General Information of the Compound
Compound ID
CP0533199
Compound Name
4-[[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]methyl]cyclohexane-1-carboxylic acid
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Structure
Formula
C22H25F3N4O3
Molecular Weight
450.461
Canonical SMILES
C\C=C\c1nnn(Cc2ccc(cc2)C(F)(F)F)c1C(=O)NCC1CCC(CC1)C(O)=O
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InChI
InChI=1S/C22H25F3N4O3/c1-2-3-18-19(20(30)26-12-14-4-8-16(9-5-14)21(31)32)29(28-27-18)13-15-6-10-17(11-7-15)22(23,24)25/h2-3,6-7,10-11,14,16H,4-5,8-9,12-13H2,1H3,(H,26,30)(H,31,32)/b3-2+
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InChIKey
VKGFOARBHNYIEL-NSCUHMNNSA-N
Physicochemical Property
logP
3.9991
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
97.11
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155555000
ChEMBL ID
CHEMBL4550862
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01534, Prostaglandin E2 receptor EP4 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 13.9 nM
   TI
   LI
   LO
   TS
Protein ID: PT02346, Prostaglandin E2 receptor EP4 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 219.7 nM
   TI
   LI
   LO
   TS