General Information of the Protein
Protein ID
PT06432
Protein Name
Atrial natriuretic peptide receptor 1
Secondarily
Protein Name
Atrial natriuretic peptide receptor type A
Guanylate cyclase A
Gene Name
NPR1
Sequence
MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGERGCSTRG
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Organism
Rattus norvegicus, Rat
Protein Classification
Enzyme
>
Lyase
>
Guanylate cyclase
>
Receptor guanylate cyclase
Function
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
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Uniprot ID
Primary ID:
P18910

Secondarily ID:
A1A5N8
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Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0447669
 Compound Info 
Carperitide
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C127H203N45O39S3
  1
1
EC50 = 1 nM
 Bioactivity Info 
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CP0548773
 Compound Info 
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(4R,10S,16R,19S,22S,28S,31S,34S,37S,40S,49S,52R)-52-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-19-(3-amino-3-oxopropyl)-49-benzyl-28,37-bis[(2S)-butan-2-yl]-31,40-bis(3-carbamimidamidopropyl)-34-(carboxymethyl)-16-(hydroxymethyl)-22-methyl-10-(2-methylpropyl)-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-hexadecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecazacyclotripentacontane-4-carbonyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
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C128H205N45O39S2
  1
1
EC50 = 1 nM
 Bioactivity Info 
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CP0406660
 Compound Info 
1-[4-(2-amino-4-butyl-5-oxo-4H-imidazol-3-yl)-6-[4-[[4-(2-amino-4-butyl-5-oxo-4H-imidazol-3-yl)-6-carbamimidamido-1,3,5-triazin-2-yl]amino]anilino]-1,3,5-triazin-2-yl]guanidine;2,2,2-trifluoroacetic acid
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C32H40F6N20O6
  1
1
EC50 = 23 nM
 Bioactivity Info 
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CP0548775
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-(propan-2-ylamino)pyrido[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C28H38FN7O2
  1
1
EC50 = 43 nM
 Bioactivity Info 
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CP0532093
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]pyrido[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C28H38FN7O3
  1
1
EC50 = 62 nM
 Bioactivity Info 
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CP0545249
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C29H39FN6O3
  1
1
EC50 = 65 nM
 Bioactivity Info 
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CP0482244
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-(1-hydroxy-2-methylpropan-2-yl)urea
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C28H37FN6O3
  1
1
EC50 = 66 nM
 Bioactivity Info 
   TI
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CP0545248
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H35FN6O2
  1
1
EC50 = 74 nM
 Bioactivity Info 
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CP0558910
 Compound Info 
2-[4-[[4-[[4-(diaminomethylideneamino)-6-[2-imino-5-(2-methylpropyl)-4-oxoimidazolidin-1-yl]-1,3,5-triazin-2-yl]amino]cyclohexyl]amino]-6-[2-imino-5-(2-methylpropyl)-4-oxoimidazolidin-1-yl]-1,3,5-triazin-2-yl]guanidine;2,2,2-trifluoroacetic acid
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C36H48F12N20O10
  1
1
EC50 = 76 nM
 Bioactivity Info 
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CP0482243
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-[1-(hydroxymethyl)cyclopentyl]urea
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C30H39FN6O3
  1
1
EC50 = 120 nM
 Bioactivity Info 
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CP0482245
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]pyrido[3,4-d]pyrimidin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C28H38FN7O3
  1
1
EC50 = 130 nM
 Bioactivity Info 
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CP0427294
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-methoxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C28H37FN6O2
  1
1
EC50 = 160 nM
 Bioactivity Info 
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CP0547323
 Compound Info 
1-cyclopropyl-3-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]urea
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C27H33FN6O2
  1
1
EC50 = 180 nM
 Bioactivity Info 
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CP0417376
 Compound Info 
CHEMBL4210169
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C28H35FN6O2
  1
1
EC50 = 270 nM
 Bioactivity Info 
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CP0417373
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]-3-[(2R)-1-hydroxy-3-methylbutan-2-yl]urea
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C29H39FN6O2
  1
1
EC50 = 290 nM
 Bioactivity Info 
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CP0417374
 Compound Info 
CHEMBL4218179
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C29H39FN6O3
  1
1
EC50 = 330 nM
 Bioactivity Info 
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CP0495340
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-(propan-2-ylamino)quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H35FN6O
  1
1
EC50 = 420 nM
 Bioactivity Info 
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CP0495338
 Compound Info 
CHEMBL4209251
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C27H35FN6O2
  1
1
EC50 = 530 nM
 Bioactivity Info 
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CP0417370
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-(2-methoxyethylamino)quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H35FN6O2
  1
1
EC50 = 610 nM
 Bioactivity Info 
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CP0389271
 Compound Info 
N-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]-3-hydroxycyclobutane-1-carboxamide
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C28H34FN5O3
  1
1
EC50 = 700 nM
 Bioactivity Info 
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CP0495339
 Compound Info 
CHEMBL4204379
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C27H33FN6O3
  1
1
EC50 = 900 nM
 Bioactivity Info 
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CP0513833
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[[(2R)-1-methoxypropan-2-yl]amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H36FN7O2
  1
1
EC50 = 1600 nM
 Bioactivity Info 
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CP0396429
 Compound Info 
1-cyclopropyl-3-[4-[[6-(3-fluorophenyl)-2-[[(2S)-1-methoxypropan-2-yl]amino]quinazolin-4-yl]amino]cyclohexyl]urea
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C28H35FN6O2
  1
1
EC50 = 1800 nM
 Bioactivity Info 
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CP0495341
 Compound Info 
3-hydroxy-N-[4-[[2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-phenylquinazolin-4-yl]amino]cyclohexyl]cyclobutane-1-carboxamide
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C28H35N5O3
  1
1
EC50 = 1800 nM
 Bioactivity Info 
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CP0548774
 Compound Info 
N-[4-[[2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-phenylquinazolin-4-yl]amino]cyclohexyl]-3-(propan-2-ylamino)cyclobutane-1-carboxamide
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C31H42N6O2
  1
1
EC50 = 2000 nM
 Bioactivity Info 
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CP0389270
 Compound Info 
1-[4-[[6-(3-fluorophenyl)-2-[2-hydroxyethyl(methyl)amino]quinazolin-4-yl]amino]cyclohexyl]-3-propan-2-ylurea
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C27H35FN6O2
  1
1
EC50 = 2100 nM
 Bioactivity Info 
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CP0417375
 Compound Info 
CHEMBL4214562
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C28H37FN6O
  1
1
EC50 = 3000 nM
 Bioactivity Info 
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CP0482246
 Compound Info 
CHEMBL4206328
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C30H40FN7O2
  1
1
EC50 = 3200 nM
 Bioactivity Info 
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Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT04372 Atrial natriuretic peptide receptor 1 Homo sapiens, Human
 Protein Info