General Information of the Compound
Compound ID
CP0446575
Compound Name
N-(1,3-thiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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Structure
Formula
C12H16N4OS
Molecular Weight
264.354
Canonical SMILES
C1N=C(Nc2nccs2)OC11CN2CCC1CC2
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InChI
InChI=1S/C12H16N4OS/c1-4-16-5-2-9(1)12(8-16)7-14-10(17-12)15-11-13-3-6-18-11/h3,6,9H,1-2,4-5,7-8H2,(H,13,14,15)
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InChIKey
YKBNMVULSUSZJK-UHFFFAOYSA-N
Physicochemical Property
logP
1.4056
Rotatable Bonds
1
Heavy Atom Count
18
Polar Areas
49.75
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
18

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58088162
ChEMBL ID
CHEMBL3902912
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02227, 5-hydroxytryptamine receptor 3A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
Protein ID: PT02118, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 200 nM
   TI
   LI
   LO
   TS
2
EC50 = 1300 nM
   TI
   LI
   LO
   TS