Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01711 , Histamine H4 receptor
Gene Name HRH4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q9H3N8
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01711
 
Compound ID Compound Name Compound Formula
CP0394325
2-[N-[(2R)-1-(1H-imidazol-5-yl)propan-2-yl]-C-phenylcarbonimidoyl]-5-methoxyphenol
   Show/Hide
C20H21N3O2
 2
1
EC50 = 6750 nM
   TI
   LI
   LO
   TS
2
Ki = 6750 nM
   TI
   LI
   LO
   TS
CP0079896
2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-(3-hydroxy-propyl)-acetamide
   Show/Hide
C22H23ClN2O4
 2
1
EC50 = 7780 nM
   TI
   LI
   LO
   TS
2
Ki = 7780 nM
   TI
   LI
   LO
   TS
CP0224333
4-[(E)-2-(3-chlorophenyl)ethenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine
   Show/Hide
C16H19ClN6
 1
1
IC50 = 439 nM
   TI
   LI
   LO
   TS
CP0209146
4-(4-chlorophenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine
   Show/Hide
C14H17ClN6
 1
1
IC50 = 512 nM
   TI
   LI
   LO
   TS
CP0411849
4-[(E)-2-(3-methylphenyl)ethenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine
   Show/Hide
C17H22N6
 1
1
IC50 = 606 nM
   TI
   LI
   LO
   TS
CP0319491
4-(4-bromophenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine
   Show/Hide
C14H17BrN6
 1
1
IC50 = 1630 nM
   TI
   LI
   LO
   TS
CP0092861
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole
   Show/Hide
C15H20N2S
 1
1
Ki = 1.1 nM
   TI
   LI
   LO
   TS
CP0280476
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-fluoro-1H-benzimidazol-2-yl)methanimine
   Show/Hide
C15H18FN5
 1
1
Ki = 4.6 nM
   TI
   LI
   LO
   TS
CP0388999
[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-fluoro-4-methyl-1H-benzimidazol-2-yl)methanimine
   Show/Hide
C16H20FN5
 1
1
Ki = 4.6 nM
   TI
   LI
   LO
   TS
CP0327320
4-Benzyl-1H-imidazole derivative, 18
   Show/Hide
C16H18N2
 1
1
Ki = 5.623 nM
   TI
   LI
   LO
   TS
CP0341974
1-[3-(1H-imidazol-4-ylmethyl)phenyl]-3,3-dimethylbutan-1-one
   Show/Hide
C16H20N2O
 1
1
Ki = 5.623 nM
   TI
   LI
   LO
   TS
CP0100102
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1H-benzimidazol-2-yl)methanimine
   Show/Hide
C15H19N5
 1
1
Ki = 6.5 nM
   TI
   LI
   LO
   TS
CP0041262
5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole
   Show/Hide
C14H16ClN3O
 1
1
Ki = 8 nM
   TI
   LI
   LO
   TS
CP0166950
2-[3-(1H-imidazol-4-ylmethyl)phenyl]-4,4,6-trimethyl-5,6-dihydro-4H-1,3-oxazine
   Show/Hide
C17H21N3O
 1
1
Ki = 8.318 nM
   TI
   LI
   LO
   TS
CP0077286
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5,6-difluoro-1H-benzimidazol-2-yl)methanimine
   Show/Hide
C15H17F2N5
 1
1
Ki = 9.5 nM
   TI
   LI
   LO
   TS
CP0072183
[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-chloro-1H-indol-2-yl)methanone
   Show/Hide
C16H18ClN3O
 1
1
Ki = 16 nM
   TI
   LI
   LO
   TS
CP0433154
N-(2,2-dimethylpropyl)-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine
   Show/Hide
C14H25N5
 1
1
Ki = 23.6 nM
   TI
   LI
   LO
   TS
CP0077287
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanimine
   Show/Hide
C15H18ClN5
 1
1
Ki = 26 nM
   TI
   LI
   LO
   TS
CP0400871
4-N-(cyclopropylmethyl)-6-N-[2-(dimethylamino)ethyl]pyrimidine-4,6-diamine
   Show/Hide
C12H21N5
 1
1
Ki = 32.4 nM
   TI
   LI
   LO
   TS
CP0066043
(5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
   Show/Hide
C13H15ClN4O
 1
1
Ki = 47.7 nM
   TI
   LI
   LO
   TS
CP0280475
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,5-difluoro-1H-benzimidazol-2-yl)methanimine
   Show/Hide
C15H17F2N5
 1
1
Ki = 49 nM
   TI
   LI
   LO
   TS
CP0074914
[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-fluoro-4-methyl-1H-benzimidazol-2-yl)methanone
   Show/Hide
C16H19FN4O
 1
1
Ki = 52 nM
   TI
   LI
   LO
   TS
CP0504043
6-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-N-(2,2-dimethylpropyl)pyrimidin-4-amine
   Show/Hide
C15H27N5
 1
1
Ki = 58.9 nM
   TI
   LI
   LO
   TS
CP0290795
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,5,6-trifluoro-1H-benzimidazol-2-yl)methanimine
   Show/Hide
C15H16F3N5
 1
1
Ki = 70 nM
   TI
   LI
   LO
   TS
CP0072184
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,5-difluoro-1H-benzimidazol-2-yl)methanone
   Show/Hide
C15H16F2N4O
 1
1
Ki = 74 nM
   TI
   LI
   LO
   TS
CP0399210
N-(3,3-dimethylbutyl)-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine
   Show/Hide
C15H27N5
 1
1
Ki = 82 nM
   TI
   LI
   LO
   TS
CP0292148
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-fluoro-1H-benzimidazol-2-yl)methanone
   Show/Hide
C15H17FN4O
 1
1
Ki = 83 nM
   TI
   LI
   LO
   TS
CP0493786
[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)methanone
   Show/Hide
C15H17ClN4O
 1
1
Ki = 83 nM
   TI
   LI
   LO
   TS
CP0074915
[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1H-benzimidazol-2-yl)methanone
   Show/Hide
C15H18N4O
 1
1
Ki = 102 nM
   TI
   LI
   LO
   TS
CP0367164
4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl)-propyl ester
   Show/Hide
C16H19IN2O2
 1
1
Ki = 118 nM
   TI
   LI
   LO
   TS
CP0036302
N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]quinolin-2-amine
   Show/Hide
C23H26Cl2N4
 1
1
Ki = 125 nM
   TI
   LI
   LO
   TS
CP0074916
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(5,6-difluoro-1H-benzimidazol-2-yl)methanone
   Show/Hide
C15H16F2N4O
 1
1
Ki = 128 nM
   TI
   LI
   LO
   TS
CP0074913
[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanone
   Show/Hide
C15H17ClN4O
 1
1
Ki = 129 nM
   TI
   LI
   LO
   TS
CP0470833
N-(1H-benzimidazol-2-ylmethyl)-2-[(1S,2R)-2-(1H-imidazol-5-yl)cyclopropyl]ethanamine
   Show/Hide
C16H19N5
 1
1
Ki = 166 nM
   TI
   LI
   LO
   TS
CP0505945
N-(3,3-dimethylbutyl)-6-piperazin-1-ylpyrimidin-4-amine
   Show/Hide
C14H25N5
 1
1
Ki = 201 nM
   TI
   LI
   LO
   TS
CP0508788
N-benzyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine
   Show/Hide
C16H21N5
 1
1
Ki = 207 nM
   TI
   LI
   LO
   TS
CP0390750
N-(2,3-dihydro-1H-inden-2-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine
   Show/Hide
C18H23N5
 1
1
Ki = 212 nM
   TI
   LI
   LO
   TS
CP0378856
benzyl 2-[[2-(acetylsulfanylmethyl)-3-(1,3-benzodioxol-5-yl)propanoyl]amino]acetate
   Show/Hide
C22H23NO6S
 1
1
Ki = 214 nM
   TI
   LI
   LO
   TS
CP0400869
N-(2,2-dimethylpropyl)-6-(4-methyl-1,4-diazepan-1-yl)pyrimidin-4-amine
   Show/Hide
C15H27N5
 1
1
Ki = 235 nM
   TI
   LI
   LO
   TS
CP0109671
4-(3-Trityloxy-propyl)-1H-imidazole
   Show/Hide
C25H24N2O
 1
1
Ki = 240 nM
   TI
   LI
   LO
   TS
CP0481811
2-[[(1S,2R)-2-(1H-imidazol-5-yl)cyclopropyl]methyl]-1H-benzimidazole
   Show/Hide
C14H14N4
 1
1
Ki = 295 nM
   TI
   LI
   LO
   TS
CP0456415
6-N-(3,3-dimethylbutyl)-4-N-[(3S)-pyrrolidin-3-yl]pyrimidine-4,6-diamine
   Show/Hide
C14H25N5
 1
1
Ki = 502 nM
   TI
   LI
   LO
   TS
CP0513416
6-N-(3,3-dimethylbutyl)-4-N-[(3S)-1-methylpyrrolidin-3-yl]pyrimidine-4,6-diamine
   Show/Hide
C15H27N5
 1
1
Ki = 593 nM
   TI
   LI
   LO
   TS
CP0400870
6-(4-cyclohexylpiperazin-1-yl)-N-(3,3-dimethylbutyl)pyrimidin-4-amine
   Show/Hide
C20H35N5
 1
1
Ki = 601 nM
   TI
   LI
   LO
   TS
CP0475649
(1R,5R)-6-[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-6-azabicyclo[3.1.1]heptane
   Show/Hide
C15H23N5
 1
1
Ki = 860 nM
   TI
   LI
   LO
   TS
CP0387450
6-methyl-2-(2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)pyridine-3-carbonitrile
   Show/Hide
C14H18N4
 1
1
Ki = 930 nM
   TI
   LI
   LO
   TS
CP0432970
6-N-(3,3-dimethylbutyl)-4-N-[(3R)-pyrrolidin-3-yl]pyrimidine-4,6-diamine
   Show/Hide
C14H25N5
 1
1
Ki = 939 nM
   TI
   LI
   LO
   TS
CP0403671
[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1H-pyrrolo[2,3-b]pyridin-2-yl)methanone
   Show/Hide
C15H18N4O
 1
1
Ki = 973 nM
   TI
   LI
   LO
   TS
CP0381178
2-(4-Methyl-piperazin-1-yl)-quinoxaline
   Show/Hide
C13H16N4
 1
1
Ki = 1060 nM
   TI
   LI
   LO
   TS
CP0408107
4-(1H-imidazol-5-yl)-N-naphthalen-1-ylpiperidine-1-carboxamide
   Show/Hide
C19H20N4O
 1
1
Ki = 1090 nM
   TI
   LI
   LO
   TS
CP0390749
4-[2-(1H-imidazol-5-yl)ethylamino]-1-[(2-methoxyphenyl)methyl]pyrimidin-2-one
   Show/Hide
C17H19N5O2
 1
1
Ki = 1600 nM
   TI
   LI
   LO
   TS
CP0169952
[(3aS,6aR)-2-ethyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanone
   Show/Hide
C16H19ClN4O
 1
1
Ki = 1960 nM
   TI
   LI
   LO
   TS
CP0403672
[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)methanone
   Show/Hide
C15H17ClN4O
 1
1
Ki = 2090 nM
   TI
   LI
   LO
   TS
CP0304519
[5-[[3-[[6-(3,3-dimethylbutylamino)pyrimidin-4-yl]amino]pyrrolidin-1-yl]methyl]furan-2-yl]methanol
   Show/Hide
C20H31N5O2
 1
1
Ki = 2110 nM
   TI
   LI
   LO
   TS
CP0388998
[(3aR,6aS)-2-propan-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanone
   Show/Hide
C17H21ClN4O
 1
1
Ki = 2670 nM
   TI
   LI
   LO
   TS
CP0378894
ethyl 2-[(4R)-4-[[2-benzyl-3-(hydroxyamino)-3-oxopropanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]acetate
   Show/Hide
C24H27N3O6
 1
1
Ki = 3018 nM
   TI
   LI
   LO
   TS
CP0378092
(4-methylpiperazin-1-yl)-(1H-pyrrolo[2,3-b]pyridin-2-yl)methanone
   Show/Hide
C13H16N4O
 1
1
Ki = 3100 nM
   TI
   LI
   LO
   TS
CP0305101
(6-chloroimidazo[1,2-a]pyridin-2-yl)-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C13H15ClN4O
 1
1
Ki = 3170 nM
   TI
   LI
   LO
   TS
CP0475647
2-(3-methoxyphenyl)-1-(2-methylphenoxy)-3-(4-methylpiperazin-1-yl)propan-2-ol
   Show/Hide
C22H30N2O3
 1
1
Ki = 3240 nM
   TI
   LI
   LO
   TS
CP0378896
N-[4-[4-(2-fluorophenyl)piperazin-1-yl]butyl]-5,6-dimethoxy-3-methyl-1H-indene-2-carboxamide
   Show/Hide
C27H34FN3O3
 1
1
Ki = 3800 nM
   TI
   LI
   LO
   TS
CP0474872
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-(3-imidazol-1-ylpropyl)acetamide
   Show/Hide
C25H25ClN4O3
 1
1
Ki = 4200 nM
   TI
   LI
   LO
   TS
CP0292149
[(3aS,6aR)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-(6-chloro-1H-benzimidazol-2-yl)methanone
   Show/Hide
C14H15ClN4O
 1
1
Ki = 5080 nM
   TI
   LI
   LO
   TS
CP0555638
phenyl-[4-(5-pyrrolidin-1-ylpentoxy)phenyl]methanone
   Show/Hide
C22H27NO2
 1
1
Ki = 13000 nM
   TI
   LI
   LO
   TS
CP0109672
1-[4-[[4-[(3-methylpiperidin-1-yl)methyl]phenyl]methoxy]phenyl]ethanone
   Show/Hide
C22H27NO2
 1
1
Ki = 16400 nM
   TI
   LI
   LO
   TS
CP0259576
oxalic acid;1-[5-(4-phenylphenoxy)pentyl]piperidine
   Show/Hide
C24H31NO5
 1
1
Ki = 19900 nM
   TI
   LI
   LO
   TS
CP0428320
6-N-(3,3-dimethylbutyl)-4-N-[(3S)-1-[[5-(methoxymethyl)furan-2-yl]methyl]pyrrolidin-3-yl]pyrimidine-4,6-diamine
   Show/Hide
C21H33N5O2
 1
1
Ki = 20000 nM
   TI
   LI
   LO
   TS
CP0433153
2-[[(3S)-3-[[6-(3,3-dimethylbutylamino)pyrimidin-4-yl]amino]pyrrolidin-1-yl]methyl]-6-fluorophenol
   Show/Hide
C21H30FN5O
 1
1
Ki = 20000 nM
   TI
   LI
   LO
   TS
CP0503441
imidazo[1,2-a]pyrazin-2-yl-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C12H15N5O
 1
1
Ki = 20100 nM
   TI
   LI
   LO
   TS
CP0343761
oxalic acid;1-[5-(4-phenylphenoxy)pentyl]azepane
   Show/Hide
C25H33NO5
 1
1
Ki = 21800 nM
   TI
   LI
   LO
   TS
CP0539975
2-N-[2-[4-(3-piperidin-1-ylpropoxy)phenyl]ethyl]pyridine-2,5-diamine
   Show/Hide
C21H30N4O
 1
1
Ki = 30000 nM
   TI
   LI
   LO
   TS
CP0391666
6-(4-methylpiperazin-1-yl)-N-[[3-(trifluoromethyl)phenyl]methyl]pyrimidine-4-carboxamide
   Show/Hide
C18H20F3N5O
 1
1
Ki = 34900 nM
   TI
   LI
   LO
   TS
CP0470832
1-[(1R,2R)-2-(6-chloro-1H-benzimidazol-2-yl)cyclopropyl]-N-[(4-chlorophenyl)methyl]methanamine
   Show/Hide
C18H17Cl2N3
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
CP0481809
1-[(1R,2S)-2-(5-chloro-1H-indol-2-yl)cyclopropyl]-N-[(4-chlorophenyl)methyl]methanamine
   Show/Hide
C19H18Cl2N2
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
CP0481810
2-[(1S,2S)-2-(5-chloro-1H-indol-2-yl)cyclopropyl]-N-[(4-chlorophenyl)methyl]ethanamine
   Show/Hide
C20H20Cl2N2
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
CP0492070
2-[(1S,2R)-2-(6-chloro-1H-benzimidazol-2-yl)cyclopropyl]-N-[(4-chlorophenyl)methyl]ethanamine
   Show/Hide
C19H19Cl2N3
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
CP0532518
N-[(4-chlorophenyl)methyl]-2-[(1S,2R)-2-(4-methylpiperazin-1-yl)cyclopropyl]ethanamine
   Show/Hide
C17H26ClN3
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
CP0534664
N-[(4-chlorophenyl)methyl]-1-[(1R,2R)-2-(4-methylpiperazin-1-yl)cyclopropyl]methanamine
   Show/Hide
C16H24ClN3
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
CP0557339
N-[(4-chlorophenyl)methyl]-2-[(1S,2R)-2-piperazin-1-ylcyclopropyl]ethanamine
   Show/Hide
C16H24ClN3
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
CP0578830
N-[(4-chlorophenyl)methyl]-1-[(1R,2R)-2-piperazin-1-ylcyclopropyl]methanamine
   Show/Hide
C15H22ClN3
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS