General Information of the Compound
Compound ID
CP0038781
Compound Name
6-[(3S)-piperidin-3-yl]oxyisoquinolin-1-amine
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Structure
Formula
C14H17N3O
Molecular Weight
243.31
Canonical SMILES
Nc1nccc2cc(O[C@H]3CCCNC3)ccc12
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InChI
InChI=1S/C14H17N3O/c15-14-13-4-3-11(8-10(13)5-7-17-14)18-12-2-1-6-16-9-12/h3-5,7-8,12,16H,1-2,6,9H2,(H2,15,17)/t12-/m0/s1
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InChIKey
YHTZIHUTLKKYNH-LBPRGKRZSA-N
Physicochemical Property
logP
1.9478
Rotatable Bonds
2
Heavy Atom Count
18
Polar Areas
60.17
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
18

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16222570
SID: 24905058
ChEMBL ID
CHEMBL1643368
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01184, Rho-associated protein kinase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 5011.87 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2137.96 nM
2 Ki = 37.15 nM