| Compound ID |
Compound Name |
Compound Formula |
|
CP0499801
|
6-amino-2-(butylamino)-9-[[6-(4-methylpiperazin-1-yl)pyridin-3-yl]methyl]-7H-purin-8-one
Show/Hide
|
C20H29N9O
|
1
|
| 1 |
EC50 = 5.4 nM
|
|
|
|
CP0428690
|
6-amino-2-(butylamino)-9-[[4-(4-methylpiperazin-1-yl)phenyl]methyl]-7H-purin-8-one
Show/Hide
|
C21H30N8O
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0238921
|
6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]methyl]-7H-purin-8-one
Show/Hide
|
C19H28N8O2
|
1
|
| 1 |
EC50 = 7.2 nM
|
|
|
|
CP0522880
|
6-amino-2-(butylamino)-9-[[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]methyl]-7H-purin-8-one
Show/Hide
|
C21H31N9O
|
1
|
| 1 |
EC50 = 7.4 nM
|
|
|
|
CP0488548
|
6-amino-2-(butylamino)-9-[(4-piperidin-1-ylphenyl)methyl]-7H-purin-8-one
Show/Hide
|
C21H29N7O
|
1
|
| 1 |
EC50 = 7.6 nM
|
|
|
|
CP0542643
|
methyl 2-[5-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]-2-methoxyphenyl]acetate
Show/Hide
|
C20H25N5O5
|
1
|
| 1 |
EC50 = 8.1 nM
|
|
|
|
CP0388784
|
1-(4-Amino-2-butyl-1H-imidazo-[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
Show/Hide
|
C18H24N4O
|
2
|
| 1 |
EC50 = 8.58 nM
|
|
|
| 2 |
EC50 = 100 nM
|
|
|
|
CP0528782
|
6-amino-2-(butylamino)-9-[[4-(dimethylamino)phenyl]methyl]-7H-purin-8-one
Show/Hide
|
C18H25N7O
|
1
|
| 1 |
EC50 = 9.3 nM
|
|
|
|
CP0538347
|
6-amino-2-(butylamino)-9-[[6-[4-(dimethylamino)piperidin-1-yl]pyridin-3-yl]methyl]-7H-purin-8-one
Show/Hide
|
C22H33N9O
|
1
|
| 1 |
EC50 = 9.4 nM
|
|
|
|
CP0510039
|
methyl 2-[4-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetate
Show/Hide
|
C19H23N5O4
|
1
|
| 1 |
EC50 = 10.3 nM
|
|
|
|
CP0499802
|
6-amino-2-(butylamino)-9-[[6-[4-(dimethylamino)butoxy]pyridin-3-yl]methyl]-7H-purin-8-one
Show/Hide
|
C21H32N8O2
|
1
|
| 1 |
EC50 = 15.2 nM
|
|
|
|
CP0511300
|
6-amino-2-(butylamino)-9-[[6-[3-(dimethylamino)propoxy]pyridin-3-yl]methyl]-7H-purin-8-one
Show/Hide
|
C20H30N8O2
|
1
|
| 1 |
EC50 = 19.6 nM
|
|
|
|
CP0568712
|
4-N-butyl-6-[[4-[(dimethylamino)methyl]-2-methoxyphenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C22H30N6O
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0489364
|
4-N-butyl-6-[[4-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C21H28N6
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0533138
|
methyl 2-[5-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]-2-fluorophenyl]acetate
Show/Hide
|
C19H22FN5O4
|
1
|
| 1 |
EC50 = 25.7 nM
|
|
|
|
CP0528674
|
4-N-butyl-6-[[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C24H30N6O
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0568471
|
4-N-butyl-6-[[4-[2-(dimethylamino)ethyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C22H30N6
|
1
|
| 1 |
EC50 = 28 nM
|
|
|
|
CP0511301
|
6-amino-2-(butylamino)-9-[(6-methoxypyridin-3-yl)methyl]-7H-purin-8-one
Show/Hide
|
C16H21N7O2
|
1
|
| 1 |
EC50 = 28.1 nM
|
|
|
|
CP0511302
|
6-amino-2-(butylamino)-9-[(3-piperidin-1-ylphenyl)methyl]-7H-purin-8-one
Show/Hide
|
C21H29N7O
|
1
|
| 1 |
EC50 = 30.1 nM
|
|
|
|
CP0440135
|
6-amino-2-(butylamino)-9-[(6-methylpyridin-3-yl)methyl]-7H-purin-8-one
Show/Hide
|
C16H21N7O
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0573940
|
4-N-butyl-6-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C23H30N6
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0188207
|
3-[5-amino-2-[2-[4-[2-[2-(3,3-difluoro-3-phosphonopropoxy)ethoxy]ethoxy]-2-methylphenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid
Show/Hide
|
C31H36F2N3O8P
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0528677
|
6-[[4-[(dimethylamino)methyl]phenyl]methyl]-4-N-(2-methoxyethyl)pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C20H26N6O
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0389723
|
4-N-butyl-6-methyl-5-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine
Show/Hide
|
C16H29N5O
|
1
|
| 1 |
EC50 = 46 nM
|
|
|
|
CP0528676
|
4-N-butyl-6-[[4-[(dimethylamino)methyl]-3-methoxyphenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C22H30N6O
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0511298
|
6-amino-2-(butylamino)-9-[(6-piperazin-1-ylpyridin-3-yl)methyl]-7H-purin-8-one
Show/Hide
|
C19H27N9O
|
1
|
| 1 |
EC50 = 48.5 nM
|
|
|
|
CP0576625
|
4-N-(2-methoxyethyl)-6-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C22H28N6O
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0447803
|
methyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetate
Show/Hide
|
C19H23N5O4
|
1
|
| 1 |
EC50 = 50.1 nM
|
|
|
|
CP0511299
|
6-amino-2-(butylamino)-9-[[6-(2-morpholin-4-ylethoxy)pyridin-3-yl]methyl]-7H-purin-8-one
Show/Hide
|
C21H30N8O3
|
1
|
| 1 |
EC50 = 50.2 nM
|
|
|
|
CP0542642
|
methyl 3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]benzoate
Show/Hide
|
C18H21N5O4
|
1
|
| 1 |
EC50 = 51.5 nM
|
|
|
|
CP0511303
|
6-amino-2-(butylamino)-9-[(4-morpholin-4-ylphenyl)methyl]-7H-purin-8-one
Show/Hide
|
C20H27N7O2
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0496496
|
4-N-butyl-6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C23H30N6O
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0336253
|
1-Benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C21H22N4
|
1
|
| 1 |
EC50 = 59.1 nM
|
|
|
|
CP0384699
|
US10457681, Compound B
Show/Hide
|
C16H19N5O2
|
1
|
| 1 |
EC50 = 63.7 nM
|
|
|
|
CP0190289
|
3-[5-amino-2-[2-[2-methyl-4-(3-phosphonopropoxy)phenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid
Show/Hide
|
C27H30N3O6P
|
1
|
| 1 |
EC50 = 65 nM
|
|
|
|
CP0576626
|
4-N-butyl-6-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C22H30N6O
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0571145
|
4-N-butyl-6-[[3-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C21H28N6
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0575146
|
4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]-N,N-dimethylbenzamide
Show/Hide
|
C21H26N6O
|
1
|
| 1 |
EC50 = 71 nM
|
|
|
|
CP0476807
|
6-amino-2-(butylamino)-9-[[6-[3-(dimethylamino)propyl-methylamino]pyridin-3-yl]methyl]-7H-purin-8-one
Show/Hide
|
C21H33N9O
|
1
|
| 1 |
EC50 = 72.8 nM
|
|
|
|
CP0533135
|
methyl 4-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]benzoate
Show/Hide
|
C18H21N5O4
|
1
|
| 1 |
EC50 = 72.9 nM
|
|
|
|
CP0539608
|
methyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]propanoate
Show/Hide
|
C20H25N5O4
|
1
|
| 1 |
EC50 = 75 nM
|
|
|
|
CP0233638
|
1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
Show/Hide
|
C17H22N4O2
|
6
|
| 1 |
EC50 = 75 nM
|
|
|
| 2 |
EC50 = 260.1 nM
|
|
|
| 3 |
EC50 = 750 nM
|
|
|
| 4 |
EC50 = 1340 nM
|
|
|
| 5 |
EC50 = 1400 nM
|
|
|
| 6 |
EC50 = 1500 nM
|
|
|
|
CP0573314
|
4-N-(2-methoxyethyl)-6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C22H28N6O2
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0537794
|
methyl 3-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]propanoate
Show/Hide
|
C20H25N5O4
|
1
|
| 1 |
EC50 = 87.5 nM
|
|
|
|
CP0089990
|
2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]ethylphosphonic acid
Show/Hide
|
C24H26N3O4P
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0406790
|
1-Benzyl-2-pentyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C22H24N4
|
1
|
| 1 |
EC50 = 91.5 nM
|
|
|
|
CP0576627
|
[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]-pyrrolidin-1-ylmethanone
Show/Hide
|
C23H28N6O
|
1
|
| 1 |
EC50 = 95 nM
|
|
|
|
CP0859647
|
4-(5-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)pentyl)piperidinium chloride
Show/Hide
|
C19H33ClN6O2
|
2
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
EC50 = 450 nM
|
|
|
|
CP0463739
|
methyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]-4-methoxyphenyl]acetate
Show/Hide
|
C20H25N5O5
|
1
|
| 1 |
EC50 = 108 nM
|
|
|
|
CP0569259
|
4-N-butyl-6-[[2-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C21H28N6
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0428688
|
6-amino-2-(butylamino)-9-[[3-(4-methylpiperazin-1-yl)phenyl]methyl]-7H-purin-8-one
Show/Hide
|
C21H30N8O
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0573268
|
4-N-butyl-6-[2-[4-[(dimethylamino)methyl]phenyl]ethyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C22H30N6
|
1
|
| 1 |
EC50 = 136 nM
|
|
|
|
CP0378722
|
4-N-butyl-5-(3-indol-1-ylpropyl)-6-methylpyrimidine-2,4-diamine
Show/Hide
|
C20H27N5
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0858002
|
4-(2-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)ethyl)piperidinium chloride
Show/Hide
|
C16H27ClN6O2
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0916759
|
4-(4-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)butyl)piperidinium chloride
Show/Hide
|
C18H31ClN6O2
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0190288
|
[(E)-2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]ethenyl]phosphonic acid
Show/Hide
|
C24H24N3O4P
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0550014
|
4-N-butyl-6-[[4-(methoxymethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C20H25N5O
|
1
|
| 1 |
EC50 = 156 nM
|
|
|
|
CP0569291
|
[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]-morpholin-4-ylmethanone
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
EC50 = 156 nM
|
|
|
|
CP0528781
|
6-amino-2-(butylamino)-9-[[6-[2-(methylamino)ethoxy]pyridin-3-yl]methyl]-7H-purin-8-one
Show/Hide
|
C18H26N8O2
|
1
|
| 1 |
EC50 = 165.7 nM
|
|
|
|
CP0440136
|
6-amino-2-(butylamino)-9-[(4-methylphenyl)methyl]-7H-purin-8-one
Show/Hide
|
C17H22N6O
|
1
|
| 1 |
EC50 = 166 nM
|
|
|
|
CP0486405
|
methyl 4-amino-1-[[4-(aminomethyl)phenyl]methyl]-2-butylimidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C24H27N5O2
|
1
|
| 1 |
EC50 = 180 nM
|
|
|
|
CP0532371
|
ethyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetate
Show/Hide
|
C20H25N5O4
|
1
|
| 1 |
EC50 = 187.9 nM
|
|
|
|
CP0378694
|
4-N-butyl-6-methyl-5-(3-phenylpropyl)pyrimidine-2,4-diamine
Show/Hide
|
C18H26N4
|
1
|
| 1 |
EC50 = 194 nM
|
|
|
|
CP0190263
|
[(E)-2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]-1-fluoroethenyl]phosphonic acid
Show/Hide
|
C24H23FN3O4P
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0406788
|
1-Benzyl-2-(but-3-ynyl)-1H-imidazo-[4,5-c]quinolin-4-amine
Show/Hide
|
C21H18N4
|
1
|
| 1 |
EC50 = 209 nM
|
|
|
|
CP0864483
|
4-(6-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)hexyl)piperidinium chloride
Show/Hide
|
C20H35ClN6O2
|
1
|
| 1 |
EC50 = 230 nM
|
|
|
|
CP0307253
|
3-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]propylphosphonic acid
Show/Hide
|
C25H28N3O4P
|
1
|
| 1 |
EC50 = 230 nM
|
|
|
|
CP0190290
|
3-[5-amino-2-[2-[4-(4,4-difluoro-4-phosphonobutoxy)-2-methylphenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid
Show/Hide
|
C28H30F2N3O6P
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0859648
|
6-amino-2-[(1S)-1-methylbutoxy]-9-[5-(4-piperidyl)pentyl]-7H-purin-8-one Hydrochloride
Show/Hide
|
C20H35ClN6O2
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0378714
|
4-N-butyl-6-methyl-5-[3-(4-methylpiperazin-1-yl)propyl]pyrimidine-2,4-diamine
Show/Hide
|
C17H32N6
|
1
|
| 1 |
EC50 = 251 nM
|
|
|
|
CP0405976
|
1-Benzyl-2-(but-3-enyl)-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C21H20N4
|
1
|
| 1 |
EC50 = 262 nM
|
|
|
|
CP0441185
|
4-N-butyl-6-methyl-5-(4-phenylbutyl)pyrimidine-2,4-diamine
Show/Hide
|
C19H28N4
|
1
|
| 1 |
EC50 = 262 nM
|
|
|
|
CP0378705
|
4-N-butyl-6-methyl-5-(5-phenylpentyl)pyrimidine-2,4-diamine
Show/Hide
|
C20H30N4
|
1
|
| 1 |
EC50 = 265 nM
|
|
|
|
CP0528675
|
4-N-butyl-6-[[4-[(dimethylamino)methyl]phenyl]methyl]quinazoline-2,4-diamine
Show/Hide
|
C22H29N5
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0533307
|
[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]methanol
Show/Hide
|
C19H23N5O
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0188206
|
[4-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]-1,1-difluorobutyl]phosphonic acid
Show/Hide
|
C26H28F2N3O4P
|
1
|
| 1 |
EC50 = 310 nM
|
|
|
|
CP0510862
|
methyl 2-[3-[[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9-yl]methyl]phenyl]acetate
Show/Hide
|
C18H21N5O5
|
1
|
| 1 |
EC50 = 312.3 nM
|
|
|
|
CP0188208
|
3-[5-amino-2-[2-[2-methyl-4-[2-[2-(2-phosphonoethoxy)ethoxy]ethoxy]phenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid
Show/Hide
|
C30H36N3O8P
|
1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0269934
|
4-N-butyl-5-[3-(1,3-dihydroisoindol-2-yl)propyl]-6-methylpyrimidine-2,4-diamine
Show/Hide
|
C20H29N5
|
1
|
| 1 |
EC50 = 375 nM
|
|
|
|
CP0097851
|
4-N-butyl-6-methyl-5-[3-(2-methylbenzimidazol-1-yl)propyl]pyrimidine-2,4-diamine
Show/Hide
|
C20H28N6
|
1
|
| 1 |
EC50 = 379 nM
|
|
|
|
CP0493255
|
1-Benzyl-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C20H21N5
|
1
|
| 1 |
EC50 = 385 nM
|
|
|
|
CP0350278
|
[2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]-1,1-difluoro-2-oxoethyl]phosphonic acid
Show/Hide
|
C24H22F2N3O5P
|
1
|
| 1 |
EC50 = 390 nM
|
|
|
|
CP0378723
|
4-N-butyl-6-methyl-5-(3-pyrazol-1-ylpropyl)pyrimidine-2,4-diamine
Show/Hide
|
C15H24N6
|
1
|
| 1 |
EC50 = 398 nM
|
|
|
|
CP0229826
|
6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8(9H)-one
Show/Hide
|
C15H17N5O3
|
2
|
| 1 |
EC50 = 399.4 nM
|
|
|
| 2 |
EC50 = 1170 nM
|
|
|
|
CP0569171
|
4-N-butyl-6-[[4-(diethoxyphosphorylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C23H32N5O3P
|
1
|
| 1 |
EC50 = 400 nM
|
|
|
|
CP0447802
|
methyl 2-[2-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetate
Show/Hide
|
C19H23N5O4
|
1
|
| 1 |
EC50 = 466.8 nM
|
|
|
|
CP0405975
|
1-Benzyl-2-ethyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C19H18N4
|
1
|
| 1 |
EC50 = 472 nM
|
|
|
|
CP0438838
|
1-Benzyl-2-hexyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C23H26N4
|
1
|
| 1 |
EC50 = 479 nM
|
|
|
|
CP0389724
|
4-N-butyl-6-methyl-5-pentylpyrimidine-2,4-diamine
Show/Hide
|
C14H26N4
|
1
|
| 1 |
EC50 = 510 nM
|
|
|
|
CP0378706
|
4-N-butyl-6-methyl-5-(3-pyrrolidin-1-ylpropyl)pyrimidine-2,4-diamine
Show/Hide
|
C16H29N5
|
1
|
| 1 |
EC50 = 562 nM
|
|
|
|
CP0378704
|
4-N,5-dibutyl-6-methylpyrimidine-2,4-diamine
Show/Hide
|
C13H24N4
|
1
|
| 1 |
EC50 = 590 nM
|
|
|
|
CP0476287
|
methyl 4-amino-1-(5-aminopentyl)-2-butylimidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C21H29N5O2
|
1
|
| 1 |
EC50 = 600 nM
|
|
|
|
CP0430856
|
methyl 2-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]benzoate
Show/Hide
|
C18H21N5O4
|
1
|
| 1 |
EC50 = 609.1 nM
|
|
|
|
CP0858003
|
4-(3-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)propyl)piperidinium chloride
Show/Hide
|
C17H29ClN6O2
|
1
|
| 1 |
EC50 = 620 nM
|
|
|
|
CP0573262
|
4-N-butyl-6-[(2-methoxyphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H23N5O
|
1
|
| 1 |
EC50 = 630 nM
|
|
|
|
CP0506154
|
1-Benzyl-2-propyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C20H20N4
|
1
|
| 1 |
EC50 = 647 nM
|
|
|
|
CP0120000
|
4-N-butyl-6-methyl-5-(3-piperidin-1-ylpropyl)pyrimidine-2,4-diamine
Show/Hide
|
C17H31N5
|
1
|
| 1 |
EC50 = 710 nM
|
|
|
|
CP0378716
|
4-N-butyl-6-methyl-5-(3-thiomorpholin-4-ylpropyl)pyrimidine-2,4-diamine
Show/Hide
|
C16H29N5S
|
1
|
| 1 |
EC50 = 714 nM
|
|
|
|
CP0411245
|
N-(1-benzyl-2-butylimidazo[4,5-c]quinolin-4-yl)hydroxylamine
Show/Hide
|
C21H22N4O
|
1
|
| 1 |
EC50 = 723 nM
|
|
|
|
CP0441193
|
5-[3-(azepan-1-yl)propyl]-4-N-butyl-6-methylpyrimidine-2,4-diamine
Show/Hide
|
C18H33N5
|
1
|
| 1 |
EC50 = 730 nM
|
|
|
|
CP0551606
|
4-N-butyl-6-[[4-(methylaminomethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C20H26N6
|
1
|
| 1 |
EC50 = 760 nM
|
|
|
|
CP0575148
|
4-N-butyl-6-[(4-methoxyphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H23N5O
|
1
|
| 1 |
EC50 = 795 nM
|
|
|
|
CP0406791
|
1-Benzyl-2-heptyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C24H28N4
|
1
|
| 1 |
EC50 = 822 nM
|
|
|
|
CP0411246
|
1-Benzyl-2-butyl-4-hydrazinyl-1Himidazo[4,5-c]quinoline
Show/Hide
|
C21H23N5
|
1
|
| 1 |
EC50 = 873 nM
|
|
|
|
CP0496501
|
4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoic acid
Show/Hide
|
C19H21N5O2
|
1
|
| 1 |
EC50 = 890 nM
|
|
|
|
CP0405974
|
1-Benzyl-2-methyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C18H16N4
|
1
|
| 1 |
EC50 = 955 nM
|
|
|
|
CP0441187
|
4-N-butyl-5-[3-(dimethylamino)propyl]-6-methylpyrimidine-2,4-diamine
Show/Hide
|
C14H27N5
|
1
|
| 1 |
EC50 = 958 nM
|
|
|
|
CP0378700
|
4-[2-amino-4-(butylamino)-6-methylpyrimidin-5-yl]butan-1-ol
Show/Hide
|
C13H24N4O
|
1
|
| 1 |
EC50 = 1020 nM
|
|
|
|
CP0406916
|
4-N-butyl-5-(3-cyclohexylpropyl)-6-methylpyrimidine-2,4-diamine
Show/Hide
|
C18H32N4
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0489380
|
4-N-butyl-6-[(2-fluorophenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C18H20FN5
|
1
|
| 1 |
EC50 = 1122 nM
|
|
|
|
CP0378711
|
4-N-butyl-6-methyl-5-[3-(1,2,4-triazol-1-yl)propyl]pyrimidine-2,4-diamine
Show/Hide
|
C14H23N7
|
1
|
| 1 |
EC50 = 1160 nM
|
|
|
|
CP0432826
|
4-N-butyl-6-methyl-5-[3-(4-phenylpiperazin-1-yl)propyl]pyrimidine-2,4-diamine
Show/Hide
|
C22H34N6
|
1
|
| 1 |
EC50 = 1160 nM
|
|
|
|
CP0496497
|
6-benzyl-4-N-butylpyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C18H21N5
|
1
|
| 1 |
EC50 = 1180 nM
|
|
|
|
CP0573267
|
6-[[4-(aminomethyl)phenyl]methyl]-4-N-butylpyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H24N6
|
1
|
| 1 |
EC50 = 1180 nM
|
|
|
|
CP0573265
|
4-N-butyl-6-[(3-fluorophenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C18H20FN5
|
1
|
| 1 |
EC50 = 1190 nM
|
|
|
|
CP0379915
|
methyl 4-amino-2-butyl-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C20H26N4O3
|
3
|
| 1 |
EC50 = 1200 nM
|
|
|
| 2 |
EC50 = 1500 nM
|
|
|
| 3 |
EC50 = 1690 nM
|
|
|
|
CP0111162
|
[3-[2-[2-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]ethoxy]ethoxy]-1,1-difluoropropyl]phosphonic acid
Show/Hide
|
C29H34F2N3O6P
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0496494
|
4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzonitrile
Show/Hide
|
C19H20N6
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0389715
|
4-N-butyl-5-[3-[2-methoxyethyl(methyl)amino]propyl]-6-methylpyrimidine-2,4-diamine
Show/Hide
|
C16H31N5O
|
1
|
| 1 |
EC50 = 1240 nM
|
|
|
|
CP0546425
|
6-benzyl-4-N-(2-methoxyethyl)pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C17H19N5O
|
1
|
| 1 |
EC50 = 1250 nM
|
|
|
|
CP0378698
|
4-N-butyl-5-ethyl-6-methylpyrimidine-2,4-diamine
Show/Hide
|
C11H20N4
|
1
|
| 1 |
EC50 = 1270 nM
|
|
|
|
CP0378724
|
2-[3-[2-amino-4-(butylamino)-6-methylpyrimidin-5-yl]propyl]isoindole-1,3-dione
Show/Hide
|
C20H25N5O2
|
1
|
| 1 |
EC50 = 1290 nM
|
|
|
|
CP0546370
|
6-[[2-(aminomethyl)phenyl]methyl]-4-N-butylpyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H24N6
|
1
|
| 1 |
EC50 = 1340 nM
|
|
|
|
CP0568473
|
4-N-butyl-6-(2-phenylethyl)pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H23N5
|
1
|
| 1 |
EC50 = 1350 nM
|
|
|
|
CP0569172
|
4-N-butyl-6-[[4-[(2,2,2-trifluoroethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C21H25F3N6
|
1
|
| 1 |
EC50 = 1360 nM
|
|
|
|
CP0378707
|
4-N-butyl-6-methyl-5-(4-morpholin-4-ylbutyl)pyrimidine-2,4-diamine
Show/Hide
|
C17H31N5O
|
1
|
| 1 |
EC50 = 1400 nM
|
|
|
|
CP0576624
|
4-N-butyl-6-[(2-methylphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H23N5
|
1
|
| 1 |
EC50 = 1550 nM
|
|
|
|
CP0496495
|
4-N-butyl-6-[(4-methylphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H23N5
|
1
|
| 1 |
EC50 = 1630 nM
|
|
|
|
CP0847786
|
N4-Butyl-6-methyl-5-(3-(piperazin-1-yl)propyl)pyrimidine-2,4-diamine trihydrochloride
Show/Hide
|
C16H33Cl3N6
|
1
|
| 1 |
EC50 = 1640 nM
|
|
|
|
CP0569661
|
methyl 4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoate
Show/Hide
|
C20H23N5O2
|
1
|
| 1 |
EC50 = 1650 nM
|
|
|
|
CP0550015
|
3-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzonitrile
Show/Hide
|
C19H20N6
|
1
|
| 1 |
EC50 = 1680 nM
|
|
|
|
CP0493569
|
methyl 4-amino-2-butyl-1-(3-hydroxypropyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C19H24N4O3
|
1
|
| 1 |
EC50 = 1720 nM
|
|
|
|
CP0394355
|
methyl 4-amino-2-butyl-1-(5-methoxy-5-oxopentyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C22H28N4O4
|
1
|
| 1 |
EC50 = 1740 nM
|
|
|
|
CP0568476
|
6-[[4-(azidomethyl)phenyl]methyl]-4-N-butylpyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H22N8
|
1
|
| 1 |
EC50 = 1790 nM
|
|
|
|
CP0493807
|
8-hydroxy-1-(2-methylpropyl)chromeno[3,4-d]imidazol-4-one
Show/Hide
|
C14H14N2O3
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0551612
|
4-N-butyl-6-[(3-methylphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H23N5
|
1
|
| 1 |
EC50 = 1835 nM
|
|
|
|
CP0496499
|
2-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzonitrile
Show/Hide
|
C19H20N6
|
1
|
| 1 |
EC50 = 1960 nM
|
|
|
|
CP0417827
|
1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
Show/Hide
|
C17H23N5O
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
|
CP0094682
|
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C14H16N4
|
5
|
| 1 |
EC50 = 2120 nM
|
|
|
| 2 |
EC50 = 6200 nM
|
|
|
| 3 |
EC50 = 10700 nM
|
|
|
| 4 |
EC50 = 11400 nM
|
|
|
| 5 |
EC50 = 12100 nM
|
|
|
|
CP0576623
|
4-N-butyl-6-(naphthalen-2-ylmethyl)pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C22H23N5
|
1
|
| 1 |
EC50 = 2152 nM
|
|
|
|
CP0389765
|
methyl 4-amino-2-butyl-1-(2-hydroxypropyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C19H24N4O3
|
2
|
| 1 |
EC50 = 2220 nM
|
|
|
| 2 |
EC50 = 3300 nM
|
|
|
|
CP0573939
|
methyl 3-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoate
Show/Hide
|
C20H23N5O2
|
1
|
| 1 |
EC50 = 2320 nM
|
|
|
|
CP0471265
|
methyl 4-amino-2-butyl-1-(2-phenylmethoxyethyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
EC50 = 2420 nM
|
|
|
|
CP0575147
|
4-N-butyl-6-[(3-methoxyphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H23N5O
|
1
|
| 1 |
EC50 = 2560 nM
|
|
|
|
CP0433985
|
methyl 4-amino-1-(2-hydroxy-2-methylpropyl)-2-pentylimidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C21H28N4O3
|
1
|
| 1 |
EC50 = 2600 nM
|
|
|
|
CP0283441
|
N-[4-(4-amino-2-ethylimidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide
Show/Hide
|
C17H23N5O2S
|
1
|
| 1 |
EC50 = 2657 nM
|
|
|
|
CP0859645
|
6-amino-2-[(1S)-1-methylbutoxy]-9-(4-piperidylmethyl)-7H-purin-8-one Hydrochloride
Show/Hide
|
C16H27ClN6O2
|
1
|
| 1 |
EC50 = 2680 nM
|
|
|
|
CP0569170
|
methyl 2-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoate
Show/Hide
|
C20H23N5O2
|
1
|
| 1 |
EC50 = 2750 nM
|
|
|
|
CP0389719
|
4-N-butyl-6-methyl-5-(2-phenylethyl)pyrimidine-2,4-diamine
Show/Hide
|
C17H24N4
|
1
|
| 1 |
EC50 = 2820 nM
|
|
|
|
CP0378702
|
5-[2-amino-4-(butylamino)-6-methylpyrimidin-5-yl]-2-methylpentan-2-ol
Show/Hide
|
C15H28N4O
|
1
|
| 1 |
EC50 = 2890 nM
|
|
|
|
CP0574719
|
methyl 4-amino-2-butyl-1-(6-methoxy-6-oxohexyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C23H30N4O4
|
1
|
| 1 |
EC50 = 2890 nM
|
|
|
|
CP0574720
|
methyl 4-amino-2-butyl-1-(2-methylsulfanylethyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C19H24N4O2S
|
1
|
| 1 |
EC50 = 2890 nM
|
|
|
|
CP0505005
|
methyl 4-amino-2-butyl-1-[(2S)-2-hydroxypropyl]imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C19H24N4O3
|
1
|
| 1 |
EC50 = 2900 nM
|
|
|
|
CP0394342
|
methyl 1-(2-acetyloxypropyl)-4-amino-2-butylimidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C21H26N4O4
|
1
|
| 1 |
EC50 = 3060 nM
|
|
|
|
CP0217014
|
2-[2-[2-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]ethoxy]ethoxy]ethylphosphonic acid
Show/Hide
|
C28H34N3O6P
|
1
|
| 1 |
EC50 = 3100 nM
|
|
|
|
CP0566681
|
methyl 4-amino-2-butyl-1-(4-hydroxybutyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C20H26N4O3
|
1
|
| 1 |
EC50 = 3210 nM
|
|
|
|
CP0569064
|
4-N-butyl-6-[(4-fluorophenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C18H20FN5
|
1
|
| 1 |
EC50 = 3250 nM
|
|
|
|
CP0378701
|
4-[2-amino-4-(butylamino)-6-methylpyrimidin-5-yl]-2-methylbutan-2-ol
Show/Hide
|
C14H26N4O
|
1
|
| 1 |
EC50 = 3260 nM
|
|
|
|
CP0536576
|
methyl 4-amino-2-butyl-1-(2-methoxy-2-oxoethyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C19H22N4O4
|
1
|
| 1 |
EC50 = 3330 nM
|
|
|
|
CP0406792
|
1-Benzyl-2-nonyl-1H-imidazo[4,5-c]quinolin-4-amine
Show/Hide
|
C26H32N4
|
1
|
| 1 |
EC50 = 3350 nM
|
|
|
|
CP0378719
|
4-N-butyl-5,6-dimethylpyrimidine-2,4-diamine
Show/Hide
|
C10H18N4
|
1
|
| 1 |
EC50 = 3400 nM
|
|
|
|
CP0566680
|
methyl 4-amino-2-butyl-1-(3-methoxy-3-oxopropyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C20H24N4O4
|
1
|
| 1 |
EC50 = 3640 nM
|
|
|
|
CP0569214
|
methyl 4-amino-2-butyl-1-(3-methylsulfanylpropyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C20H26N4O2S
|
1
|
| 1 |
EC50 = 3840 nM
|
|
|
|
CP0859646
|
4-((6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)methyl)piperidinium chloride
Show/Hide
|
C15H25ClN6O2
|
2
|
| 1 |
EC50 = 3950 nM
|
|
|
| 2 |
EC50 = 19800 nM
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CP0496498
|
4-N-butyl-6-[[2-(trifluoromethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H20F3N5
|
1
|
| 1 |
EC50 = 3950 nM
|
|
|
|
CP0520501
|
4-(3-methylpiperidin-1-yl)-2-(trifluoromethyl)quinazoline
Show/Hide
|
C15H16F3N3
|
1
|
| 1 |
EC50 = 4000 nM
|
|
|
|
CP0859644
|
6-amino-9-[[1-(2-hydroxyethyl)-4-piperidyl]methyl]-2-[(1S)-1-methylbutoxy]-7H-purin-8-one Hydrochloride
Show/Hide
|
C18H31ClN6O3
|
1
|
| 1 |
EC50 = 4060 nM
|
|
|
|
CP0434076
|
methyl 4-amino-2-butyl-1-[(2R)-2-hydroxypropyl]imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C19H24N4O3
|
1
|
| 1 |
EC50 = 4400 nM
|
|
|
|
CP0489763
|
N-(2-methylpropyl)-2-(trifluoromethyl)quinazolin-4-amine
Show/Hide
|
C13H14F3N3
|
1
|
| 1 |
EC50 = 4400 nM
|
|
|
|
CP0551605
|
4-N-butyl-6-[[4-(trifluoromethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H20F3N5
|
1
|
| 1 |
EC50 = 4500 nM
|
|
|
|
CP0476288
|
methyl 4-amino-2-butyl-1-(4-methoxy-4-oxobutyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C21H26N4O4
|
1
|
| 1 |
EC50 = 4530 nM
|
|
|
|
CP0461772
|
methyl 4-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C23H24N4O3
|
1
|
| 1 |
EC50 = 4800 nM
|
|
|
|
CP0569173
|
[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]methyl-trimethylazanium;chloride
Show/Hide
|
C22H31ClN6
|
1
|
| 1 |
EC50 = 5000 nM
|
|
|
|
CP0190262
|
[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridine-8-carbonyl]phosphonic acid
Show/Hide
|
C23H22N3O5P
|
1
|
| 1 |
EC50 = 5600 nM
|
|
|
|
CP0389763
|
methyl 4-amino-2-butyl-1-(2-methoxyethyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C19H24N4O3
|
1
|
| 1 |
EC50 = 5700 nM
|
|
|
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CP0568474
|
methyl 4-[2-[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]ethyl]benzoate
Show/Hide
|
C21H25N5O2
|
1
|
| 1 |
EC50 = 6060 nM
|
|
|
|
CP0476733
|
N-(2-methylpropyl)-2-(trifluoromethyl)quinolin-4-amine
Show/Hide
|
C14H15F3N2
|
1
|
| 1 |
EC50 = 6300 nM
|
|
|
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CP0486404
|
methyl 4-amino-2-butyl-1-(2-ethylsulfanylethyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C20H26N4O2S
|
1
|
| 1 |
EC50 = 6670 nM
|
|
|
|
CP0870709
|
6-amino-9-[[1-(2-aminoethyl)-4-piperidyl]methyl]-2-[(1S)-1-methylbutoxy]-7H-purin-8-one Hydrochloride
Show/Hide
|
C18H32ClN7O2
|
1
|
| 1 |
EC50 = 6710 nM
|
|
|
|
CP0446608
|
1-(4-Amino-2-((diethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
Show/Hide
|
C19H27N5O
|
1
|
| 1 |
EC50 = 7710 nM
|
|
|
|
CP0520499
|
N-cyclohexyl-2-(trifluoromethyl)quinazolin-4-amine
Show/Hide
|
C15H16F3N3
|
1
|
| 1 |
EC50 = 8300 nM
|
|
|
|
CP0504044
|
3-(((4-Amino-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-2-yl)methyl)(ethyl)amino)-propanenitrile
Show/Hide
|
C20H26N6O
|
1
|
| 1 |
EC50 = 8390 nM
|
|
|
|
CP0573266
|
4-N-butyl-6-[[3-(trifluoromethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H20F3N5
|
1
|
| 1 |
EC50 = 10000 nM
|
|
|
|
CP0441019
|
N-cyclopentyl-2-(trifluoromethyl)quinazolin-4-amine
Show/Hide
|
C14H14F3N3
|
1
|
| 1 |
EC50 = 10900 nM
|
|
|
|
CP0496500
|
2-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoic acid
Show/Hide
|
C19H21N5O2
|
1
|
| 1 |
EC50 = 10900 nM
|
|
|
|
CP0546368
|
3-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoic acid
Show/Hide
|
C19H21N5O2
|
1
|
| 1 |
EC50 = 10900 nM
|
|
|
|
CP0489353
|
6-benzyl-4-N-butylpteridine-2,4-diamine
Show/Hide
|
C17H20N6
|
1
|
| 1 |
EC50 = 13000 nM
|
|
|
|
CP0461771
|
methyl 4-amino-2-butyl-1-(2-hydroxyethyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C18H22N4O3
|
2
|
| 1 |
EC50 = 14370 nM
|
|
|
| 2 |
EC50 = 23000 nM
|
|
|
|
CP0476732
|
N-(cyclopropylmethyl)-2-(trifluoromethyl)quinazolin-4-amine
Show/Hide
|
C13H12F3N3
|
1
|
| 1 |
EC50 = 15000 nM
|
|
|
|
CP0550013
|
[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]methylphosphonic acid
Show/Hide
|
C19H24N5O3P
|
1
|
| 1 |
EC50 = 15000 nM
|
|
|
|
CP0539440
|
4-pyrrolidin-1-yl-2-(trifluoromethyl)quinazoline
Show/Hide
|
C13H12F3N3
|
1
|
| 1 |
EC50 = 15400 nM
|
|
|
|
CP0423712
|
N-cyclopropyl-2-(trifluoromethyl)quinazolin-4-amine
Show/Hide
|
C12H10F3N3
|
1
|
| 1 |
EC50 = 16800 nM
|
|
|
|
CP0402138
|
6-amino-2-butoxy-9-[[1-(2-hydroxyethyl)piperidin-4-yl]methyl]-7H-purin-8-one;hydrochloride
Show/Hide
|
C17H29ClN6O3
|
1
|
| 1 |
EC50 = 23100 nM
|
|
|
|
CP0381975
|
methyl 4-amino-1-(2-hydroxy-2-methylpropyl)-2-propylimidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C19H24N4O3
|
1
|
| 1 |
EC50 = 23800 nM
|
|
|
|
CP0544699
|
4-N-butyl-6-(4-methoxyphenyl)pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C18H21N5O
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0550012
|
4-N-butyl-6-(1-phenylethyl)pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H23N5
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0568470
|
4-N-butyl-6-phenylpyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C17H19N5
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0568472
|
6-benzyl-4-butylsulfanylpyrido[3,2-d]pyrimidin-2-amine
Show/Hide
|
C18H20N4S
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0568475
|
4-N-butyl-6-[(E)-2-phenylethenyl]pyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H21N5
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0568701
|
6-benzyl-4-piperidin-1-ylpyrido[3,2-d]pyrimidin-2-amine
Show/Hide
|
C19H21N5
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0569660
|
6-benzyl-4-N-butyl-4-N-methylpyrido[3,2-d]pyrimidine-2,4-diamine
Show/Hide
|
C19H23N5
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0573264
|
6-benzyl-4-butoxypyrido[3,2-d]pyrimidin-2-amine
Show/Hide
|
C18H20N4O
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0573937
|
6-benzyl-4-morpholin-4-ylpyrido[3,2-d]pyrimidin-2-amine
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0508687
|
methyl 4-amino-2-ethyl-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C18H22N4O3
|
1
|
| 1 |
EC50 = 29100 nM
|
|
|
|
CP0520500
|
7-(diethylamino)-1-(2-methylpropyl)chromeno[3,4-d]imidazol-4-one
Show/Hide
|
C18H23N3O2
|
1
|
| 1 |
EC50 = 29900 nM
|
|
|
|
CP0437656
|
6-amino-9-[[1-(2-aminoethyl)piperidin-4-yl]methyl]-2-butoxy-7H-purin-8-one;hydrochloride
Show/Hide
|
C17H30ClN7O2
|
1
|
| 1 |
EC50 = 30000 nM
|
|
|
|
CP0859661
|
6-amino-2-[(1R)-1-methylbutoxy]-9-(4-piperidylmethyl)-7H-purin-8-one Hydrochloride
Show/Hide
|
C16H27ClN6O2
|
1
|
| 1 |
EC50 = 35800 nM
|
|
|
|
CP0516848
|
6-amino-2-(butylamino)-9-(piperidin-4-ylmethyl)-7H-purin-8-one;hydrochloride
Show/Hide
|
C15H26ClN7O
|
1
|
| 1 |
EC50 = 40000 nM
|
|
|
|
CP0423715
|
N-propyl-2-(trifluoromethyl)quinazolin-4-amine
Show/Hide
|
C12H12F3N3
|
1
|
| 1 |
EC50 = 44000 nM
|
|
|
|
CP0389766
|
methyl 4-amino-1-(2-hydroxy-2-methylpropyl)-2-methylimidazo[4,5-c]quinoline-7-carboxylate
Show/Hide
|
C17H20N4O3
|
1
|
| 1 |
EC50 = 49200 nM
|
|
|
|
CP0539437
|
N-propan-2-yl-2-(trifluoromethyl)quinazolin-4-amine
Show/Hide
|
C12H12F3N3
|
1
|
| 1 |
EC50 = 57400 nM
|
|
|
|
CP0441021
|
N-(1-cyclopropylpiperidin-4-yl)-2-(trifluoromethyl)quinazolin-4-amine
Show/Hide
|
C17H19F3N4
|
1
|
| 1 |
EC50 = 66600 nM
|
|
|
|
CP0379914
|
1-(4-aminoimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
Show/Hide
|
C14H16N4O
|
1
|
| 1 |
EC50 = 95000 nM
|
|
|
|
CP0950854
|
2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole
Show/Hide
|
C23H29N3
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0574442
|
US10660877, Example 73
Show/Hide
|
C22H26FN3
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0543450
|
US10660877, Example 77
Show/Hide
|
C23H28FN3
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0543454
|
2-(2-fluoro-6-methylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole
Show/Hide
|
C22H26FN3
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0568589
|
US10660877, Example 46
Show/Hide
|
C23H29N3O
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0579429
|
US10660877, Example 31
Show/Hide
|
C23H29N3
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0543452
|
US10660877, Example 5
Show/Hide
|
C22H27N3
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0543449
|
US10660877, Example 39
Show/Hide
|
C24H31N3
|
1
|
| 1 |
IC50 = 7.2 nM
|
|
|
|
CP0579792
|
US10660877, Example 75
Show/Hide
|
C23H29N3
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0576818
|
US10660877, Example 83
Show/Hide
|
C21H23F2N3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0569162
|
US10660877, Example 82
Show/Hide
|
C22H27N3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0547011
|
US10660877, Example 74
Show/Hide
|
C23H26F3N3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0568586
|
2-(2-cyclopropyl-6-methylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole
Show/Hide
|
C25H31N3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0575860
|
US10660877, Example 63
Show/Hide
|
C21H25N3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0543453
|
US10660877, Example 30
Show/Hide
|
C23H29N3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0547004
|
US10660877, Example 6
Show/Hide
|
C22H24F3N3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0543448
|
US10660877, Example 38
Show/Hide
|
C21H25N3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0568588
|
2-(2-ethyl-6-methylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole
Show/Hide
|
C24H31N3
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0547009
|
3-isopropyl-2-(2-methoxypyridin-4-yl)-5-(piperidin-4-yl)-1H-indole
Show/Hide
|
C22H27N3O
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0571722
|
US10660877, Example 22
Show/Hide
|
C22H27N3O
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0571037
|
2-(2-cyclopropylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole
Show/Hide
|
C24H29N3
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0578452
|
US10660877, Example 23
Show/Hide
|
C22H27N3
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0568585
|
US10660877, Example 19
Show/Hide
|
C22H27N3O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0388427
|
2-[4-[2-(3,4-dimethoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
Show/Hide
|
C25H33N3O2
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0001611
|
2-(2,4-dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C16H10Cl2N4O2S
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0547005
|
US10660877, Example 43
Show/Hide
|
C25H33N3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0429768
|
2-(3,5-dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C16H10Cl2N4O2S
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0545848
|
2-(2,3-dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C16H10Cl2N4O2S
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0547003
|
US10660877, Example 777
Show/Hide
|
C23H30N4O
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0543455
|
US10660877, Example 776
Show/Hide
|
C22H28N4
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0578600
|
US10660877, Example 81
Show/Hide
|
C21H24FN3
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0389058
|
3,5-bis[(4-methoxyphenyl)methyl]-2-phenylimidazo[4,5-c]quinolin-5-ium
Show/Hide
|
C32H28N3O2+
|
3
|
| 1 |
IC50 = 820 nM
|
|
|
| 2 |
IC50 = 2790 nM
|
|
|
| 3 |
IC50 = 4550 nM
|
|
|
|
CP0478025
|
2-(3-bromophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C16H11BrN4O2S
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0545847
|
N'-(pyridine-2-carbonyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C17H11F3N4O2S
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0390876
|
2-(3-chlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C16H11ClN4O2S
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0575424
|
(3R,5R)-N-cyclopropyl-3-methyl-5-[8-(trifluoromethyl)quinolin-5-yl]piperidine-1-carboxamide
Show/Hide
|
C20H22F3N3O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0534466
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-bromo-6-fluorobenzamide
Show/Hide
|
C21H11BrF7NO2
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0429769
|
N'-(pyridine-2-carbonyl)-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C17H11F3N4O2S
|
1
|
| 1 |
IC50 = 1020 nM
|
|
|
|
CP0476504
|
N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-6-fluorobenzamide
Show/Hide
|
C15H7ClF7NO
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0545846
|
2-(4-methylphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C17H14N4O2S
|
1
|
| 1 |
IC50 = 1830 nM
|
|
|
|
CP0429770
|
2-[4-(dimethylamino)phenyl]-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C18H17N5O2S
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0351217
|
6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole
Show/Hide
|
C27H35N3O3
|
1
|
| 1 |
IC50 = 1990 nM
|
|
|
|
CP0429766
|
2-(4-chlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C16H11ClN4O2S
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0390877
|
2-(4-ethylphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C18H16N4O2S
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
|
CP0141465
|
1-pentyl-4-(2-phenylmethoxyphenyl)imidazol-2-amine;hydrochloride
Show/Hide
|
C21H26ClN3O
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
|
CP0532739
|
2-(3-fluorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C16H11FN4O2S
|
1
|
| 1 |
IC50 = 2600 nM
|
|
|
|
CP0533372
|
2-chloro-6-fluoro-N-[4-[3-(trifluoromethyl)phenoxy]phenyl]benzamide
Show/Hide
|
C20H12ClF4NO2
|
1
|
| 1 |
IC50 = 2650 nM
|
|
|
|
CP0438452
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-chloro-6-fluorobenzamide
Show/Hide
|
C21H11ClF7NO2
|
1
|
| 1 |
IC50 = 2880 nM
|
|
|
|
CP0476471
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C22H13ClF7NO2
|
1
|
| 1 |
IC50 = 2900 nM
|
|
|
|
CP0549061
|
2-(4-methoxyphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C17H14N4O3S
|
1
|
| 1 |
IC50 = 3090 nM
|
|
|
|
CP0577540
|
2-[4-[2-(5-methoxypyridin-3-yl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
Show/Hide
|
C23H30N4O
|
1
|
| 1 |
IC50 = 3300 nM
|
|
|
|
CP0547502
|
2-(3,4-dimethoxyphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C18H16N4O4S
|
1
|
| 1 |
IC50 = 3900 nM
|
|
|
|
CP0549493
|
2-(4-fluorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C16H11FN4O2S
|
1
|
| 1 |
IC50 = 4400 nM
|
|
|
|
CP0238617
|
1-methyl-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine
Show/Hide
|
C26H34N4O2
|
1
|
| 1 |
IC50 = 4570 nM
|
|
|
|
CP0241920
|
4-[(dimethylamino)methyl]-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide
Show/Hide
|
C30H34N4O3
|
1
|
| 1 |
IC50 = 4710 nM
|
|
|
|
CP0574225
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]-2-hydroxyphenyl]-2-fluoro-6-iodobenzamide
Show/Hide
|
C21H11F7INO3
|
1
|
| 1 |
IC50 = 4730 nM
|
|
|
|
CP0512943
|
3-(2-nonylimidazo[4,5-c]quinolin-3-yl)propan-1-ol
Show/Hide
|
C22H31N3O
|
1
|
| 1 |
IC50 = 4810 nM
|
|
|
|
CP0351219
|
2-(3-piperidin-4-ylphenyl)-6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazole
Show/Hide
|
C25H31N3O2
|
1
|
| 1 |
IC50 = 4990 nM
|
|
|
|
CP0539158
|
2-[4-[2-(4-methoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
Show/Hide
|
C24H31N3O
|
1
|
| 1 |
IC50 = 5500 nM
|
|
|
|
CP0549060
|
2-phenyl-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C16H12N4O2S
|
1
|
| 1 |
IC50 = 5800 nM
|
|
|
|
CP0540174
|
2-[4-[2-(3-methoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
Show/Hide
|
C24H31N3O
|
1
|
| 1 |
IC50 = 6200 nM
|
|
|
|
CP0476503
|
4-[3,5-bis(trifluoromethyl)phenoxy]-N-(2-chloro-6-fluorophenyl)benzamide
Show/Hide
|
C21H11ClF7NO2
|
1
|
| 1 |
IC50 = 7100 nM
|
|
|
|
CP0521006
|
N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine
Show/Hide
|
C25H32N4O2
|
1
|
| 1 |
IC50 = 7550 nM
|
|
|
|
CP0545845
|
3-hydroxy-N'-[4-(trifluoromethoxy)benzoyl]pyridine-2-carbohydrazide
Show/Hide
|
C14H10F3N3O4
|
1
|
| 1 |
IC50 = 7900 nM
|
|
|
|
CP0315415
|
1-benzyl-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine
Show/Hide
|
C32H38N4O2
|
1
|
| 1 |
IC50 = 8090 nM
|
|
|
|
CP0571764
|
6-(3-pyrrolidin-1-ylpropoxy)-2-[3-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]-1,3-benzoxazole
Show/Hide
|
C25H29N3O2
|
1
|
| 1 |
IC50 = 8300 nM
|
|
|
|
CP0438010
|
2-nonyl-3-prop-2-ynylimidazo[4,5-c]quinoline
Show/Hide
|
C22H27N3
|
1
|
| 1 |
IC50 = 8580 nM
|
|
|
|
CP0543451
|
2-[4-[2-(6-methoxypyridin-2-yl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
Show/Hide
|
C23H30N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0572227
|
N-methyl-2-[4-(3-methyl-2-pyridin-3-yl-1H-indol-5-yl)piperidin-1-yl]ethanamine
Show/Hide
|
C22H28N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0572228
|
2-[4-[2-(6-methoxypyridin-3-yl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
Show/Hide
|
C23H30N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0483629
|
3-methyl-2-nonylimidazo[4,5-c]quinoline
Show/Hide
|
C20H27N3
|
1
|
| 1 |
IC50 = 10140 nM
|
|
|
|
CP0509533
|
1-[3-[4-[6-[3-(3-aminopyrrolidin-1-yl)propoxy]-1,3-benzoxazol-2-yl]phenoxy]propyl]pyrrolidin-3-amine
Show/Hide
|
C27H37N5O3
|
1
|
| 1 |
IC50 = 10840 nM
|
|
|
|
CP0429760
|
3-hydroxy-N'-[4-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide
Show/Hide
|
C14H10F3N3O3
|
1
|
| 1 |
IC50 = 13400 nM
|
|
|
|
CP0414886
|
2-propan-2-yl-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C13H14N4O2S
|
1
|
| 1 |
IC50 = 14000 nM
|
|
|
|
CP0390870
|
3-hydroxy-N'-[3-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide
Show/Hide
|
C14H10F3N3O3
|
1
|
| 1 |
IC50 = 14200 nM
|
|
|
|
CP0458275
|
2-methyl-1-(2-nonylimidazo[4,5-c]quinolin-3-yl)propan-2-ol
Show/Hide
|
C23H33N3O
|
1
|
| 1 |
IC50 = 14400 nM
|
|
|
|
CP0494470
|
2-phenyl-3-prop-2-ynylimidazo[4,5-c]quinoline
Show/Hide
|
C19H13N3
|
1
|
| 1 |
IC50 = 14850 nM
|
|
|
|
CP0390871
|
N'-[3-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide
Show/Hide
|
C14H10F3N3O2
|
1
|
| 1 |
IC50 = 15000 nM
|
|
|
|
CP0538666
|
3-amino-N'-[3-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide
Show/Hide
|
C14H11F3N4O2
|
1
|
| 1 |
IC50 = 16000 nM
|
|
|
|
CP0389965
|
N'-(4-bromobenzoyl)pyridine-2-carbohydrazide
Show/Hide
|
C13H10BrN3O2
|
1
|
| 1 |
IC50 = 17000 nM
|
|
|
|
CP0549492
|
N'-[4-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide
Show/Hide
|
C14H10F3N3O2
|
1
|
| 1 |
IC50 = 17000 nM
|
|
|
|
CP0429765
|
N'-(4-bromobenzoyl)-3-hydroxypyridine-2-carbohydrazide
Show/Hide
|
C13H10BrN3O3
|
1
|
| 1 |
IC50 = 17260 nM
|
|
|
|
CP0512937
|
3-[(4-methoxyphenyl)methyl]-2-nonylimidazo[4,5-c]quinoline
Show/Hide
|
C27H33N3O
|
1
|
| 1 |
IC50 = 19440 nM
|
|
|
|
CP0459645
|
2-cyclohexyl-3-[(4-methoxyphenyl)methyl]imidazo[4,5-c]quinoline
Show/Hide
|
C24H25N3O
|
1
|
| 1 |
IC50 = 19900 nM
|
|
|
|
CP0412004
|
1-[(3R,5S)-3-methyl-5-[8-(trifluoromethyl)quinolin-5-yl]piperidin-1-yl]-3-pyrazol-1-ylpropan-1-one
Show/Hide
|
C22H23F3N4O
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0476472
|
2-[4-(3-iodo-2-nitrophenoxy)phenyl]-1,3,4-oxadiazole
Show/Hide
|
C14H8IN3O4
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0483628
|
3-(2-cyclohexylimidazo[4,5-c]quinolin-3-yl)propan-1-ol
Show/Hide
|
C19H23N3O
|
1
|
| 1 |
IC50 = 20320 nM
|
|
|
|
CP0438019
|
N-[2-(ethylaminomethyl)-3-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinolin-4-yl]benzamide
Show/Hide
|
C24H27N5O2
|
1
|
| 1 |
IC50 = 21170 nM
|
|
|
|
CP0459646
|
3-methyl-2-phenylimidazo[4,5-c]quinoline
Show/Hide
|
C17H13N3
|
1
|
| 1 |
IC50 = 21630 nM
|
|
|
|
CP0459647
|
2-cyclohexyl-3-prop-2-ynylimidazo[4,5-c]quinoline
Show/Hide
|
C19H19N3
|
1
|
| 1 |
IC50 = 21870 nM
|
|
|
|
CP0540505
|
N'-[4-(trifluoromethoxy)benzoyl]pyridine-2-carbohydrazide
Show/Hide
|
C14H10F3N3O3
|
1
|
| 1 |
IC50 = 22000 nM
|
|
|
|
CP0459648
|
2-cyclohexyl-3-methylimidazo[4,5-c]quinoline
Show/Hide
|
C17H19N3
|
1
|
| 1 |
IC50 = 22040 nM
|
|
|
|
CP0542695
|
N'-(pyridine-2-carbonyl)-2-pyridin-3-yl-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C15H11N5O2S
|
1
|
| 1 |
IC50 = 23200 nM
|
|
|
|
CP0558565
|
N'-(4-chlorobenzoyl)pyridine-2-carbohydrazide
Show/Hide
|
C13H10ClN3O2
|
1
|
| 1 |
IC50 = 24700 nM
|
|
|
|
CP0429764
|
3-amino-N'-[4-(trifluoromethyl)benzoyl]pyrazine-2-carbohydrazide
Show/Hide
|
C13H10F3N5O2
|
1
|
| 1 |
IC50 = 25000 nM
|
|
|
|
CP0438009
|
N-[(3-prop-2-ynylimidazo[4,5-c]quinolin-2-yl)methyl]ethanamine
Show/Hide
|
C16H16N4
|
1
|
| 1 |
IC50 = 26100 nM
|
|
|
|
CP0477803
|
3-amino-N'-[4-(trifluoromethoxy)benzoyl]pyrazine-2-carbohydrazide
Show/Hide
|
C13H10F3N5O3
|
1
|
| 1 |
IC50 = 27000 nM
|
|
|
|
CP0390874
|
N'-(4-chlorobenzoyl)-3-hydroxypyridine-2-carbohydrazide
Show/Hide
|
C13H10ClN3O3
|
1
|
| 1 |
IC50 = 27800 nM
|
|
|
|
CP0397888
|
N-[[3-[(4-methoxyphenyl)methyl]imidazo[4,5-c]quinolin-2-yl]methyl]ethanamine
Show/Hide
|
C21H22N4O
|
1
|
| 1 |
IC50 = 28020 nM
|
|
|
|
CP0429763
|
2-methyl-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C11H10N4O2S
|
1
|
| 1 |
IC50 = 30000 nM
|
|
|
|
CP0459643
|
N-[(3-methylimidazo[4,5-c]quinolin-2-yl)methyl]ethanamine
Show/Hide
|
C14H16N4
|
1
|
| 1 |
IC50 = 30440 nM
|
|
|
|
CP0494469
|
3-(2-phenylimidazo[4,5-c]quinolin-3-yl)propan-1-ol
Show/Hide
|
C19H17N3O
|
1
|
| 1 |
IC50 = 37240 nM
|
|
|
|
CP0390872
|
3-amino-N'-[3-(trifluoromethyl)benzoyl]pyrazine-2-carbohydrazide
Show/Hide
|
C13H10F3N5O2
|
1
|
| 1 |
IC50 = 38000 nM
|
|
|
|
CP0503006
|
2-methyl-1-(2-phenylimidazo[4,5-c]quinolin-3-yl)propan-2-ol
Show/Hide
|
C20H19N3O
|
1
|
| 1 |
IC50 = 38420 nM
|
|
|
|
CP0389057
|
1-(2-cyclohexylimidazo[4,5-c]quinolin-3-yl)-2-methylpropan-2-ol
Show/Hide
|
C20H25N3O
|
1
|
| 1 |
IC50 = 38730 nM
|
|
|
|
CP0429762
|
N'-(4-chlorobenzoyl)-2-methyl-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C12H10ClN3O2S
|
1
|
| 1 |
IC50 = 44800 nM
|
|
|
|
CP0397890
|
1-[2-(ethylaminomethyl)-5-oxidoimidazo[4,5-c]quinolin-5-ium-3-yl]-2-methylpropan-2-ol
Show/Hide
|
C17H22N4O2
|
1
|
| 1 |
IC50 = 46500 nM
|
|
|
|
CP0438454
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodobenzamide
Show/Hide
|
C21H11F7INO2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0438457
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-3-fluoropyridine-2-carboxamide
Show/Hide
|
C20H11F7N2O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0482366
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-(trifluoromethoxy)benzamide
Show/Hide
|
C22H11F10NO3
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0482367
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluorobenzamide
Show/Hide
|
C21H12F7NO2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0485612
|
4-amino-N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluorobenzamide
Show/Hide
|
C21H13F7N2O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0492032
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-4-iodobenzamide
Show/Hide
|
C21H11F7INO2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0534960
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-3H-benzimidazole-5-carboxamide
Show/Hide
|
C22H13F6N3O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0534961
|
N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-1H-indole-6-carboxamide
Show/Hide
|
C23H14F6N2O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0553749
|
4-[3,5-bis(trifluoromethyl)phenoxy]-N-[(2-chloro-6-fluorophenyl)methyl]aniline
Show/Hide
|
C21H13ClF7NO
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0388424
|
2-[4-[2-(3,4-dimethoxyphenyl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
Show/Hide
|
C27H37N3O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0397891
|
1-(2-((ethylamino)methyl)-3H-imidazo[4,5-c]quinolin-3-yl)-2-methylpropan-2-ol bis(2,2,2-trifluoroacetate)
Show/Hide
|
C17H22N4O
|
1
|
| 1 |
IC50 = 56310 nM
|
|
|
|
CP0545832
|
N'-(3-chlorobenzoyl)-2-methyl-1,3-thiazole-4-carbohydrazide
Show/Hide
|
C12H10ClN3O2S
|
1
|
| 1 |
IC50 = 60000 nM
|
|
|
|
CP0548732
|
4-(aminomethyl)-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide
Show/Hide
|
C28H30N4O3
|
1
|
| 1 |
IC50 = 66170 nM
|
|
|
|
CP0379721
|
2-[4-[4-[7-(3-morpholin-4-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]phenyl]piperazin-1-yl]ethanol
Show/Hide
|
C25H36N6O2
|
1
|
| 1 |
IC50 > 970 nM
|
|
|
|
CP0412002
|
5-[(3R,5R)-5-methyl-1-[2-(3-methyl-3-azabicyclo[3.1.1]heptan-6-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrile
Show/Hide
|
C25H30N4O
|
1
|
| 1 |
IC50 < 1000 nM
|
|
|
|
CP0412003
|
5-[5-methyl-1-[(1-methylpyrrolidin-3-yl)methyl]piperidin-3-yl]quinoline-8-carbonitrile
Show/Hide
|
C22H28N4
|
1
|
| 1 |
IC50 < 1000 nM
|
|
|
|
CP0412005
|
5-[(3R,5R)-5-methyl-1-[2-(1-methylpiperidin-4-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrile
Show/Hide
|
C24H30N4O
|
1
|
| 1 |
IC50 < 1000 nM
|
|
|
|
CP0445760
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(3R,5R)-3-(8-cyanoquinolin-5-yl)-5-methyl-N-(1-methylpiperidin-4-yl)piperidine-1-carboxamide
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C23H29N5O
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1
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| 1 |
IC50 < 1000 nM
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CP0540903
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1-[(3R,5R)-3-methyl-5-(8-methylquinolin-5-yl)piperidin-1-yl]-2-(1-methylpiperidin-4-yl)ethanone
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C24H33N3O
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1
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| 1 |
IC50 < 1000 nM
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CP0564624
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5-[(3S,5R)-1-[2-[(1S,5R)-3-azabicyclo[3.1.0]hexan-6-yl]acetyl]-5-methylpiperidin-3-yl]quinoline-8-carbonitrile
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C23H26N4O
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1
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| 1 |
IC50 < 1000 nM
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CP0564625
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5-[(3R,5R)-5-methyl-1-[2-(4-methylpiperazin-1-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrile
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C23H29N5O
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1
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| 1 |
IC50 < 1000 nM
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CP0566053
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(1S,3S,5S)-3-methyl-5-[8-(trifluoromethyl)quinoxalin-5-yl]cyclohexan-1-amine
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C16H18F3N3
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1
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| 1 |
IC50 < 1000 nM
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CP0566304
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(1S,3S,5R)-3-methyl-5-[8-(trifluoromethyl)quinoxalin-5-yl]cyclohexan-1-amine
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C16H18F3N3
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1
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| 1 |
IC50 < 1000 nM
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CP0575425
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(2S)-2-hydroxy-3,3-dimethyl-N-[(1R,3R,5R)-3-methyl-5-[8-(trifluoromethyl)quinoxalin-5-yl]cyclohexyl]butanamide
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C22H28F3N3O2
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1
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| 1 |
IC50 < 1000 nM
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