General Information of the Protein
Protein ID
PT04548
Protein Name
Prostaglandin E2 receptor EP4 subtype
Secondarily
Protein Name
Prostanoid EP4 receptor
Gene Name
PTGER4
Sequence
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Prostanoid receptor
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
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Uniprot ID
Primary ID:
P43114

Secondarily ID:
O08728
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Ensembl ID
ENSG00000171522
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0410312
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(pyridin-2-ylmethoxy)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C26H32N2O5S
  1
1
EC50 = 0.61 nM
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CP0387595
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-(3-methylphenyl)but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C21H24N2O4S2
  1
1
EC50 = 0.79 nM
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CP0395230
 Compound Info 
4-[2-[(1R,2R)-2-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]butanoic acid
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C23H32O5S
  1
1
EC50 = 1.1 nM
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CP0395226
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C22H31NO5S
  1
1
EC50 = 1.3 nM
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CP0224474
 Compound Info 
4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxy-4-(3-(methoxymethyl)phenyl)but-1-enyl)-5-oxocyclopentyl)ethylthio)butanoic acid
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C23H32O6S
  1
1
EC50 = 1.4 nM
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CP0378129
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C28H27N3O5S2
  1
1
EC50 = 1.6 nM
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CP0401107
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-4-(3-ethylphenyl)-3-hydroxybut-1-enyl]-2-oxo-1,3-thiazolidin-3-yl]ethylsulfanyl]butanoic acid
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C21H29NO4S2
  1
1
EC50 = 1.9 nM
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CP0378148
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-4-[3-(1,3-benzoxazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C27H25N3O5S2
  1
1
EC50 = 2.2 nM
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CP0431080
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-2-oxo-1,3-thiazolidin-3-yl]ethylsulfanyl]butanoic acid
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C21H29NO5S2
  1
1
EC50 = 2.4 nM
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CP0410231
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-4-[3-(1,3-benzothiazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C27H30N2O4S2
  1
1
EC50 = 3.2 nM
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CP0388033
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]but-1-enyl]-2-oxo-1,3-thiazolidin-3-yl]ethylsulfanyl]butanoic acid
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C20H24F3NO4S2
  1
1
EC50 = 4.3 nM
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CP0388032
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-phenylbut-1-enyl]-2-oxo-1,3-thiazolidin-3-yl]ethylsulfanyl]butanoic acid
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C19H25NO4S2
  1
1
EC50 = 4.8 nM
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CP0410311
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-4-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C27H24ClN3O5S2
  1
1
EC50 = 4.9 nM
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CP0423877
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C28H26N2O5S2
  1
1
EC50 = 5.3 nM
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CP0427837
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-4-(3-fluorophenyl)-3-hydroxybut-1-enyl]-2-oxo-1,3-thiazolidin-3-yl]ethylsulfanyl]butanoic acid
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C19H24FNO4S2
  1
1
EC50 = 5.7 nM
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CP0378128
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-(3-methylphenyl)but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C21H29NO4S
  1
1
EC50 = 5.7 nM
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CP0431204
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-(3-propylphenyl)but-1-enyl]-2-oxo-1,3-thiazolidin-3-yl]ethylsulfanyl]butanoic acid
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C22H31NO4S2
  1
1
EC50 = 6.1 nM
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CP0480109
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C28H31NO5S
  1
1
EC50 = 7 nM
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CP0400839
 Compound Info 
7-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-5-sulfanylidenepyrrolidin-1-yl]heptanoic acid
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C23H33NO4S
  1
1
EC50 = 7.3 nM
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CP0391384
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-(3-methylphenyl)but-1-enyl]-5-sulfanylidenepyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C21H29NO3S2
  1
1
EC50 = 7.7 nM
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CP0410241
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C29H29N3O5S2
  1
1
EC50 = 7.7 nM
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CP0410233
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-(3-phenylphenyl)but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C26H26N2O4S2
  1
1
EC50 = 8 nM
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CP0410240
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C28H27N3O5S2
  1
1
EC50 = 8.8 nM
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CP0391383
 Compound Info 
7-[(2R)-2-[(E,3S)-4-(3-ethylphenyl)-3-hydroxybut-1-enyl]-5-sulfanylidenepyrrolidin-1-yl]heptanoic acid
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C23H33NO3S
  1
1
EC50 = 9.4 nM
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CP0410235
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-4-[3-(5-chloro-1,3-benzothiazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C27H24ClN3O4S3
  1
1
EC50 = 9.7 nM
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CP0400838
 Compound Info 
7-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]but-1-enyl]-5-sulfanylidenepyrrolidin-1-yl]heptanoic acid
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C22H28F3NO3S
  1
1
EC50 = 10 nM
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CP0395231
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]but-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C20H24F3NO5S
  1
1
EC50 = 12 nM
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CP0410237
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-4-[3-(1,3-benzothiazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C27H25N3O4S3
  1
1
EC50 = 13 nM
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CP0432929
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-4-[3-(1,3-benzoxazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C27H30N2O5S
  1
1
EC50 = 13 nM
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CP0403544
 Compound Info 
7-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]heptanoic acid
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C23H33NO5
  1
1
EC50 = 15 nM
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CP0378130
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(4-methylphenyl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C27H28N2O4S2
  1
1
EC50 = 15 nM
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CP0410234
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(4-methoxyphenyl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C27H28N2O5S2
  1
1
EC50 = 15 nM
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CP0400837
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-4-(3-ethylphenyl)-3-hydroxybut-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C21H29NO5S
  1
1
EC50 = 18 nM
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CP0423860
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(pyridin-3-ylmethoxy)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C26H32N2O5S
  1
1
EC50 = 19 nM
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CP0410239
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-4-[3-(3,4-dimethylphenyl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C28H30N2O4S2
  1
1
EC50 = 21 nM
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CP0388030
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-4-(3-chlorophenyl)-3-hydroxybut-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C19H24ClNO5S
  1
1
EC50 = 23 nM
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CP0401106
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C21H29NO6S
  1
1
EC50 = 24 nM
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CP0388031
 Compound Info 
7-[(2R)-2-[(E,3S)-4-(3-fluorophenyl)-3-hydroxybut-1-enyl]-5-sulfanylidenepyrrolidin-1-yl]heptanoic acid
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C21H28FNO3S
  1
1
EC50 = 26 nM
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CP0392256
 Compound Info 
7-[(2R)-2-[(E,3S)-3-hydroxy-4-(3-propylphenyl)but-1-enyl]-5-sulfanylidenepyrrolidin-1-yl]heptanoic acid
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C24H35NO3S
  1
1
EC50 = 27 nM
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CP0410236
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-4-[3-(4-chlorophenyl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C26H25ClN2O4S2
  1
1
EC50 = 27 nM
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CP0410238
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-4-[3-(1,3-dihydroisoindol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C28H34N2O4S
  1
1
EC50 = 28 nM
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CP0410310
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(4-methyl-1,3-benzoxazol-2-yl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C28H27N3O5S2
  1
1
EC50 = 28 nM
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CP0388034
 Compound Info 
7-[(2R)-2-[(E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-sulfanylidenepyrrolidin-1-yl]heptanoic acid
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C21H29NO3S
  1
1
EC50 = 29 nM
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CP0427503
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-(3-methylphenyl)but-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C20H27NO5S
  1
1
EC50 = 33 nM
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CP0401105
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-4-(3-fluorophenyl)-3-hydroxybut-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C19H24FNO5S
  1
1
EC50 = 35 nM
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CP0403545
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-phenylbut-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C19H25NO5S
  1
1
EC50 = 36 nM
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CP0410232
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(pyridin-4-ylmethoxy)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C26H32N2O5S
  1
1
EC50 = 46 nM
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CP0423862
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-(3-phenylphenyl)but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C26H31NO4S
  1
1
EC50 = 52 nM
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CP0416072
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(1H-indol-5-yl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C28H32N2O4S
  1
1
EC50 = 85 nM
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CP0378146
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-(3-pyridin-2-ylphenyl)but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C25H30N2O4S
  1
1
EC50 = 86 nM
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CP0388029
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-(3-propylphenyl)but-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C22H31NO5S
  1
1
EC50 = 93 nM
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CP0423859
 Compound Info 
4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-(3-naphthalen-2-ylphenyl)but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
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C30H33NO4S
  1
1
EC50 = 96 nM
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CP0400840
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-[3-(trifluoromethoxy)phenyl]but-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C20H24F3NO6S
  1
1
EC50 = 160 nM
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CP0410313
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-4-[3-(2,4-dimethylphenyl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C28H30N2O4S2
  1
1
EC50 = 160 nM
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CP0463502
 Compound Info 
4-[2-[(4S)-4-[(E,3S)-3-hydroxy-4-(3-phenylphenyl)but-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]butanoic acid
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C25H29NO5S
  1
1
EC50 = 450 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0387597
 Compound Info 
2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-(3-naphthalen-2-ylphenyl)but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
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C30H28N2O4S2
  1
1
EC50 = 480 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000065 , HEK293-EBNA
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0125740
 Compound Info 
5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylic acid
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C23H26F3NO4S
  1
1 IC50 = 6 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02346 Prostaglandin E2 receptor EP4 subtype Mus musculus, Mouse
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT01534 Prostaglandin E2 receptor EP4 subtype Homo sapiens, Human
 Protein Info