Protein Information

General Information of the Protein

Protein ID	PT02429
Protein Name	Neurotensin receptor type 1
Secondarily Protein Name	High-affinity levocabastine-insensitive neurotensin receptor NTRH
Gene Name	NTSR1
Secondarily Gene Name	NTRR
Sequence	MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > Neurotensin receptor
Function	G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). Show/Hide
Uniprot ID	Primary ID: P30989 Secondarily ID: Q9H4H1 Q9H4T5 Show/Hide
HGNC ID	HGNC:8039
Subcellular Location	Cell membrane Membrane raft

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0405472 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Show/Hide	C38H64N12O8	2
1	EC50 = 0.0416 nM Bioactivity Info	TI LI LO TS
2	EC50 = 0.06918 nM Bioactivity Info	TI LI LO TS
CP0444541 Compound Info	4-[2-[(1E,3E,5E)-5-[1-[6-[2-[2-[2-[[N'-[(4S)-4-amino-5-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-3-methylbutyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethoxy]ethoxy]ethylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-2-ylidene]penta-1,3-dienyl]-3,3-dimethylindol-1-ium-1-yl]butane-1-sulfonate;2,2,2-trifluoroacetic acid Show/Hide	C84H122F6N16O22S2	4
1	EC50 = 0.3715 nM Bioactivity Info	TI LI LO TS
2	Kd = 6.761 nM Bioactivity Info	TI LI LO TS
3	Kd = 25.7 nM Bioactivity Info	TI LI LO TS
4	Ki = 1.549 nM Bioactivity Info	TI LI LO TS
CP0444540 Compound Info	4-[2-[(1E,3E,5E)-5-[1-[6-[4-[[N'-[(4S)-4-amino-5-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-3-methylbutyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-oxopentyl]carbamimidoyl]carbamoylamino]butylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-2-ylidene]penta-1,3-dienyl]-3,3-dimethylindol-1-ium-1-yl]butane-1-sulfonate;2,2,2-trifluoroacetic acid Show/Hide	C82H118F6N16O20S2	5
1	EC50 = 0.4169 nM Bioactivity Info	TI LI LO TS
2	Kd = 3.802 nM Bioactivity Info	TI LI LO TS
3	Kd = 3.89 nM Bioactivity Info	TI LI LO TS
4	Kd = 6.31 nM Bioactivity Info	TI LI LO TS
5	Ki = 1.318 nM Bioactivity Info	TI LI LO TS
CP0436919 Compound Info	(2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxamido)-4-methylpentanoic acid Show/Hide	C26H25ClN4O4	1
1	EC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0244251 Compound Info	(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid Show/Hide	C27H27ClN4O5	1
1	EC50 = 298 nM Bioactivity Info	TI LI LO TS
CP0073850 Compound Info	2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline Show/Hide	C24H28N4O3	2
1	EC50 = 2000 nM Bioactivity Info	TI LI LO TS
2	EC50 > 80000 nM Bioactivity Info	TI LI LO TS
CP0510989 Compound Info	(2S)-4-methyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]pentanoic acid Show/Hide	C25H25N3O3	1
1	EC50 = 2050 nM Bioactivity Info	TI LI LO TS
CP0494489 Compound Info	(2S)-2-[[2-[5-[bis(quinolin-4-ylmethyl)amino]indol-1-yl]acetyl]amino]-4-methylpentanoic acid Show/Hide	C36H35N5O3	1
1	EC50 = 2120 nM Bioactivity Info	TI LI LO TS
CP0379255 Compound Info	(2S)-4-methyl-2-[[2-(6-naphthalen-1-ylindol-1-yl)acetyl]amino]pentanoic acid Show/Hide	C26H26N2O3	1
1	EC50 = 2850 nM Bioactivity Info	TI LI LO TS
CP0537622 Compound Info	(2S)-2-[[2-(5-isoquinolin-4-ylindol-1-yl)acetyl]amino]-4-methylpentanoic acid Show/Hide	C25H25N3O3	1
1	EC50 = 3240 nM Bioactivity Info	TI LI LO TS
CP0559129 Compound Info	(2S)-4-methyl-2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]pentanoic acid Show/Hide	C26H26N2O3	1
1	EC50 = 3260 nM Bioactivity Info	TI LI LO TS
CP0379254 Compound Info	(2S)-4-methyl-2-[[2-(6-quinolin-3-ylindol-1-yl)acetyl]amino]pentanoic acid Show/Hide	C25H25N3O3	1
1	EC50 = 3280 nM Bioactivity Info	TI LI LO TS
CP0396803 Compound Info	(2S)-3-phenyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]propanoic acid Show/Hide	C28H23N3O3	1
1	EC50 = 4330 nM Bioactivity Info	TI LI LO TS
CP0400159 Compound Info	(2S)-2-[[2-(5-isoquinolin-5-ylindol-1-yl)acetyl]amino]-4-methylpentanoic acid Show/Hide	C25H25N3O3	1
1	EC50 = 4960 nM Bioactivity Info	TI LI LO TS
CP0508212 Compound Info	N-[(1S)-3-methyl-1-(2H-tetrazol-5-yl)butyl]-2-(5-quinolin-3-ylindol-1-yl)acetamide Show/Hide	C25H25N7O	1
1	EC50 = 5170 nM Bioactivity Info	TI LI LO TS
CP0510991 Compound Info	(2S)-2-[(2-indol-1-ylacetyl)amino]-4-methylpentanoic acid Show/Hide	C16H20N2O3	1
1	EC50 = 6650 nM Bioactivity Info	TI LI LO TS
CP0410450 Compound Info	(2S)-2-[[2-(6-isoquinolin-4-ylindol-1-yl)acetyl]amino]-4-methylpentanoic acid Show/Hide	C25H25N3O3	1
1	EC50 = 7460 nM Bioactivity Info	TI LI LO TS
CP0379258 Compound Info	(2S)-2-[[2-[5-(isoquinolin-6-ylamino)indol-1-yl]acetyl]amino]-4-methylpentanoic acid Show/Hide	C25H26N4O3	1
1	EC50 = 7720 nM Bioactivity Info	TI LI LO TS
CP0386502 Compound Info	(S)-4-methyl-2-(2-(5-(quinoline-8-sulfonamido)-1H-indol-1-yl)acetamido)pentanoic acid Show/Hide	C25H26N4O5S	1
1	EC50 = 8990 nM Bioactivity Info	TI LI LO TS
CP0510993 Compound Info	(2S)-4-methyl-2-[[2-[5-(naphthalen-1-ylsulfonylamino)indol-1-yl]acetyl]amino]pentanoic acid Show/Hide	C26H27N3O5S	1
1	EC50 = 9390 nM Bioactivity Info	TI LI LO TS
CP0510992 Compound Info	(2S)-4-methyl-2-[[2-(5-phenylindol-1-yl)acetyl]amino]pentanoic acid Show/Hide	C22H24N2O3	1
1	EC50 = 9440 nM Bioactivity Info	TI LI LO TS
CP0513082 Compound Info	(2S)-2-[[2-(5-bromoindol-1-yl)acetyl]amino]-4-methylpentanoic acid Show/Hide	C16H19BrN2O3	1
1	EC50 = 9990 nM Bioactivity Info	TI LI LO TS
CP0379257 Compound Info	(2S)-4-methyl-2-[[2-(5-pyridin-3-ylindol-1-yl)acetyl]amino]pentanoic acid Show/Hide	C21H23N3O3	1
1	EC50 = 15380 nM Bioactivity Info	TI LI LO TS
CP0539081 Compound Info	(2S)-2-[[2-[5-[[2-(3-methoxyphenyl)acetyl]amino]indol-1-yl]acetyl]amino]-4-methylpentanoic acid Show/Hide	C25H29N3O5	1
1	EC50 = 24200 nM Bioactivity Info	TI LI LO TS
CP0379256 Compound Info	(2S)-2-[[2-(5-aminoindol-1-yl)acetyl]amino]-4-methylpentanoic acid Show/Hide	C16H21N3O3	1
1	EC50 = 25820 nM Bioactivity Info	TI LI LO TS
CP0539080 Compound Info	(2S)-4-methyl-2-[[2-[5-(quinoline-4-carbonylamino)indol-1-yl]acetyl]amino]pentanoic acid Show/Hide	C26H26N4O4	1
1	EC50 = 55070 nM Bioactivity Info	TI LI LO TS
CP0396802 Compound Info	(2S)-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]propanoic acid Show/Hide	C22H19N3O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0410449 Compound Info	2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]acetic acid Show/Hide	C21H17N3O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0410649 Compound Info	methyl (2S)-4-methyl-2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]pentanoate Show/Hide	C27H28N2O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0481752 Compound Info	methyl (2S)-4-methyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]pentanoate Show/Hide	C26H27N3O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0546283 Compound Info	(2R)-4-methyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]pentanoic acid Show/Hide	C25H25N3O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0551446 Compound Info	(2R)-4-methyl-2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]pentanoic acid Show/Hide	C26H26N2O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0556739 Compound Info	2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]acetic acid Show/Hide	C22H18N2O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0559130 Compound Info	N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-2-(5-quinolin-3-ylindol-1-yl)acetamide Show/Hide	C25H27N3O2	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0571409 Compound Info	(2S)-3-methyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]butanoic acid Show/Hide	C24H23N3O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0571410 Compound Info	methyl (2R)-4-methyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]pentanoate Show/Hide	C26H27N3O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0571411 Compound Info	(2S)-3-methyl-2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]butanoic acid Show/Hide	C25H24N2O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0571412 Compound Info	methyl (2R)-4-methyl-2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]pentanoate Show/Hide	C27H28N2O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0076458 Compound Info	(2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)-4-methylpentanoic acid Show/Hide	C27H27ClN4O5	1
1	EC50 < 156 nM Bioactivity Info	TI LI LO TS
CP0064604 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-4-carboxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]propanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Show/Hide	C78H121N21O20	2
1	IC50 = 0.49 nM Bioactivity Info	TI LI LO TS
2	Kd = 0.59 nM Bioactivity Info	TI LI LO TS
CP0531006 Compound Info	(S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-5-Amino-2-((S)-2,5-diamino-pentanoylamino)-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid Show/Hide	C36H60N8O8	1
1	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0531003 Compound Info	(S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-5-(3-Amino-propylamino)-2-azido-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid Show/Hide	C34H55N9O7	1
1	IC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0236745 Compound Info	CAS_184162-64-9 Show/Hide	C39H51N5O6	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0421433 Compound Info	(S)-2-{(2S,3S)-2-[(S)-2-[((S)-1-{(S)-5-[2-(2-Amino-ethylamino)-ethylamino]-2-azido-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid Show/Hide	C35H58N10O7	1
1	IC50 = 8.8 nM Bioactivity Info	TI LI LO TS
CP0548468 Compound Info	(S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-5-(4-Amino-butylamino)-2-azido-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid Show/Hide	C35H57N9O7	1
1	IC50 = 9.3 nM Bioactivity Info	TI LI LO TS
CP0540182 Compound Info	(S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-5-(2-Amino-ethylamino)-2-azido-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid Show/Hide	C33H53N9O7	1
1	IC50 = 14.7 nM Bioactivity Info	TI LI LO TS
CP0299701 Compound Info	(S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid Show/Hide	C32H52N8O7	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0391450 Compound Info	(S)-2-{(2S,3S)-2-[(S)-2-({(S)-1-[(S)-2-Azido-5-(2-piperazin-1-yl-ethylamino)-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid Show/Hide	C37H60N10O7	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0137804 Compound Info	2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carbonyl]-amino}-adamantane-2-carboxylic acid Show/Hide	C32H31ClN4O5	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0795225 Compound Info	1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylaminocarbonyl)oxime Show/Hide	C19H16N2O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0444542 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-[[amino-[2-[2-[2-[6-[(2E)-3,3-dimethyl-2-[(2E,4E)-5-(1,3,3-trimethylindol-1-ium-2-yl)penta-2,4-dienylidene]indol-1-yl]hexanoylamino]ethoxy]ethoxy]ethylcarbamoylamino]methylidene]amino]pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acid Show/Hide	C85H118F12N16O20	3
1	Kd = 2.455 nM Bioactivity Info	TI LI LO TS
2	Kd = 10.23 nM Bioactivity Info	TI LI LO TS
3	Ki = 2.455 nM Bioactivity Info	TI LI LO TS
CP0424109 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-[[amino-[4-[6-[(2E)-3,3-dimethyl-2-[(2E,4E)-5-(1,3,3-trimethylindol-1-ium-2-yl)penta-2,4-dienylidene]indol-1-yl]hexanoylamino]butylcarbamoylamino]methylidene]amino]pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acid Show/Hide	C81H113F9N16O16	4
1	Kd = 3.631 nM Bioactivity Info	TI LI LO TS
2	Kd = 8.128 nM Bioactivity Info	TI LI LO TS
3	Kd = 15.14 nM Bioactivity Info	TI LI LO TS
4	Ki = 7.079 nM Bioactivity Info	TI LI LO TS
CP0425790 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-2-((S)-3-amino-6-guanidinohexanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O8	1
1	Ki = 0.23 nM Bioactivity Info	TI LI LO TS
CP0877791 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxycyclohexa-1,3-dienyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H66N12O8	1
1	Ki = 0.24 nM Bioactivity Info	TI LI LO TS
CP0520992 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-2-((R)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N12O8	1
1	Ki = 0.61 nM Bioactivity Info	TI LI LO TS
CP0424111 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-[[amino-[2-[2-[2-[4-[(1E,3E)-4-[4-(dimethylamino)phenyl]buta-1,3-dienyl]-2,6-dimethylpyridin-1-ium-1-yl]ethoxy]ethoxy]ethylcarbamoylamino]methylidene]amino]pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid;2,2,2-trifluoroacetate;2,2,2-trifluoroacetic acid Show/Hide	C72H101F12N15O19	1
1	Ki = 1.288 nM Bioactivity Info	TI LI LO TS
CP0456304 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-6-amino-2-(2-(4-aminobutylamino)acetamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N8O8	1
1	Ki = 1.6 nM Bioactivity Info	TI LI LO TS
CP0424105 Compound Info	4-[(2Z)-2-[(2E,4E)-5-[1-[6-[2-[2-[2-[[N'-[(4S)-4-amino-5-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-3-methylbutyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethoxy]ethoxy]ethylamino]-6-oxohexyl]-3,3-dimethylindol-1-ium-2-yl]penta-2,4-dienylidene]-3,3-dimethylindol-1-yl]butane-1-sulfonate;2,2,2-trifluoroacetic acid Show/Hide	C86H123F9N16O21S	1
1	Ki = 2.512 nM Bioactivity Info	TI LI LO TS
CP0232097 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)-2,6-diaminohexanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N8O8	1
1	Ki = 2.7 nM Bioactivity Info	TI LI LO TS
CP0478016 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-3-((S)-2-amino-5-guanidinopentanamido)-6-guanidinohexanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O8	1
1	Ki = 3.4 nM Bioactivity Info	TI LI LO TS
CP0456305 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Show/Hide	C35H57N9O8	1
1	Ki = 4.6 nM Bioactivity Info	TI LI LO TS
CP0425794 Compound Info	(S)-2-((2S,3S)-2-((S)-3-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-4-(4-hydroxyphenyl)butanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O8	1
1	Ki = 8.4 nM Bioactivity Info	TI LI LO TS
CP0456306 Compound Info	(S)-3-((2S,3S)-2-((S)-2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-5-methylhexanoic acid Show/Hide	C39H66N12O8	1
1	Ki = 8.4 nM Bioactivity Info	TI LI LO TS
CP0456307 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Show/Hide	C35H57N9O8	1
1	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0495431 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-(2-((S)-2,6-diamino-N-(4-aminobutyl)hexanamido)acetyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N8O8	1
1	Ki = 17 nM Bioactivity Info	TI LI LO TS
CP0441155 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Show/Hide	C36H62N12O8	1
1	Ki = 26 nM Bioactivity Info	TI LI LO TS
CP0507780 Compound Info	(S)-2-((2S,3S)-2-((S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidin-2-yl)acetamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O8	1
1	Ki = 47 nM Bioactivity Info	TI LI LO TS
CP0478017 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-((R)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N12O8	1
1	Ki = 71 nM Bioactivity Info	TI LI LO TS
CP0503235 Compound Info	2-{(S)-2-[2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-4-methyl-pentanoic acid Show/Hide	C35H58N12O8	1
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
CP0456309 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-4-(4-hydroxyphenyl)butanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O8	1
1	Ki = 210 nM Bioactivity Info	TI LI LO TS
CP0456310 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((R)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N12O8	1
1	Ki = 220 nM Bioactivity Info	TI LI LO TS
CP0478019 Compound Info	(S)-2-((3S,4S)-3-((S)-2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-4-methylhexanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O8	1
1	Ki = 250 nM Bioactivity Info	TI LI LO TS
CP0514021 Compound Info	(2S)-2-[[(2S,3S)-2-[[(3S,6S,12S)-12-[3-(diaminomethylideneamino)propyl]-5,11,14-trioxo-20-oxa-4,10,13-triazatricyclo[19.2.2.06,10]pentacosa-1(24),21(25),22-triene-3-carbonyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Show/Hide	C38H60N8O8	1
1	Ki = 450 nM Bioactivity Info	TI LI LO TS
CP0478018 Compound Info	(S)-2-((2S,3S)-2-((R)-2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N12O8	1
1	Ki = 890 nM Bioactivity Info	TI LI LO TS
CP0456311 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]propanoic acid Show/Hide	C35H58N12O8	1
1	Ki = 1100 nM Bioactivity Info	TI LI LO TS
CP0495432 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Show/Hide	C32H60N12O7	1
1	Ki = 1300 nM Bioactivity Info	TI LI LO TS
CP0511311 Compound Info	(R)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N12O8	1
1	Ki = 1300 nM Bioactivity Info	TI LI LO TS
CP0520993 Compound Info	(S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-phenethylpyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O7	1
1	Ki = 2600 nM Bioactivity Info	TI LI LO TS
CP0456312 Compound Info	2-((2S,3S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)-2,6-diaminohexanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-N-isobutyl-3-methylpentanamido)acetic acid Show/Hide	C38H64N8O8	1
1	Ki = 3700 nM Bioactivity Info	TI LI LO TS
CP0329956 Compound Info	(S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2,6-diaminohexanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N10O8	1
1	Ki = 8300 nM Bioactivity Info	TI LI LO TS
CP0921562 Compound Info	(S)-2-((S)-2-((S)-3-((S)-1-((S)-5-guanidino-2-((S)-5-guanidino-2-methylpentanamido)pentanoyl)pyrrolidine-2-carboxamido)-4-(naphthalen-1-yl)but-1-en-2-ylamino)-4,4-dimethylpentanamido)-4-methylpentanoic acid Show/Hide	C45H71N11O6	1
1	Ki = 8500 nM Bioactivity Info	TI LI LO TS
CP0456308 Compound Info	(S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(2-(pyridin-2-yl)ethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H65N13O7	1
1	Ki = 10000 nM Bioactivity Info	TI LI LO TS
CP0441156 Compound Info	(S)-2-((2R,3S)-2-((S)-2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N12O8	1
1	Ki = 13000 nM Bioactivity Info	TI LI LO TS
CP0287588 Compound Info	(S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O8	1
1	Ki = 28000 nM Bioactivity Info	TI LI LO TS
CP0522126 Compound Info	(S)-2-((2S,3S)-2-(2-((S)-1-((S)-6-amino-2-((S)-2,6-diaminohexanamido)hexanoyl)-N-(4-hydroxybenzyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N8O8	1
1	Ki = 30000 nM Bioactivity Info	TI LI LO TS
CP0422801 Compound Info	(S)-2-((2S,3S)-2-(2-((S)-1-((S)-6-amino-2-((S)-2,6-diaminohexanamido)hexanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N8O8	1
1	Ki = 32000 nM Bioactivity Info	TI LI LO TS
CP0425793 Compound Info	(S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-methoxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C40H68N12O8	1
1	Ki = 47000 nM Bioactivity Info	TI LI LO TS
CP0240966 Compound Info	(S)-2-((2S,3S)-2-(2-((S)-1-((S)-6-amino-2-((S)-2-amino-5-guanidinopentanamido)hexanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N10O8	1
1	Ki = 80000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000007 , HT-29

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Cell Line ID: CL000202 , WiDr

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0118261 Compound Info	(3S,6S,9S,12S,15S,18S,24S,27S,30S,33S,36S,39S)-3,6,24,27-tetrakis(4-aminobutyl)-12,33-bis[(2S)-butan-2-yl]-15,36-bis[(4-hydroxyphenyl)methyl]-9,30-bis(2-methylpropyl)-1,4,7,10,13,16,22,25,28,31,34,37-dodecazatricyclo[37.3.0.018,22]dotetracontane-2,5,8,11,14,17,23,26,29,32,35,38-dodecone Show/Hide	C76H124N16O14	1
1	Activity = 1.55 nM
CP0064604 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-4-carboxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]propanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Show/Hide	C78H121N21O20	9
1	IC50 = 0.24 nM
2	IC50 = 0.33 nM
3	IC50 = 1.4 nM
4	IC50 = 1.8 nM
5	IC50 = 2.19 nM
6	Ki = 0.27 nM
7	Ki = 1.2 nM
8	Ki = 1.5 nM
9	Ki = 1.64 nM
CP0718178 Compound Info	2-[(5-(2,6-Dimethoxy-phenyl)-1-{4-[(3-dimethylamino-propyl)-methyl-carbamoyl]-2-isopropyl-phenyl}-1H-pyrazole-3-carbonyl)-amino]-adamantane-2-carboxylic acid hydrochloride Show/Hide	C39H52ClN5O6	1
1	IC50 = 0.24 nM
CP0150134 Compound Info	(S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid Show/Hide	C38H64N12O8	6
1	IC50 = 0.3 nM
2	IC50 = 1.4 nM
3	Kd = 0.16 nM
4	Ki = 0.14 nM
5	Ki = 0.27 nM
6	Ki = 1.05 nM
CP0232097 Compound Info	(S)-2-((2S,3S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)-2,6-diaminohexanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H64N8O8	1
1	IC50 = 0.33 nM
CP0339682 Compound Info	(S)-2-((2S,3R)-2-((S)-2-((S)-1-((S)-5-guanidino-2-((S)-5-guanidino-2-(methylamino)pentanamido)pentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O8	2
1	IC50 = 0.383 nM
2	Ki = 0.29 nM
CP0212154 Compound Info	(S)-2-((2S,3R)-2-((S)-2-((S)-1-((S)-2-((S)-2-azido-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H62N14O8	2
1	IC50 = 0.97 nM
2	Ki = 0.73 nM
CP0137804 Compound Info	2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carbonyl]-amino}-adamantane-2-carboxylic acid Show/Hide	C32H31ClN4O5	1
1	IC50 = 0.99 nM
CP0223316 Compound Info	(S)-2-((2S,3R)-2-((S)-2-((S)-1-((S)-2-((S)-2-acetamido-5-guanidinopentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C40H66N12O9	2
1	IC50 = 2.42 nM
2	Ki = 1.81 nM
CP0090597 Compound Info	(S)-2-((2S,3R)-2-((S)-2-((S)-1-((S)-5-guanidino-2-(5-guanidinopentanamido)pentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C38H63N11O8	2
1	IC50 = 2.68 nM
2	Ki = 2.01 nM
CP0058950 Compound Info	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[2-[[2-[[3-(2-aminoethylamino)-2-[(2-aminoethylamino)methyl]propanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3,3-dimethylbutanoyl]amino]-4-methylpentanoic acid Show/Hide	C48H87N17O9	1
1	IC50 = 2.9 nM
CP0344903 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-2-(7-aminoheptanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C39H65N9O8	2
1	IC50 = 3.99 nM
2	Ki = 2.99 nM
CP0236745 Compound Info	CAS_184162-64-9 Show/Hide	C39H51N5O6	1
1	IC50 = 4 nM
CP0272509 Compound Info	(S)-2-((2S,3R)-2-((S)-2-((S)-1-((S)-2-((S)-2-amino-5-guanidino-2-methylpentanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid Show/Hide	C39H66N12O8	2
1	IC50 = 6.5 nM
2	Ki = 4.87 nM
CP0090598 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-2-((S)-7-amino-3-azidoheptanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C39H64N12O8	3
1	IC50 = 7.32 nM
2	Ki = 4.5 nM
3	Ki = 5.49 nM
CP0457618 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-2-((S)-3,7-diaminoheptanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C39H66N10O8	2
1	IC50 = 10.8 nM
2	Ki = 8.07 nM
CP0052233 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-2-((S)-3,7-diamino-3-methylheptanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C40H68N10O8	3
1	IC50 = 13.9 nM
2	Ki = 9.9 nM
3	Ki = 10.4 nM
CP0339683 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-2-((S)-7-amino-3-(methylamino)heptanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C40H68N10O8	2
1	IC50 = 27 nM
2	Ki = 20.3 nM
CP0234378 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)-2-azido-5-guanidinopentanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(1H-indol-3-yl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C40H63N13O7	2
1	IC50 = 140 nM
2	Ki = 105 nM
CP0137802 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-2-((S)-3-acetamido-7-aminoheptanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C41H68N10O9	2
1	IC50 = 181 nM
2	Ki = 136 nM
CP0270332 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)-5-guanidino-2-(methylamino)pentanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(1H-indol-3-yl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C41H67N11O7	3
1	IC50 = 240 nM
2	Ki = 95 nM
3	Ki = 180 nM
CP0042645 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)-2-amino-5-guanidinopentanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(1H-indol-3-yl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C40H65N11O7	2
1	IC50 = 403 nM
2	Ki = 303 nM
CP0333896 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-6-amino-2-(5-guanidinopentanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(1H-indol-3-yl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C40H64N10O7	2
1	IC50 = 842 nM
2	Ki = 631 nM
CP0157890 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-2-((S)-2-acetamido-5-guanidinopentanamido)-6-aminohexanoyl)pyrrolidine-2-carboxamido)-3-(1H-indol-3-yl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C42H67N11O8	2
1	IC50 = 863 nM
2	Ki = 647 nM
CP0234442 Compound Info	(S)-2-((S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)-2-amino-5-guanidino-2-methylpentanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(1H-indol-3-yl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid Show/Hide	C41H67N11O7	2
1	IC50 = 2900 nM
2	Ki = 2170 nM
CP0405472 Compound Info	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid Show/Hide	C38H64N12O8	1
1	Ki = 0.24 nM
CP0774177 Compound Info	4-Methyl-2-{(S)-methyl-1-(S)-2-[(S)-2-[((S)-{1-[(S)-2-((S)-2-amino-5-guanidino-pentanoylamino)-5-guanidino-1-oxo-pentyl]-pyrrolidin-2-yl}-oxo-methyl)-methyl-amino]-3-(4-hydroxy-phenyl)-1-oxo-propylamino]-3-oxo-pentylamino}-pentanoic acid Show/Hide	C39H66N12O8	1
1	Ki = 1400 nM
CP0076458 Compound Info	(2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)-4-methylpentanoic acid Show/Hide	C27H27ClN4O5	1
1	Ki = 3300 nM
CP0244251 Compound Info	(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid Show/Hide	C27H27ClN4O5	1
1	Ki = 10000 nM

Clinical Information about the Protein

Target 1 ( Neurotensin receptor type 1 (NTSR1) )

Target Type	Clinical trial Target
Disease	1 Target-related Disease				1
1	Inflammatory bowel disease [ICD-11: DD72]
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	Meclinertant	Drug Info	Phase 2/3	Inflammatory bowel disease

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han