N-(12-chloro-23-methyl-22-oxo-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide

N-(10,12-difluoro-23-methyl-22-oxo-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide

N-(10,12-difluoro-23-methyl-22-oxo-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide

4-ethylsulfonyl-23-methyl-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9,11,13,20-octaen-22-one

US9296741, 21

N-(12-chloro-23-methyl-22-oxo-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide

US9296741, 4

12-chloro-4-ethylsulfonyl-23-methyl-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-22-one

N-[4-(4-chlorophenoxy)-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide

US9296741, 57

12-chloro-23-methyl-4-(methylsulfonylmethyl)-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-22-one

US9296741, 62

US10633379, Compound X

US9296741, 59

US9296741, 27

US9296741, 5

12-chloro-23-methyl-4-(methylsulfonylmethyl)-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-22-one

US9296741, 6

4-ethylsulfonyl-22-methyl-8,18-dioxa-22-azatetracyclo[17.4.0.02,7.09,14]tricosa-1(23),2(7),3,5,9,11,13,19-octaen-21-one

N-[4-(4-chlorophenoxy)-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide

12-chloro-4-ethylsulfonyl-23-methyl-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-22-one

US9296741, 34

N-(12-chloro-24-methyl-23-oxo-8,20-dioxa-24-azatetracyclo[19.4.0.02,7.09,14]pentacosa-1(25),2(7),3,5,9(14),10,12,21-octaen-4-yl)ethanesulfonamide

US9296741, 95

N-[4-(2,4-difluorophenoxy)-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide

N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-phenoxyphenyl]ethanesulfonamide

3-[2-(2,4-difluorophenoxy)-5-(methylsulfonylmethyl)phenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one

US9296741, 22

N-[6-(2,4-difluorophenoxy)-5-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)pyridin-3-yl]ethanesulfonamide

N-[4-(2,4-difluorophenoxy)-3-(1-methyl-7-oxo-6H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]methanesulfonamide

N-[4-(4-fluorophenoxy)-3-(1-methyl-7-oxo-6H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]ethanesulfonamide

US9296741, 90

N-[4-(2,4-difluorophenoxy)-3-[1-methyl-4-(oxetan-3-yloxy)-6-oxopyridin-3-yl]phenyl]ethanesulfonamide

US9296741, 85

N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)-4-phenoxyphenyl]methanesulfonamide

N-[4-(4-cyanophenoxy)-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide

N-[4-(2,4-difluorophenoxy)-3-(1-methyl-7-oxo-6H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]ethanesulfonamide

N-[4-(2,4-difluorophenoxy)-3-(4-methoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide

N-[3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-[4-(trifluoromethyl)phenoxy]phenyl]ethanesulfonamide

5-[2-(2,4-difluorophenoxy)-5-ethylsulfonylphenyl]-4-ethoxy-1-methylpyridin-2-one

US9296741, 11

N-[3-(4-methoxy-1-methyl-6-oxopyridin-3-yl)-4-phenoxyphenyl]ethanesulfonamide

N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-(4-fluorophenoxy)phenyl]ethanesulfonamide

US9296741, 13

US9296741, 19

N-[4-(2,4-difluorophenoxy)-3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)phenyl]methanesulfonamide

N-[3-(7-methyl-1-oxo-2,6-dihydropyrrolo[3,4-d]pyridazin-5-yl)-4-phenoxyphenyl]ethanesulfonamide

N-[3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-[2-(trifluoromethyl)phenoxy]phenyl]methanesulfonamide

N-[3-(4-methoxy-1-methyl-6-oxopyridin-3-yl)-4-phenoxyphenyl]methanesulfonamide

US9296741, 144

US9296741, 23

US9296741, 29

1-methyl-3-(5-methylsulfonyl-2-phenoxyphenyl)-6H-pyrrolo[2,3-c]pyridin-7-one

N-[4-(2,4-difluorophenoxy)-3-[1-methyl-6-oxo-4-(2,2,2-trifluoroethoxy)pyridin-3-yl]phenyl]ethanesulfonamide

US9296741, 63

N-[3-(3-methyl-4-oxo-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-1-yl)-4-phenoxyphenyl]methanesulfonamide

N-[4-(2,4-difluorophenoxy)-3-[4-(ethylamino)-1-methyl-6-oxopyridin-3-yl]phenyl]ethanesulfonamide

3-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one

N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-pyridin-3-yloxyphenyl]ethanesulfonamide

(+)-JQ1

US9296741, 141

N-[3-(7-methyl-1-oxo-2,6-dihydropyrrolo[3,4-d]pyridazin-5-yl)-4-phenoxyphenyl]methanesulfonamide

N-[4-(2,4-difluorophenoxy)-3-[1-methyl-4-(2-methylpropoxy)-6-oxopyridin-3-yl]phenyl]ethanesulfonamide

N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-[4-(trifluoromethoxy)phenoxy]phenyl]ethanesulfonamide

7-methyl-5-(2-phenoxyphenyl)-2,6-dihydropyrrolo[3,4-d]pyridazin-1-one

5-[2-(2,4-difluorophenoxy)-5-(methylsulfonylmethyl)phenyl]-4-ethoxy-1-methylpyridin-2-one

N-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]methanesulfonamide

N-[4-[4-(dimethylamino)cyclohexyl]oxy-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide

3-methyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

N-[4-(2,4-difluorophenoxy)-3-(7-methyl-1-oxo-2,6-dihydropyrrolo[3,4-d]pyridazin-5-yl)phenyl]methanesulfonamide

3-methyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-4-one

5-[2-(4-chlorophenoxy)phenyl]-2-methyl-1H-pyrrole-3-carboxamide

1-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-3-methyl-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-4-one

1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

N-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]acetamide

N-[4-(4,4-difluorocyclohexyl)oxy-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide

N-[3-(5-methyl-4-oxo-3,6-dihydropyrrolo[3,4-d]pyrimidin-7-yl)-4-phenoxyphenyl]methanesulfonamide

N-[4-(2,4-difluorophenoxy)-3-(3-methyl-4-oxo-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-1-yl)phenyl]methanesulfonamide

2-methyl-5-(2-phenoxyphenyl)-1H-pyrrole-3-carboxamide

US9296741, 1

4-ethylsulfonyl-21-methyl-8,17-dioxa-21-azatetracyclo[16.4.0.02,7.09,14]docosa-1(22),2(7),3,5,9,11,13,18-octaen-20-one

3-methyl-1-(2-phenoxyphenyl)-2,5-dihydropyrrolo[3,4-c]pyridin-4-one

5-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-7-methyl-2,6-dihydropyrrolo[3,4-d]pyridazin-1-one

N-[3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-(1-methylpiperidin-4-yl)oxyphenyl]ethanesulfonamide

5-(5-amino-2-phenoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

1-methyl-3-(2-phenoxyphenyl)-6H-pyrrolo[2,3-c]pyridin-7-one

N-[4-(2,4-difluorophenoxy)-3-[4-(2-hydroxy-2-methylpropoxy)-1-methyl-6-oxopyridin-3-yl]phenyl]ethanesulfonamide

5-[5-(methanesulfonamido)-2-phenoxyphenyl]-2-methyl-1H-pyrrole-3-carboxamide

N-ethyl-3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)-4-phenoxybenzamide

1-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-3-methyl-2,5,6,7-tetrahydroisoindol-4-one

5-methyl-7-(2-phenoxyphenyl)-3,6-dihydropyrrolo[3,4-d]pyrimidin-4-one

US9776990, Example 53

5-(2-amino-6-phenoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

N-[4-(2,4-difluorophenoxy)-3-[1-methyl-4-(2-morpholin-4-ylethoxy)-6-oxopyridin-3-yl]phenyl]ethanesulfonamide

3-methyl-5-(2-phenoxyphenyl)-1H-pyridin-2-one

5-[2-(2,4-difluorophenoxy)-5-(methanesulfonamido)phenyl]-2-methyl-1H-pyrrole-3-carboxamide

5-(2-anilinophenyl)-2-methyl-1H-pyrrole-3-carboxamide

1-ethyl-3-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]urea

4-methoxy-1-methyl-5-(2-phenoxyphenyl)pyridin-2-one

6-(5-amino-2-phenoxyphenyl)-5-methoxy-2-methylpyridazin-3-one

5-methoxy-2-methyl-6-(2-phenoxyphenyl)pyridazin-3-one

1-methyl-5-(2-phenoxyphenyl)pyridin-2-one

5-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-2-methyl-1H-pyrrole-3-carboxamide

ethyl N-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]carbamate

1-(2-aminophenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

3-amino-1-methyl-5-(2-phenoxyphenyl)pyridin-2-one

5-(2-aminophenyl)-2-methyl-1H-pyrrole-3-carboxamide

8-(4-fluorophenyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

15-methyl-4-(methylsulfonylmethyl)-8-pyridin-2-yl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

12-methyl-4-(methylsulfonylmethyl)-8-pyridin-2-yl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

8-(4-fluorophenyl)-12-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

8-(2,4-difluorophenyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

8-(4,4-difluorocyclohexyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

N-[8-(2,4-difluorophenyl)-15-methyl-14-oxo-6,8,12,15-tetrazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-4-yl]ethanesulfonamide

N-[8-(4-fluorophenyl)-12-methyl-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-4-yl]ethanesulfonamide

8-(cyclopropylmethyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

8-(2,4-difluorophenyl)-12-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

15-methyl-4-(methylsulfonylmethyl)-8-propanoyl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

N-(12-methyl-14-oxo-8-pyridin-2-yl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-4-yl)ethanesulfonamide

US9296741, 329

8-(cyclopropanecarbonyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

8-(cyclopropylmethyl)-15-methyl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2,4,6,10,13(17)-hexaen-14-one

8-(cyclopropylmethyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.014,17]heptadeca-1(16),2(7),3,5,10,14(17)-hexaen-13-one

8-(cyclopropylmethyl)-15-methyl-4-methylsulfonyl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

8-(cyclopropanecarbonyl)-12-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

N-[8-(2,4-difluorophenyl)-12-methyl-14-oxo-6,8,12,15-tetrazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-4-yl]ethanesulfonamide

methyl 12-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-8-carboxylate

US9296741, 328

8-(cyclopropylmethyl)-15-methyl-8,12,15-triazatetracyclo[8.6.1.02,7.014,17]heptadeca-1(16),2,4,6,10,14(17)-hexaen-13-one

3-[2-(cyclopropylmethylamino)-5-methylsulfonylphenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one

8-(cyclopropylmethyl)-15-methyl-4-methylsulfonyl-8,12,15-triazatetracyclo[8.6.1.02,7.014,17]heptadeca-1(16),2(7),3,5,10,14(17)-hexaen-13-one

3-[2-(cyclopropylmethylamino)-5-(methylsulfonylmethyl)phenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one

US9296741, 352

3-[2-(cyclopropylmethylamino)phenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one