US10112942, Example 163

3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methylphenol

2-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-N-(4-propan-2-ylphenyl)acetamide

2-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamino)phenyl)-N-((S)-1-phenylethyl)acetamide

N-[(3-fluorophenyl)methyl]-2-[4-[[4-[4-(2-hydroxyethyl)piperazin-1-yl]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]acetamide

3-{[7-(pyridin-2-yl)quinolin-4-yl]amino}phenol

N-[(3-fluorophenyl)methyl]-2-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]acetamide

N-(3-fluorophenyl)-2-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]acetamide

N-(4-fluorophenyl)-2-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]acetamide

N-cyclopropyl-2-[4-[[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]amino]phenyl]acetamide

N-cyclopropyl-2-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]acetamide

N-cyclopropyl-2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[4-(2-morpholin-4-ylethyl)piperazin-1-yl]pyrimidin-2-yl]amino]phenyl]acetamide

2-[4-[[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]amino]phenyl]-N-[(3-fluorophenyl)methyl]acetamide

2-[4-[[4-(4-ethylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-N-[(3-fluorophenyl)methyl]acetamide

2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-N-(2-fluorophenyl)acetamide

2-[4-[[4-(4-ethylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-N-[(4-methoxyphenyl)methyl]acetamide

2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[4-(2-morpholin-4-ylethyl)piperazin-1-yl]pyrimidin-2-yl]amino]phenyl]-N-(4-propan-2-ylphenyl)acetamide

2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-N-(3-fluorophenyl)acetamide

N-cyclopropyl-2-[4-[[4-[4-(2-hydroxyethyl)piperazin-1-yl]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]acetamide

2-[4-[[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]amino]phenyl]-N-(4-propan-2-ylphenyl)acetamide

4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde

4-chloro-2-fluoro-5-({7-[2-(hydroxymethyl)-1,3-thiazol-4-yl]quinolin-4-yl}amino)phenol

2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-N-(4-propan-2-ylphenyl)acetamide

3-({6-methanesulfonyl-7-[2-(morpholin-4-ylmethyl)-1,3-thiazol-4-yl]quinolin-4-yl}amino)-4-methylphenol

2-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamino)phenyl)-N-((R)-1-phenylethyl)acetamide

2-[4-[[4-(4-ethylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-N-(4-propan-2-ylphenyl)acetamide

4-methyl-3-{[7-(pyridin-2-yl)quinolin-4-yl]amino}phenol

2-chloro-4-fluoro-5-({7-[3-({[2-(morpholin-4-yl)ethyl]amino}methyl)phenyl]quinolin-4-yl}amino)phenol

4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}phenol

5-{[7-(1-benzofuran-2-yl)quinolin-4-yl]amino}-2-bromophenol

6-substituted 4-anilinoquinoline, 37

N-(2-fluorophenyl)-2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]pyrimidin-2-yl]amino]phenyl]acetamide

4-[(5-hydroxy-2-methylphenyl)amino]-N-(propan-2-yl)quinoline-6-carboxamide

N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

3-{[3-chloro-7-(1,3-thiazol-5-yl)quinolin-4-yl]amino}phenol

N-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-morpholin-4-ylpyrimidin-2-yl]amino]phenyl]acetamide

2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]pyrimidin-2-yl]amino]phenyl]-N-(4-propan-2-ylphenyl)acetamide

N-(3-fluoro-4-methylphenyl)-2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]pyrimidin-2-yl]amino]phenyl]acetamide

N-(3-fluorophenyl)-2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]pyrimidin-2-yl]amino]phenyl]acetamide

N-(4-tert-butylphenyl)-2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-morpholin-4-ylpyrimidin-2-yl]amino]phenyl]acetamide

2-[4-[[4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]amino]phenyl]-N-(4-propan-2-ylphenyl)acetamide

4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide

2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-morpholin-4-ylpyrimidin-2-yl]amino]phenyl]-N-(4-propan-2-ylphenyl)acetamide

(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one

N-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]pyrimidin-2-yl]amino]phenyl]acetamide

3-((4-(dimethylamino)naphthalen-1-yl)methylene)-4-methylindolin-2-one

2-[4-[[4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]amino]phenyl]-N-cyclopropylacetamide

N-(2-fluorophenyl)-2-[4-[[4-(1-methylpyrazol-4-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]acetamide

2-[4-[[4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]amino]phenyl]-N-[(3-fluorophenyl)methyl]acetamide

N-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-[[4-(1-methylpyrazol-4-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]acetamide

(3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one

2-[4-[[4-(1-methylpyrazol-4-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-N-(4-propan-2-ylphenyl)acetamide

(3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one

(3Z)-5-amino-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one

(Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-pyridin-3-yl-1,3-dihydro-indol-2-one

2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-4-(3-thienyl)pyridine-3,5-dicarbonitrile

(Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one

(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE

(3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one

(E)-5-Amino-3-(4-diethylamino-benzylidene)-1,3-dihydroindol-2-one

3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indolinone

(Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-furan-3-yl-1,3-dihydro-indol-2-one

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-5-Bromo-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one

Su-9516

2-(benzylthio)-4-(thiophen-2-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

(Z)-4-bromo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indolin-2-one

(Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-trifluoromethoxy-1,3-dihydro-indol-2-one

(E)-3-(4-hydroxybenzylidene)indolin-2-one

2-[(2-Oxo-2-phenylethyl)sulfanyl]-4-(3-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

2-Amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(3-thienyl)pyridine-3,5-dicarbonitrile

2-Amino-6-({2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl}sulfanyl)-4-(3-thienyl)pyridine-3,5-dicarbonitrile

2-Amino-6-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-4-(3-thienyl)pyridine-3,5-dicarbonitrile

(Z)-4-(4-((4-methyl-2-oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde

(Z)3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one

2-(4-fluorobenzylsulfanyl)-4-(2-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

2-Amino-6-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl}-4-(3-thienyl)pyridine-3,5-dicarbonitrile

(3Z)-5-AMINO-3-[(4-METHOXYPHENYL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE

(Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-7-methoxy-1,3-dihydro-indol-2-one

(Z)-N-[3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-5-yl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide

(Z)-3-(1H-Indol-3-ylmethylene)-5-nitro-1,3-dihydro-indol-2-one

(Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-methyl-1,3-dihydro-indol-2-one

2-(Benzylsulfanyl)-4-(3-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

2-Amino-6-[(4-chlorobenzyl)sulfanyl]-4-(3-thienyl)pyridine-3,5-dicarbonitrile

2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-4-(3-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

2-Amino-6-[(3,4-dichlorobenzyl)sulfanyl]-4-(3-thienyl)pyridine-3,5-dicarbonitrile

2-[(4-Chlorobenzyl)sulfanyl]-4-(3-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

2-Amino-6-[(4-methylbenzyl)sulfanyl]-4-(3-thienyl)pyridine-3,5-dicarbonitrile

(E)-3-[2,3']Bifuranyl-5-ylmethylene-5-nitro-1,3-dihydro-indol-2-one

2-Amino-6-[(4-methoxybenzyl)sulfanyl]-4-(3-thienyl)pyridine-3,5-dicarbonitrile

N-(4-chlorophenyl)-2-[(3-cyano-4-thiophen-3-yl-5,6,7,8-tetrahydroquinolin-2-yl)sulfanyl]acetamide

2-Amino-6-(benzylsulfanyl)-4-(3-thienyl)pyridine-3,5-dicarbonitrile

(Z)-5-(1-Methyl-1H-pyrazol-4-yl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one

(E)-3-(5-Bromo-furan-2-ylmethylene)-5-nitro-1,3-dihydro-indol-2-one

3-(biphenyl-4-ylmethylene)-4-methylindolin-2-one

2-Amino-6-{[2-(3-chlorophenyl)-2-oxoethyl]sulfanyl}-4-(3-thienyl)pyridine-3,5-dicarbonitrile

2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-6-methyl-4-(3-thienyl)-5,6,7,8-tetrahydro[1,6]naphthyridine-3-carbonitrile

(E)-5-Amino-3-[2,3']bifuranyl-5-ylmethylene-1,3-dihydroindol-2-one

2-Amino-6-{[2-(4-cyanophenyl)-2-oxoethyl]sulfanyl}-4-(3-thienyl)pyridine-3,5-dicarbonitrile

(Z)-5-Furan-2-yl-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one

3-((4-(dimethylamino)naphthalen-1-yl)methylene)indolin-2-one

(E)-5-Amino-3-(4-methoxybenzylidene)indolin-2-one

(3Z)-5-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one

(E)-5-Amino-3-(5-bromo-furan-2-ylmethylene)-1,3-dihydro-indol-2-one

(E)-5-Nitro-3-(5-thiophen-3-yl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one

(3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-dihydro-1H-indol-2-one

(Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-one

4-Anilino-6,7-disubstituted quinoline, 41

4-methyl-3-(7-(pyridin-4-yl)-2-(trifluoromethyl)quinolin-4-ylamino)phenol

3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide

3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide