| Compound ID |
Compound Name |
Compound Formula |
|
CP0404087
|
(3R)-6'-methylspiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
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|
C16H19N3O
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0022280
|
(3R)-N-quinazolin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C17H19N5O
|
1
|
| 1 |
EC50 = 6.7 nM
|
|
|
|
CP0404086
|
(3R)-5'-methylspiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C16H19N3O
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0530704
|
(3R)-6'-methoxyspiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
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|
C16H19N3O2
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0022275
|
(3R)-N-(4-phenylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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|
C19H21N5O
|
1
|
| 1 |
EC50 = 7.9 nM
|
|
|
|
CP0401035
|
(3R)-N-(4-phenylpyridin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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|
C20H22N4O
|
1
|
| 1 |
EC50 = 8.9 nM
|
|
|
|
CP0003085
|
(3R)-N-isoquinolin-3-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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|
C18H20N4O
|
3
|
| 1 |
EC50 = 9.3 nM
|
|
|
| 2 |
EC50 = 140 nM
|
|
|
| 3 |
Ki = 4.4 nM
|
|
|
|
CP0031331
|
(3R)-N-(6-phenylpyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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|
C19H21N5O
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0002604
|
(3R)-spiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C15H17N3O
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0569426
|
(3R)-6'-(trifluoromethyl)spiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C16H16F3N3O
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0411030
|
N-[[3-[1-(1-azabicyclo[2.2.2]octan-3-ylmethyl)-2-oxoquinolin-4-yl]phenyl]methyl]methanesulfonamide
Show/Hide
|
C25H29N3O3S
|
2
|
| 1 |
EC50 = 14 nM
|
|
|
| 2 |
EC50 = 260 nM
|
|
|
|
CP0536869
|
(3R)-7'-chlorospiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
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|
C15H16ClN3O
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0384747
|
(3R)-5'-chlorospiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C15H16ClN3O
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0018460
|
(3R)-N-(5-methoxypyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0022592
|
(3R)-N-(5-methylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0482414
|
(3R)-5',6'-dibromospiro[1-azabicyclo[2.2.2]octane-3,2'-3H-imidazo[2,1-b][1,3]oxazole]
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|
C11H13Br2N3O
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0451973
|
N-(1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C16H18N4OS
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
EC50 = 500 nM
|
|
|
|
CP0458720
|
(3R)-N-(1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C16H18N4OS
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0446622
|
(3R,4R)-N-(1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.1]heptane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C15H16N4OS
|
2
|
| 1 |
EC50 = 22 nM
|
|
|
| 2 |
EC50 = 280 nM
|
|
|
|
CP0404312
|
(3R)-5'-(trifluoromethyl)spiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C16H16F3N3O
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0411032
|
1-(1-azabicyclo[2.2.2]octan-3-ylmethyl)-4-(1H-indol-4-yl)quinolin-2-one
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|
C25H25N3O
|
2
|
| 1 |
EC50 = 23 nM
|
|
|
| 2 |
EC50 = 540 nM
|
|
|
|
CP0451446
|
(3R)-N-quinolin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H20N4O
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0384752
|
(3R)-5'-(4-methoxyphenyl)spiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0019974
|
(3R)-N-(1,7-naphthyridin-6-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C17H19N5O
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0549706
|
(3R)-6'-chlorospiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C15H16ClN3O
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0386152
|
N-[[3-[1-(1-azabicyclo[2.2.2]octan-3-ylmethyl)-2-oxoquinolin-4-yl]phenyl]methyl]acetamide
Show/Hide
|
C26H29N3O2
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0404085
|
5',6'-dibromospiro[1-azabicyclo[2.2.2]octane-3,2'-3H-imidazo[2,1-b][1,3]oxazole]
Show/Hide
|
C11H13Br2N3O
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0018457
|
(3R)-N-(5-chloropyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C13H16ClN5O
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0569425
|
(3R)-7'-methylspiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C16H19N3O
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0022276
|
(3R)-N-(5-methoxypyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O2
|
1
|
| 1 |
EC50 = 34 nM
|
|
|
|
CP0019978
|
(3R)-N-(6-methoxypyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O2
|
1
|
| 1 |
EC50 = 43 nM
|
|
|
|
CP0482413
|
(3R)-7'-(trifluoromethyl)spiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C16H16F3N3O
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
|
CP0527758
|
N-[[3-[2-oxo-1-(piperidin-3-ylmethyl)quinolin-4-yl]phenyl]methyl]methanesulfonamide
Show/Hide
|
C23H27N3O3S
|
1
|
| 1 |
EC50 = 77 nM
|
|
|
|
CP0019975
|
(3R)-N-(4-propan-2-ylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C16H23N5O
|
1
|
| 1 |
EC50 = 78 nM
|
|
|
|
CP0024602
|
(3R)-N-(5-methylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O
|
1
|
| 1 |
EC50 = 84 nM
|
|
|
|
CP0527757
|
N-[[3-[2-oxo-1-(piperidin-3-ylmethyl)quinolin-4-yl]phenyl]methyl]acetamide
Show/Hide
|
C24H27N3O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0488118
|
4-(1H-indol-4-yl)-1-(piperidin-3-ylmethyl)quinolin-2-one
Show/Hide
|
C23H23N3O
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0022281
|
(3R)-N-pyridin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H18N4O
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0022278
|
(3R)-N-(4-methoxypyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O2
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0446574
|
N-(6-methoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C17H20N4O2S
|
2
|
| 1 |
EC50 = 120 nM
|
|
|
| 2 |
EC50 = 600 nM
|
|
|
|
CP0446619
|
N-(6-methyl-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C17H20N4OS
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0019973
|
(3R)-N-(4-methylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0022279
|
(3R)-N-[5-(3-methylphenyl)pyrimidin-2-yl]spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C20H23N5O
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0018229
|
(3R)-N-pyrimidin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C13H17N5O
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0005884
|
(3R)-N-(6-methoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C17H20N4O2S
|
3
|
| 1 |
EC50 = 140 nM
|
|
|
| 2 |
EC50 = 400 nM
|
|
|
| 3 |
Ki = 38 nM
|
|
|
|
CP0386153
|
1-(1-azabicyclo[2.2.2]octan-3-ylmethyl)-4-phenylquinolin-2-one
Show/Hide
|
C23H24N2O
|
2
|
| 1 |
EC50 = 150 nM
|
|
|
| 2 |
EC50 = 760 nM
|
|
|
|
CP0531146
|
N-(6-chloro-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C16H17ClN4OS
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0451436
|
N-pyridin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H18N4O
|
1
|
| 1 |
EC50 = 180 nM
|
|
|
|
CP0446575
|
N-(1,3-thiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C12H16N4OS
|
2
|
| 1 |
EC50 = 200 nM
|
|
|
| 2 |
EC50 = 1300 nM
|
|
|
|
CP0460475
|
N-spiro[1,4-dihydroimidazole-5,3'-1-azabicyclo[2.2.2]octane]-2-yl-1,3-benzothiazol-2-amine
Show/Hide
|
C16H19N5S
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0449098
|
4-phenyl-1-(piperidin-3-ylmethyl)quinolin-2-one
Show/Hide
|
C21H22N2O
|
2
|
| 1 |
EC50 = 210 nM
|
|
|
| 2 |
EC50 = 2500 nM
|
|
|
|
CP0432227
|
(3R)-N-isoquinolin-1-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H20N4O
|
1
|
| 1 |
EC50 = 210 nM
|
|
|
|
CP0391795
|
1-(morpholin-2-ylmethyl)-4-phenylquinolin-2-one
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|
C20H20N2O2
|
2
|
| 1 |
EC50 = 260 nM
|
|
|
| 2 |
EC50 = 1200 nM
|
|
|
|
CP0451433
|
N-(1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.1]heptane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C15H16N4OS
|
1
|
| 1 |
EC50 = 260 nM
|
|
|
|
CP0549708
|
(3R)-8'-chlorospiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C15H16ClN3O
|
1
|
| 1 |
EC50 = 268 nM
|
|
|
|
CP0415429
|
(5R)-N-(1,3-benzothiazol-2-yl)spiro[1-azabicyclo[3.2.1]octane-6,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C16H18N4OS
|
1
|
| 1 |
EC50 = 290 nM
|
|
|
|
CP0510737
|
N-(6-ethoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H22N4O2S
|
1
|
| 1 |
EC50 = 320 nM
|
|
|
|
CP0520694
|
N-(5-phenyl-1,3-thiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H20N4OS
|
1
|
| 1 |
EC50 = 400 nM
|
|
|
|
CP0030408
|
(3R)-N-(6-propan-2-ylpyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C16H23N5O
|
1
|
| 1 |
EC50 = 440 nM
|
|
|
|
CP0465199
|
N-(4-phenyl-1,3-thiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H20N4OS
|
1
|
| 1 |
EC50 = 450 nM
|
|
|
|
CP0426245
|
2-oxo-4-phenyl-1-(piperidin-3-ylmethyl)quinoline-3-carbonitrile
Show/Hide
|
C22H21N3O
|
1
|
| 1 |
EC50 = 460 nM
|
|
|
|
CP0019977
|
(3R)-N-(6-chloropyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C13H16ClN5O
|
1
|
| 1 |
EC50 = 470 nM
|
|
|
|
CP0019976
|
(3R)-N-(6-methylpyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O
|
1
|
| 1 |
EC50 = 480 nM
|
|
|
|
CP0180651
|
6-methyl-N-spiro[1,4-dihydroimidazole-5,3'-1-azabicyclo[2.2.2]octane]-2-yl-1,3-benzoxazol-2-amine
Show/Hide
|
C17H21N5O
|
1
|
| 1 |
EC50 = 500 nM
|
|
|
|
CP0020637
|
N-pyrazin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C13H17N5O
|
1
|
| 1 |
EC50 = 630 nM
|
|
|
|
CP0022274
|
(3R)-N-pyrazin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C13H17N5O
|
1
|
| 1 |
EC50 = 630 nM
|
|
|
|
CP0415426
|
N-(1,3-benzothiazol-2-yl)spiro[1-azabicyclo[3.2.1]octane-6,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C16H18N4OS
|
1
|
| 1 |
EC50 = 700 nM
|
|
|
|
CP0465158
|
(3R)-N-(5-phenylpyridin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
EC50 = 750 nM
|
|
|
|
CP0451437
|
N-(4-methoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C17H20N4O2S
|
1
|
| 1 |
EC50 = 830 nM
|
|
|
|
CP0022277
|
N-pyrimidin-4-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C13H17N5O
|
1
|
| 1 |
EC50 = 840 nM
|
|
|
|
CP0411034
|
1-[3-(methylamino)propyl]-2-oxo-4-phenylquinoline-3-carbonitrile
Show/Hide
|
C20H19N3O
|
1
|
| 1 |
EC50 = 900 nM
|
|
|
|
CP0446620
|
2-(spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-ylamino)-1,3-benzothiazol-6-ol
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C16H18N4O2S
|
1
|
| 1 |
EC50 = 980 nM
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CP0566226
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N-(5-methoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
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C17H20N4O2S
|
1
|
| 1 |
EC50 = 1100 nM
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CP0308344
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N-(5-chloropyrimidin-2-yl)spiro[1,4-dihydroimidazole-5,3'-1-azabicyclo[2.2.2]octane]-2-amine
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C13H17ClN6
|
1
|
| 1 |
EC50 = 1100 nM
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CP0274283
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N-(1'-methylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-imidazole]-2'-yl)-1,3-benzothiazol-2-amine
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C17H21N5S
|
1
|
| 1 |
EC50 = 1200 nM
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CP0460450
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6-chloro-N-spiro[1,4-dihydroimidazole-5,3'-1-azabicyclo[2.2.2]octane]-2-yl-1,3-benzothiazol-2-amine
Show/Hide
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C16H18ClN5S
|
1
|
| 1 |
EC50 = 1200 nM
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CP0020421
|
1-[3-(dimethylamino)propyl]-2-oxo-4-phenylquinoline-3-carbonitrile
Show/Hide
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C21H21N3O
|
2
|
| 1 |
EC50 = 1300 nM
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| 2 |
EC50 = 8200 nM
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CP0488100
|
4-(3-methoxyphenyl)-1-(piperidin-3-ylmethyl)quinolin-2-one
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C22H24N2O2
|
1
|
| 1 |
EC50 = 1300 nM
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CP0446573
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(3S)-N-(1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C16H18N4OS
|
1
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| 1 |
EC50 = 1300 nM
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CP0452709
|
4-(2-methylphenyl)-1-(piperidin-3-ylmethyl)quinolin-2-one
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|
C22H24N2O
|
1
|
| 1 |
EC50 = 1500 nM
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CP0019980
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(3R)-N-(6-methylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O
|
1
|
| 1 |
EC50 = 1600 nM
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CP0005233
|
5-Morpholin-4-ylpentanoic acid(4-pyridin-3-ylphenyl)amide hydrochloride
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C20H25N3O2
|
3
|
| 1 |
EC50 = 1650 nM
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| 2 |
Ki = 500 nM
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| 3 |
Ki = 670 nM
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CP0018458
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(3R)-N-(5-phenylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H21N5O
|
1
|
| 1 |
EC50 = 1800 nM
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CP0415427
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(3S)-N-(6-methoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C17H20N4O2S
|
1
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| 1 |
EC50 = 1900 nM
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CP0018461
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(3R)-N-(3-methylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H19N5O
|
1
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| 1 |
EC50 = 2100 nM
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CP0500247
|
1-[3-(dimethylamino)propyl]-4-phenylquinolin-2-one
Show/Hide
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C20H22N2O
|
1
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| 1 |
EC50 = 2800 nM
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CP0424417
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N-[4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl]-4-pyridin-2-ylbenzamide
Show/Hide
|
C28H34N4O3
|
1
|
| 1 |
EC50 = 2840 nM
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CP0451435
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N-(1,3-benzothiazol-5-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C16H18N4OS
|
1
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| 1 |
EC50 = 3100 nM
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CP0415428
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N-(6-methoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,6'-4,5-dihydro-1,3-oxazine]-2'-amine
Show/Hide
|
C18H22N4O2S
|
1
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| 1 |
EC50 = 3700 nM
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CP0389076
|
(3S)-5',6'-dibromospiro[1-azabicyclo[2.2.2]octane-3,2'-3H-imidazo[2,1-b][1,3]oxazole]
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|
C11H13Br2N3O
|
1
|
| 1 |
EC50 = 4030 nM
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CP0500246
|
1-[3-[ethyl(methyl)amino]propyl]-2-oxo-4-phenylquinoline-3-carbonitrile
Show/Hide
|
C22H23N3O
|
1
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| 1 |
EC50 = 4300 nM
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CP0446621
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N-phenylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C15H19N3O
|
1
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| 1 |
EC50 = 5400 nM
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CP0482401
|
(3S)-spiro[1-azabicyclo[2.2.2]octane-3,2'-1H-[1,3]oxazolo[3,2-a]benzimidazole]
Show/Hide
|
C15H17N3O
|
1
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| 1 |
EC50 = 6400 nM
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CP0510738
|
N-(6-methoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C17H20N4O2S
|
1
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| 1 |
EC50 = 7800 nM
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CP0452708
|
2-oxo-4-phenyl-1-(3-pyrrolidin-1-ylpropyl)quinoline-3-carbonitrile
Show/Hide
|
C23H23N3O
|
1
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| 1 |
EC50 = 9300 nM
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CP0391794
|
1-[2-(dimethylamino)ethyl]-4-phenylquinolin-2-one
Show/Hide
|
C19H20N2O
|
1
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| 1 |
EC50 > 10000 nM
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CP0449099
|
1-[3-(dimethylamino)butyl]-4-phenylquinolin-2-one
Show/Hide
|
C21H24N2O
|
1
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| 1 |
EC50 > 10000 nM
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CP0449100
|
1-[4-(dimethylamino)butyl]-4-phenylquinolin-2-one
Show/Hide
|
C21H24N2O
|
1
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| 1 |
EC50 > 10000 nM
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CP0488097
|
1-[(1-methylpiperidin-3-yl)methyl]-2-oxo-4-phenylquinoline-3-carbonitrile
Show/Hide
|
C23H23N3O
|
1
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| 1 |
EC50 > 10000 nM
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CP0488098
|
1-[3-(dimethylamino)propyl]-2-oxoquinoline-3-carbonitrile
Show/Hide
|
C15H17N3O
|
1
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| 1 |
EC50 > 10000 nM
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CP0488099
|
1-[3-(dimethylamino)propyl]-2-oxo-4-phenylpyridine-3-carbonitrile
Show/Hide
|
C17H19N3O
|
1
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| 1 |
EC50 > 10000 nM
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CP0500245
|
4-(4-methylphenyl)-1-(piperidin-3-ylmethyl)quinolin-2-one
Show/Hide
|
C22H24N2O
|
1
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| 1 |
EC50 > 10000 nM
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CP0528671
|
1-[3-(dimethylamino)-2-methylpropyl]-4-phenylquinolin-2-one
Show/Hide
|
C21H24N2O
|
1
|
| 1 |
EC50 > 10000 nM
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CP0019979
|
(3R)-N-pyrimidin-5-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C13H17N5O
|
1
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| 1 |
EC50 > 10000 nM
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CP0465198
|
N-pyridin-4-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H18N4O
|
1
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| 1 |
EC50 = 11000 nM
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CP0510735
|
N-(5,6-dimethoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H22N4O3S
|
1
|
| 1 |
EC50 = 11000 nM
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CP0455068
|
N-pyridin-3-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
Show/Hide
|
C14H18N4O
|
1
|
| 1 |
EC50 = 21000 nM
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CP0451430
|
(E)-N-(6-methoxy-1,3-benzothiazol-2-yl)-3-methylspiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2-imine
Show/Hide
|
C18H22N4O2S
|
1
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| 1 |
EC50 > 100000 nM
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CP0027747
|
(3R)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3H-furo[2,3-b]pyridine]
Show/Hide
|
C13H16N2O
|
1
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| 1 |
Ki = 5 nM
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CP0008443
|
(1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane
Show/Hide
|
C16H18N4
|
1
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| 1 |
Ki = 5.9 nM
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CP0007954
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(1S,4S)-2-methyl-5-(4-phenylphenyl)-2,5-diazabicyclo[2.2.1]heptane
Show/Hide
|
C18H20N2
|
1
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| 1 |
Ki = 34 nM
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CP0000457
|
5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene; dihydrochloride
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|
C13H13N3
|
1
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| 1 |
Ki = 62 nM
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CP0006719
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N-[4-(2-fluoropyridin-3-yl)phenyl]-5-morpholin-4-ylpentanamide
Show/Hide
|
C20H24FN3O2
|
1
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| 1 |
Ki = 85 nM
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CP0005582
|
(1S,4S)-2-methyl-5-(4-pyridin-3-ylphenyl)-2,5-diazabicyclo[2.2.1]heptane
Show/Hide
|
C17H19N3
|
1
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| 1 |
Ki = 140 nM
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CP0003078
|
N-(4-phenylphenyl)-5-piperidin-1-ylpentanamide
Show/Hide
|
C22H28N2O
|
1
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| 1 |
Ki = 190 nM
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CP0001989
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-[2-(3-methylphenyl)ethynyl]pyridine
Show/Hide
|
C18H18N2O
|
1
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| 1 |
Ki = 200 nM
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CP0007770
|
5-(piperidin-1-yl)-N-(4-(pyridin-3-yl)phenyl)pentanamide
Show/Hide
|
C21H27N3O
|
1
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| 1 |
Ki = 220 nM
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CP0005250
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3-[2-[5-[[(2S)-azetidin-2-yl]methoxy]pyridin-3-yl]ethynyl]-5-fluoro-N,N-dimethylaniline
Show/Hide
|
C19H20FN3O
|
1
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| 1 |
Ki = 250 nM
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CP0005787
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N-[4-(1H-indol-5-yl)phenyl]-5-morpholin-4-ylpentanamide
Show/Hide
|
C23H27N3O2
|
1
|
| 1 |
Ki = 310 nM
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CP0011238
|
5-morpholin-4-yl-N-(4-pyridin-2-ylphenyl)pentanamide
Show/Hide
|
C20H25N3O2
|
1
|
| 1 |
Ki = 330 nM
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CP0003309
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5-morpholin-4-yl-N-(4-pyridin-4-ylphenyl)pentanamide
Show/Hide
|
C20H25N3O2
|
1
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| 1 |
Ki = 350 nM
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CP0003079
|
4-phenyl-N-(4-piperidin-1-ylbutyl)benzamide
Show/Hide
|
C22H28N2O
|
1
|
| 1 |
Ki = 410 nM
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CP0000885
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-[2-(3-chlorophenyl)ethynyl]pyridine
Show/Hide
|
C17H15ClN2O
|
1
|
| 1 |
Ki = 480 nM
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CP0000063
|
CAS_29790-52-1
Show/Hide
|
C10H14N2
|
1
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| 1 |
Ki = 520 nM
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CP0002026
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-(2-phenylethynyl)pyridine
Show/Hide
|
C17H16N2O
|
1
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| 1 |
Ki = 580 nM
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CP0000889
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-[2-(3-fluoro-5-methylphenyl)ethynyl]pyridine
Show/Hide
|
C18H17FN2O
|
1
|
| 1 |
Ki = 590 nM
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CP0005788
|
N-(5-phenyl-1H-pyrazol-3-yl)-5-piperidin-1-ylpentanamide
Show/Hide
|
C19H26N4O
|
1
|
| 1 |
Ki = 660 nM
|
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CP0001441
|
6-[5-[[(2S)-azetidin-2-yl]methoxy]pyridin-3-yl]hex-5-yn-1-ol
Show/Hide
|
C15H20N2O2
|
1
|
| 1 |
Ki = 670 nM
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CP0001991
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-[2-(3-fluorophenyl)ethynyl]pyridine
Show/Hide
|
C17H15FN2O
|
1
|
| 1 |
Ki = 720 nM
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CP0007966
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-[2-(2-fluorophenyl)ethynyl]pyridine
Show/Hide
|
C17H15FN2O
|
1
|
| 1 |
Ki = 1100 nM
|
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CP0000890
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyridine
Show/Hide
|
C18H15F3N2O
|
1
|
| 1 |
Ki = 1300 nM
|
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CP0011169
|
N-(4-piperidin-1-ylbutyl)-4-pyridin-3-ylbenzamide
Show/Hide
|
C21H27N3O
|
1
|
| 1 |
Ki = 1400 nM
|
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CP0000891
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-[2-(3-fluoro-5-methoxyphenyl)ethynyl]pyridine
Show/Hide
|
C18H17FN2O2
|
1
|
| 1 |
Ki = 1500 nM
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CP0000888
|
3-[[(2R)-azetidin-2-yl]methoxy]-5-(2-phenylethynyl)pyridine
Show/Hide
|
C17H16N2O
|
1
|
| 1 |
Ki = 1600 nM
|
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CP0003308
|
5-(4-methylpiperazin-1-yl)-N-(4-phenylphenyl)pentanamide
Show/Hide
|
C22H29N3O
|
1
|
| 1 |
Ki = 1620 nM
|
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CP0000886
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-[2-(3,5-difluorophenyl)ethynyl]pyridine
Show/Hide
|
C17H14F2N2O
|
1
|
| 1 |
Ki = 1800 nM
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CP0002168
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3-[[(2S)-azetidin-2-yl]methoxy]-5-hex-1-ynylpyridine
Show/Hide
|
C15H20N2O
|
1
|
| 1 |
Ki = 1900 nM
|
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CP0000887
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-[2-(4-fluorophenyl)ethynyl]pyridine
Show/Hide
|
C17H15FN2O
|
1
|
| 1 |
Ki = 2000 nM
|
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CP0007771
|
5-morpholin-4-yl-N-(5-phenyl-1H-pyrazol-3-yl)pentanamide
Show/Hide
|
C18H24N4O2
|
1
|
| 1 |
Ki = 2600 nM
|
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|
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CP0003562
|
3-[[(2S)-azetidin-2-yl]methoxy]-5-(6-azidohex-1-ynyl)pyridine
Show/Hide
|
C15H19N5O
|
1
|
| 1 |
Ki = 2700 nM
|
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CP0005216
|
5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-N-(4-phenylphenyl)pentanamide
Show/Hide
|
C23H29N3O
|
1
|
| 1 |
Ki = 3200 nM
|
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CP0004469
|
2-morpholin-4-yl-N-(4-pyridin-3-ylphenyl)acetamide
Show/Hide
|
C17H19N3O2
|
1
|
| 1 |
Ki = 3900 nM
|
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CP0005785
|
3-(4-Methyl-piperazin-1-yl)-6-phenyl-pyridazine; hydrochloride
Show/Hide
|
C15H18N4
|
1
|
| 1 |
Ki = 4070 nM
|
|
|
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CP0005217
|
N-[4-(4-methylpiperazin-1-yl)butyl]-4-phenylbenzamide
Show/Hide
|
C22H29N3O
|
1
|
| 1 |
Ki = 5400 nM
|
|
|
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CP0005234
|
N-[4-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]butyl]-4-phenylbenzamide
Show/Hide
|
C23H29N3O
|
1
|
| 1 |
Ki = 6100 nM
|
|
|
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CP0005249
|
3-[[(2S)-1-methylazetidin-2-yl]methoxy]-5-(2-phenylethynyl)pyridine
Show/Hide
|
C18H18N2O
|
1
|
| 1 |
Ki = 7700 nM
|
|
|
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CP0010615
|
1-methyl-4-(4-phenylphenyl)piperazine
Show/Hide
|
C17H20N2
|
1
|
| 1 |
Ki = 7700 nM
|
|
|
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CP0002169
|
3-hex-1-ynyl-5-[[(2R)-pyrrolidin-2-yl]methoxy]pyridine
Show/Hide
|
C16H22N2O
|
1
|
| 1 |
Ki = 9100 nM
|
|
|
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CP0001529
|
5-(4-Methylpiperazin-1-yl)pentanoic acid(4-pyridin-3-ylphenyl)amide
Show/Hide
|
C21H28N4O
|
1
|
| 1 |
Ki = 9330 nM
|
|
|
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CP0005094
|
1-methyl-4-(4-pyridin-3-ylphenyl)piperazine
Show/Hide
|
C16H19N3
|
1
|
| 1 |
Ki = 9400 nM
|
|
|
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CP0004783
|
4-morpholin-4-yl-N-(4-pyridin-3-ylphenyl)butanamide
Show/Hide
|
C19H23N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0007708
|
6-morpholin-4-yl-N-(4-pyridin-3-ylphenyl)hexanamide
Show/Hide
|
C21H27N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0011468
|
3-morpholin-4-yl-N-(4-pyridin-3-ylphenyl)propanamide
Show/Hide
|
C18H21N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0001002
|
4-(4-pyridin-3-ylphenyl)morpholine
Show/Hide
|
C15H16N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0001530
|
4-(4-phenylphenyl)morpholine
Show/Hide
|
C16H17NO
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0003077
|
5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-N-(4-pyridin-3-ylphenyl)pentanamide
Show/Hide
|
C21H25N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0003080
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5-morpholin-4-yl-N-(6-phenylpyridazin-3-yl)pentanamide
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C19H24N4O2
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1
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| 1 |
Ki > 10000 nM
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CP0004232
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4-[6-(1H-indol-5-yl)pyridazin-3-yl]morpholine
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C16H16N4O
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1
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| 1 |
Ki > 10000 nM
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CP0005432
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5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-N-(4-phenylphenyl)pentanamide
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C22H26N2O2
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1
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| 1 |
Ki > 10000 nM
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CP0005433
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1-(4-phenylphenyl)piperidine
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C17H19N
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1
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| 1 |
Ki > 10000 nM
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CP0005581
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3-(4-piperidin-1-ylphenyl)pyridine
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C16H18N2
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1
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| 1 |
Ki > 10000 nM
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CP0005786
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N-[4-(4-methylpiperazin-1-yl)butyl]-4-pyridin-3-ylbenzamide
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C21H28N4O
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1
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| 1 |
Ki > 10000 nM
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CP0006411
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N-[4-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]butyl]-4-pyridin-3-ylbenzamide
Show/Hide
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C22H28N4O
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1
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| 1 |
Ki > 10000 nM
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CP0006718
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3-phenyl-6-piperidin-1-ylpyridazine
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C15H17N3
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1
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| 1 |
Ki > 10000 nM
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CP0008033
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4-(6-phenylpyridazin-3-yl)morpholine
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C14H15N3O
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1
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| 1 |
Ki > 10000 nM
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CP0008504
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5-(4-methylpiperazin-1-yl)-N-(5-phenyl-1H-pyrazol-3-yl)pentanamide
Show/Hide
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C19H27N5O
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1
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| 1 |
Ki > 10000 nM
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CP0009015
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5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-N-(4-pyridin-3-ylphenyl)pentanamide
Show/Hide
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C22H28N4O
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1
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| 1 |
Ki > 10000 nM
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CP0005251
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3-((S)-1-Azetidin-2-ylmethoxy)-5-phenyl-pyridine
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C15H16N2O
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1
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| 1 |
Ki = 11000 nM
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CP0012945
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3-[[(2R)-azetidin-2-yl]methoxy]-5-hex-1-ynylpyridine
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C15H20N2O
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1
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| 1 |
Ki = 13000 nM
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CP0000892
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N-[2-[5-(2-phenylethynyl)pyridin-3-yl]oxyethyl]propan-1-amine
Show/Hide
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C18H20N2O
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1
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| 1 |
Ki > 25000 nM
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CP0006523
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3-hex-1-ynyl-5-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine
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C16H22N2O
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1
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| 1 |
Ki = 35000 nM
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CP0002170
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3-[5-[[(2S)-azetidin-2-yl]methoxy]pyridin-3-yl]-4,5,6,7-tetrahydrotriazolo[1,5-a]pyridine
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C15H19N5O
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1
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| 1 |
Ki = 51000 nM
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CP0006524
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4-[1-[5-[[(2S)-azetidin-2-yl]methoxy]pyridin-3-yl]triazol-4-yl]butan-1-ol
Show/Hide
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C15H21N5O2
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1
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| 1 |
Ki = 100000 nM
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