General Information of the Compound
| Compound ID |
CP0035896
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| Compound Name |
GM6001
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| Synonyms |
(R)-N(sup 1)-Hydroxy-N-((S)-2-indol-3-yl-1-(methylcarbamoyl)ethyl)-2-isobutylsuccinamide
(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
(S-(R*,S*))-N(sup 4)-Hydroxy-N(sup
142880-36-2
3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE
CHEMBL19611
CS 610
GM 6001
GM-6001
GM6001
Galardin
I0403ML141
ILOMASTAT
Illomastat
Ilomastat
Ilomastat (GM6001, Galardin)
N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide
NCGC00163450-02
UNII-I0403ML141
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| Structure |
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| Formula |
C20H28N4O4
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| Molecular Weight |
388.468
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| Canonical SMILES |
CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
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| InChI |
InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
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| InChIKey |
NITYDPDXAAFEIT-DYVFJYSZSA-N
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| CAS |
142880-36-2
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01178, A disintegrin and metalloproteinase with thrombospondin motifs 4
Protein ID: PT01250, A disintegrin and metalloproteinase with thrombospondin motifs 5
Clinical Information about the Compound
Drug 1 ( GM6001 )
| Drug Name | GM6001 | ||
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| Indication | |||
| Target(s) |
Matrix metalloproteinase-3 (MMP-3)
Inhibitor
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