Brief Information of the Cell Line and Protein
Cell Line ID: CL000064 , Chem-1
Synonyms
ChemiSCREEN Chem-1
Wild-type control Chem-1 cell line
ChemiSCREEN Chem-1 parental cell line
Category Undefined cell line type
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_L474
Protein ID: PT01534 , Prostaglandin E2 receptor EP4 subtype
Gene Name PTGER4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P35408
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000064  Protein ID: PT01534
 
Compound ID Compound Name Compound Formula
CP0055947
(15S)-prostaglandin E2
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C20H32O5
 3
1
IC50 = 1.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 5 nM
   TI
   LI
   LO
   TS
3
Ki = 0.45 nM
   TI
   LI
   LO
   TS
CP0168917
Omidenepag
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C23H22N6O4S
 1
1
IC50 = 5480 nM
   TI
   LI
   LO
   TS
CP0440482
De-117
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C26H28N6O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0435681
US8686018, 107
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C22H18F5N3O4
 1
1
Ki = 8 nM
   TI
   LI
   LO
   TS
CP0563348
US8686018, 109
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C23H18F5N3O4
 1
1
Ki = 8 nM
   TI
   LI
   LO
   TS
CP0490566
US8686018, 110
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C22H19F4N3O5
 1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
CP0510187
US8686018, 108
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C21H16Cl2F3N3O4
 1
1
Ki = 13 nM
   TI
   LI
   LO
   TS
CP0510186
US8686018, 103
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C22H20F3N3O4
 1
1
Ki = 14 nM
   TI
   LI
   LO
   TS
CP0560304
US8686018, 105
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C23H17F6N3O4
 1
1
Ki = 16 nM
   TI
   LI
   LO
   TS
CP0479318
US8686018, 111
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C22H19F4N3O4
 1
1
Ki = 26 nM
   TI
   LI
   LO
   TS
CP0565293
US8686018, 104
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C23H20F3N3O4
 1
1
Ki = 43 nM
   TI
   LI
   LO
   TS
CP0490565
US8686018, 106
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C21H18ClF2N3O4
 1
1
Ki = 50 nM
   TI
   LI
   LO
   TS
CP0112283
APD-811
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C23H26ClNO5
 1
1
Ki = 678 nM
   TI
   LI
   LO
   TS
CP0857864
1-(2-(4-((E)-3-(2-((E)-2-Carboxyvinyl)phenyl)allyl)-2-methoxyphenoxy)ethyl)-4-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dienyl)-2,6-dimethylpyridinium boron tetrafluoride
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C40H43BF4N2O4
 1
1
Ki = 902 nM
   TI
   LI
   LO
   TS
CP0112284
CHEMBL3933704
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C23H26FNO5
 1
1
Ki = 1200 nM
   TI
   LI
   LO
   TS
CP0397467
(E)-3-[2-[(E)-3-[4-[2-(1-cyanoisoindol-2-yl)ethoxy]-3-methoxyphenyl]prop-1-enyl]phenyl]prop-2-enoic acid
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C30H26N2O4
 1
1
Ki = 3183 nM
   TI
   LI
   LO
   TS
CP0179414
3-(2-((E)-3-(4-(benzyloxy)-3-methoxyphenyl)prop-1-enyl)phenyl)-N-(thiophen-2-ylsulfonyl)acrylamide
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C30H27NO5S2
 1
1
Ki = 4304 nM
   TI
   LI
   LO
   TS
CP0452225
(E)-3-{2-[(E)-3-(4-Benzyloxy-3-methoxy-phenyl)-propenyl]-phenyl}-acrylic acid; compound with (E)-3-{2-[(E)-3-(4-benzyloxy-3-methoxy-phenyl)-allyl]-phenyl}-acrylic acid
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C26H24O4
 1
1
Ki = 6313 nM
   TI
   LI
   LO
   TS
CP0314860
(E)-3-[2-[(E)-3-[4-[2-(1-cyanoisoindol-2-yl)ethoxy]-3-methoxyphenyl]prop-1-enyl]phenyl]-N-thiophen-2-ylsulfonylprop-2-enamide
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C34H29N3O5S2
 1
1
Ki = 9448 nM
   TI
   LI
   LO
   TS
CP0058712
N-[5-(2,6-dichlorophenyl)-1,3,4-thiadiazol-2-yl]-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamide
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C19H16Cl2N4O2S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0380092
N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamide
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C16H18N4O2S
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS