Brief Information of the Cell Line and Protein
Cell Line ID: CL000752 , PBMC iPSC #1
Category Induced pluripotent stem cell
Organism
Homo sapiens (Human)
Protein ID: PT01107 , 11-beta-hydroxysteroid dehydrogenase 1
Gene Name HSD11B1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P28845
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000752  Protein ID: PT01107
 
Compound ID Compound Name Compound Formula
CP0544885
(3R)-1'-[1-(4-chlorophenyl)cyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one
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C21H18ClNO3
 1
1
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
CP0579722
(1R)-1'-[1-(4-chlorophenyl)cyclopropanecarbonyl]spiro[furo[3,4-c]pyridine-1,3'-pyrrolidine]-3-one
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C20H17ClN2O3
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0579726
N-methyl-5-[4-[1-[(1R)-3-oxospiro[2-benzofuran-1,3'-pyrrolidine]-1'-carbonyl]cyclopropyl]phenyl]pyridine-2-carboxamide
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C28H25N3O4
 1
1
IC50 = 1.1 nM
   TI
   LI
   LO
   TS
CP0579724
(3R)-1'-[1-(4-pyridin-3-ylphenyl)cyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one
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C26H22N2O3
 1
1
IC50 = 1.2 nM
   TI
   LI
   LO
   TS
CP0575306
(3R,5S)-7-cyclohexyl-1-(1-cyclohexylethyl)-3-hydroxy-1,7-diazaspiro[4.4]nonan-6-one
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C21H36N2O2
 1
1
IC50 = 1.9 nM
   TI
   LI
   LO
   TS
CP0576720
(3R)-1'-[1-(6-phenylpyridin-3-yl)cyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one
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C26H22N2O3
 1
1
IC50 = 2.2 nM
   TI
   LI
   LO
   TS
CP0579723
(3R)-1'-[1-(4-pyridin-2-ylphenyl)cyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one
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C26H22N2O3
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0579725
N-methyl-6-[4-[1-[(1R)-3-oxospiro[2-benzofuran-1,3'-pyrrolidine]-1'-carbonyl]cyclopropyl]phenyl]pyridine-3-carboxamide
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C28H25N3O4
 1
1
IC50 = 3.7 nM
   TI
   LI
   LO
   TS
CP0573674
(3R,5S)-1-(1-cyclobutylethyl)-7-cyclohexyl-3-hydroxy-1,7-diazaspiro[4.4]nonan-6-one
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C19H32N2O2
 1
1
IC50 = 3.9 nM
   TI
   LI
   LO
   TS
CP0543236
(3R)-1'-[1-(4-pyridin-4-ylphenyl)cyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one
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C26H22N2O3
 1
1
IC50 = 4.2 nM
   TI
   LI
   LO
   TS
CP0577651
N,N-dimethyl-5-[4-[1-[(1R)-3-oxospiro[2-benzofuran-1,3'-pyrrolidine]-1'-carbonyl]cyclopropyl]phenyl]pyridine-2-carboxamide
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C29H27N3O4
 1
1
IC50 = 4.6 nM
   TI
   LI
   LO
   TS
CP0577449
5-[4-[[(3R,5S)-7-cyclohexyl-3-hydroxy-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl]methyl]-2-fluorophenyl]-N-propan-2-ylpyridine-2-carboxamide
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C29H37FN4O3
 1
1
IC50 = 4.9 nM
   TI
   LI
   LO
   TS
CP0578772
N,N-dimethyl-6-[4-[1-[(1R)-3-oxospiro[2-benzofuran-1,3'-pyrrolidine]-1'-carbonyl]cyclopropyl]phenyl]pyridine-3-carboxamide
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C29H27N3O4
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0573676
(3S,5S)-1-[(4-chlorophenyl)methyl]-7-cyclohexyl-3-fluoro-1,7-diazaspiro[4.4]nonan-6-one
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C20H26ClFN2O
 1
1
IC50 = 5.1 nM
   TI
   LI
   LO
   TS
CP0545282
5-[4-[[(3S,5S)-7-cyclohexyl-3-fluoro-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl]methyl]phenyl]-N-methylpyridine-2-carboxamide
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C27H33FN4O2
 1
1
IC50 = 5.9 nM
   TI
   LI
   LO
   TS
CP0577448
(3R,5S)-1-[(4-chlorophenyl)methyl]-7-cyclohexyl-3-hydroxy-1,7-diazaspiro[4.4]nonan-6-one
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C20H27ClN2O2
 1
1
IC50 = 6.2 nM
   TI
   LI
   LO
   TS
CP0570998
(3R,5S)-7-cyclohexyl-3-hydroxy-1-[(4-pyridin-4-ylphenyl)methyl]-1,7-diazaspiro[4.4]nonan-6-one
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C25H31N3O2
 1
1
IC50 = 6.6 nM
   TI
   LI
   LO
   TS
CP0578968
(3R,5S)-7-cyclohexyl-1-(cyclohexylmethyl)-3-hydroxy-1,7-diazaspiro[4.4]nonan-6-one
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C20H34N2O2
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0573675
5-[4-[[(3R,5S)-7-cyclohexyl-3-hydroxy-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl]methyl]phenyl]-N-methylpyridine-2-carboxamide
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C27H34N4O3
 1
1
IC50 = 7.2 nM
   TI
   LI
   LO
   TS
CP0576224
5-[4-[[(3R,5S)-7-cyclohexyl-3-hydroxy-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl]methyl]-2-fluorophenyl]-N-methylpyridine-2-carboxamide
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C27H33FN4O3
 1
1
IC50 = 9.5 nM
   TI
   LI
   LO
   TS
CP0550050
N,N-dimethyl-4-[5-[1-[(1R)-3-oxospiro[2-benzofuran-1,3'-pyrrolidine]-1'-carbonyl]cyclopropyl]pyridin-2-yl]benzamide
   Show/Hide
C29H27N3O4
 1
1
IC50 = 9.5 nM
   TI
   LI
   LO
   TS
CP0575165
5-[4-[[(3R,5S)-7-cyclohexyl-3-hydroxy-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl]methyl]-3-fluorophenyl]-N-methylpyridine-2-carboxamide
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C27H33FN4O3
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0367898
(3S,5S)-7-cyclohexyl-1-ethyl-3-hydroxy-1,7-diazaspiro[4.4]nonan-6-one
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C15H26N2O2
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0569045
N-methyl-4-[5-[1-[(1R)-3-oxospiro[2-benzofuran-1,3'-pyrrolidine]-1'-carbonyl]cyclopropyl]pyridin-2-yl]benzamide
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C28H25N3O4
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0580031
4-[5-[[(3R,5S)-7-cyclohexyl-3-hydroxy-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl]methyl]pyridin-2-yl]benzonitrile
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C26H30N4O2
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0543357
N-methyl-3-[5-[1-[(1R)-3-oxospiro[2-benzofuran-1,3'-pyrrolidine]-1'-carbonyl]cyclopropyl]pyridin-2-yl]benzamide
   Show/Hide
C28H25N3O4
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0577650
(3R)-1'-(1-pyridin-3-ylcyclopropanecarbonyl)spiro[2-benzofuran-3,3'-pyrrolidine]-1-one
   Show/Hide
C20H18N2O3
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0571014
(3R)-1'-(1-pyridin-4-ylcyclopropanecarbonyl)spiro[2-benzofuran-3,3'-pyrrolidine]-1-one
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C20H18N2O3
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0543803
(3R,5S)-7-cyclohexyl-1-(1-cyclopropylethyl)-3-hydroxy-1,7-diazaspiro[4.4]nonan-6-one
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C18H30N2O2
 1
1
IC50 > 37 nM
   TI
   LI
   LO
   TS
CP0545283
(3S,5R)-1-[(4-chlorophenyl)methyl]-7-cyclohexyl-3-hydroxy-1,7-diazaspiro[4.4]nonan-6-one
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C20H27ClN2O2
 1
1
IC50 > 37 nM
   TI
   LI
   LO
   TS
CP0545284
3-[5-[[(3R,5S)-7-cyclohexyl-3-hydroxy-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl]methyl]pyridin-2-yl]benzonitrile
   Show/Hide
C26H30N4O2
 1
1
IC50 > 37 nM
   TI
   LI
   LO
   TS
CP0545285
5-[5-[[(3R,5S)-7-cyclohexyl-3-hydroxy-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl]methyl]-2-fluorophenyl]-N-ethylpyridine-2-carboxamide
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C28H35FN4O3
 1
1
IC50 > 37 nM
   TI
   LI
   LO
   TS
CP0573482
(3R,5S)-7-cyclohexyl-3-hydroxy-1-propan-2-yl-1,7-diazaspiro[4.4]nonan-6-one
   Show/Hide
C16H28N2O2
 1
1
IC50 > 37 nM
   TI
   LI
   LO
   TS
CP0577515
5-[3-[[(3R,5S)-7-cyclohexyl-3-hydroxy-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl]methyl]phenyl]-N-ethylpyridine-2-carboxamide
   Show/Hide
C28H36N4O3
 1
1
IC50 > 37 nM
   TI
   LI
   LO
   TS
CP0578967
(5S)-1-[(4-chlorophenyl)methyl]-7-cyclohexyl-3-hydroxy-3-methyl-1,7-diazaspiro[4.4]nonan-6-one
   Show/Hide
C21H29ClN2O2
 1
1
IC50 > 37 nM
   TI
   LI
   LO
   TS
CP0579331
(3R,5S)-7-cyclohexyl-1-[[6-(4-fluorophenyl)pyridin-3-yl]methyl]-3-hydroxy-1,7-diazaspiro[4.4]nonan-6-one
   Show/Hide
C25H30FN3O2
 1
1
IC50 > 37 nM
   TI
   LI
   LO
   TS