General Information of the Protein
Protein ID
PT04372
Protein Name
Atrial natriuretic peptide receptor 1
Secondarily
Protein Name
Atrial natriuretic peptide receptor type A
Guanylate cyclase A
Gene Name
NPR1
Secondarily
Gene Name
ANPRA
Sequence
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Lyase
>
Guanylate cyclase
>
Receptor guanylate cyclase
Function
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
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Uniprot ID
Primary ID:
P16066

Secondarily ID:
B0ZBF0
Q5SR08
Q6P4Q3
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HGNC ID
HGNC:7943
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0447669
 Compound Info 
Carperitide
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C127H203N45O39S3
  1
1
EC50 = 0.1 nM
 Bioactivity Info 
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CP0423150
 Compound Info 
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(4S,10S,16S,19S,22S,28S,31S,34S,37S,40S,49S,52R)-52-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-19-(3-amino-3-oxopropyl)-49-benzyl-28-[(2S)-butan-2-yl]-31,40-bis(3-carbamimidamidopropyl)-34-(carboxymethyl)-16-(hydroxymethyl)-22-methyl-10-(2-methylpropyl)-37-(2-methylsulfanylethyl)-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-hexadecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecazacyclotripentacontane-4-carbonyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
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C127H203N45O39S3
  1
1
EC50 = 0.1 nM
 Bioactivity Info 
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CP0396428
 Compound Info 
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(4R,10S,16R,19S,22S,28S,31S,34S,37S,40S,49S,52R)-52-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-19-(3-amino-3-oxopropyl)-49-benzyl-28-[(2S)-butan-2-yl]-31,40-bis(3-carbamimidamidopropyl)-34-(carboxymethyl)-16-(hydroxymethyl)-22-methyl-10-(2-methylpropyl)-37-(2-methylsulfanylethyl)-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-hexadecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecazacyclotripentacontane-4-carbonyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
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C127H203N45O39S3
  1
1
EC50 = 0.1 nM
 Bioactivity Info 
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CP0441743
 Compound Info 
Atrial natriuretic peptide analogue
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C75H117N27O19S4
  1
1
EC50 = 0.68 nM
 Bioactivity Info 
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CP0406660
 Compound Info 
1-[4-(2-amino-4-butyl-5-oxo-4H-imidazol-3-yl)-6-[4-[[4-(2-amino-4-butyl-5-oxo-4H-imidazol-3-yl)-6-carbamimidamido-1,3,5-triazin-2-yl]amino]anilino]-1,3,5-triazin-2-yl]guanidine;2,2,2-trifluoroacetic acid
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C32H40F6N20O6
  1
1
EC50 = 2 nM
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CP0432232
 Compound Info 
Atrial natriuretic peptide analogue
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C74H112N24O19S4
  1
1
EC50 = 4.94 nM
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CP0447668
 Compound Info 
1-[4-[2-amino-4-(2-methylpropyl)-5-oxo-4H-imidazol-3-yl]-6-[4-[[4-[2-amino-4-(2-methylpropyl)-5-oxo-4H-imidazol-3-yl]-6-carbamimidamido-1,3,5-triazin-2-yl]amino]anilino]-1,3,5-triazin-2-yl]guanidine;2,2,2-trifluoroacetic acid
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C32H40F6N20O6
  1
1
EC50 = 5.8 nM
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CP0558910
 Compound Info 
2-[4-[[4-[[4-(diaminomethylideneamino)-6-[2-imino-5-(2-methylpropyl)-4-oxoimidazolidin-1-yl]-1,3,5-triazin-2-yl]amino]cyclohexyl]amino]-6-[2-imino-5-(2-methylpropyl)-4-oxoimidazolidin-1-yl]-1,3,5-triazin-2-yl]guanidine;2,2,2-trifluoroacetic acid
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C36H48F12N20O10
  1
1
EC50 = 8.1 nM
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CP0509545
 Compound Info 
Atrial natriuretic peptide analogue
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C74H116N26O18S4
  1
1
EC50 = 8.28 nM
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CP0539276
 Compound Info 
1-[4-(2-amino-4-methyl-5-oxo-4H-imidazol-3-yl)-6-[4-[[4-[2-amino-4-(2-methylpropyl)-5-oxo-4H-imidazol-3-yl]-6-carbamimidamido-1,3,5-triazin-2-yl]amino]anilino]-1,3,5-triazin-2-yl]guanidine;2,2,2-trifluoroacetic acid
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C29H34F6N20O6
  1
1
EC50 = 19 nM
 Bioactivity Info 
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CP0502719
 Compound Info 
Atrial natriuretic peptide analogue
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C72H110N24O19S4
  1
1
EC50 = 30.11 nM
 Bioactivity Info 
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CP0417374
 Compound Info 
CHEMBL4218179
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C29H39FN6O3
  1
1
EC50 = 41 nM
 Bioactivity Info 
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CP0494900
 Compound Info 
Atrial natriuretic peptide analogue
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C78H121N27O19S4
  1
1
EC50 = 46.74 nM
 Bioactivity Info 
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CP0463727
 Compound Info 
Atrial natriuretic peptide analogue
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C75H115N27O19S3
  1
1
EC50 = 65.85 nM
 Bioactivity Info 
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CP0545249
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C29H39FN6O3
  1
1
EC50 = 71 nM
 Bioactivity Info 
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CP0458005
 Compound Info 
N-[4-[[6-(3-fluorophenyl)-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]-1-methylpiperidine-3-carboxamide
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C30H39FN6O
  1
1
EC50 = 73 nM
 Bioactivity Info 
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CP0482243
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-[1-(hydroxymethyl)cyclopentyl]urea
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C30H39FN6O3
  1
1
EC50 = 78 nM
 Bioactivity Info 
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CP0548775
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-(propan-2-ylamino)pyrido[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C28H38FN7O2
  1
1
EC50 = 98 nM
 Bioactivity Info 
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CP0502471
 Compound Info 
Atrial natriuretic peptide analogue
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C78H121N27O19S4
  1
1
EC50 = 107.95 nM
 Bioactivity Info 
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CP0532093
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]pyrido[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C28H38FN7O3
  1
1
EC50 = 110 nM
 Bioactivity Info 
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CP0463653
 Compound Info 
1-methyl-N-[4-[[6-phenyl-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]piperidine-3-carboxamide
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C30H40N6O
  1
1
EC50 = 170 nM
 Bioactivity Info 
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CP0549000
 Compound Info 
Atrial natriuretic peptide analogue
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C74H116N26O18S4
  1
1
EC50 = 176.99 nM
 Bioactivity Info 
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CP0559937
 Compound Info 
Atrial natriuretic peptide analogue
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C73H113N27O19S3
  1
1
EC50 = 198.41 nM
 Bioactivity Info 
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CP0427294
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-methoxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C28H37FN6O2
  1
1
EC50 = 200 nM
 Bioactivity Info 
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CP0512164
 Compound Info 
Atrial natriuretic peptide analogue
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C73H114N26O18S4
  1
1
EC50 = 215.24 nM
 Bioactivity Info 
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CP0567296
 Compound Info 
N-[4-[[6-(2-fluorophenyl)-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]-1-methylpiperidine-3-carboxamide
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C30H39FN6O
  1
1
EC50 = 220 nM
 Bioactivity Info 
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CP0482244
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-(1-hydroxy-2-methylpropan-2-yl)urea
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C28H37FN6O3
  1
1
EC50 = 220 nM
 Bioactivity Info 
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CP0494501
 Compound Info 
CHEMBL4082303
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C30H39ClN6O
  1
1
EC50 = 260 nM
 Bioactivity Info 
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CP0567297
 Compound Info 
N-[4-[[6-(4-fluorophenyl)-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]-1-methylpiperidine-3-carboxamide
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C30H39FN6O
  1
1
EC50 = 310 nM
 Bioactivity Info 
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CP0545248
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H35FN6O2
  1
1
EC50 = 320 nM
 Bioactivity Info 
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CP0548774
 Compound Info 
N-[4-[[2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-phenylquinazolin-4-yl]amino]cyclohexyl]-3-(propan-2-ylamino)cyclobutane-1-carboxamide
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C31H42N6O2
  1
1
EC50 = 320 nM
 Bioactivity Info 
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CP0547323
 Compound Info 
1-cyclopropyl-3-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]urea
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C27H33FN6O2
  1
1
EC50 = 330 nM
 Bioactivity Info 
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CP0417376
 Compound Info 
CHEMBL4210169
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C28H35FN6O2
  1
1
EC50 = 340 nM
 Bioactivity Info 
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CP0417370
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-(2-methoxyethylamino)quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H35FN6O2
  1
1
EC50 = 380 nM
 Bioactivity Info 
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CP0495339
 Compound Info 
CHEMBL4204379
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C27H33FN6O3
  1
1
EC50 = 420 nM
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CP0495338
 Compound Info 
CHEMBL4209251
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C27H35FN6O2
  1
1
EC50 = 460 nM
 Bioactivity Info 
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CP0389271
 Compound Info 
N-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-hydroxycyclobutane-1-carboxamide
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C28H34FN5O3
  1
1
EC50 = 470 nM
 Bioactivity Info 
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CP0482245
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]pyrido[3,4-d]pyrimidin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C28H38FN7O3
  1
1
EC50 = 620 nM
 Bioactivity Info 
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CP0569248
 Compound Info 
1-methyl-N-[3-[[[6-phenyl-2-(propan-2-ylamino)quinazolin-4-yl]amino]methyl]phenyl]piperidine-3-carboxamide
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C31H36N6O
  1
1
EC50 = 720 nM
 Bioactivity Info 
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CP0389270
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[2-hydroxyethyl(methyl)amino]quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H35FN6O2
  1
1
EC50 = 720 nM
 Bioactivity Info 
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CP0482246
 Compound Info 
CHEMBL4206328
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C30H40FN7O2
  1
1
EC50 = 780 nM
 Bioactivity Info 
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CP0396429
 Compound Info 
1-cyclopropyl-3-[4-[[6-(3-fluorophenyl)-2-[[(2S)-1-methoxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]urea
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C28H35FN6O2
  1
1
EC50 = 850 nM
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CP0495341
 Compound Info 
3-hydroxy-N-[4-[[2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-phenylquinazolin-4-yl]amino]cyclohexyl]cyclobutane-1-carboxamide
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C28H35N5O3
  1
1
EC50 = 900 nM
 Bioactivity Info 
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CP0417373
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C29H39FN6O2
  1
1
EC50 = 1000 nM
 Bioactivity Info 
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CP0404565
 Compound Info 
N-[4-[[6-(3-methoxyphenyl)-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]-1-methylpiperidine-3-carboxamide
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C31H42N6O2
  1
1
EC50 = 1100 nM
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CP0548324
 Compound Info 
1-methyl-N-[2-[[[6-phenyl-2-(propan-2-ylamino)quinazolin-4-yl]amino]methyl]phenyl]piperidine-3-carboxamide
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C31H36N6O
  1
1
EC50 = 1400 nM
 Bioactivity Info 
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CP0460791
 Compound Info 
1-methyl-N-[4-[[[6-phenyl-2-(propan-2-ylamino)quinazolin-4-yl]amino]methyl]phenyl]piperidine-3-carboxamide
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C31H36N6O
  1
1
EC50 = 1500 nM
 Bioactivity Info 
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CP0495340
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H35FN6O
  1
1
EC50 = 1500 nM
 Bioactivity Info 
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CP0575543
 Compound Info 
1-methyl-N-[4-[[7-phenyl-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]piperidine-3-carboxamide
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C30H40N6O
  1
1
EC50 = 3400 nM
 Bioactivity Info 
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CP0406661
 Compound Info 
2-[4-[2-amino-4-(2-methylpropyl)-5-oxo-4H-imidazol-3-yl]-6-anilino-1,3,5-triazin-2-yl]guanidine
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C17H22N10O
  1
1
EC50 = 4000 nM
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CP0417375
 Compound Info 
CHEMBL4214562
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C28H37FN6O
  1
1
EC50 = 4000 nM
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CP0513833
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-methoxypropan-2-yl]amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H36FN7O2
  1
1
EC50 = 4000 nM
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CP0539350
 Compound Info 
1-methyl-N-[2-[[[6-phenyl-2-(propan-2-ylamino)thieno[3,2-d]pyrimidin-4-yl]amino]methyl]phenyl]piperidine-3-carboxamide
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C29H34N6OS
  1
1
EC50 = 5000 nM
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CP0538679
 Compound Info 
6-phenyl-2-N-propan-2-yl-4-N-(pyridin-3-ylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine
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C21H21N5S
  1
1
EC50 = 7900 nM
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CP0519397
 Compound Info 
Atrial natriuretic peptide analogue
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C76H119N27O17S4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0447667
 Compound Info 
1-[4-(2-amino-4-methyl-5-oxo-4H-imidazol-3-yl)-6-[4-[[4-(2-amino-4-methyl-5-oxo-4H-imidazol-3-yl)-6-carbamimidamido-1,3,5-triazin-2-yl]amino]anilino]-1,3,5-triazin-2-yl]guanidine;2,2,2-trifluoroacetic acid
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C26H28F6N20O6
  1
1
EC50 > 10000 nM
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CP0472835
 Compound Info 
2-N-ethyl-6-phenyl-4-N-(pyridin-3-ylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine
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C20H19N5S
  1
1
EC50 = 10000 nM
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CP0477394
 Compound Info 
6-phenyl-2-N-propan-2-yl-4-N-(pyridin-4-ylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine
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C21H21N5S
  1
1
EC50 = 13000 nM
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CP0567295
 Compound Info 
6-phenyl-2-N-propan-2-yl-4-N-(pyridin-2-ylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine
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C21H21N5S
  1
1
EC50 = 13000 nM
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CP0543536
 Compound Info 
2-N-(2-methylpropyl)-6-phenyl-4-N-(pyridin-3-ylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine
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C22H23N5S
  1
1
EC50 = 22000 nM
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CP0538678
 Compound Info 
N-[2-[[[6-phenyl-2-(propan-2-ylamino)thieno[3,2-d]pyrimidin-4-yl]amino]methyl]phenyl]acetamide
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C24H25N5OS
  1
1
EC50 = 30000 nM
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CP0575542
 Compound Info 
N-[3-[[[6-phenyl-2-(propan-2-ylamino)thieno[3,2-d]pyrimidin-4-yl]amino]methyl]phenyl]acetamide
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C24H25N5OS
  1
1
EC50 = 45000 nM
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CP0404566
 Compound Info 
N-[3-[[[6-phenyl-2-(propan-2-ylamino)quinazolin-4-yl]amino]methyl]phenyl]pyridine-3-carboxamide
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C30H28N6O
  1
1
EC50 > 50000 nM
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CP0472856
 Compound Info 
1-methyl-N-[4-[[2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]piperidine-3-carboxamide
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C24H36N6O
  1
1
EC50 > 50000 nM
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CP0539046
 Compound Info 
1-[4-[2-amino-4-(2-methylpropyl)-5-oxo-4H-imidazol-3-yl]-6-anilino-1,3,5-triazin-2-yl]-1,2,3,3-tetramethylguanidine
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C21H30N10O
  1
1
EC50 = 64000 nM
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Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Atrial natriuretic peptide receptor A (NPR1) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 Congestive heart failure [ICD-11: BD10]
Approved Drug(s) 1 Approved Drug  1
1 Nesiritide
 Drug Info 
Approved
Congestive heart failure
Target 2 ( NPR1 messenger RNA (NPR1 mRNA) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06432 Atrial natriuretic peptide receptor 1 Rattus norvegicus, Rat
 Protein Info