General Information of the Cell Line
Cell Line ID
CL001023
Cell Line Name
3T3/HH FlashII-7
Category
Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0594
Tissue Information
Embryo
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02397, Protein smoothened
 Protein Info 
Compound ID Compound Name Compound Formula
CP0429582
 Compound Info 
LY-2940680
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C26H24F4N6O
  1
1
IC50 = 1.18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0495141
 Compound Info 
1-[4-[5-chloro-2-(oxan-4-ylamino)pyrimidin-4-yl]sulfanylphenyl]-3-[1-[4,5-dimethyl-6-(2-methylpyrazol-3-yl)pyridazin-3-yl]piperidin-4-yl]urea
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C31H37ClN10O2S
  1
1
IC50 = 17.59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569869
 Compound Info 
1-[4-[5-chloro-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]oxyphenyl]-3-[1-[4,5-dimethyl-6-(2-methylpyrazol-3-yl)pyridazin-3-yl]piperidin-4-yl]urea
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C30H33ClN12O2
  1
1
IC50 = 17.79 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0570817
 Compound Info 
1-[4-[[5-chloro-2-(oxan-4-ylamino)pyrimidin-4-yl]amino]phenyl]-3-[1-[4,5-dimethyl-6-(2-methylpyrazol-3-yl)pyridazin-3-yl]piperidin-4-yl]urea
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C31H38ClN11O2
  1
1
IC50 = 63.92 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0571974
 Compound Info 
1-[1-[4,5-dimethyl-6-(2-methylpyrazol-3-yl)pyridazin-3-yl]piperidin-4-yl]-3-[4-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]oxyphenyl]urea
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C32H40N10O3
  1
1
IC50 = 149.65 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0260228
 Compound Info 
1-[1-[4,5-dimethyl-6-(2-methylpyrazol-3-yl)pyridazin-3-yl]piperidin-4-yl]-3-[4-[2-(oxan-4-ylamino)-5-(trifluoromethyl)pyrimidin-4-yl]sulfanylphenyl]urea
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C32H37F3N10O2S
  1
1
IC50 = 154.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0575442
 Compound Info 
1-[1-[4,5-dimethyl-6-(2-methylpyrazol-3-yl)pyridazin-3-yl]piperidin-4-yl]-3-[4-[2-(oxan-4-ylamino)-5-(trifluoromethyl)pyrimidin-4-yl]oxyphenyl]urea
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C32H37F3N10O3
  1
1
IC50 = 190.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0488414
 Compound Info 
1-[4-[5-chloro-2-(oxan-4-ylamino)pyrimidin-4-yl]oxyphenyl]-3-[1-[4,5-dimethyl-6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]urea
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C31H37ClN10O3
  1
1
IC50 = 409.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0570816
 Compound Info 
1-[4-[5-chloro-2-(oxan-4-ylamino)pyrimidin-4-yl]oxyphenyl]-3-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]urea
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C29H33ClN10O3
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Embryo)
Cell Line Name Organism Disease
Bm5
 Cell Line Info 
Bombyx mori (Silk moth) -
Schneider 2
 Cell Line Info 
Drosophila melanogaster (Fruit fly) -
NIH 3T3
 Cell Line Info 
Mus musculus (Mouse) -
BALB/3T3 clone A31
 Cell Line Info 
Mus musculus (Mouse) -
NIH-3T3-G185
 Cell Line Info 
Mus musculus (Mouse) -
HER14
 Cell Line Info 
Mus musculus (Mouse) -
B104-1-1
 Cell Line Info 
Mus musculus (Mouse) -
3T3-L1
 Cell Line Info 
Mus musculus (Mouse) -
C3H/10T1/2 clone 8
 Cell Line Info 
Mus musculus (Mouse) -
Shh Light II
 Cell Line Info 
Mus musculus (Mouse) -
MEF3.8
 Cell Line Info 
Mus musculus (Mouse) -
NIH 3T3-ras
 Cell Line Info 
Mus musculus (Mouse) -
NIH-3T3-A14
 Cell Line Info 
Mus musculus (Mouse) -
TSC1-/- MEF
 Cell Line Info 
Mus musculus (Mouse) -
MEF-1 [Mouse fibroblast]
 Cell Line Info 
Mus musculus (Mouse) -
Ptch-deficient MEF
 Cell Line Info 
Mus musculus (Mouse) -
Rat1
 Cell Line Info 
Rattus norvegicus (Rat) -
REF52
 Cell Line Info 
Rattus norvegicus (Rat) -
SR-3Y1-1
 Cell Line Info 
Rattus norvegicus (Rat) -
SAE
 Cell Line Info 
Squalus acanthias (Spiny dogfish) -
BTI-Tn-5B1-4
 Cell Line Info 
Trichoplusia ni (Cabbage looper) -