Protein Information

General Information of the Protein

Protein ID	PT03119
Protein Name	Cytochrome P450 11B1, mitochondrial
Secondarily Protein Name	CYPXIB1 Cytochrome P-450c11 Steroid 11-beta-hydroxylase CYP11B1
Gene Name	CYP11B1
Secondarily Gene Name	S11BH
Sequence	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Cytochrome P450 > Cytochrome P450 family 11 > Cytochrome P450 family 11B > Cytochrome P450 11B1
Function	A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:1775135, PubMed:1518866, PubMed:12530636, PubMed:18215163, PubMed:23322723). Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19 (By similarity). Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone (PubMed:18215163, PubMed:1518866, PubMed:1775135, PubMed:12530636, PubMed:23322723). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:18215163). Due to its lack of 18-oxidation activity, it is incapable of generating aldosterone (PubMed:23322723). Could also be involved in the androgen metabolic pathway (Probable). Show/Hide
Uniprot ID	Primary ID: P15538 Secondarily ID: Q14095 Q4VAQ8 Q4VAQ9 Q9UML2 Show/Hide
Ensembl ID	ENSG00000160882
HGNC ID	HGNC:2591
Subcellular Location	Mitochondrion inner membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000192 , AD-293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0891297 Compound Info	1-(4-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)piperazin-1-yl)ethanone Show/Hide	C25H26FN3O	1
1	IC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0392479 Compound Info	1-[4-[(E)-2-[3-chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-pyridin-3-ylsulfonylpiperazine Show/Hide	C27H26ClN5O2S	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0774136 Compound Info	1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(3-(trifluoromethoxy)phenylsulfonyl)piperazine Show/Hide	C29H26ClF3N4O3S	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0883498 Compound Info	3-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazine-1-carbonyl)benzonitrile Show/Hide	C30H26ClN5O	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0883500 Compound Info	3-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-ylsulfonyl)benzonitrile Show/Hide	C29H26ClN5O2S	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0910975 Compound Info	(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)(3-nitrophenyl)methanone Show/Hide	C29H26ClN5O3	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0914790 Compound Info	1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(3-nitrophenylsulfonyl)piperazine Show/Hide	C28H26ClN5O4S	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0865289 Compound Info	(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)(pyridin-3-yl)methanone Show/Hide	C28H26ClN5O	1
1	IC50 = 4.9 nM Bioactivity Info	TI LI LO TS
CP0412675 Compound Info	US9725436, Entry 12 Show/Hide	C25H29FN4O2S	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0874119 Compound Info	1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(cyclopropylsulfonyl)piperazine Show/Hide	C28H32Cl2N4O5S	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0475305 Compound Info	1-[4-[(E)-2-[3-chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-(1H-imidazol-5-ylsulfonyl)piperazine Show/Hide	C25H25ClN6O2S	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0904003 Compound Info	3-((4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)methyl)benzonitrile Show/Hide	C30H28ClN5	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0874099 Compound Info	1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(cyclopropylmethyl)piperazine Show/Hide	C26H29ClN4	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0665725 Compound Info	1-(4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazin-1-yl)ethanone Show/Hide	C27H30Cl2N4O4	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0855353 Compound Info	1-(4-(4-(((2r,5r)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazin-1-yl)ethanone Show/Hide	C27H30Cl2N4O4	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0900139 Compound Info	1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(pyridin-3-ylsulfonyl)piperazine Show/Hide	C30H31Cl2N5O5S	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0875637 Compound Info	1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(3-chloropropylsulfonyl)piperazine Show/Hide	C25H28Cl2N4O2S	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0883496 Compound Info	1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(3-(trifluoromethoxy)phenylsulfonyl)piperazine Show/Hide	C32H31Cl2F3N4O6S	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0849847 Compound Info	1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(1H-imidazol-4-ylsulfonyl)piperazine Show/Hide	C28H30Cl2N6O5S	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0357005 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylimidazol-2-yl)sulfonylpiperazine Show/Hide	C28H30Cl2N6O5S	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0429489 Compound Info	US9725436, Entry 15 Show/Hide	C26H28FN5O	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0874091 Compound Info	(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazin-1-yl)(cyclopropyl)methanone Show/Hide	C26H27ClN4O	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0396651 Compound Info	1-[4-[(E)-2-[3-chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-cyclopropylsulfonylpiperazine Show/Hide	C25H27ClN4O2S	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0390356 Compound Info	1-[4-[(E)-2-[3-chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-ethylsulfonylpiperazine Show/Hide	C24H27ClN4O2S	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0865071 Compound Info	4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)pyridine Show/Hide	C26H23Cl2N3O3	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0429484 Compound Info	US9725436, Entry 2 Show/Hide	C23H25ClN4O2S	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0874071 Compound Info	1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(isopropylsulfonyl)piperazine Show/Hide	C28H34Cl2N4O5S	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0766321 Compound Info	ethyl 2-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperazine-1-carboxamido)acetate Show/Hide	C27H30ClN5O3	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0910969 Compound Info	1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(3-chloropropylsulfonyl)piperazine Show/Hide	C28H33Cl3N4O5S	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0089866 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(difluoromethylsulfonyl)piperazine Show/Hide	C25H26Cl2F2N4O5S	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0089867 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(trifluoromethylsulfonyl)piperazine Show/Hide	C25H25Cl2F3N4O5S	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0874118 Compound Info	3-(4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazin-1-ylsulfonyl)benzonitrile Show/Hide	C32H31Cl2N5O5S	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0121431 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylsulfonylpiperazine Show/Hide	C27H32Cl2N4O5S	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0383245 Compound Info	1-[4-[4-[(E)-2-[3-chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazin-1-yl]ethanone Show/Hide	C24H25ClN4O	1
1	IC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0457624 Compound Info	US9725436, Entry 11 Show/Hide	C23H25FN4O2S	1
1	IC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0390354 Compound Info	US9725436, Entry 7 Show/Hide	C26H26ClN3O2S	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0865288 Compound Info	1-(4-(4-(3-((1H-imidazol-1-yl)methyl)-5-hydroxystyryl)phenyl)piperazin-1-yl)ethanone Show/Hide	C24H26N4O2	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0904002 Compound Info	1-(cyclopropylmethyl)-4-(4-(3-fluoro-5-(pyridin-4-yl)styryl)phenyl)piperazine Show/Hide	C27H28FN3	1
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0900138 Compound Info	1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(4-chloro-3-nitrophenylsulfonyl)piperazine Show/Hide	C28H25Cl2N5O4S	1
1	IC50 = 57 nM Bioactivity Info	TI LI LO TS
CP0303595 Compound Info	1-cyclopropylsulfonyl-4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine Show/Hide	C27H30Cl2N4O5S	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0383249 Compound Info	US9725436, Entry 8 Show/Hide	C26H28ClN3O2S	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0324016 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-ethylsulfonylpiperazine Show/Hide	C26H30Cl2N4O5S	1
1	IC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0357339 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(methylsulfonylmethylsulfonyl)piperazine Show/Hide	C26H30Cl2N4O7S2	1
1	IC50 = 67 nM Bioactivity Info	TI LI LO TS
CP0122467 Compound Info	2-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]sulfonylacetonitrile Show/Hide	C26H27Cl2N5O5S	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0891298 Compound Info	4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C28H34ClN5O4	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0412679 Compound Info	2-[4-[4-[(E)-2-[3-fluoro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazin-1-yl]sulfonylacetonitrile Show/Hide	C24H24FN5O2S	1
1	IC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0910977 Compound Info	ethyl 2-(3-(1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)piperidin-4-yl)ureido)acetate Show/Hide	C28H32ClN5O3	1
1	IC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0121432 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-thiophen-2-ylsulfonylpiperazine Show/Hide	C28H28Cl2N4O5S2	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0875635 Compound Info	1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(methylsulfonyl)piperazine Show/Hide	C26H31ClN4O5S	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0854006 Compound Info	ethyl 2-(4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazine-1-carboxamido)acetate Show/Hide	C30H36ClN5O6	1
1	IC50 = 107 nM Bioactivity Info	TI LI LO TS
CP0303596 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(2-methoxyethylsulfonyl)piperazine Show/Hide	C27H32Cl2N4O6S	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0005212 Compound Info	US8987315, Ketoconazole Show/Hide	C26H28Cl2N4O4	1
1	IC50 = 116 nM Bioactivity Info	TI LI LO TS
CP0412677 Compound Info	US9725436, Entry 14 Show/Hide	C25H26FN5O	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0412714 Compound Info	US9725436, Entry 17 Show/Hide	C25H26ClN5O	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0081085 Compound Info	1-cyclopropylsulfonyl-4-[4-[(E)-2-(3-fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazine Show/Hide	C26H26FN3O2S	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0874090 Compound Info	1-(4-(4-(3-chloro-5-((pyridin-3-yloxy)methyl)styryl)phenyl)piperazin-1-yl)ethanone Show/Hide	C26H26ClN3O2	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0854005 Compound Info	2-methoxyethyl 4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazine-1-carboxylate Show/Hide	C29H35ClN4O6	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0874088 Compound Info	ethyl 2-(4-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)piperazine-1-carboxamido)acetate Show/Hide	C28H31FN4O3	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0859774 Compound Info	1-(4-(4-(3-chloro-5-(pyridin-3-ylmethyl)styryl)phenyl)piperazin-1-yl)ethanone Show/Hide	C26H26ClN3O	1
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0902827 Compound Info	1-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)-4-(trifluoromethylsulfonyl)piperazine Show/Hide	C24H23F4N3O2S	1
1	IC50 = 183 nM Bioactivity Info	TI LI LO TS
CP0111111 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(oxan-4-ylsulfonyl)piperazine Show/Hide	C29H34Cl2N4O6S	1
1	IC50 = 187 nM Bioactivity Info	TI LI LO TS
CP0198415 Compound Info	1-ethylsulfonyl-4-[4-[(E)-2-(3-fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazine Show/Hide	C25H26FN3O2S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0389979 Compound Info	US9725436, Entry 3 Show/Hide	C24H24FN3O2S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0924406 Compound Info	1-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(ethylsulfonyl)piperazine Show/Hide	C27H32Cl2N4O5S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0910976 Compound Info	1-(4-(3-fluoro-5-(pyridin-4-yl)styryl)phenyl)-4-(pyridin-3-ylsulfonyl)piperazine Show/Hide	C28H25FN4O2S	1
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0874092 Compound Info	1-(4-(3-((1H-imidazol-1-yl)methyl)-5-chlorostyryl)phenyl)-4-(isopropylsulfonyl)piperazine Show/Hide	C25H29ClN4O2S	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0849855 Compound Info	1-(ethylsulfonyl)-4-(4-(3-fluoro-5-(pyridin-4-yl)phenethyl)phenyl)piperazine Show/Hide	C25H28FN3O2S	1
1	IC50 = 330 nM Bioactivity Info	TI LI LO TS
CP0865287 Compound Info	1-(4-(4-(3-chloro-5-(1-hydroxy-2-methyl-1-(pyridin-3-yl)propyl)styryl)phenyl)piperazin-1-yl)ethanone Show/Hide	C29H32ClN3O2	1
1	IC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0945763 Compound Info	4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)pyridine Show/Hide	C26H24ClN3O3	1
1	IC50 = 440 nM Bioactivity Info	TI LI LO TS
CP0476118 Compound Info	US9725436, Entry 4 Show/Hide	C24H24ClN3O2S	1
1	IC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0121427 Compound Info	1-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-methylsulfonylpiperazine Show/Hide	C25H28Cl2N4O5S	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0860881 Compound Info	1-(4-(4-(((2s,5s)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazin-1-yl)ethanone Show/Hide	C27H31ClN4O4	1
1	IC50 = 521 nM Bioactivity Info	TI LI LO TS
CP0179479 Compound Info	1-[4-[4-[(E)-2-(3-fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazin-1-yl]ethanone Show/Hide	C25H24FN3O	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0457623 Compound Info	US9725436, Entry 1 Show/Hide	C23H25ClN6	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0883499 Compound Info	ethyl 2-(4-(4-(3-fluoro-5-(pyridin-4-yl)styryl)phenyl)piperazine-1-carboxamido)acetate Show/Hide	C28H29FN4O3	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0402478 Compound Info	US9725436, Entry 13 Show/Hide	C23H25FN6	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0874097 Compound Info	3-(4-bromostyryl)-5-(1H-imidazol-1-yl)phenol Show/Hide	C17H13BrN2O	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0074421 Compound Info	1-[4-[(E)-2-(3-fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]-4-(trifluoromethylsulfonyl)piperazine Show/Hide	C24H21F4N3O2S	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0464846 Compound Info	US9725436, Entry 6 Show/Hide	C26H25FN4O	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0891294 Compound Info	1-(4-(4-(3-chloro-5-(2-methyl-1-(pyridin-3-yl)prop-1-enyl)styryl)phenyl)piperazin-1-yl)ethanone Show/Hide	C29H30ClN3O	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0536564 Compound Info	US9725436, Entry 10 Show/Hide	C26H25ClN4O	1
1	IC50 = 3500 nM Bioactivity Info	TI LI LO TS
CP0402467 Compound Info	US9725436, Entry 5 Show/Hide	C24H24FN5	1
1	IC50 = 3600 nM Bioactivity Info	TI LI LO TS
CP0910978 Compound Info	4-(3-fluoro-5-(4-(pyridin-4-yl)styryl)phenyl)pyridine Show/Hide	C24H17FN2	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0849853 Compound Info	1-(4-(4-(3-hydroxy-5-(1H-imidazol-1-yl)styryl)phenyl)piperazin-1-yl)ethanone Show/Hide	C23H24N4O2	1
1	IC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0855352 Compound Info	ethyl 2-(4-(4-(((2r,5r)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)piperazine-1-carboxamido)acetate Show/Hide	C30H36ClN5O6	1
1	IC50 = 5800 nM Bioactivity Info	TI LI LO TS
CP0402471 Compound Info	1-[4-[4-[(E)-2-(3-chloro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazin-1-yl]ethanone Show/Hide	C25H24ClN3O	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0536483 Compound Info	US9725436, Entry 9 Show/Hide	C24H24ClN5	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0849854 Compound Info	4-(3-(4-bromostyryl)-5-fluorophenyl)pyridine Show/Hide	C19H13BrFN	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0849856 Compound Info	1-(4-(4-(3-chloro-5-(pyridin-3-yl)styryl)phenyl)piperazin-1-yl)ethanone Show/Hide	C25H24ClN3O	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0849857 Compound Info	4-(3-fluoro-5-(4-(pyridin-4-yl)phenethyl)phenyl)pyridine Show/Hide	C24H19FN2	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0902828 Compound Info	1-(4-(4-(3-fluoro-5-(pyridin-3-yl)styryl)phenyl)piperazin-1-yl)ethanone Show/Hide	C25H24FN3O	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0849858 Compound Info	1-(4-(((2r,5r)-2-((1H-imidazol-1-yl)methyl)-2-(2-chlorophenyl)-1,3-dioxan-5-yloxy)methyl)phenyl)-4-(methylsulfonyl)piperazine Show/Hide	C26H31ClN4O5S	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000405 , G-402

Cell Line Info

Cell Line ID: CL000050 , HEK293-A

Cell Line Info

Cell Line ID: CL000263 , NCI-H295R

Cell Line Info

Cell Line ID: CL000191 , V79

Cell Line Info

Cell Line ID: CL000170 , V79MZ

Cell Line Info

Cell Line ID: CL000195 , V79MZh11B1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0134578 Compound Info	4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile Show/Hide	C13H10FN3	1
1	IC50 = 2.5 nM
CP0055292 Compound Info	3-(2-Naphthyl)pyridine Show/Hide	C15H11N	1
1	IC50 = 5826 nM
CP0263990 Compound Info	8-fluoro-7-pyridin-3-yl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline Show/Hide	C15H11FN4	1
1	IC50 = 7900 nM
CP0149815 Compound Info	8-fluoro-1-methyl-7-pyridin-3-yl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline Show/Hide	C16H13FN4	1
1	IC50 = 12620 nM
CP0134182 Compound Info	9-fluoro-7-pyridin-3-yl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline Show/Hide	C15H11FN4	1
1	IC50 = 16100 nM
CP0353826 Compound Info	9-fluoro-1-methyl-7-pyridin-3-yl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline Show/Hide	C16H13FN4	1
1	IC50 = 16990 nM

Clinical Information about the Protein

Target 1 ( Steroid 11-beta-hydroxylase (CYP11B1) )

Target Type	Successful Target
Disease	2 Target-related Diseases				2
1	Breast cancer [ICD-11: 2C60-2C65]
2	Cushing disease [ICD-11: 5A70]
Approved Drug(s)	3 Approved Drugs				3
1	FADROZOLE	Drug Info	Approved	Breast cancer
2	Metyrapone	Drug Info	Approved	Cushing disease
3	Osilodrostat	Drug Info	Approved	Cushing disease

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT02875	Cytochrome P450 11B1, mitochondrial	Rattus norvegicus, Rat	Protein Info
PT03120	Cytochrome P450 11B2, mitochondrial	Homo sapiens, Human	Protein Info
PT04507	Cytochrome P450 11B2, mitochondrial	Rattus norvegicus, Rat	Protein Info
PT06518	Cytochrome P450 11B2, mitochondrial	Mus musculus, Mouse	Protein Info

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