Brief Information of the Cell Line and Protein
Cell Line ID: CL000040 , THP-1
Synonyms
THP1
THP 1
THPI
THP-1(ATCC)
THP-1-O
O-THP-1
Tohoku Hospital Pediatrics-1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0006
Protein ID: PT01231 , MAP kinase-activated protein kinase 2
Gene Name MAPKAPK2
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P49137
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000040  Protein ID: PT01231
 
Compound ID Compound Name Compound Formula
CP0222011
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]-3-(trifluoromethoxy)benzamide
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C24H22F3N5O3
 1
1
EC50 = 130 nM
   TI
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CP0095398
3,4-dimethyl-N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-pyrrolidine]-2-yl)pyridin-2-yl]benzamide
   Show/Hide
C24H25N5O2
 1
1
EC50 = 240 nM
   TI
   LI
   LO
   TS
CP0191246
4-(15-piperazin-1-yl-8-oxa-2,5-diazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(13),3,5,7(11),9,14,16-heptaen-9-yl)benzonitrile
   Show/Hide
C25H21N5O
 1
1
EC50 = 260 nM
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CP0197173
4-(15-piperazin-1-yl-8-oxa-2,4,5-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(13),3,5,7(11),9,14,16-heptaen-9-yl)benzonitrile
   Show/Hide
C24H20N6O
 1
1
EC50 = 260 nM
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CP0268229
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]naphthalene-2-carboxamide
   Show/Hide
C27H25N5O2
 1
1
EC50 = 280 nM
   TI
   LI
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   TS
CP0332147
3,4-dimethyl-N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]benzamide
   Show/Hide
C25H27N5O2
 1
1
EC50 = 350 nM
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   LI
   LO
   TS
CP0066026
5-(4-chlorophenyl)-N-(4-piperazin-1-ylphenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide
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C27H25ClN4O2
 1
1
EC50 = 350 nM
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   TS
CP0211219
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-pyrrolidine]-2-yl)pyridin-2-yl]naphthalene-2-carboxamide
   Show/Hide
C26H23N5O2
 1
1
EC50 = 390 nM
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CP0035338
(S)-2'-(2-(6-(3-methoxypropoxy)pyridin-3-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-3,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C24H28N6O3
 1
1
EC50 = 400 nM
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   LI
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   TS
CP0335269
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-pyrrolidine]-2-yl)pyridin-2-yl]-3-(trifluoromethoxy)benzamide
   Show/Hide
C23H20F3N5O3
 1
1
EC50 = 400 nM
   TI
   LI
   LO
   TS
CP0268222
3-fluoro-N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-pyrrolidine]-2-yl)pyridin-2-yl]benzamide
   Show/Hide
C22H20FN5O2
 1
1
EC50 = 480 nM
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   LI
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   TS
CP0136275
(S)-2'-(2-(benzo[d][1,3]dioxol-5-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-3,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C22H21N5O3
 1
1
EC50 = 500 nM
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CP0354792
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]naphthalene-1-carboxamide
   Show/Hide
C27H25N5O2
 1
1
EC50 = 520 nM
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CP0222010
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]pyridine-2-carboxamide
   Show/Hide
C22H22N6O2
 1
1
EC50 = 550 nM
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CP0095399
3,5-difluoro-N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-2-yl)pyridin-2-yl]benzamide
   Show/Hide
C23H21F2N5O2
 1
1
EC50 = 590 nM
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CP0155454
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-2-yl)pyridin-2-yl]-3-(trifluoromethyl)benzamide
   Show/Hide
C24H22F3N5O2
 1
1
EC50 = 590 nM
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   TS
CP0209410
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-2-yl)pyridin-2-yl]-3-(trifluoromethoxy)benzamide
   Show/Hide
C24H22F3N5O3
 1
1
EC50 = 610 nM
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CP0136237
2'-(2-(benzo[d][1,3]dioxol-5-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C22H21N5O3
 1
1
EC50 = 620 nM
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   TS
CP0146233
3-fluoro-N-[4-(1'-methyl-4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]benzamide
   Show/Hide
C24H24FN5O2
 1
1
EC50 = 640 nM
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   TS
CP0222008
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-pyrrolidine]-2-yl)pyridin-2-yl]pyridine-2-carboxamide
   Show/Hide
C21H20N6O2
 1
1
EC50 = 660 nM
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   TS
CP0275368
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-2-yl)pyridin-2-yl]pyridine-2-carboxamide
   Show/Hide
C22H22N6O2
 1
1
EC50 = 660 nM
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CP0217029
3-fluoro-N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]benzamide
   Show/Hide
C23H22FN5O2
 1
1
EC50 = 680 nM
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CP0282679
N-[4-(1'-methyl-4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]naphthalene-2-carboxamide
   Show/Hide
C28H27N5O2
 1
1
EC50 = 730 nM
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CP0133903
3-[5-(4-chlorophenyl)furan-2-yl]-4-(4-piperazin-1-ylphenyl)-5-(2-pyrimidin-5-ylphenyl)-5H-1,2,4-oxadiazole
   Show/Hide
C32H27ClN6O2
 1
1
EC50 = 730 nM
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CP0340195
3-[5-(4-fluorophenyl)furan-2-yl]-4-(4-piperazin-1-ylphenyl)-5-(2-pyrimidin-5-ylphenyl)-5H-1,2,4-oxadiazole
   Show/Hide
C32H27FN6O2
 1
1
EC50 = 760 nM
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CP0338517
3-[5-(4-chlorophenyl)furan-2-yl]-4-(4-piperazin-1-ylphenyl)-5-(4-pyrimidin-5-ylphenyl)-5H-1,2,4-oxadiazole
   Show/Hide
C32H27ClN6O2
 1
1
EC50 = 820 nM
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CP0146232
N-[4-(1'-methyl-4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]-3-(trifluoromethoxy)benzamide
   Show/Hide
C25H24F3N5O3
 1
1
EC50 = 830 nM
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   TS
CP0275367
4-fluoro-N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-pyrrolidine]-2-yl)pyridin-2-yl]benzamide
   Show/Hide
C22H20FN5O2
 1
1
EC50 = 840 nM
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CP0035348
2-[2-(5-methoxypyridin-3-yl)pyrimidin-4-yl]spiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-4-one
   Show/Hide
C21H22N6O2
 1
1
EC50 = 900 nM
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CP0080969
3,4-dimethyl-N-[4-(1'-methyl-4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]benzamide
   Show/Hide
C26H29N5O2
 1
1
EC50 = 920 nM
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CP0035344
2-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]spiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-4-one
   Show/Hide
C22H21N5O3
 1
1
EC50 = 930 nM
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CP0250562
(S)-2'-(2-(5-methoxypyridin-3-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-3,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C21H22N6O2
 1
1
EC50 = 1100 nM
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CP0085235
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-2-yl)pyridin-2-yl]naphthalene-1-carboxamide
   Show/Hide
C27H25N5O2
 1
1
EC50 = 1100 nM
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CP0035328
(S)-2'-(2-(pyridin-3-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-3,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C20H20N6O
 1
1
EC50 = 1200 nM
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CP0136273
2'-(2-(benzofuran-2-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C23H21N5O2
 1
1
EC50 = 1200 nM
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CP0335270
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-2-yl)pyridin-2-yl]-4-(trifluoromethyl)benzamide
   Show/Hide
C24H22F3N5O2
 1
1
EC50 = 1200 nM
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   TS
CP0268227
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]-4-(trifluoromethyl)benzamide
   Show/Hide
C24H22F3N5O2
 1
1
EC50 = 1300 nM
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   TS
CP0035326
2-[2-[6-(3-methoxypropoxy)pyridin-3-yl]pyrimidin-4-yl]spiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-4-one
   Show/Hide
C24H28N6O3
 1
1
EC50 = 1400 nM
   TI
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   TS
CP0341838
9-(4-chlorophenyl)-15-piperazin-1-yl-8-oxa-2,5-diazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(13),3,5,7(11),9,14,16-heptaene
   Show/Hide
C24H21ClN4O
 1
1
EC50 = 1500 nM
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   TS
CP0035346
2'-(2-(benzofuran-2-yl)pyrimidin-4-yl)-1-methyl-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C24H23N5O2
 1
1
EC50 = 1600 nM
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CP0066029
5-(4-chlorophenyl)-N-(4-piperazin-1-ylphenyl)furan-2-carboxamide
   Show/Hide
C21H20ClN3O2
 1
1
EC50 = 2000 nM
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CP0035349
2-(2-pyridin-3-ylpyrimidin-4-yl)spiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,3'-piperidine]-4-one
   Show/Hide
C20H20N6O
 1
1
EC50 = 2100 nM
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CP0298453
9-(4-chlorophenyl)-15-piperazin-1-yl-8-oxa-2,4,5-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(13),3,5,7(11),9,14,16-heptaene
   Show/Hide
C23H20ClN5O
 1
1
EC50 = 2100 nM
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CP0241914
(R)-2'-(2-(5-methoxypyridin-3-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-3,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C21H22N6O2
 1
1
EC50 = 2300 nM
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CP0338515
3-[5-(4-chlorophenyl)furan-2-yl]-5-(1H-imidazol-5-yl)-4-(4-piperazin-1-ylphenyl)-5H-1,2,4-oxadiazole
   Show/Hide
C25H23ClN6O2
 1
1
EC50 = 2400 nM
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CP0079816
9-(4-chlorophenyl)-3-methyl-15-piperazin-1-yl-8-oxa-2,5-diazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(13),3,5,7(11),9,14,16-heptaene
   Show/Hide
C25H23ClN4O
 1
1
EC50 = 2500 nM
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CP0049116
Pyrrolopyridine, 23
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C18H14FN3O
 2
1
EC50 = 2700 nM
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2
IC50 = 8900 nM
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CP0550526
3-[5-(4-chlorophenyl)furan-2-yl]-4-(4-piperazin-1-ylphenyl)-5-pyridin-4-yl-5H-1,2,4-oxadiazole
   Show/Hide
C27H24ClN5O2
 1
1
EC50 = 2700 nM
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CP0169838
3-[5-(4-chlorophenyl)furan-2-yl]-4-(4-piperazin-1-ylphenyl)-5-pyridin-2-yl-5H-1,2,4-oxadiazole
   Show/Hide
C27H24ClN5O2
 1
1
EC50 = 3000 nM
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CP0337906
4-fluoro-N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]benzamide
   Show/Hide
C23H22FN5O2
 1
1
EC50 = 3700 nM
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CP0329348
3-[5-(4-chlorophenyl)furan-2-yl]-5-(5-fluoropyridin-2-yl)-4-(4-piperazin-1-ylphenyl)-5H-1,2,4-oxadiazole
   Show/Hide
C27H23ClFN5O2
 1
1
EC50 = 3700 nM
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CP0035345
(R)-2'-(2-(pyridin-3-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-3,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C20H20N6O
 1
1
EC50 = 5800 nM
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   TS
CP0169836
3-[5-(4-chlorophenyl)furan-2-yl]-5-phenyl-4-(4-piperazin-1-ylphenyl)-5H-1,2,4-oxadiazole
   Show/Hide
C28H25ClN4O2
 1
1
EC50 = 6700 nM
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CP0170204
(R)-2'-(2-(benzo[d][1,3]dioxol-5-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-3,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C22H21N5O3
 1
1
EC50 = 7700 nM
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CP0035340
2'-(2-(benzofuran-2-yl)pyrimidin-4-yl)-1-ethyl-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C25H25N5O2
 1
1
EC50 > 10000 nM
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CP0250569
(R)-2'-(2-(6-(3-methoxypropoxy)pyridin-3-yl)pyrimidin-4-yl)-5',6'-dihydrospiro[piperidine-3,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one
   Show/Hide
C24H28N6O3
 1
1
EC50 > 10000 nM
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CP0211220
N-[4-(4-oxospiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-2-yl)pyridin-2-yl]pyridine-4-carboxamide
   Show/Hide
C22H22N6O2
 1
1
EC50 > 10000 nM
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CP0262880
4-(2-fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C22H19FN4O
 1
1
IC50 = 100 nM
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CP0262877
4-(3-fluorophenyl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C23H21FN4O
 1
1
IC50 = 200 nM
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CP0337966
4-(3-fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C22H19FN4O
 1
1
IC50 = 200 nM
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CP0255889
4-(2-fluorophenyl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C23H21FN4O
 1
1
IC50 = 300 nM
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CP0243805
4-(3-fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-one
   Show/Hide
C22H18FN3O
 1
1
IC50 = 500 nM
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CP0315870
4-(3-fluoro-4-methoxyphenyl)-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11(16)-hexaen-12-one
   Show/Hide
C21H16FN3O2
 1
1
IC50 = 500 nM
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CP0046929
4-(4-methoxyphenyl)-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaen-12-one
   Show/Hide
C21H19N3O2
 1
1
IC50 = 700 nM
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   TS
CP0262879
4-(2-fluorophenyl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,4'-piperidine]-12-one
   Show/Hide
C25H25FN4O
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0302460
4-(2-fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-one
   Show/Hide
C22H18FN3O
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0302461
4-(4-methoxyphenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-one
   Show/Hide
C23H21N3O2
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0337967
4-(4-methoxyphenyl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C24H24N4O2
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0073084
4-[5-(2-methoxyethoxy)pyridin-3-yl]-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11(16)-hexaen-12-one
   Show/Hide
C22H20N4O3
 2
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
2
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0313128
4-(4-methoxyphenyl)-14-methyl-5,13,14,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11(16)-hexaen-12-one
   Show/Hide
C21H18N4O2
 1
1
IC50 = 875 nM
   TI
   LI
   LO
   TS
CP0258055
4-(3-fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,1'-cyclopropane]-12-one
   Show/Hide
C22H18FN3O
 1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0309048
4-(6-fluoropyridin-3-yl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-one
   Show/Hide
C21H17FN4O
 1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0073086
4-(4-methoxyphenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,1'-cyclopropane]-12-one
   Show/Hide
C23H21N3O2
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0262878
1'-methyl-4-[4-(2-morpholin-4-ylethoxy)phenyl]spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C29H33N5O3
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0315123
4-(6-fluoropyridin-3-yl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C22H20FN5O
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0283485
4-[3-(2-morpholin-4-ylethoxy)phenyl]-5,13,16-triazatetracyclo[8.6.0.02,7.011,15]hexadeca-1(10),2,4,6,8,11(15)-hexaen-12-one
   Show/Hide
C25H24N4O3
 1
1
IC50 = 1280 nM
   TI
   LI
   LO
   TS
CP0243803
4-(3-fluorophenyl)-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaen-12-one
   Show/Hide
C20H16FN3O
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0255892
4-(2-fluorophenyl)-17-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C23H21FN4O
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0303239
4-[3-(2-morpholin-4-ylethoxy)phenyl]-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11(16)-hexaen-12-one
   Show/Hide
C26H26N4O3
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0243150
4-[5-(3-methoxypropoxy)pyridin-3-yl]-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C26H29N5O3
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0262882
4-[4-(2-morpholin-4-ylethoxy)phenyl]spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-one
   Show/Hide
C28H30N4O3
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0309046
4-(6-fluoropyridin-3-yl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,1'-cyclopropane]-12-one
   Show/Hide
C21H17FN4O
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0243802
1'-ethyl-4-(2-fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C24H23FN4O
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0170947
4-[5-(2-methoxyethoxy)pyridin-3-yl]-5,13,16-triazatetracyclo[8.6.0.02,7.011,15]hexadeca-1(10),2,4,6,8,11(15)-hexaen-12-one
   Show/Hide
C21H18N4O3
 1
1
IC50 = 1680 nM
   TI
   LI
   LO
   TS
CP0243804
4-(2-fluorophenyl)-1',17-dimethylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C24H23FN4O
 1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0309047
4-[5-(2-methoxyethoxy)pyridin-3-yl]-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaen-12-one
   Show/Hide
C22H22N4O3
 1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0160608
4-(6-fluoropyridin-3-yl)-1'-methylspiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C21H19FN6O
 1
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0074188
4-(4-methoxyphenyl)spiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-one
   Show/Hide
C22H20N4O2
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0271340
4-[5-(2-morpholin-4-ylethoxy)pyridin-3-yl]-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11(16)-hexaen-12-one
   Show/Hide
C25H25N5O3
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0332074
4-(2-fluorophenyl)-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaen-12-one
   Show/Hide
C20H16FN3O
 1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0314162
1'-methyl-4-[4-(2-morpholin-4-ylethoxy)phenyl]spiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C28H32N6O3
 1
1
IC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0169211
4-(4-methoxyphenyl)-1'-methylspiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C23H23N5O2
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0299915
4-(4-methoxyphenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,3'-azetidine]-12-one
   Show/Hide
C23H22N4O2
 1
1
IC50 = 3100 nM
   TI
   LI
   LO
   TS
CP0048734
4-[4-(2-morpholin-4-ylethoxy)phenyl]spiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-one
   Show/Hide
C27H29N5O3
 1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0086560
4-[5-(2-methoxyethoxy)pyridin-3-yl]-5,14,18-triazatetracyclo[9.7.0.02,7.012,17]octadeca-1(11),2,4,6,12(17)-pentaen-13-one
   Show/Hide
C23H24N4O3
 1
1
IC50 = 4300 nM
   TI
   LI
   LO
   TS
CP0255897
4-(4-methoxyphenyl)-3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaen-12-one
   Show/Hide
C20H18N4O2
 1
1
IC50 = 4300 nM
   TI
   LI
   LO
   TS
CP0286936
4-(3-fluorophenyl)-1'-methylspiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C22H20FN5O
 1
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0313129
4-(2-fluorophenyl)-5,13,16-triazatetracyclo[8.6.0.02,7.011,15]hexadeca-1(10),2,4,6,8,11(15)-hexaen-12-one
   Show/Hide
C19H12FN3O
 1
1
IC50 = 5078 nM
   TI
   LI
   LO
   TS
CP0262881
4-(2-fluorophenyl)-1'-methylspiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C22H20FN5O
 1
1
IC50 = 5600 nM
   TI
   LI
   LO
   TS
CP0332075
4-(4-methoxyphenyl)spiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,1'-cyclopropane]-12-one
   Show/Hide
C22H20N4O2
 1
1
IC50 = 5600 nM
   TI
   LI
   LO
   TS
CP0270953
4-(3-fluoro-4-methoxyphenyl)-5,16-diazatetracyclo[8.6.0.02,7.011,15]hexadeca-1(10),2,4,6,8,11(15)-hexaen-12-one
   Show/Hide
C21H15FN2O2
 1
1
IC50 = 5800 nM
   TI
   LI
   LO
   TS
CP0314163
1'-(2-fluoroethyl)-4-(2-fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C24H22F2N4O
 1
1
IC50 = 6500 nM
   TI
   LI
   LO
   TS
CP0291497
4-[5-(2-methoxyethoxy)pyridin-3-yl]-1'-methylspiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C24H26N6O3
 1
1
IC50 = 6700 nM
   TI
   LI
   LO
   TS
CP0038368
4-[5-(2-methoxyethoxy)pyridin-3-yl]-5,13,18-triazatetracyclo[8.8.0.02,7.011,17]octadeca-1(10),2,4,6,8,11(17)-hexaen-12-one
   Show/Hide
C23H22N4O3
 1
1
IC50 = 8300 nM
   TI
   LI
   LO
   TS
CP0290793
4-[5-(2-morpholin-4-ylethoxy)pyridin-3-yl]-5,13,16-triazatetracyclo[8.6.0.02,7.011,15]hexadeca-1(10),2,4,6,8,11(15)-hexaen-12-one
   Show/Hide
C24H23N5O3
 1
1
IC50 = 9330 nM
   TI
   LI
   LO
   TS
CP0046930
12-(2-fluorophenyl)-1'-methylspiro[4,8,13-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-1(9),2(7),10,12,14-pentaene-6,3'-azetidine]-3-one
   Show/Hide
C22H19FN4O
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0310195
4-(6-fluoropyridin-3-yl)spiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-one
   Show/Hide
C20H16FN5O
 1
1
IC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0347053
4-(2-fluorophenyl)spiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-one
   Show/Hide
C21H17FN4O
 1
1
IC50 = 15300 nM
   TI
   LI
   LO
   TS
CP0299918
4-(3-fluorophenyl)spiro[17-oxa-5,13-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C22H18FN3O2
 1
1
IC50 = 17000 nM
   TI
   LI
   LO
   TS
CP0310194
4-(4-methoxyphenyl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,3'-azetidine]-12-one
   Show/Hide
C24H24N4O2
 1
1
IC50 = 17000 nM
   TI
   LI
   LO
   TS
CP0302459
1'-acetyl-4-(2-fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-one
   Show/Hide
C24H21FN4O2
 1
1
IC50 = 25000 nM
   TI
   LI
   LO
   TS
CP0297522
4-[5-(2-morpholin-4-ylethoxy)pyridin-3-yl]-5,13,18-triazatetracyclo[8.8.0.02,7.011,17]octadeca-1(10),2,4,6,8,11(17)-hexaen-12-one
   Show/Hide
C26H27N5O3
 1
1
IC50 > 30000 nM
   TI
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   LO
   TS