Brief Information of the Compound and Protein
Compound Name
4-piperazin-1-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
    Show/Hide
PubChem ID
CID: 10333981
SID: 15344618
Canonical SMILES
N#Cc1c2CCCCn2c2c(ncnc12)N1CCNCC1
    Show/Hide
Compound Formula C15H18N6
Compound Structure
Protein Name
Multidrug resistance-associated protein 1
Protein Classification
Transporter
>
Primary active transporter
>
ATP-binding cassette
>
ABCC subfamily
Uniprot ID
P33527
Gene Name
ABCC1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000348 H69AR Homo sapiens (Human)  5
1
GI50 = 1830 nM
   TI
   LI
   LO
   TS
2
GI50 = 2480 nM
   TI
   LI
   LO
   TS
3
GI50 = 2940 nM
   TI
   LI
   LO
   TS
4
IC50 = 10800 nM
   TI
   LI
   LO
   TS
5
IC50 = 27300 nM
   TI
   LI
   LO
   TS