Brief Information of the Cell Line and Protein
Cell Line ID: CL000076 , CHO/Galpha16
Synonyms
CHO/Ga16
RD-HGA16
CHO-RD-HGA16
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_IY41
Protein ID: PT01534 , Prostaglandin E2 receptor EP4 subtype
Gene Name PTGER4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P35408
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000076  Protein ID: PT01534
 
Compound ID Compound Name Compound Formula
CP0576839
4-[(1S)-1-[[2-[(4-methylphenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H25NO4S
 1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0569366
4-[(1S)-1-[[2-[(4-chlorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C24H22ClNO4S
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0579483
4-[1-[[2-[[3-(trifluoromethyl)phenyl]methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]cyclopropyl]benzoic acid
   Show/Hide
C26H22F3NO4S
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0564321
4-[(1S)-1-[[2-[[3-(trifluoromethyl)phenyl]methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H22F3NO4S
 1
1
IC50 = 1.7 nM
   TI
   LI
   LO
   TS
CP0552065
4-[(1S)-1-[[2-[(3-fluoro-4-methoxyphenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H24FNO5S
 1
1
IC50 = 1.9 nM
   TI
   LI
   LO
   TS
CP0564322
4-[(1S)-1-[[2-[(3-methoxyphenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H25NO5S
 1
1
IC50 = 1.9 nM
   TI
   LI
   LO
   TS
CP0550439
4-[(1S)-1-[[2-[(4-methoxyphenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H25NO5S
 1
1
IC50 = 2.1 nM
   TI
   LI
   LO
   TS
CP0575940
4-[(1S)-1-[[2-[[4-(trifluoromethyl)phenyl]methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H22F3NO4S
 1
1
IC50 = 2.1 nM
   TI
   LI
   LO
   TS
CP0452755
4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}-carbonyl)amino]cyclopropyl}benzoic Acid
   Show/Hide
C25H22F3NO3S
 1
1
IC50 = 2.5 nM
   TI
   LI
   LO
   TS
CP0579647
4-[(1S)-1-[[2-[(2,4-dichloro-5-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C24H20Cl2FNO4S
 1
1
IC50 = 2.5 nM
   TI
   LI
   LO
   TS
CP0568147
4-[(1S)-1-[[2-[(4-propan-2-ylphenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C27H29NO4S
 1
1
IC50 = 2.7 nM
   TI
   LI
   LO
   TS
CP0568146
4-[(1S)-1-[[2-[(3-chlorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C24H22ClNO4S
 1
1
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
CP0569367
4-[1-[[2-[(4-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]cyclopropyl]benzoic acid
   Show/Hide
C25H22FNO4S
 1
1
IC50 = 3.4 nM
   TI
   LI
   LO
   TS
CP0570161
4-[[[2-[[3-(trifluoromethyl)phenyl]methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]methyl]benzoic acid
   Show/Hide
C24H20F3NO4S
 1
1
IC50 = 3.4 nM
   TI
   LI
   LO
   TS
CP0569215
4-[[[2-[(4-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]methyl]benzoic acid
   Show/Hide
C23H20FNO4S
 1
1
IC50 = 4.3 nM
   TI
   LI
   LO
   TS
CP0578933
4-[(1S)-1-[[2-[(4-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C24H22FNO4S
 1
1
IC50 = 4.5 nM
   TI
   LI
   LO
   TS
CP0579924
4-[(1S)-1-[[2-[(3-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C24H22FNO4S
 1
1
IC50 = 5.1 nM
   TI
   LI
   LO
   TS
CP0576838
4-[(1S)-1-[[2-[[3-chloro-4-(trifluoromethoxy)phenyl]methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H21ClF3NO5S
 1
1
IC50 = 6.6 nM
   TI
   LI
   LO
   TS
CP0435681
US8686018, 107
   Show/Hide
C22H18F5N3O4
 1
1
IC50 = 7.5 nM
   TI
   LI
   LO
   TS
CP0564324
4-[(1S)-1-[[2-[(4-tert-butylphenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C28H31NO4S
 1
1
IC50 = 9.5 nM
   TI
   LI
   LO
   TS
CP0576837
4-[(1S)-1-[[2-[2-(4-fluorophenyl)ethyl]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H24FNO3S
 1
1
IC50 = 10.3 nM
   TI
   LI
   LO
   TS
CP0564320
4-[(1S)-1-[[2-[2-(3-methoxyphenyl)ethynyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C26H23NO5S
 1
1
IC50 = 12.4 nM
   TI
   LI
   LO
   TS
CP0564319
4-[(1S)-1-[[2-[2-(4-fluorophenyl)ethyl]-6,7-dihydro-4H-thieno[3,2-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H24FNO4S
 1
1
IC50 = 13.1 nM
   TI
   LI
   LO
   TS
CP0570157
4-[(1S)-1-[[2-[2-(4-fluorophenyl)ethynyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H20FNO4S
 1
1
IC50 = 15.8 nM
   TI
   LI
   LO
   TS
CP0569739
4-[(1S)-1-[[2-[2-(4-fluorophenyl)ethyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H24FNO4S
 1
1
IC50 = 19.1 nM
   TI
   LI
   LO
   TS
CP0580247
4-[(1S)-1-[[2-[2-(6-methoxynaphthalen-2-yl)ethynyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C30H25NO5S
 1
1
IC50 = 27.2 nM
   TI
   LI
   LO
   TS
CP0564330
4-[(1S)-1-[[2-[2-(4-fluorophenyl)ethyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C26H26FNO3S
 1
1
IC50 = 27.8 nM
   TI
   LI
   LO
   TS
CP0569368
4-[[[2-[(4-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]methyl]cyclohexane-1-carboxylic acid
   Show/Hide
C23H26FNO4S
 1
1
IC50 = 30.3 nM
   TI
   LI
   LO
   TS
CP0564380
4-[(1S)-1-[[2-[[4-(trifluoromethyl)phenyl]methylamino]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H23F3N2O4S
 1
1
IC50 = 32.9 nM
   TI
   LI
   LO
   TS
CP0579246
4-[(1S)-1-[[2-[2-(4-fluorophenyl)ethyl]-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C27H28FNO4S
 1
1
IC50 = 36.2 nM
   TI
   LI
   LO
   TS
CP0570162
4-[[[2-[[3-(trifluoromethyl)phenyl]methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]methyl]cyclohexane-1-carboxylic acid
   Show/Hide
C24H26F3NO4S
 1
1
IC50 = 36.6 nM
   TI
   LI
   LO
   TS
CP0564325
2-[(4-fluorophenyl)methyl]-N-[(1S)-1-[4-(hydrazinecarbonyl)phenyl]ethyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide
   Show/Hide
C24H24FN3O3S
 1
1
IC50 = 74.9 nM
   TI
   LI
   LO
   TS
CP0578379
2-[(4-fluorophenyl)methyl]-N-[(1S)-1-[4-[methoxy(methyl)carbamoyl]phenyl]ethyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide
   Show/Hide
C26H27FN2O4S
 1
1
IC50 = 186.9 nM
   TI
   LI
   LO
   TS
CP0578918
4-[(1S)-1-[[2-[2-(4-fluorophenyl)ethyl]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C27H28FNO3S
 1
1
IC50 = 205.5 nM
   TI
   LI
   LO
   TS
CP0580216
4-[(1S)-1-[[2-[2-(4-fluorophenyl)ethyl]-6-[(2-methylpropan-2-yl)oxycarbonyl]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C30H33FN2O5S
 1
1
IC50 = 315 nM
   TI
   LI
   LO
   TS
CP0575939
4-[(1S)-1-[[2-[2-(6-oxo-1H-pyridin-3-yl)ethynyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C24H20N2O5S
 1
1
IC50 = 642.3 nM
   TI
   LI
   LO
   TS
CP0579482
4-[(1S)-1-[[6-ethyl-2-[2-(4-fluorophenyl)ethyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C28H30FNO3S
 1
1
IC50 = 648.5 nM
   TI
   LI
   LO
   TS
CP0579925
4-[(1R)-1-[[2-[(4-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C24H22FNO4S
 1
1
IC50 = 786.1 nM
   TI
   LI
   LO
   TS
CP0543689
3-[[[2-[[3-(trifluoromethyl)phenyl]methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]methyl]benzoic acid
   Show/Hide
C24H20F3NO4S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0579247
4-[(1S)-1-[[6-acetyl-2-[2-(4-fluorophenyl)ethyl]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C27H27FN2O4S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0579291
methyl 4-[(1S)-1-[[2-[(4-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoate
   Show/Hide
C25H24FNO4S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0580179
4-[(1S)-1-[[2-[(4-fluorobenzoyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C24H21FN2O5S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0580231
4-[(1S)-1-[[2-[(E)-[3-(trifluoromethyl)phenyl]methylideneamino]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]ethyl]benzoic acid
   Show/Hide
C25H21F3N2O4S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS