General Information of the Compound
Compound ID
CP0234378
Compound Name
(S)-2-((S)-2-((S)-2-((S)-1-((S)-6-amino-2-((S)-2-azido-5-guanidinopentanamido)hexanoyl)pyrrolidine-2-carboxamido)-3-(1H-indol-3-yl)propanamido)-3,3-dimethylbutanamido)-4-methylpentanoic acid
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Structure
Formula
C40H63N13O7
Molecular Weight
838.028
Canonical SMILES
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N=[N+]=[N-])C(C)(C)C)C(O)=O
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InChI
InChI=1S/C40H63N13O7/c1-23(2)20-30(38(59)60)49-36(57)32(40(3,4)5)50-34(55)29(21-24-22-46-26-13-7-6-12-25(24)26)48-35(56)31-16-11-19-53(31)37(58)28(14-8-9-17-41)47-33(54)27(51-52-44)15-10-18-45-39(42)43/h6-7,12-13,22-23,27-32,46H,8-11,14-21,41H2,1-5H3,(H,47,54)(H,48,56)(H,49,57)(H,50,55)(H,59,60)(H4,42,43,45)/t27-,28-,29-,30-,31-,32+/m0/s1
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InChIKey
KIUIXEPJBSCRHW-VRBLGLBQSA-N
Physicochemical Property
logP
1.6789
Rotatable Bonds
23
Heavy Atom Count
60
Polar Areas
328.98
Hydrogen Bond Donor Count
9
Hydrogen Bond Acceptor Count
9
Complexity
60

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44572625
ChEMBL ID
CHEMBL508380
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02429, Neurotensin receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000007 HT-29 Homo sapiens (Human)  1
1
EC50 = 151 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 140 nM
2 Ki = 105 nM