| Compound ID |
Compound Name |
Compound Formula |
|
CP0853710
|
(3aR,9bS)-6-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C12H15ClN2O
|
2
|
| 1 |
EC50 = 1.1 nM
|
|
|
| 2 |
Ki = 3.9 nM
|
|
|
|
CP0446160
|
(R)-8-ethyl-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 1.4 nM
|
|
|
| 2 |
Ki = 37 nM
|
|
|
|
CP0376735
|
8-chloro-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7-a]quinazolin-7(1H)-one
Show/Hide
|
C12H14ClN3O
|
2
|
| 1 |
EC50 = 1.8 nM
|
|
|
| 2 |
Ki = 9 nM
|
|
|
|
CP0372018
|
8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7-a]quinazolin-7(1H)-one
Show/Hide
|
C13H17N3O
|
2
|
| 1 |
EC50 = 2 nM
|
|
|
| 2 |
Ki = 2.9 nM
|
|
|
|
CP0853713
|
Trans-6-chloro-7-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C12H14Cl2N2O
|
2
|
| 1 |
EC50 = 2.2 nM
|
|
|
| 2 |
Ki = 4.9 nM
|
|
|
|
CP0850853
|
(3aR,9bS)-6-chloro-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C11H12Cl2N2O
|
2
|
| 1 |
EC50 = 2.6 nM
|
|
|
| 2 |
Ki = 73 nM
|
|
|
|
CP0395804
|
(4R,11aR)-4-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 3 nM
|
|
|
| 2 |
Ki = 58 nM
|
|
|
|
CP0396112
|
(11aR)-8-methoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O2
|
2
|
| 1 |
EC50 = 3 nM
|
|
|
| 2 |
Ki = 37 nM
|
|
|
|
CP0853707
|
(3aR,9bS)-4-methyl-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C13H14ClF3N2O
|
2
|
| 1 |
EC50 = 3.3 nM
|
|
|
| 2 |
Ki = 46 nM
|
|
|
|
CP0864127
|
Trans-6,7-dichloro-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C11H11Cl3N2O
|
2
|
| 1 |
EC50 = 3.3 nM
|
|
|
| 2 |
Ki = 13 nM
|
|
|
|
CP0387715
|
(11aR)-8-ethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 = 4 nM
|
|
|
| 2 |
Ki = 33 nM
|
|
|
|
CP0850855
|
Trans-8-ethyl-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C14H16ClF3N2O
|
2
|
| 1 |
EC50 = 4.3 nM
|
|
|
| 2 |
Ki = 34 nM
|
|
|
|
CP0405794
|
(R)-7-chloro-10-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O2
|
2
|
| 1 |
EC50 = 5 nM
|
|
|
| 2 |
Ki = 59 nM
|
|
|
|
CP0375891
|
(11aR)-7-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 5 nM
|
|
|
| 2 |
Ki = 9 nM
|
|
|
|
CP0405776
|
(R)-9-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 6 nM
|
|
|
| 2 |
Ki = 9 nM
|
|
|
|
CP0395796
|
(11aR)-10-methoxy-7-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 6 nM
|
|
|
| 2 |
Ki = 52 nM
|
|
|
|
CP0437018
|
(R)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H11F3N2O
|
2
|
| 1 |
EC50 = 7 nM
|
|
|
| 2 |
Ki = 7 nM
|
|
|
|
CP0395807
|
(11aR)-8-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 8 nM
|
|
|
| 2 |
Ki = 92 nM
|
|
|
|
CP0847928
|
(4S,10bR)-4-isopropyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C15H17F3N2O
|
2
|
| 1 |
EC50 = 10 nM
|
|
|
| 2 |
Ki = 13 nM
|
|
|
|
CP0375902
|
(11aR)-8-chloro-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C12H13ClN2O
|
2
|
| 1 |
EC50 = 10 nM
|
|
|
| 2 |
Ki = 30 nM
|
|
|
|
CP0442070
|
(R)-9-methoxy-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O2
|
2
|
| 1 |
EC50 = 11 nM
|
|
|
| 2 |
Ki = 40 nM
|
|
|
|
CP0867971
|
Trans-6-chloro-9-ethyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C13H16Cl2N2O
|
2
|
| 1 |
EC50 = 11 nM
|
|
|
| 2 |
Ki = 55 nM
|
|
|
|
CP0399465
|
(R)-8-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O2
|
2
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
Ki = 176 nM
|
|
|
|
CP0850854
|
Trans-8-ethyl-6-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C14H19ClN2O
|
2
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
Ki = 46 nM
|
|
|
|
CP0396445
|
(11aR)-7-methoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O2
|
2
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
Ki = 203 nM
|
|
|
|
CP0397747
|
(11aR)-10-methoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O2
|
2
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
Ki = 78 nM
|
|
|
|
CP0442066
|
(R)-9-cyclopropyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C15H15F3N2O
|
2
|
| 1 |
EC50 = 14 nM
|
|
|
| 2 |
Ki = 35 nM
|
|
|
|
CP0380657
|
(11aR)-7,9-dimethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 = 14 nM
|
|
|
| 2 |
Ki = 24 nM
|
|
|
|
CP0404524
|
(11aR)-7-ethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 = 14 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0046618
|
1-(3-chlorophenyl)piperazine
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|
C10H13ClN2
|
2
|
| 1 |
EC50 = 15 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0104596
|
(R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C14H15F3N2O
|
2
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0373544
|
2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7-a]quinazolin-7(1H)-one
Show/Hide
|
C12H15N3O
|
2
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
Ki = 49 nM
|
|
|
|
CP0407526
|
(17R)-3-oxa-12,15-diazatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2(7),8-trien-11-one
Show/Hide
|
C15H18N2O2
|
2
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
Ki = 26 nM
|
|
|
|
CP0433506
|
(11aR)-7-(trifluoromethyl)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
Ki = 33 nM
|
|
|
|
CP0442062
|
(R)-9-ethyl-8-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 17 nM
|
|
|
| 2 |
Ki = 36 nM
|
|
|
|
CP0853679
|
Trans-6-chloro-8-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C12H14Cl2N2O
|
2
|
| 1 |
EC50 = 17 nM
|
|
|
| 2 |
Ki = 253 nM
|
|
|
|
CP0379007
|
(4S,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 18 nM
|
|
|
| 2 |
Ki = 22 nM
|
|
|
|
CP0396115
|
(11aR)-8-(trifluoromethyl)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 18 nM
|
|
|
| 2 |
Ki = 39 nM
|
|
|
|
CP0437020
|
(R)-7,8-dichloro-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H10Cl2N2O
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
Ki = 107 nM
|
|
|
|
CP0886365
|
Trans-6,8-dimethyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C13H17ClN2O
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
Ki = 86 nM
|
|
|
|
CP0407525
|
(11aR)-7-chloro-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C12H13ClN2O
|
2
|
| 1 |
EC50 = 22 nM
|
|
|
| 2 |
Ki = 57 nM
|
|
|
|
CP0378520
|
(+/-)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H11F3N2O
|
2
|
| 1 |
EC50 = 24 nM
|
|
|
| 2 |
Ki = 19 nM
|
|
|
|
CP0395802
|
(11aR)-10-ethoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
Ki = 19 nM
|
|
|
|
CP0437014
|
(+/-)-1,3,4,10b-tetrahydro-7-trifluoromethoxypyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H11F3N2O2
|
2
|
| 1 |
EC50 = 26 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0850856
|
Trans-6-chloro-8-ethyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C13H16Cl2N2O
|
2
|
| 1 |
EC50 = 26 nM
|
|
|
| 2 |
Ki = 44 nM
|
|
|
|
CP0850465
|
Trans-8-cyclopropyl-6-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C15H19ClN2O
|
2
|
| 1 |
EC50 = 27 nM
|
|
|
| 2 |
Ki = 87 nM
|
|
|
|
CP0419740
|
(1S,10bR)-1-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 28 nM
|
|
|
| 2 |
Ki = 29 nM
|
|
|
|
CP0395799
|
(11aR)-10-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 28 nM
|
|
|
| 2 |
Ki = 114 nM
|
|
|
|
CP0850464
|
Rac-cis-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C12H12ClF3N2O
|
2
|
| 1 |
EC50 = 30 nM
|
|
|
| 2 |
Ki = 192 nM
|
|
|
|
CP0396118
|
(4S,11aR)-4-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 33 nM
|
|
|
| 2 |
Ki = 2777 nM
|
|
|
|
CP0382676
|
9-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C12H15N3O
|
2
|
| 1 |
EC50 = 34 nM
|
|
|
| 2 |
Ki = 479 nM
|
|
|
|
CP0405769
|
(R)-10-chloro-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H10ClF3N2O
|
2
|
| 1 |
EC50 = 35 nM
|
|
|
| 2 |
Ki = 1084 nM
|
|
|
|
CP0395816
|
(11aR)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C12H14N2O
|
2
|
| 1 |
EC50 = 36 nM
|
|
|
| 2 |
Ki = 24 nM
|
|
|
|
CP0378517
|
(+/-)-7-chloro-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H11ClN2O
|
2
|
| 1 |
EC50 = 37 nM
|
|
|
| 2 |
Ki = 31 nM
|
|
|
|
CP0903448
|
Trans-8-ethyl-4-methyl-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C15H18ClF3N2O
|
2
|
| 1 |
EC50 = 41 nM
|
|
|
| 2 |
Ki = 151 nM
|
|
|
|
CP0399469
|
(+/-)-7-methylthio-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H14N2OS
|
2
|
| 1 |
EC50 = 42 nM
|
|
|
| 2 |
Ki = 40 nM
|
|
|
|
CP0405773
|
(R)-9-ethenyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindo l-6(2H)-one
Show/Hide
|
C14H13F3N2O
|
2
|
| 1 |
EC50 = 43 nM
|
|
|
| 2 |
Ki = 43 nM
|
|
|
|
CP0376709
|
7-chloro-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C11H12ClN3O
|
2
|
| 1 |
EC50 = 43 nM
|
|
|
| 2 |
Ki = 223 nM
|
|
|
|
CP0864126
|
(3aR,9bS)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C11H13ClN2O
|
2
|
| 1 |
EC50 = 43 nM
|
|
|
| 2 |
Ki = 1062 nM
|
|
|
|
CP0442060
|
(R)-7-chloro-10-ethyl-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C13H15ClN2O
|
2
|
| 1 |
EC50 = 46 nM
|
|
|
| 2 |
Ki = 425 nM
|
|
|
|
CP0396441
|
(11aR)-10-ethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 = 48 nM
|
|
|
| 2 |
Ki = 269 nM
|
|
|
|
CP0399467
|
(R)-7-chloro-9-ethyl-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C13H15ClN2O
|
2
|
| 1 |
EC50 = 49 nM
|
|
|
| 2 |
Ki = 124 nM
|
|
|
|
CP0405768
|
(R)-7-chloro-10-methyl-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O
|
2
|
| 1 |
EC50 = 54 nM
|
|
|
| 2 |
Ki = 927 nM
|
|
|
|
CP0442063
|
(R)-9-(1-methylcyclopropyl)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C16H17F3N2O
|
2
|
| 1 |
EC50 = 54 nM
|
|
|
| 2 |
Ki = 34 nM
|
|
|
|
CP0396446
|
(11aR)-9-ethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 = 55 nM
|
|
|
| 2 |
Ki = 56 nM
|
|
|
|
CP0477791
|
(11aR)-9-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 55 nM
|
|
|
| 2 |
Ki = 143 nM
|
|
|
|
CP0396117
|
(11R,11aR)-11-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 56 nM
|
|
|
| 2 |
Ki = 319 nM
|
|
|
|
CP0853705
|
Trans-8-isopropyl-6-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C15H21ClN2O
|
2
|
| 1 |
EC50 = 59 nM
|
|
|
| 2 |
Ki = 83 nM
|
|
|
|
CP0850852
|
(3aS,9bR)-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C12H12ClF3N2O
|
2
|
| 1 |
EC50 = 62 nM
|
|
|
| 2 |
Ki = 1052 nM
|
|
|
|
CP0405785
|
(R)-9-ethoxy-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol -6(2H)-one
Show/Hide
|
C14H15F3N2O2
|
2
|
| 1 |
EC50 = 63 nM
|
|
|
| 2 |
Ki = 158 nM
|
|
|
|
CP0396116
|
(11aR)-7-cyclopropyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C15H18N2O
|
2
|
| 1 |
EC50 = 64 nM
|
|
|
| 2 |
Ki = 80 nM
|
|
|
|
CP0395801
|
(11aR)-10-propoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C15H20N2O2
|
2
|
| 1 |
EC50 = 70 nM
|
|
|
| 2 |
Ki = 78 nM
|
|
|
|
CP0405771
|
(R)-9-isopropyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C15H17F3N2O
|
2
|
| 1 |
EC50 = 72 nM
|
|
|
| 2 |
Ki = 51 nM
|
|
|
|
CP0395795
|
(11aR)-10-methoxy-9-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 77 nM
|
|
|
| 2 |
Ki = 235 nM
|
|
|
|
CP0442059
|
(4R,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 82 nM
|
|
|
| 2 |
Ki = 74 nM
|
|
|
|
CP0886026
|
Trans-6-chloro-8-ethyl-4-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C14H18Cl2N2O
|
2
|
| 1 |
EC50 = 82 nM
|
|
|
| 2 |
Ki = 393 nM
|
|
|
|
CP0405795
|
(R)-7-chloro-9-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O2
|
2
|
| 1 |
EC50 = 86 nM
|
|
|
| 2 |
Ki = 209 nM
|
|
|
|
CP0376711
|
7-(trifluoromethyl)-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C12H12F3N3O
|
2
|
| 1 |
EC50 = 92 nM
|
|
|
| 2 |
Ki = 153 nM
|
|
|
|
CP0407527
|
(11aR)-9-ethyl-7-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C15H20N2O
|
2
|
| 1 |
EC50 = 92 nM
|
|
|
| 2 |
Ki = 98 nM
|
|
|
|
CP0405772
|
(R)-9-propyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C15H17F3N2O
|
2
|
| 1 |
EC50 = 94 nM
|
|
|
| 2 |
Ki = 48 nM
|
|
|
|
CP0373770
|
(+/-)-7-isopropoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 107 nM
|
|
|
| 2 |
Ki = 115 nM
|
|
|
|
CP0396450
|
(11aR)-9-propyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C15H20N2O
|
2
|
| 1 |
EC50 = 108 nM
|
|
|
| 2 |
Ki = 77 nM
|
|
|
|
CP0382675
|
8-chloro-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C11H12ClN3O
|
2
|
| 1 |
EC50 = 110 nM
|
|
|
| 2 |
Ki = 757 nM
|
|
|
|
CP0372021
|
8-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C12H15N3O
|
2
|
| 1 |
EC50 = 133 nM
|
|
|
| 2 |
Ki = 998 nM
|
|
|
|
CP0378519
|
(+/-)-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H14N2O2
|
2
|
| 1 |
EC50 = 136 nM
|
|
|
| 2 |
Ki = 133 nM
|
|
|
|
CP0376740
|
3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C11H13N3O
|
2
|
| 1 |
EC50 = 137 nM
|
|
|
| 2 |
Ki = 1936 nM
|
|
|
|
CP0395803
|
(11aR)-9-chloro-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C12H13ClN2O
|
2
|
| 1 |
EC50 = 171 nM
|
|
|
| 2 |
Ki = 234 nM
|
|
|
|
CP0396440
|
(11aR)-2-methyl-3,4,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 193 nM
|
|
|
| 2 |
Ki = 585 nM
|
|
|
|
CP0864171
|
Trans-6-chloro-8-propyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C14H18Cl2N2O
|
2
|
| 1 |
EC50 = 218 nM
|
|
|
| 2 |
Ki = 556 nM
|
|
|
|
CP0407522
|
(11aR)-9-methoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O2
|
2
|
| 1 |
EC50 = 241 nM
|
|
|
| 2 |
Ki = 255 nM
|
|
|
|
CP0399468
|
(R)-9-chloro-8-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O2
|
2
|
| 1 |
EC50 = 246 nM
|
|
|
| 2 |
Ki = 2330 nM
|
|
|
|
CP0425115
|
(+/-)-7-nitrile-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H11N3O
|
2
|
| 1 |
EC50 = 281 nM
|
|
|
| 2 |
Ki = 300 nM
|
|
|
|
CP0379006
|
(10bR)-2-methyl-7-(trifluoromethyl)-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 296 nM
|
|
|
| 2 |
Ki = 430 nM
|
|
|
|
CP0395800
|
(11aR)-6-oxo-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinoline-7-carbonitrile
Show/Hide
|
C13H13N3O
|
2
|
| 1 |
EC50 = 320 nM
|
|
|
| 2 |
Ki = 1661 nM
|
|
|
|
CP0396447
|
(3S,11aR)-3-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 330 nM
|
|
|
| 2 |
Ki = 399 nM
|
|
|
|
CP0405774
|
(R)-9-butyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C16H19F3N2O
|
2
|
| 1 |
EC50 = 363 nM
|
|
|
| 2 |
Ki = 57 nM
|
|
|
|
CP0379002
|
(3S,10bR)-3-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 478 nM
|
|
|
| 2 |
Ki = 369 nM
|
|
|
|
CP0378993
|
(1S,10bR)-1-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C14H15F3N2O
|
2
|
| 1 |
EC50 = 480 nM
|
|
|
| 2 |
Ki = 335 nM
|
|
|
|
CP0437019
|
(+/-)-7-hydroxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H12N2O2
|
2
|
| 1 |
EC50 = 514 nM
|
|
|
| 2 |
Ki = 980 nM
|
|
|
|
CP0395806
|
(11aR)-9-(trifluoromethyl)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 583 nM
|
|
|
| 2 |
Ki = 456 nM
|
|
|
|
CP0396443
|
(11aR)-6-oxo-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinoline-8-carbonitrile
Show/Hide
|
C13H13N3O
|
2
|
| 1 |
EC50 = 600 nM
|
|
|
| 2 |
Ki = 1760 nM
|
|
|
|
CP0396442
|
(11aR)-6-oxo-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinoline-9-carbonitrile
Show/Hide
|
C13H13N3O
|
2
|
| 1 |
EC50 = 610 nM
|
|
|
| 2 |
Ki = 5931 nM
|
|
|
|
CP0397206
|
(11aR)-11a-methyl-2,3,4,11-tetrahydro-1H-pyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 1358 nM
|
|
|
| 2 |
Ki = 3453 nM
|
|
|
|
CP0435876
|
1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H12N2O
|
2
|
| 1 |
EC50 = 1500 nM
|
|
|
| 2 |
Ki = 630 nM
|
|
|
|
CP0437017
|
(10bR)-3,3-dimethyl-7-(trifluoromethyl)-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C14H15F3N2O
|
2
|
| 1 |
EC50 = 1580 nM
|
|
|
| 2 |
Ki = 1450 nM
|
|
|
|
CP0378518
|
(+/-)-7-fluoro-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H11FN2O
|
2
|
| 1 |
EC50 = 1730 nM
|
|
|
| 2 |
Ki = 1030 nM
|
|
|
|
CP0396448
|
(3R,11aR)-3-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 1744 nM
|
|
|
| 2 |
Ki = 2000 nM
|
|
|
|
CP0405793
|
(S)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H11F3N2O
|
2
|
| 1 |
EC50 = 1840 nM
|
|
|
| 2 |
Ki = 1100 nM
|
|
|
|
CP0407521
|
(11aR)-10-(trifluoromethyl)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 3337 nM
|
|
|
| 2 |
Ki = 1428 nM
|
|
|
|
CP0458927
|
10-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C12H15N3O
|
2
|
| 1 |
EC50 = 4197 nM
|
|
|
| 2 |
Ki = 6145 nM
|
|
|
|
CP0373769
|
(3R,10bR)-3-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 321 nM
|
|
|
|
CP0387174
|
10-chloro-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C11H12ClN3O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0045063
|
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
Show/Hide
|
C17H20N4S
|
1
|
| 1 |
Ki = 7.1 nM
|
|
|
|
CP0025667
|
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
Show/Hide
|
C18H19ClN4
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0378316
|
6-chloro-8-methoxy-4,5-dimethyl-1,4-dihydroquinazolin-2-amine
Show/Hide
|
C11H14ClN3O
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0288769
|
5,6-dichloro-4-methyl-1,4-dihydroquinazolin-2-amine
Show/Hide
|
C9H9Cl2N3
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0378318
|
6-chloro-5-methoxy-4-methyl-1,4-dihydroquinazolin-2-amine
Show/Hide
|
C10H12ClN3O
|
1
|
| 1 |
Ki = 74 nM
|
|
|
|
CP0438872
|
5,8-dichloro-4-methyl-1,4-dihydroquinazolin-2-amine
Show/Hide
|
C9H9Cl2N3
|
1
|
| 1 |
Ki = 74 nM
|
|
|
|
CP0121646
|
4-[(10R,15S)-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5(16),6,8-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C24H27FN2O
|
1
|
| 1 |
Ki = 83 nM
|
|
|
|
CP0480060
|
4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-phenylbutan-1-one
Show/Hide
|
C24H29N3O
|
1
|
| 1 |
Ki = 89 nM
|
|
|
|
CP0378320
|
5,6-dichloro-N,4-dimethyl-3,4-dihydro-1H-quinazolin-2-imine
Show/Hide
|
C10H11Cl2N3
|
1
|
| 1 |
Ki = 94 nM
|
|
|
|
CP0411748
|
4-[(10S,15R)-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5(16),6,8-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C24H27FN2O
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0416218
|
1-(4-fluorophenyl)-4-[(10R,15S)-4-thia-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
|
C23H25FN2OS
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0079728
|
5-chloro-4-methyl-1,4-dihydroquinazolin-2-amine
Show/Hide
|
C9H10ClN3
|
1
|
| 1 |
Ki = 152 nM
|
|
|
|
CP0441065
|
5,6-dichloro-4-ethyl-1,4-dihydroquinazolin-2-amine
Show/Hide
|
C10H11Cl2N3
|
1
|
| 1 |
Ki = 155 nM
|
|
|
|
CP0115745
|
1-(4-fluorophenyl)-4-[(10R,15S)-4-methyl-1,4-diaza-12-azoniatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one;4-methylbenzenesulfonate
Show/Hide
|
C31H36FN3O4S
|
1
|
| 1 |
Ki = 173 nM
|
|
|
|
CP0398728
|
4-[(11S,16R)-10,14-diazatetracyclo[8.6.1.05,17.011,16]heptadeca-1,3,5(17)-trien-14-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C25H29FN2O
|
1
|
| 1 |
Ki = 195 nM
|
|
|
|
CP0288744
|
5,6-dichloro-1,4-dihydroquinazolin-2-amine
Show/Hide
|
C8H7Cl2N3
|
1
|
| 1 |
Ki = 208 nM
|
|
|
|
CP0490337
|
5-chloro-N,4-dimethyl-3,4-dihydro-1H-quinazolin-2-imine
Show/Hide
|
C10H12ClN3
|
1
|
| 1 |
Ki = 235 nM
|
|
|
|
CP0480444
|
4-[(10R,15S)-4-butyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C27H34FN3O
|
1
|
| 1 |
Ki = 240 nM
|
|
|
|
CP0480064
|
(10R,15S)-12-[3-(4-fluorophenoxy)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-triene
Show/Hide
|
C23H28FN3O
|
1
|
| 1 |
Ki = 259 nM
|
|
|
|
CP0115747
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1-(4-fluorophenyl)-4-[(10R,15S)-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
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C23H26FN3O
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1
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| 1 |
Ki = 280 nM
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CP0474721
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4-[(10R,15S)-2,4-dimethyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
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C25H30FN3O
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1
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| 1 |
Ki = 280 nM
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CP0115744
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3-[3-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]propyl]-1,2-benzoxazole
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C24H28N4O
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1
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| 1 |
Ki = 287 nM
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CP0411744
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4-[(10R,15S)-4-ethyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
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C25H30FN3O
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1
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| 1 |
Ki = 287 nM
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CP0059921
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6-fluoro-3-[3-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]propyl]-1,2-benzoxazole
Show/Hide
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C24H27FN4O
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1
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| 1 |
Ki = 300 nM
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CP0405775
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(R)-9-ethynyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
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C14H11F3N2O
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1
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| 1 |
Ki = 332 nM
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CP0393077
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5-chloro-4-ethyl-1,4-dihydroquinazolin-2-amine
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C10H12ClN3
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1
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| 1 |
Ki = 380 nM
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CP0480056
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4-[(10R,15S)-4-benzyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
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C30H32FN3O
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1
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| 1 |
Ki = 385 nM
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CP0405786
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(R)-9-hydroxymethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
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C13H13F3N2O2
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1
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| 1 |
Ki = 460 nM
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CP0378319
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4-methyl-8-propan-2-yloxy-1,4-dihydroquinazolin-2-amine
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C12H17N3O
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1
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| 1 |
Ki = 488 nM
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CP0398729
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1-(4-fluorophenyl)-4-[(10R,15S)-4-propan-2-yl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
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C26H32FN3O
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1
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| 1 |
Ki = 498 nM
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CP0480058
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1-(4-fluorophenyl)-4-[(2S,8S)-14-methyl-1,5,14-triazatetracyclo[7.7.1.02,8.013,17]heptadeca-9(17),10,12-trien-5-yl]butan-1-one
Show/Hide
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C25H30FN3O
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1
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| 1 |
Ki = 503 nM
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CP0483361
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4-[(2R,7S)-4,8-diazatetracyclo[6.6.1.02,7.011,15]pentadeca-1(14),11(15),12-trien-4-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
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C23H25FN2O
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1
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| 1 |
Ki = 507 nM
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CP0132711
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1-(4-fluorophenyl)-4-[(10R,15S)-4-oxa-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
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C23H25FN2O2
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1
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| 1 |
Ki = 520 nM
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CP0480065
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1-(4-fluorophenyl)-4-[(10S,15R)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
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C24H28FN3O
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1
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| 1 |
Ki = 532 nM
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CP0496556
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8-methoxy-4-methyl-1,4-dihydroquinazolin-2-amine
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C10H13N3O
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1
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| 1 |
Ki = 556 nM
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CP0411745
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4-[(10R,15S)-7-bromo-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
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C24H27BrFN3O
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1
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| 1 |
Ki = 582 nM
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CP0414459
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1-(4-fluorophenyl)-4-[(2S,8S)-14-oxa-1,5-diazatetracyclo[7.7.1.02,8.013,17]heptadeca-9(17),10,12-trien-5-yl]butan-1-one
Show/Hide
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C24H27FN2O2
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1
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| 1 |
Ki = 641 nM
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CP0371440
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5-chloro-1,4-dihydroquinazolin-2-amine
Show/Hide
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C8H8ClN3
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1
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| 1 |
Ki = 658 nM
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CP0541477
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1-(4-fluorophenyl)-4-[(10S,15R)-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
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C23H26FN3O
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1
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| 1 |
Ki = 702 nM
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CP0416214
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1-(4-fluorophenyl)-4-[(10R,15S)-2,2,4-trimethyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
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C26H32FN3O
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1
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| 1 |
Ki = 862 nM
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CP0379019
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(R)-9-chloro-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
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C12H10ClF3N2O
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1
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| 1 |
Ki = 900 nM
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CP0378317
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N,4-dimethyl-8-propan-2-yloxy-3,4-dihydro-1H-quinazolin-2-imine
Show/Hide
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C13H19N3O
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1
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| 1 |
Ki = 970 nM
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CP0398730
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4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-pyridin-4-ylbutan-1-one
Show/Hide
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C23H28N4O
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1
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| 1 |
Ki = 1090 nM
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CP0480445
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1-(4-fluorophenyl)-4-[(10R,15S)-7-methoxy-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
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C25H30FN3O2
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1
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| 1 |
Ki = 1090 nM
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CP0398727
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1-(4-fluorophenyl)-4-[(2R,8R)-14-methyl-1,5,14-triazatetracyclo[7.7.1.02,8.013,17]heptadeca-9(17),10,12-trien-5-yl]butan-1-one
Show/Hide
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C25H30FN3O
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1
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| 1 |
Ki = 1280 nM
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CP0382677
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8-chloro-2,3,4,5,5a,6-hexahydro-1H-[1,4]diazepino[1,2-a]quinazolin-7-one
Show/Hide
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C12H14ClN3O
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1
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| 1 |
Ki = 1547 nM
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CP0405770
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(R)-9-acetyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
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C14H13F3N2O2
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1
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| 1 |
Ki = 1610 nM
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CP0387726
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(11aS)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
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C12H14N2O
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1
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| 1 |
Ki = 1780 nM
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CP0474718
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3-(4-fluorophenyl)-5-[[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]methyl]-4,5-dihydro-1,2-oxazole
Show/Hide
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C24H27FN4O
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1
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| 1 |
Ki = 3280 nM
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CP0405767
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((R)-10-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2 H)-one
Show/Hide
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C12H13ClN2O2
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1
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| 1 |
Ki = 5060 nM
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CP0398726
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1-(4-fluorophenyl)-4-[(10S,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
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C24H28FN3O
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1
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| 1 |
Ki > 1000 nM
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CP0398731
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4-fluoro-N-[2-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]ethyl]benzamide
Show/Hide
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C23H27FN4O
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1
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| 1 |
Ki > 1000 nM
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CP0411747
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1-(4-fluorophenyl)-4-[(10R,15R)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
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C24H28FN3O
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1
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| 1 |
Ki > 1000 nM
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CP0474717
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(3aR,7aS)-2-[4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
Show/Hide
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C26H36N4O2
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1
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| 1 |
Ki > 1000 nM
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CP0480057
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6-chloro-5-[2-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]ethyl]-1,3-dihydroindol-2-one
Show/Hide
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C24H27ClN4O
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1
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| 1 |
Ki > 1000 nM
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CP0480062
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1-(4,4-difluoropiperidin-1-yl)-4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
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C23H32F2N4O
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1
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| 1 |
Ki > 1000 nM
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