Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[1-[4,5-dimethyl-6-(2-methylpyrazol-3-yl)pyridazin-3-yl]piperidin-4-yl]-3-[4-[2-(oxan-4-ylamino)-5-(trifluoromethyl)pyrimidin-4-yl]sulfanylphenyl]urea
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 PubChem ID
CID: 163215599
Canonical SMILES
Cc1c(C)c(nnc1N1CCC(CC1)NC(=O)Nc1ccc(Sc2nc(NC3CCOCC3)ncc2C(F)(F)F)cc1)-c1ccnn1C
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Compound Formula C32H37F3N10O2S
Compound Structure
Protein Name
 Protein Info 
Protein smoothened
Protein Classification
Membrane receptor
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Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
P56726
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL001023 3T3/HH FlashII-7
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 154.9 nM
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