Brief Information of the Compound and Protein
Compound Name
5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-amine
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PubChem ID
CID: 49870878
SID: 104545758
Canonical SMILES
Nc1nccc2c(cccc12)S(=O)(=O)N1CCCNCC1
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Compound Formula C14H18N4O2S
Compound Structure
Protein Name
Rho-associated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
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AGC protein kinase group
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AGC protein kinase DMPK family
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AGC protein kinase ROCK subfamily
Uniprot ID
Q13464
Gene Name
ROCK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 6918.31 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 758.58 nM
2 IC50 = 3162.28 nM
3 Ki = 34.67 nM