Brief Information of the Compound and Protein
Compound Name
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
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PubChem ID
CID: 3081361
SID: 14761077
Canonical SMILES
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
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Compound Formula C22H24BrFN4O2
Compound Structure
Protein Name
Proto-oncogene tyrosine-protein kinase receptor Ret
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Ret family
Uniprot ID
P07949
Gene Name
RET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 97 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.13 nM
2 IC50 = 7 nM
3 IC50 = 9 nM
4 IC50 = 100 nM
5 IC50 = 102 nM
6 IC50 = 130 nM
7 IC50 = 950 nM
8 IC50 = 2049 nM
9 IC50 = 2597 nM
10 IC50 = 3597 nM
11 IC50 > 5000 nM
12 Kd = 14 nM
13 Kd = 34 nM
14 Kd > 10000 nM