General Information of the Cell Line
Cell Line ID
CL001055
Cell Line Name
TSC1-/- MEF
Category
Transformed cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_4240
Tissue Information
Embryo
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02733, Serine/threonine-protein kinase mTOR
 Protein Info 
Compound ID Compound Name Compound Formula
CP0000815
 Compound Info 
Rapamycin C-7, analog 4
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C51H79NO13
  1
1
IC50 = 0.05 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0558253
 Compound Info 
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24E,26E,28E,32S,35R)-30-(1,1-dioxothiazetidin-2-yl)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19-methoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,20-tetrone
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C52H82N2O13S
  1
1
IC50 = 0.17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420756
 Compound Info 
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-30-(1,1-dioxo-1,2-thiazolidin-2-yl)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19-methoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,20-tetrone
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C53H84N2O13S
  1
1
IC50 = 0.274 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0550705
 Compound Info 
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24E,26E,28E,32S,35R)-30-(1,1-dioxothiazetidin-2-yl)-1,18-dihydroxy-19-methoxy-12-[(2R)-1-[(1S,3R,4S)-3-methoxy-4-(tetrazol-1-yl)cyclohexyl]propan-2-yl]-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,20-tetrone
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C53H82N6O12S
  1
1
IC50 = 0.374 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568553
 Compound Info 
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24E,26E,28E,32S,35R)-12-[(2R)-1-[(1S,3R,4R)-4-dimethylphosphoryloxy-3-methoxycyclohexyl]propan-2-yl]-30-(1,1-dioxo-1,2-thiazolidin-2-yl)-1,18-dihydroxy-19-methoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,20-tetrone
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C55H89N2O14PS
  1
1
IC50 = 3.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0731398
 Compound Info 
(3R)-4-[8-(1H-indol-4-yl)-2-[(3S)-3-methylmorpholin-4-yl]-9H-purin-6-yl]-3-methylmorpholine
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C23H27N7O2
  1
1
IC50 = 38 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568555
 Compound Info 
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24E,26E,28E,32S,35R)-1,18-dihydroxy-30-[3-(2-hydroxyethyl)-2-oxoimidazolidin-1-yl]-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19-methoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,20-tetrone
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C55H87N3O13
  1
1
IC50 = 153 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0001930
 Compound Info 
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine
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C18H21F3N6O2
  1
1
IC50 = 832 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0576748
 Compound Info 
(4S,5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one
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C18H20F3N7O4
  1
1
IC50 = 1633 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Embryo)
Cell Line Name Organism Disease
Bm5
 Cell Line Info 
Bombyx mori (Silk moth) -
Schneider 2
 Cell Line Info 
Drosophila melanogaster (Fruit fly) -
NIH 3T3
 Cell Line Info 
Mus musculus (Mouse) -
BALB/3T3 clone A31
 Cell Line Info 
Mus musculus (Mouse) -
NIH-3T3-G185
 Cell Line Info 
Mus musculus (Mouse) -
HER14
 Cell Line Info 
Mus musculus (Mouse) -
B104-1-1
 Cell Line Info 
Mus musculus (Mouse) -
3T3-L1
 Cell Line Info 
Mus musculus (Mouse) -
C3H/10T1/2 clone 8
 Cell Line Info 
Mus musculus (Mouse) -
Shh Light II
 Cell Line Info 
Mus musculus (Mouse) -
MEF3.8
 Cell Line Info 
Mus musculus (Mouse) -
NIH 3T3-ras
 Cell Line Info 
Mus musculus (Mouse) -
NIH-3T3-A14
 Cell Line Info 
Mus musculus (Mouse) -
3T3/HH FlashII-7
 Cell Line Info 
Mus musculus (Mouse) -
MEF-1 [Mouse fibroblast]
 Cell Line Info 
Mus musculus (Mouse) -
Ptch-deficient MEF
 Cell Line Info 
Mus musculus (Mouse) -
Rat1
 Cell Line Info 
Rattus norvegicus (Rat) -
REF52
 Cell Line Info 
Rattus norvegicus (Rat) -
SR-3Y1-1
 Cell Line Info 
Rattus norvegicus (Rat) -
SAE
 Cell Line Info 
Squalus acanthias (Spiny dogfish) -
BTI-Tn-5B1-4
 Cell Line Info 
Trichoplusia ni (Cabbage looper) -