Protein Information

General Information of the Protein

Protein ID	PT00900
Protein Name	Neutrophil collagenase
Secondarily Protein Name	Matrix metalloproteinase-8 PMNL collagenase
Gene Name	MMP8
Secondarily Gene Name	CLG1
Sequence	MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Protease > Metallo protease > Metallo protease MAM clan > Metallo protease M10A subfamily
Function	Can degrade fibrillar type I, II, and III collagens. Show/Hide
Uniprot ID	Primary ID: P22894 Secondarily ID: Q45F99 Show/Hide
Ensembl ID	ENSG00000118113
HGNC ID	HGNC:7175
Subcellular Location	Cytoplasmic granule Secreted Extracellular space Extracellular matrix

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0099232 Compound Info	5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]-N-[(2S)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]furan-2-carboxamide Show/Hide	C25H27FN4O4S	1
1	IC50 > 5000 nM
CP0117835 Compound Info	5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]-N-[(2R)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]furan-2-carboxamide Show/Hide	C25H27FN4O4S	1
1	IC50 > 5000 nM
CP0159081 Compound Info	N-[(1R)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]-5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]furan-2-carboxamide Show/Hide	C28H31FN4O4S	1
1	IC50 > 5000 nM
CP0228998 Compound Info	N-[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]-5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]furan-2-carboxamide Show/Hide	C28H31FN4O4S	1
1	IC50 > 5000 nM
CP0038814 Compound Info	2-[(4-chlorobenzyl)thio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one Show/Hide	C14H13ClN2OS	1
1	IC50 > 100000 nM

Clinical Information about the Protein

Target 1 ( Matrix metalloproteinase-8 (MMP-8) )