5S	1
1	Ki > 2900 nM
CP0058712 Compound Info	N-[5-(2,6-dichlorophenyl)-1,3,4-thiadiazol-2-yl]-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamide Show/Hide	C19H16Cl2N4O2S	1
1	Ki > 10000 nM
CP0413856 Compound Info	4-[4-[(2,6-dimethylphenyl)carbamoyl]quinolin-2-yl]benzoic acid Show/Hide	C25H20N2O3	1
1	Ki > 19200 nM
CP0108218 Compound Info	(R)-2-(4-(4-chlorobenzyl)-5-acetyl-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid Show/Hide	C23H22ClNO5S	1
1	Ki > 20000 nM

Clinical Information about the Protein

Target 1 ( Prostaglandin E2 receptor EP4 (PTGER4) )

Target Type	Clinical trial Target
Disease	8 Target-related Diseases				8
1	Stem cell engraftment [ICD-11: QB63.8]
2	Migraine [ICD-11: 8A80]
3	Asthma [ICD-11: CA23]
4	Pain [ICD-11: MG30-MG3Z]
5	Rectal adenocarcinoma [ICD-11: 2B92]
6	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
7	Fracture [ICD-11: ND56]
8	Inflammation [ICD-11: 1A00-CA43.1]
Clinical Trial Drug(s)	6 Clinical Trial Drugs				6
1	16,16-dimethyl-PGE2	Drug Info	Phase 2	Stem cell engraftment
2	BGC-20-1531	Drug Info	Phase 2	Migraine
3	ONO-AE1-437	Drug Info	Phase 2	Asthma
4	RQ-00000007 (oral)	Drug Info	Phase 2	Pain
5	E7046	Drug Info	Phase 1	Rectal adenocarcinoma
6	PGF2alpha	Drug Info	Clinical trial	Solid tumour/cancer
Discontinued Drug(s)	1 Discontinued Drug				1
1	ONO-4819	Drug Info	Discontinued in Phase 2	Fracture
Investigative Drug(s)	2 Investigative Drugs				2
1	MK-2894	Drug Info	Investigative	Inflammation
2	RQ-00000008	Drug Info	Investigative	Inflammation

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT02346	Prostaglandin E2 receptor EP4 subtype	Mus musculus, Mouse	Protein Info
PT04548	Prostaglandin E2 receptor EP4 subtype	Rattus norvegicus, Rat	Protein Info

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About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han