Brief Information of the Compound and Protein
Compound Name
4-N-(2,3-dihydro-1H-inden-2-yl)-6-piperazin-1-yl-2-N-pyridin-4-ylpyrimidine-2,4-diamine
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PubChem ID
CID: 45483179
Canonical SMILES
C1C(Cc2ccccc12)Nc1cc(nc(Nc2ccncc2)n1)N1CCNCC1
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Compound Formula C22H25N7
Compound Structure
Protein Name
Rho-associated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
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AGC protein kinase group
>
AGC protein kinase DMPK family
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AGC protein kinase ROCK subfamily
Uniprot ID
Q13464
Gene Name
ROCK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 154 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 14 nM