General Information of the Cell Line
Cell Line ID
CL001057
Cell Line Name
Ptch-deficient MEF
Category
Transformed cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_4240
Tissue Information
Embryo
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02397, Protein smoothened
Compound ID Compound Name Compound Formula
CP0136263
(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
   Show/Hide
C27H41NO2
 2
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
2
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0381132
2-[(3R,8E,11S)-3-(4-chlorophenyl)-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl]-N-[(4-chlorophenyl)methyl]acetamide
   Show/Hide
C25H26Cl2N2O4
 2
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
2
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CP0445334
2-[(3R,8E,11S)-3-benzyl-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl]-N-[(4-chlorophenyl)methyl]acetamide
   Show/Hide
C26H29ClN2O4
 2
1
IC50 = 8100 nM
   TI
   LI
   LO
   TS
2
IC50 = 8800 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Embryo)
Cell Line Name Organism Disease
Bm5 Bombyx mori (Silk moth) -
Schneider 2 Drosophila melanogaster (Fruit fly) -
NIH 3T3 Mus musculus (Mouse) -
BALB/3T3 clone A31 Mus musculus (Mouse) -
NIH-3T3-G185 Mus musculus (Mouse) -
HER14 Mus musculus (Mouse) -
B104-1-1 Mus musculus (Mouse) -
3T3-L1 Mus musculus (Mouse) -
C3H/10T1/2 clone 8 Mus musculus (Mouse) -
Shh Light II Mus musculus (Mouse) -
MEF3.8 Mus musculus (Mouse) -
NIH 3T3-ras Mus musculus (Mouse) -
NIH-3T3-A14 Mus musculus (Mouse) -
3T3/HH FlashII-7 Mus musculus (Mouse) -
TSC1-/- MEF Mus musculus (Mouse) -
MEF-1 [Mouse fibroblast] Mus musculus (Mouse) -
Rat1 Rattus norvegicus (Rat) -
REF52 Rattus norvegicus (Rat) -
SR-3Y1-1 Rattus norvegicus (Rat) -
SAE Squalus acanthias (Spiny dogfish) -
BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper) -