Brief Information of the Cell Line and Protein
Cell Line ID: CL000348 , H69AR
Synonyms
H-69AR
NCI-H69AR
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_3513
Protein ID: PT02516 , Multidrug resistance-associated protein 1
Gene Name ABCC1
Organism Homo sapiens, Human
Protein Classification Transporter
Uniprot ID P33527
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000348  Protein ID: PT02516
 
Compound ID Compound Name Compound Formula
CP0391014
2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide
   Show/Hide
C28H30N6OS
 4
1
EC50 = 2690 nM
   TI
   LI
   LO
   TS
2
GI50 = 975 nM
   TI
   LI
   LO
   TS
3
GI50 = 1260 nM
   TI
   LI
   LO
   TS
4
IC50 = 5040 nM
   TI
   LI
   LO
   TS
CP0504953
4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C23H26N6
 5
1
GI50 = 375 nM
   TI
   LI
   LO
   TS
2
GI50 = 636 nM
   TI
   LI
   LO
   TS
3
GI50 = 934 nM
   TI
   LI
   LO
   TS
4
IC50 = 197 nM
   TI
   LI
   LO
   TS
5
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0445461
5-phenyl-4-[4-(2-phenylethyl)piperazin-1-yl]pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C25H24N6
 5
1
GI50 = 389 nM
   TI
   LI
   LO
   TS
2
GI50 = 535 nM
   TI
   LI
   LO
   TS
3
GI50 = 782 nM
   TI
   LI
   LO
   TS
4
IC50 = 340 nM
   TI
   LI
   LO
   TS
5
IC50 = 750 nM
   TI
   LI
   LO
   TS
CP0455917
5-cyclopropyl-4-[4-(2-phenylethyl)piperazin-1-yl]pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C22H24N6
 5
1
GI50 = 395 nM
   TI
   LI
   LO
   TS
2
GI50 = 588 nM
   TI
   LI
   LO
   TS
3
GI50 = 827 nM
   TI
   LI
   LO
   TS
4
IC50 = 200 nM
   TI
   LI
   LO
   TS
5
IC50 = 247 nM
   TI
   LI
   LO
   TS
CP0509817
4-(3-phenylpropylamino)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C20H21N5
 5
1
GI50 = 450 nM
   TI
   LI
   LO
   TS
2
GI50 = 751 nM
   TI
   LI
   LO
   TS
3
GI50 = 2410 nM
   TI
   LI
   LO
   TS
4
IC50 = 2500 nM
   TI
   LI
   LO
   TS
5
IC50 = 2840 nM
   TI
   LI
   LO
   TS
CP0386544
4-piperazin-1-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C15H18N6
 5
1
GI50 = 1830 nM
   TI
   LI
   LO
   TS
2
GI50 = 2480 nM
   TI
   LI
   LO
   TS
3
GI50 = 2940 nM
   TI
   LI
   LO
   TS
4
IC50 = 10800 nM
   TI
   LI
   LO
   TS
5
IC50 = 27300 nM
   TI
   LI
   LO
   TS
CP0508239
4-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C23H24N6O2
 1
1
IC50 = 322 nM
   TI
   LI
   LO
   TS
CP0380590
4-[4-(2-phenylethyl)piperazin-1-yl]-5-propylpyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C22H26N6
 2
1
IC50 = 418 nM
   TI
   LI
   LO
   TS
2
IC50 = 543 nM
   TI
   LI
   LO
   TS
CP0459447
4-[4-(2-phenylethyl)piperazin-1-yl]-5-(3-phenylpropyl)pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C28H30N6
 2
1
IC50 = 586 nM
   TI
   LI
   LO
   TS
2
IC50 = 956 nM
   TI
   LI
   LO
   TS
CP0511252
5-benzyl-4-[4-(2-phenylethyl)piperazin-1-yl]pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C26H26N6
 2
1
IC50 = 623 nM
   TI
   LI
   LO
   TS
2
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0380589
4-(4-benzylpiperazin-1-yl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C22H24N6
 2
1
IC50 = 636 nM
   TI
   LI
   LO
   TS
2
IC50 = 671 nM
   TI
   LI
   LO
   TS
CP0380588
5,6-di(cycloheptyl)-4-[4-(2-phenylethyl)piperazin-1-yl]pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C33H44N6
 2
1
IC50 = 643 nM
   TI
   LI
   LO
   TS
2
IC50 = 833 nM
   TI
   LI
   LO
   TS
CP0504952
5-methyl-4-[4-(2-phenylethyl)piperazin-1-yl]pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C20H22N6
 2
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
2
IC50 = 714 nM
   TI
   LI
   LO
   TS
CP0539206
6-methoxy-4-[4-[(3-propan-2-yl-1,2,4-oxadiazol-5-yl)methyl]piperidin-1-yl]quinoline-3-carbonitrile
   Show/Hide
C22H25N5O2
 2
1
IC50 = 764 nM
   TI
   LI
   LO
   TS
2
IC50 = 9660 nM
   TI
   LI
   LO
   TS
CP0445473
5-ethyl-4-[4-(2-phenylethyl)piperazin-1-yl]pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C21H24N6
 2
1
IC50 = 789 nM
   TI
   LI
   LO
   TS
2
IC50 = 1060 nM
   TI
   LI
   LO
   TS
CP0420066
4-[4-(2-phenylethyl)piperazin-1-yl]-5-propan-2-ylpyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C22H26N6
 2
1
IC50 = 821 nM
   TI
   LI
   LO
   TS
2
IC50 = 1240 nM
   TI
   LI
   LO
   TS
CP0455915
4-(4-benzylpiperazin-1-yl)-5-phenylpyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C24H22N6
 2
1
IC50 = 866 nM
   TI
   LI
   LO
   TS
2
IC50 = 1220 nM
   TI
   LI
   LO
   TS
CP0472823
5-benzyl-4-(4-benzylpiperazin-1-yl)pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C25H24N6
 2
1
IC50 = 876 nM
   TI
   LI
   LO
   TS
2
IC50 = 2770 nM
   TI
   LI
   LO
   TS
CP0455918
4-(4-benzylpiperazin-1-yl)-5-(2-phenylethyl)pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C26H26N6
 2
1
IC50 = 910 nM
   TI
   LI
   LO
   TS
2
IC50 = 983 nM
   TI
   LI
   LO
   TS
CP0504951
4-(4-benzylpiperazin-1-yl)-5,6-di(cycloheptyl)pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C32H42N6
 2
1
IC50 = 981 nM
   TI
   LI
   LO
   TS
2
IC50 = 1060 nM
   TI
   LI
   LO
   TS
CP0380587
4-(4-benzhydrylpiperazin-1-yl)-5,6-di(cycloheptyl)pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C38H46N6
 2
1
IC50 = 1010 nM
   TI
   LI
   LO
   TS
2
IC50 = 1950 nM
   TI
   LI
   LO
   TS
CP0493654
5-(2-phenylethyl)-4-[4-(2-phenylethyl)piperazin-1-yl]pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C27H28N6
 2
1
IC50 = 1020 nM
   TI
   LI
   LO
   TS
2
IC50 = 1120 nM
   TI
   LI
   LO
   TS
CP0455914
4-(4-benzhydrylpiperazin-1-yl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C28H28N6
 2
1
IC50 = 1070 nM
   TI
   LI
   LO
   TS
2
IC50 = 1620 nM
   TI
   LI
   LO
   TS
CP0485143
6-propan-2-yl-4-[4-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,4-diazepan-1-yl]quinoline-3-carbonitrile
   Show/Hide
C21H21F3N6S
 2
1
IC50 = 2260 nM
   TI
   LI
   LO
   TS
2
IC50 = 9110 nM
   TI
   LI
   LO
   TS
CP0539201
6-methoxy-N-propan-2-yl-N-[(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)methyl]-2-(trifluoromethyl)quinazolin-4-amine
   Show/Hide
C21H19F3N6O2
 2
1
IC50 = 2330 nM
   TI
   LI
   LO
   TS
2
IC50 = 5630 nM
   TI
   LI
   LO
   TS
CP0447621
4-(4-benzylpiperazin-1-yl)-5-(3-phenylpropyl)pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C27H28N6
 2
1
IC50 = 2360 nM
   TI
   LI
   LO
   TS
2
IC50 = 3150 nM
   TI
   LI
   LO
   TS
CP0420699
4-(4-phenylpiperazin-1-yl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C21H22N6
 2
1
IC50 = 2560 nM
   TI
   LI
   LO
   TS
2
IC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0534245
4-(4-methylpiperazin-1-yl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C16H20N6
 2
1
IC50 = 2870 nM
   TI
   LI
   LO
   TS
2
IC50 = 5060 nM
   TI
   LI
   LO
   TS
CP0036222
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
   Show/Hide
C62H111N11O12
 4
1
IC50 = 2950 nM
   TI
   LI
   LO
   TS
2
IC50 = 2970 nM
   TI
   LI
   LO
   TS
3
IC50 = 3530 nM
   TI
   LI
   LO
   TS
4
IC50 = 3770 nM
   TI
   LI
   LO
   TS
CP0528179
N-(3-methylsulfanylphenyl)-2-phenylquinolin-4-amine
   Show/Hide
C22H18N2S
 1
1
IC50 = 2980 nM
   TI
   LI
   LO
   TS
CP0451205
N-(3-methylsulfanylphenyl)-2-phenylquinazolin-4-amine
   Show/Hide
C21H17N3S
 1
1
IC50 = 3730 nM
   TI
   LI
   LO
   TS
CP0425272
4-[[6-(4-hydroxyanilino)-2-phenylpyrimidin-4-yl]amino]benzonitrile
   Show/Hide
C23H17N5O
 1
1
IC50 = 4040 nM
   TI
   LI
   LO
   TS
CP0425619
4-[[6-(3-hydroxyanilino)-2-phenylpyrimidin-4-yl]amino]benzonitrile
   Show/Hide
C23H17N5O
 1
1
IC50 = 4080 nM
   TI
   LI
   LO
   TS
CP0485144
4-[4-(2-methylquinolin-8-yl)sulfonylpiperazin-1-yl]thieno[3,2-c]pyridine
   Show/Hide
C21H20N4O2S2
 2
1
IC50 = 4380 nM
   TI
   LI
   LO
   TS
2
IC50 = 14200 nM
   TI
   LI
   LO
   TS
CP0171970
4-Phenethylamino-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C19H19N5
 2
1
IC50 = 4980 nM
   TI
   LI
   LO
   TS
2
IC50 = 8370 nM
   TI
   LI
   LO
   TS
CP0490376
N-[3-[(2-phenylquinolin-4-yl)amino]phenyl]acetamide
   Show/Hide
C23H19N3O
 1
1
IC50 = 5800 nM
   TI
   LI
   LO
   TS
CP0393131
N-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)quinazolin-4-amine
   Show/Hide
C23H21N3O3
 1
1
IC50 = 7720 nM
   TI
   LI
   LO
   TS
CP0451195
4-(2-Phenyl-quinazolin-4-ylamino)-benzoic acid methyl ester
   Show/Hide
C22H17N3O2
 1
1
IC50 = 8130 nM
   TI
   LI
   LO
   TS
CP0532850
4-[(2-phenylquinazolin-4-yl)amino]benzoic acid
   Show/Hide
C21H15N3O2
 1
1
IC50 = 8770 nM
   TI
   LI
   LO
   TS
CP0420065
4-(benzylamino)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C18H17N5
 2
1
IC50 = 8800 nM
   TI
   LI
   LO
   TS
2
IC50 = 14200 nM
   TI
   LI
   LO
   TS
CP0420698
5,6-di(cycloheptyl)-4-(4-phenylpiperazin-1-yl)pyrrolo[3,2-d]pyrimidine-7-carbonitrile
   Show/Hide
C31H40N6
 2
1
IC50 = 8980 nM
   TI
   LI
   LO
   TS
2
IC50 = 15100 nM
   TI
   LI
   LO
   TS
CP0425259
4-[[2-phenyl-6-(propan-2-ylamino)pyrimidin-4-yl]amino]benzonitrile
   Show/Hide
C20H19N5
 1
1
IC50 = 9050 nM
   TI
   LI
   LO
   TS
CP0493653
4-anilino-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
   Show/Hide
C17H15N5
 2
1
IC50 = 9410 nM
   TI
   LI
   LO
   TS
2
IC50 = 14200 nM
   TI
   LI
   LO
   TS
CP0425266
4-[[2-phenyl-6-(propylamino)pyrimidin-4-yl]amino]benzonitrile
   Show/Hide
C20H19N5
 1
1
IC50 = 9580 nM
   TI
   LI
   LO
   TS
CP0477032
N-(3,4-dimethoxyphenyl)-2-thiophen-2-ylquinazolin-4-amine
   Show/Hide
C20H17N3O2S
 1
1
IC50 = 9680 nM
   TI
   LI
   LO
   TS
CP0480103
5-[(2,5-dimethylquinolin-4-yl)oxymethyl]-3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole
   Show/Hide
C23H23N3O5
 2
1
IC50 = 11000 nM
   TI
   LI
   LO
   TS
2
IC50 = 16700 nM
   TI
   LI
   LO
   TS
CP0387307
(4-methoxyphenyl)-[2-(4-pyridyl)quinazolin-4-yl]amine
   Show/Hide
C20H16N4O
 1
1
IC50 = 15900 nM
   TI
   LI
   LO
   TS
CP0420361
4-[(6-methyl-2-phenylpyrimidin-4-yl)amino]-2-nitrophenol
   Show/Hide
C17H14N4O3
 1
1
IC50 = 15900 nM
   TI
   LI
   LO
   TS
CP0420849
N-(3,4-dimethoxyphenyl)-2-(1H-pyrrol-2-yl)quinazolin-4-amine
   Show/Hide
C20H18N4O2
 1
1
IC50 = 17300 nM
   TI
   LI
   LO
   TS
CP0516921
4-[[2-phenyl-6-(pyridin-3-ylmethylamino)pyrimidin-4-yl]amino]benzonitrile
   Show/Hide
C23H18N6
 1
1
IC50 = 20700 nM
   TI
   LI
   LO
   TS
CP0459141
N-(2-methyl-1,3-benzothiazol-5-yl)-1-(6-pyrazol-1-ylpyrimidin-4-yl)piperidine-3-carboxamide
   Show/Hide
C21H21N7OS
 1
1
IC50 = 22700 nM
   TI
   LI
   LO
   TS
CP0030165
US8592579, 104
   Show/Hide
C23H24FN9O
 1
1
IC50 = 36300 nM
   TI
   LI
   LO
   TS
CP0529577
(2-pyridin-3-ylquinolin-4-yl)-[4-(thiophen-2-ylmethyl)piperazin-1-yl]methanone
   Show/Hide
C24H22N4OS
 1
1
IC50 = 39300 nM
   TI
   LI
   LO
   TS
CP0393143
2-(3,4-dimethoxyphenyl)-N-(4-nitrophenyl)quinazolin-4-amine
   Show/Hide
C22H18N4O4
 1
1
IC50 = 40600 nM
   TI
   LI
   LO
   TS
CP0393144
N-(4-bromo-3-methoxyphenyl)-2-(3,4-dimethoxyphenyl)quinazolin-4-amine
   Show/Hide
C23H20BrN3O3
 1
1
IC50 = 44200 nM
   TI
   LI
   LO
   TS
CP0420847
3-[[2-(1H-pyrrol-2-yl)quinazolin-4-yl]amino]benzonitrile
   Show/Hide
C19H13N5
 1
1
IC50 = 85100 nM
   TI
   LI
   LO
   TS