Brief Information of the Cell Line and Protein
Cell Line ID: CL000040 , THP-1
 Cell Line Info 
Synonyms
THP1
THP 1
THPI
THP-1(ATCC)
THP-1-O
O-THP-1
Tohoku Hospital Pediatrics-1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0006
Protein ID: PT01184 , Rho-associated protein kinase 1
 Protein Info 
Gene Name ROCK1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q13464
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000040
 Cell Line Info 
 Protein ID: PT01184
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0357708
 Compound Info 
4-N-(2,3-dihydro-1H-inden-2-yl)-2-piperazin-1-yl-6-N-pyridin-4-ylpyrimidine-4,6-diamine
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C22H25N7
  1
1
IC50 = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0271653
 Compound Info 
6-(1,4-diazepan-1-yl)-N2-(2,3-dihydro-1H-inden-2-yl)-N4-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine
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C22H26N8
  1
1
IC50 = 17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0230283
 Compound Info 
(R)-N2-(2,3-dihydro-1H-inden-2-yl)-6-(3-methylpiperazin-1-yl)-N4-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine
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C22H26N8
  1
1
IC50 = 26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0039567
 Compound Info 
2-N-(2,3-dihydro-1H-inden-2-yl)-6-piperazin-1-yl-4-N-pyridin-4-yl-1,3,5-triazine-2,4-diamine
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C21H24N8
  1
1
IC50 = 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0303457
 Compound Info 
4-(2,3-dihydro-1H-inden-2-yloxy)-6-(piperazin-1-yl)-N-(pyridin-4-yl)-1,3,5-triazin-2-amine
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C21H23N7O
  1
1
IC50 = 57 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0191570
 Compound Info 
4-N-(2,3-dihydro-1H-inden-2-yl)-6-piperazin-1-yl-2-N-pyridin-4-ylpyrimidine-2,4-diamine
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C22H25N7
  1
1
IC50 = 154 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0231441
 Compound Info 
6-[(3S)-1-benzylpiperidin-3-yl]oxyisoquinoline
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C21H22N2O
  1
1
IC50 = 331.13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0053129
 Compound Info 
6-[(3S)-piperidin-3-yl]oxy-2H-isoquinolin-1-one
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C14H16N2O2
  1
1
IC50 = 660.69 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0162590
 Compound Info 
6-[(3S)-1-benzylpiperidin-3-yl]oxyisoquinolin-1-amine
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C21H23N3O
  1
1
IC50 = 776.25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0038781
 Compound Info 
6-[(3S)-piperidin-3-yl]oxyisoquinolin-1-amine
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C14H17N3O
  1
1
IC50 = 5011.87 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0231442
 Compound Info 
5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-amine
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C14H18N4O2S
  1
1
IC50 = 6918.31 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS