| Compound ID |
Compound Name |
Compound Formula |
|
CP0745149
|
3-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-4-yl)benzonitrile
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|
C25H21N9O2S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0726235
|
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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|
C20H25N5O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0909397
|
2-(4-(4-(1H-pyrrol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C20H21N7O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0951452
|
2-(5-methyl-4-(4-(4-(pyridin-3-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C25H25N7O2S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0957703
|
3-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)oxazol-5-yl)benzonitrile
Show/Hide
|
C19H21N7O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0745147
|
2-(5-methyl-4-(4-(4-(pyridin-4-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C25H25N7O2S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0772462
|
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C18H20F3N7O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0823468
|
2-(5-methyl-4-(4-(4,4,4-trifluorobutanoyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C20H21F3N6O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0962073
|
tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate
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|
C23H29N7O4
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0951353
|
2-(4-(4-(2-chloropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C21H20ClN7O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0970224
|
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)oxazole-4-carbonitrile
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|
C20H18N8O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0738386
|
2-(5-methyl-4-(4-propionylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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|
C20H25N5O3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0823462
|
2-(5-methyl-4-(4-(1,1,1-trifluoro-3-methoxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C20H23F3N6O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0823463
|
2-(4-(4-(2,2-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C18H20F2N8O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0823466
|
2-(4-(4-acetyl-4-phenylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C24H24N6O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0909350
|
2-(5-methyl-4-(4-(1,1,1-trifluoro-3-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C19H21F3N6O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0909399
|
2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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|
C20H20F3N7O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0761063
|
2-(5-methyl-4-(4-(3,3,3-trifluoroprop-1-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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|
C20H22F3N5O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0829397
|
2-(5-methyl-4-(4-(5-(pyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C25H27N9O2S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0947194
|
2-(4-(4-(6-fluoropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20FN7O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0951356
|
2-(5-methyl-4-(4-(1,1,1,4-tetrafluorobutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C20H22F4N6O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0839342
|
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C18H22N8O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0909343
|
2-(4-(2-(3-chlorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C23H18ClN7O2S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0909352
|
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-3-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H23N7O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0963567
|
2-(4-(4-(6-fluoropyridin-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20FN7O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0772463
|
2-(4-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H22N8O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0761015
|
2-(5-methyl-4-(7-oxo-3-azaspiro[5.5]undecane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C21H24N6O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0947195
|
2-(4-(3-(2-fluoropyridin-4-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H16FN7O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0951351
|
2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C19H17F3N8O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0969864
|
2-(5-methyl-4-(9-(2,2,2-trifluoroethylidene)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C21H21F3N6O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0964668
|
2-(4-(4-(2-chloro-1H-pyrrol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H20ClN7O2
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0745028
|
2-(4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C15H15F3N8O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
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CP0761064
|
2-(5-methyl-4-(4-(4-(pyridin-3-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C24H22N8O2S
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0812551
|
7-fluoro-2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C16H14F4N6O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
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CP0823457
|
2-(4-(3-cyclobutyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H25N7O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0951358
|
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)-1H-pyrrole-3-carbonitrile
Show/Hide
|
C21H20N8O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0964693
|
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
|
C21H26N6O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
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CP0713487
|
2-(4-(4-(difluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C18H21F2N5O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0745169
|
2-(5-methyl-4-(3-(trifluoromethyl)-8-azabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H19F3N6O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0746926
|
2-(5-methyl-4-(4-(4-phenyloxazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C25H23N7O3
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0831450
|
2-(5-methyl-4-(4-(4-(trifluoromethyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H17F3N8O2S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0962124
|
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H19N7O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
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CP0713504
|
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H18F6N6O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0721044
|
2-(4-(4-(5-(6-fluoropyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H20FN9O2S
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0962125
|
2-(4-(4-(3,3-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H20F2N8O2
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0738349
|
2-(5-methyl-4-(4-(1,1,1,3,3-pentafluoropropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H19F5N6O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
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CP0738374
|
2-(4-(3-hydroxy-3-phenyl-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H24N6O3
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
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CP0823454
|
2-(5-methyl-4-(4-(3,3,3-trifluoroprop-1-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H19F3N6O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
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CP0838151
|
2-(5-methyl-4-(4-(1,1,1-trifluorobutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H23F3N6O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
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CP0905462
|
2-(5-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H19F3N8O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
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CP0955450
|
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-3-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H16F2N6O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
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CP0913640
|
(S)-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
|
C21H26N6O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
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CP0713542
|
1-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclobutanecarbonitrile
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
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CP0750097
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2-(4-(4-butyrylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H24N6O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
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CP0823467
|
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H17F3N8O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
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CP0957699
|
2-(5-methyl-4-((1R,5S,9r)-9-(2,2,2-trifluoroethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H23F3N6O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
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CP0831445
|
2-(5-methyl-4-(4-(4-(pyridin-2-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C25H25N7O2S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
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CP0713482
|
2-(4-(2-(4-chlorophenyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H17ClN6O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
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CP0713509
|
4-methyl-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
|
C19H22N6O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
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CP0746915
|
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C18H20F3N5O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
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CP0823469
|
2-(4-(2-(6-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H16FN7O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
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CP0750095
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2-(5-methyl-4-(4-(trifluoromethyl)azepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O2
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1
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| 1 |
IC50 = 35 nM
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CP0823464
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2-(4-(4-cyclopropyl-1,4-diazepane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H23N7O2
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1
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| 1 |
IC50 = 35 nM
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CP0844487
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2-(5-methyl-4-(4-(2-(trifluoromethyl)cyclopropyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20F3N7O2
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1
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| 1 |
IC50 = 35 nM
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CP0947192
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2-(5-methyl-4-(4-(thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C20H22N6O2S
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1
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| 1 |
IC50 = 35 nM
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CP0762707
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2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H19F3N8O2
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1
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| 1 |
IC50 = 36 nM
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CP0823470
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2-(4-(4-cyclobutylpiperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H20N8O2
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1
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| 1 |
IC50 = 36 nM
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CP0909335
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2-(5-methyl-4-(4-(1-(trifluoromethyl)cyclopropyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H21F3N6O2
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1
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| 1 |
IC50 = 36 nM
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CP0909347
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2-(5-methyl-4-((1R,5S)-9-(2,2,2-trifluoroethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H23F3N6O2
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1
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| 1 |
IC50 = 36 nM
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CP0962081
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2-(5-methyl-4-(2-(trifluoromethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H14F3N7O2S
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1
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| 1 |
IC50 = 36 nM
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CP0738350
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2-(5-methyl-4-(4-(4-(pyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H21N9O2S
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1
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| 1 |
IC50 = 37 nM
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CP0761016
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2-(4-(4-cyclopropylpiperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C16H18N8O2
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1
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| 1 |
IC50 = 37 nM
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CP0823421
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C18H21F3N6O2
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1
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| 1 |
IC50 = 37 nM
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CP0823456
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2-(5-methyl-4-(4-propionylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H22N6O3
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1
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| 1 |
IC50 = 37 nM
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CP0966695
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2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H21N7O2
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1
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| 1 |
IC50 = 37 nM
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CP0768978
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2-(5-methyl-4-(4-(1-(trifluoromethyl)cyclopropyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C21H24F3N5O2
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1
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| 1 |
IC50 = 38 nM
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CP0868872
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2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H21F3N6O3
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1
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| 1 |
IC50 = 38 nM
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CP0909396
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2-(4-(4-(5-chloropyridin-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H19ClN8O2
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1
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| 1 |
IC50 = 39 nM
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CP0951355
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2-(4-(4-ethyl-4-(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H21F3N6O2
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1
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| 1 |
IC50 = 40 nM
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CP0966425
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2-(5-methyl-4-(1-oxo-8-azaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H22N6O3
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1
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| 1 |
IC50 = 40 nM
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CP0713488
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2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C19H24N6O2
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1
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| 1 |
IC50 = 41 nM
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CP0909400
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2-(5-methyl-4-(4-(4-(pyridin-4-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O2S
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1
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| 1 |
IC50 = 41 nM
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CP0761068
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2-allyl-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
Show/Hide
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C24H27N7O2
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1
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| 1 |
IC50 = 43 nM
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CP0839309
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2-(4-(4-(2,2-difluorocyclopentyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H23F2N7O2
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1
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| 1 |
IC50 = 43 nM
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CP0713493
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2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
Show/Hide
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C19H21N7O2
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1
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| 1 |
IC50 = 44 nM
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CP0829378
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1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
Show/Hide
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C20H21N7O2
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1
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| 1 |
IC50 = 44 nM
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CP0734272
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2-(5-methyl-4-(7-(2,2,2-trifluoroethyl)-2,7-diazaspiro[3.5]nonane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H22F3N7O2
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1
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| 1 |
IC50 = 45 nM
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CP0738377
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tert-butyl 7-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate
Show/Hide
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C23H29N7O4
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1
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| 1 |
IC50 = 45 nM
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CP0761002
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2-(4-(4-(5-(4-chlorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C24H21ClN8O3
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1
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| 1 |
IC50 = 45 nM
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CP0838156
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2-(4-(4-(difluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H18F2N6O2
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1
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| 1 |
IC50 = 45 nM
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CP0902945
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2-(5-methyl-4-(4-((tetrahydrofuran-2-yl)methyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H25N7O3
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1
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| 1 |
IC50 = 45 nM
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CP0944287
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2-(4-(4-(3,4-difluorophenylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H20F2N6O4S
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1
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| 1 |
IC50 = 45 nM
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CP0969528
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2-(4-(4-(5-fluoropyridin-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H20FN7O2
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1
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| 1 |
IC50 = 45 nM
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CP0761019
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2-(4-(4-(2-fluorocyclopropyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20FN7O2
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1
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| 1 |
IC50 = 46 nM
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CP0761067
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2-(4-(9-hydroxy-9-(trifluoromethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H21F3N6O3
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1
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| 1 |
IC50 = 46 nM
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CP0839343
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H18F3N7O2
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1
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| 1 |
IC50 = 46 nM
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CP0745025
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2-(4-(4-(4-(6-fluoropyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H20FN9O2S
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1
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| 1 |
IC50 = 47 nM
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CP0829380
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4-methyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C18H19N7O2
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1
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| 1 |
IC50 = 47 nM
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CP0944133
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2-(5-methyl-4-(5-azaspiro[2.4]heptane-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H18N6O2
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1
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| 1 |
IC50 = 47 nM
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CP0964667
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2-(4-(6-cyclopropyl-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H21N7O2
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1
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| 1 |
IC50 = 47 nM
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CP0754196
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2-(5-methyl-4-(9-methylene-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H22N6O2
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1
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| 1 |
IC50 = 48 nM
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CP0761071
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2-(4-(3-(5-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H16FN7O2
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1
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| 1 |
IC50 = 48 nM
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CP0829398
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2-(4-(4-(5-(2-chloropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H20ClN9O2S
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1
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| 1 |
IC50 = 48 nM
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CP0838157
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(R)-tert-butyl 2-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
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C21H27N7O4
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1
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| 1 |
IC50 = 48 nM
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CP0966424
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2-(5-methyl-4-(4-(4-(pyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H21N9O2S
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1
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| 1 |
IC50 = 48 nM
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CP0750105
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2-(4-((3aS,6aR)-4,4-difluorooctahydrocyclopenta[c]pyrrole-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H18F2N6O2
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1
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| 1 |
IC50 = 49 nM
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CP0761066
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2-(5-methyl-4-(4-(4-(trifluoromethyl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H18F3N7O2S
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1
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| 1 |
IC50 = 50 nM
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CP0831448
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2-(4-(3-(5-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H16FN7O2
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1
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| 1 |
IC50 = 50 nM
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CP0954048
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2-(4-(6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C19H23N5O2
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1
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| 1 |
IC50 = 50 nM
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CP0713494
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2-(4-(4-cyclobutylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H23N7O2
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1
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| 1 |
IC50 = 51 nM
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CP0772465
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tert-butyl 7-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate
Show/Hide
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C24H32N6O4
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1
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| 1 |
IC50 = 51 nM
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CP0909328
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2-(4-(4-(2-fluoropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H20FN7O2
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1
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| 1 |
IC50 = 51 nM
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CP0951357
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2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-3-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H19F2N7O2
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1
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| 1 |
IC50 = 51 nM
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CP0734273
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2-(5-methyl-4-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H19F3N8O2
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1
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| 1 |
IC50 = 52 nM
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CP0959089
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2-(4-(4-(4-(2-fluoropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H20FN9O2S
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1
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| 1 |
IC50 = 52 nM
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CP0738369
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1-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
Show/Hide
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C21H24N6O2
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1
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| 1 |
IC50 = 53 nM
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CP0761023
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2-(4-(2-(5-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H16FN7O2
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1
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| 1 |
IC50 = 53 nM
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CP0761025
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2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C19H23N5O2
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1
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| 1 |
IC50 = 54 nM
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CP0823417
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4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C18H20N8O2
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1
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| 1 |
IC50 = 55 nM
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CP0838149
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2-(5-methyl-4-(4-(4-phenylthiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C26H26N6O2S
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1
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| 1 |
IC50 = 55 nM
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CP0962080
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2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
Show/Hide
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C22H26N6O2
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1
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| 1 |
IC50 = 55 nM
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CP0963564
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(R)-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
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C21H26N6O2
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1
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| 1 |
IC50 = 55 nM
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CP0838153
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2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C16H15F2N7O2
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1
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| 1 |
IC50 = 56 nM
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CP0844486
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2-(4-(4-(2-chloro-1H-imidazol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19ClN8O2
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1
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| 1 |
IC50 = 56 nM
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CP0823412
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tert-butyl 2-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C21H27N7O4
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1
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| 1 |
IC50 = 57 nM
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CP0831449
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2-(5-methyl-4-(8-(trifluoromethyl)-3-azabicyclo[3.2.1]octane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O2
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1
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| 1 |
IC50 = 57 nM
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CP0891290
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2-(5-methyl-4-(9-(trifluoromethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O2
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1
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| 1 |
IC50 = 57 nM
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CP0738385
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2-(4-fluoro-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H25FN6O2
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1
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| 1 |
IC50 = 58 nM
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CP0772464
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N-cyclopropyl-N-methyl-6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-6-azaspiro[2.5]octane-1-carboxamide
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C23H27N7O3
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1
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| 1 |
IC50 = 58 nM
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CP0891289
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2-(5-methyl-4-(3-(thiazol-2-yl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H20N8O2S
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1
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| 1 |
IC50 = 58 nM
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CP0909345
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2-(4-(6-cyclobutyl-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23N7O2
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1
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| 1 |
IC50 = 58 nM
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CP0947196
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2-(4-(4-(5-(6-chloropyridin-3-yl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H19ClN10O3
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1
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| 1 |
IC50 = 59 nM
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CP0954047
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2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
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C21H23N7O2
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1
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| 1 |
IC50 = 59 nM
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CP0761065
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2-(5-methyl-4-(4-(4-(pyridin-2-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O2S
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1
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| 1 |
IC50 = 60 nM
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CP0829395
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2-(5-methyl-4-(6-(3,3,3-trifluoropropyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20F3N7O2
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1
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| 1 |
IC50 = 60 nM
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CP0838150
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2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H23F3N6O2
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1
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| 1 |
IC50 = 60 nM
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CP0909349
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2-(4-(4-(cyclopropanecarbonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N6O3
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1
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| 1 |
IC50 = 61 nM
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CP0909351
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2-(4-(4-(5-(2-fluoropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O2S
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1
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| 1 |
IC50 = 62 nM
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CP0746927
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2-(4-(4-(azetidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H22F3N7O3
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1
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| 1 |
IC50 = 63 nM
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CP0823414
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2-(4-(8-hydroxy-8-(trifluoromethyl)-3-azabicyclo[3.2.1]octane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O3
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1
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| 1 |
IC50 = 63 nM
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CP0768922
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2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)benzonitrile
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C22H20N8O4S
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1
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| 1 |
IC50 = 64 nM
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CP0947189
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2-(5-methyl-4-(2-azaspiro[3.4]octane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20N6O2
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1
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| 1 |
IC50 = 65 nM
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CP0883864
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2-(4-fluoro-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
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C20H22FN7O2
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1
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| 1 |
IC50 = 66 nM
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CP0955211
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2-(5-methyl-4-(1-(piperidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H29N7O3
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1
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| 1 |
IC50 = 67 nM
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CP0962089
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(R)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
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C22H30N6O4
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1
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| 1 |
IC50 = 67 nM
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CP0761062
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2-(5-methyl-4-(3-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
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1
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| 1 |
IC50 = 68 nM
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CP0964666
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2-(4-(4-(4-(2-chloropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H20ClN9O2S
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1
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| 1 |
IC50 = 68 nM
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CP0761012
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2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H20N8O2
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1
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| 1 |
IC50 = 69 nM
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CP0754201
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tert-butyl 3-methyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-ylcarbamate
Show/Hide
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C20H25N7O4
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1
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| 1 |
IC50 = 70 nM
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CP0772456
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2-(4-(3-(6-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H16FN7O2
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1
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| 1 |
IC50 = 70 nM
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CP0772466
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2-(4-(3-(6-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H16FN7O2
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1
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| 1 |
IC50 = 70 nM
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CP0868876
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2-(5-methyl-4-(4-(3-(trifluoromethylsulfonyl)-1H-pyrrol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H20F3N7O4S
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1
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| 1 |
IC50 = 70 nM
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CP0957702
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2-(5-methyl-4-(2-(pyridin-3-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H18N8O2S
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1
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| 1 |
IC50 = 70 nM
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CP0772438
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2-(4-(2,2-difluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H20F2N6O2
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1
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| 1 |
IC50 = 72 nM
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CP0823415
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2-(4-(4-cyclopropyl-4-hydroxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H22N6O3
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1
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| 1 |
IC50 = 72 nM
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CP0909336
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tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate
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C23H29N7O4
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1
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| 1 |
IC50 = 72 nM
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CP0745155
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(Z)-2-(5-methyl-4-(4-(1,1,1-trifluorobut-2-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H21F3N6O2
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1
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| 1 |
IC50 = 74 nM
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CP0761061
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2-(5-methyl-4-(4-(4-phenyloxazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C26H26N6O3
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1
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| 1 |
IC50 = 74 nM
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CP0768907
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tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-yl)carbamate
Show/Hide
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C20H25N7O4
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1
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| 1 |
IC50 = 74 nM
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CP0947190
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2-(4-(3,3-difluoro-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H18F2N6O2
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1
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| 1 |
IC50 = 74 nM
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CP0761006
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N-(1-isopropyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-1H-pyrazol-5-yl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C20H21F3N8O3
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1
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| 1 |
IC50 = 75 nM
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CP0909341
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H18F3N7O2
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1
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| 1 |
IC50 = 75 nM
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CP0761069
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2-(4-(4-(6-chloropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H20ClN7O2
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1
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| 1 |
IC50 = 76 nM
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CP0962064
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(R)-tert-butyl 3-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
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C21H27N7O4
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1
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| 1 |
IC50 = 76 nM
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CP0905460
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2-(4-(4-(3,3-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H21F2N7O2
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1
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| 1 |
IC50 = 77 nM
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CP0721047
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2-(5-methyl-4-(4-(propylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H23N7O4S
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1
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| 1 |
IC50 = 79 nM
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CP0754197
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2-(5-methyl-4-(4-(2-(trifluoromethyl)-1H-pyrrol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H20F3N7O2
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1
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| 1 |
IC50 = 79 nM
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CP0831452
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1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)-1H-pyrrole-2-carbonitrile
Show/Hide
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C21H20N8O2
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1
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| 1 |
IC50 = 79 nM
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CP0823410
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2-(4-(4-methoxy-4-methylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H22N6O3
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1
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| 1 |
IC50 = 80 nM
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CP0894171
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2-(4-(4-(2,4-difluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H19F2N7O4S
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1
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| 1 |
IC50 = 80 nM
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CP0705960
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
Show/Hide
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C17H18F3N7O2
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1
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| 1 |
IC50 = 81 nM
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CP0838155
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2-(4-(6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20N6O2
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1
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| 1 |
IC50 = 81 nM
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CP0909344
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2-(5-methyl-4-(2-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C24H18F3N7O2S
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1
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| 1 |
IC50 = 81 nM
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CP0754424
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2-(5-methyl-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H19F3N6O3
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1
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| 1 |
IC50 = 82 nM
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CP0746918
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1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-(pyridin-2-yl)piperidine-4-carbonitrile
Show/Hide
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C22H20N8O2
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1
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| 1 |
IC50 = 83 nM
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CP0829374
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2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxybutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H23F3N6O3
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1
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| 1 |
IC50 = 83 nM
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CP0883863
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2-(5-methyl-4-(4-(pyrrolidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H24F3N7O3
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1
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| 1 |
IC50 = 83 nM
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CP0762706
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5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazole-3-carboxamide
Show/Hide
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C19H21F3N6O3
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1
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| 1 |
IC50 = 84 nM
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CP0829396
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4-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-4-yl)benzonitrile
Show/Hide
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C25H21N9O2S
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1
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| 1 |
IC50 = 84 nM
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CP0946656
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2-(5-methyl-4-(4-(piperidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H26F3N7O3
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1
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| 1 |
IC50 = 84 nM
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CP0947191
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2-(4-(4-(isopropylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H24N6O4S
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1
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| 1 |
IC50 = 86 nM
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CP0959282
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2-(5-methyl-4-(4-(3,3,3-trifluoropropylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20F3N7O4S
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1
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| 1 |
IC50 = 86 nM
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CP0768979
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2-(4-(2-ethyl-2,7-diazaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H25N7O2
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1
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| 1 |
IC50 = 87 nM
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CP0954729
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2-(5-methyl-4-(4-(naphthalen-1-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C25H23N7O4S
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1
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| 1 |
IC50 = 87 nM
|
|
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CP0970014
|
2-(4-(4-(2-chlorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20ClN7O4S
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0713489
|
2-(4-(2-fluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H21FN6O2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0720795
|
2-(4-(4-(benzo[c][1,2,5]thiadiazol-4-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H19N9O4S2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0864191
|
2-(4-(4-(isopropylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H23N7O4S
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0913639
|
(S)-tert-butyl 3-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
|
C21H27N7O4
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0839340
|
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H18F3N7O2
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0768921
|
2-(4-(4-(mesitylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H27N7O4S
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0829379
|
2-(4-(6,6-difluoro-3-azabicyclo[3.2.0]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H16F2N6O2
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0734255
|
2-(4-(4-(cyclohexylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H27N7O4S
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0831444
|
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)thiazole-4-carbonitrile
Show/Hide
|
C20H18N8O2S
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0909342
|
2-(5-methyl-4-(4-(5-(pyridin-3-yl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H21N9O3
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0909398
|
4-fluoro-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
|
C20H22FN7O2
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0951354
|
2-(4-(4-(2,2-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H21F2N7O2
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0768924
|
2-(5-methyl-4-(4-(2-(trifluoromethoxy)phenylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C22H20F3N7O5S
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0838154
|
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H20F3N7O2
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0734281
|
2-(4-(3-cyclopropyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H23N7O2
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0746914
|
2-(5-methyl-4-(4-(2-(trifluoromethyl)-1H-imidazol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H19F3N8O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0772457
|
2-(3-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H18F3N7O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0870568
|
2-(5-methyl-4-(octahydro-2H-pyrano[3,2-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H22N6O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0883883
|
2-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one
Show/Hide
|
C16H15F3N6O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0897051
|
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)butanenitrile
Show/Hide
|
C21H24N6O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0913637
|
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H21N7O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0950444
|
2-(4-(4-(2-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20FN7O4S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0964669
|
(S)-2-(4-(7,7-difluorooctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H17F2N7O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0966139
|
2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H19N7O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0745031
|
2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20FN7O4S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0761008
|
2-(4-(2-(4-fluorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H18FN7O2S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0761010
|
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H18F2N8O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0768977
|
1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-(2,2,2-trifluoroethyl)piperidine-4-carbonitrile
Show/Hide
|
C19H18F3N7O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0823411
|
2-(5-methyl-4-(1-(pyrrolidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H27N7O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0823453
|
2-(5-methyl-4-(4-(phenylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H21N7O4S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0823460
|
2-(4-(4-(4-(6-chloropyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H20ClN9O2S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0829388
|
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)thiazole-4-carbonitrile
Show/Hide
|
C21H21N7O2S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0829389
|
2-(4-(4-hydroxy-4-(trifluoromethyl)azepane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H19F3N6O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0829392
|
2-(4-(4-(4-(3-fluorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H21FN8O2S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0829394
|
2-(5-methyl-4-(4-(3,3,3-trifluoropropyl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H22F3N7O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0950446
|
methyl 3-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)thiophene-2-carboxylate
Show/Hide
|
C21H21N7O6S2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0954733
|
2-(4-(4-(benzylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C22H23N7O4S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0957873
|
2-(5-methyl-4-(4-(trifluoromethylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C16H16F3N7O4S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0959283
|
2-(4-(4-(3-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20FN7O4S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0970015
|
2-(4-(4-(2-chloro-4-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H19ClFN7O4S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0713490
|
2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)acetonitrile
Show/Hide
|
C17H18N8O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0726224
|
4-ethyl-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
|
C20H24N6O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0754200
|
4-fluoro-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
|
C21H25FN6O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0820605
|
2-(4-(4-(3-chlorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20ClN7O4S
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0829376
|
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C16H17F3N8O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0839257
|
2-(5-methyl-4-(4-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H19F3N6O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0897050
|
2-(5-methyl-4-(3-(trifluoromethyl)-1,3'-biazetidine-1'-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H18F3N7O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0713491
|
2-(5-methyl-4-(3-methyl-4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H20F3N7O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0713492
|
(S)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
Show/Hide
|
C21H27N7O4
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0713541
|
2-(5-methyl-4-(9-(2,2,2-trifluoroethyl)-3,9-diazabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C21H25F3N6O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0721045
|
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H22F3N7O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0726213
|
4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
|
C19H21N7O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0734280
|
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)thiazole-4-carboxamide
Show/Hide
|
C21H23N7O3S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0745032
|
2-(5-methyl-4-(4-(thiophen-2-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H19N7O4S2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0745158
|
2-(5-methyl-4-(2-thia-6-azaspiro[3.3]heptane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C16H16N6O2S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0762915
|
2-(5-methyl-4-(2-(pyridin-2-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C22H18N8O2S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0831454
|
2-(4-(4-(2,4-dimethylthiazol-5-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H22N8O4S2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0870569
|
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H22F2N6O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0762916
|
2-(5-methyl-4-(4-(5-(2-(trifluoromethyl)phenyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C25H21F3N8O3
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0831440
|
2-(4-(1,1-difluoro-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H18F2N6O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0713496
|
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H19F2N7O2
|
1
|
| 1 |
IC50 = 150 nM
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|
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CP0754428
|
2-(5-methyl-4-(1-(piperidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C25H32N6O3
|
1
|
| 1 |
IC50 = 150 nM
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|
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CP0761017
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2-(4-(4-(2,2-difluorocyclobutyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H18F2N8O2
|
1
|
| 1 |
IC50 = 150 nM
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|
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CP0768923
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2-(5-methyl-4-(4-(pyridin-3-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H20N8O4S
|
1
|
| 1 |
IC50 = 150 nM
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|
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CP0829401
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2-(4-(4-(5-chlorothiophen-2-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H18ClN7O4S2
|
1
|
| 1 |
IC50 = 150 nM
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|
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CP0909310
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2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)acetonitrile
Show/Hide
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C18H19N7O2
|
1
|
| 1 |
IC50 = 150 nM
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|
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CP0909348
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2-(5-methyl-4-(5-(2,2,2-trifluoroethyl)-5,8-diazaspiro[3.5]nonane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H22F3N7O2
|
1
|
| 1 |
IC50 = 150 nM
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|
|
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CP0746916
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2-(5-methyl-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C19H22F3N5O3
|
1
|
| 1 |
IC50 = 160 nM
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|
|
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CP0750096
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2-(5-methyl-4-(4-(4-(trifluoromethyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H17F3N8O3
|
1
|
| 1 |
IC50 = 160 nM
|
|
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CP0772458
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2-(4-hydroxy-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
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C20H23N7O3
|
1
|
| 1 |
IC50 = 160 nM
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|
|
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CP0772461
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2-(4-(3-(3,3-difluoropiperidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H21F2N7O2
|
1
|
| 1 |
IC50 = 160 nM
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|
|
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CP0823461
|
2-(4-(4-(5-(3-fluorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H20FN9O3
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0838152
|
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)cyclopropanecarbonitrile
Show/Hide
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C20H19N7O2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0909346
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tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
Show/Hide
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C21H25N7O4
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0950445
|
2-(5-methyl-4-(4-(quinolin-8-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C24H22N8O4S
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
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CP0962072
|
2-(5-methyl-4-(4-(thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H19N7O2S
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0963565
|
2-(5-methyl-4-(1-(morpholine-4-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H30N6O4
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0966426
|
4-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-5-yl)benzonitrile
Show/Hide
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C25H21N9O2S
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0726180
|
N,N-dimethyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-sulfonamide
Show/Hide
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C17H22N8O4S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0762709
|
2-(5-methyl-4-(3-(phenylsulfonyl)azetidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H18N6O4S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0834668
|
2-(5-methyl-4-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H17N7O2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0913638
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2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H16F2N6O2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0959281
|
2-(4-(4-(ethylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H21N7O4S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0969656
|
4-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)benzonitrile
Show/Hide
|
C22H20N8O4S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0721046
|
2-(4-(4-(5-(2-fluorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H21FN8O2S
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0762917
|
2-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-4-yl)benzonitrile
Show/Hide
|
C25H21N9O2S
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0812528
|
2-(4-(4,4-difluoro-1,4'-bipiperidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H25F2N7O2
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0905461
|
2-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)oxazol-5-yl)benzonitrile
Show/Hide
|
C25H21N9O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0966423
|
tert-butyl 4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
|
C20H25N7O4
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0738370
|
(S)-2-(4-(7,7-difluorooctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H19F2N7O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0745045
|
(R)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H19N7O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0905459
|
2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H16F3N9O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0959088
|
2-(5-methyl-4-(2-(pyridin-4-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C22H18N8O2S
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0964687
|
2-(4-(4-(4-(2-fluorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H21FN8O2S
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0772460
|
(R)-2-(4-(4-(cyclobutylmethyl)-3-methylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H27N7O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0812525
|
2-(5-methyl-4-(1-(morpholine-4-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H27N7O4
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0761093
|
2-(5-methyl-4-(1-(pyrrolidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H30N6O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0823455
|
2-(4-(3-(3-fluoropropyl)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H21FN6O2
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0823458
|
2-(4-(4-(5-(2-fluorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H21FN8O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0887753
|
2-(4-(4-(3,5-dimethylisoxazol-4-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H22N8O5S
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0738364
|
2-(5-methyl-4-(4-(1,1,1-trifluorobutan-2-ylidene)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H21F3N6O2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0761040
|
2-(5-methyl-4-(4-(3,3,3-trifluoropropyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H20F3N7O2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0746917
|
1-ethyl-6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-6-azaspiro[2.5]octane-1-carbonitrile
Show/Hide
|
C21H23N7O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0761005
|
2-(4-(4-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H20ClN9O3
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0838158
|
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H18F3N7O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0891288
|
2-(4-(4-tert-butylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H25N7O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0726179
|
3-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)benzonitrile
Show/Hide
|
C22H20N8O4S
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0745033
|
2-(4-(4-(6-chloropyridin-3-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H19ClN8O4S
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0823477
|
2-(5-methyl-4-(4-(2-(trifluoromethyl)phenylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C22H20F3N7O4S
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0829375
|
2-(4-((1S,4S)-5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H23N7O2
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0912321
|
v2-(4-(4-(2,5-dichlorothiophen-3-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H17Cl2N7O4S2
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0947197
|
2-(4-(4-(5-(4-fluorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H21FN8O3
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0745150
|
2-(4-(2-(6-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H16FN7O2
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0772469
|
2-(4-(4-(2,6-dichlorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H19Cl2N7O4S
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0966693
|
2-(4-(4-(4-(3-chlorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H21ClN8O2S
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0761009
|
2-(4-(4-(5-(3-chlorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H21ClN8O3
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0962079
|
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C17H16F3N5O2S
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0745027
|
2-(4-(4-(5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H20ClN9O3
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0745167
|
2-(4-(1-(azetidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C22H25N7O3
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0762918
|
2-(5-methyl-4-(4-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C25H21F3N8O2S
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0959284
|
2-(4-(3-(2-(difluoromethyl)pyridin-4-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H17F2N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0745021
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N-(1-isopropyl-4-(3,3,3-trifluoroprop-1-en-2-yl)-1H-pyrazol-5-yl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
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C20H19F3N8O2
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1
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| 1 |
IC50 = 310 nM
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CP0909333
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2-(4-(4-(5-(2-chlorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O3
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1
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| 1 |
IC50 = 310 nM
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CP0966694
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2-(5-methyl-4-(4-(5-(pyridin-4-yl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N9O3
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1
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| 1 |
IC50 = 310 nM
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CP0768918
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-5,7-dihydrofuro[3,4-d]pyrimidin-4(3H)-one
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C17H19F3N6O3
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1
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| 1 |
IC50 = 320 nM
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CP0947193
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1-(4-hydroxy-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
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C20H21N7O3
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1
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| 1 |
IC50 = 330 nM
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CP0964690
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C17H18F3N7O2
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1
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| 1 |
IC50 = 330 nM
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CP0772459
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2-(4-(3-fluoro-3-phenylazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H17FN6O2
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1
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| 1 |
IC50 = 340 nM
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CP0734279
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2-(4-(1-(azetidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H28N6O3
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1
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| 1 |
IC50 = 350 nM
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CP0839341
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2-(4-(4-(5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O3
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1
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| 1 |
IC50 = 350 nM
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CP0761003
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2-(4-(4-(4-(4-chlorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O2S
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1
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| 1 |
IC50 = 360 nM
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CP0844489
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2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C17H16F2N6O2
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1
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| 1 |
IC50 = 360 nM
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CP0761070
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2-(4-(4,4-difluoroazepane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F2N6O2
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1
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| 1 |
IC50 = 370 nM
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CP0762708
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2-(5-methyl-4-(3-(2-(trifluoromethyl)pyridin-4-yl)azetidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H16F3N7O2
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1
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| 1 |
IC50 = 370 nM
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CP0823471
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2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C17H16F2N6O2
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1
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| 1 |
IC50 = 370 nM
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CP0969142
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2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H16F2N8O2
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1
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| 1 |
IC50 = 370 nM
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CP0868883
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2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H17N5O2S
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1
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| 1 |
IC50 = 380 nM
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CP0957695
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2-(4-(2-(4-chlorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18ClN7O2S
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1
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| 1 |
IC50 = 380 nM
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CP0957696
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2-(4-(4-(4-(2-chlorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O2S
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1
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| 1 |
IC50 = 380 nM
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CP0745057
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2-(5-methyl-4-(2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
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1
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| 1 |
IC50 = 410 nM
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CP0838166
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2-(4-(azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C14H14N6O2
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1
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| 1 |
IC50 = 410 nM
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CP0844485
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2-(4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H15F3N8O2
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1
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| 1 |
IC50 = 410 nM
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CP0959087
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2-(5-methyl-4-(4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O2S
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1
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| 1 |
IC50 = 420 nM
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CP0868873
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2-(4-(3,3-difluoroazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C14H12F2N6O2
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1
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| 1 |
IC50 = 440 nM
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CP0745023
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2-(5-methyl-4-(4-(5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O3
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1
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| 1 |
IC50 = 450 nM
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CP0964724
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(R)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O2
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1
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| 1 |
IC50 = 450 nM
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CP0823459
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2-(4-(4-(5-(3-fluorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O3
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1
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| 1 |
IC50 = 490 nM
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CP0944132
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2-(4-(2-(2-chlorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18ClN7O2S
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1
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| 1 |
IC50 = 520 nM
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CP0745022
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2-(5-methyl-4-(2-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H18F3N7O2S
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1
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| 1 |
IC50 = 540 nM
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CP0844488
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2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C18H19F2N7O2
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1
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| 1 |
IC50 = 580 nM
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CP0868875
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2-(5-methyl-4-(4-(2-(trifluoromethylsulfonyl)-1H-pyrrol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20F3N7O4S
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1
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| 1 |
IC50 = 600 nM
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CP0947157
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2-(5-methyl-4-(4-(5-(3-(trifluoromethyl)phenyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O3
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1
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| 1 |
IC50 = 600 nM
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CP0761007
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2-(5-methyl-4-(4-(4-(2-(trifluoromethyl)phenyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C25H21F3N8O2S
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1
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| 1 |
IC50 = 630 nM
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CP0947198
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2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C15H13F2N7O2
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1
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| 1 |
IC50 = 700 nM
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CP0946655
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2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
Show/Hide
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C20H18N6O2
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1
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| 1 |
IC50 = 740 nM
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CP0864190
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2-(5-methyl-4-(4-(methylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H19N7O4S
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1
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| 1 |
IC50 = 780 nM
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CP0823472
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2-(4-(2-(5-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H16FN7O2
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1
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| 1 |
IC50 = 820 nM
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CP0762922
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2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
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C18H19F2N7O2
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1
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| 1 |
IC50 = 870 nM
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CP0964688
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2-(4-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H27N7O3
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1
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| 1 |
IC50 = 890 nM
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CP0761014
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2-(5-methyl-4-(1-oxo-7-azaspiro[3.5]nonane-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20N6O3
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1
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| 1 |
IC50 = 920 nM
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CP0823465
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2-(5-methyl-4-(4-propionylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O3
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1
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| 1 |
IC50 = 1000 nM
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CP0954051
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2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
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C17H17F3N6O2
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1
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| 1 |
IC50 = 1100 nM
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CP0894170
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2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C18H18F3N7O2
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1
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| 1 |
IC50 = 1200 nM
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CP0745024
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N-(3,3-difluorocyclobutyl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C15H14F2N6O2
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1
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| 1 |
IC50 = 1300 nM
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CP0768933
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2-[4-[4-(trifluoromethyL)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H,5H,7H-furo[3,4-d]pyrimidin-4-one
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C16H16F3N5O3
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1
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| 1 |
IC50 = 1300 nM
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CP0823404
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3-fluoro-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidine-3-carbonitrile
Show/Hide
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C16H14FN7O2
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1
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| 1 |
IC50 = 2100 nM
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CP0909334
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6-methyl-2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
Show/Hide
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C19H19N5O2
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1
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| 1 |
IC50 = 2200 nM
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CP0768916
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2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
Show/Hide
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C18H18F3N7O2
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1
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| 1 |
IC50 = 2400 nM
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CP0831451
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2-(5-methyl-4-(4-(5-(5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H19F3N10O3
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1
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| 1 |
IC50 = 2600 nM
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CP0698027
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2-(5-methyl-4-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H16N8O2
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1
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| 1 |
IC50 = 2700 nM
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