General Information of the Protein
Protein ID
PT00968
Protein Name
Matrix metalloproteinase-14
Secondarily
Protein Name
MMP-X1
Membrane-type matrix metalloproteinase 1
Membrane-type-1 matrix metalloproteinase
Gene Name
MMP14
Sequence
MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MAM clan
>
Metallo protease M10A subfamily
Function
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).
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Uniprot ID
Primary ID:
P50281

Secondarily ID:
A8K5L0
Q6GSF3
Q92678
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Ensembl ID
ENSG00000157227
HGNC ID
HGNC:7160
Subcellular Location
Membrane
Melanosome
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0069428
 Compound Info 
US9206139, 1
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C18H20F3N3O3
  1
1
IC50 = 3890 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0199497
 Compound Info 
US9206139, 2
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C19H22F3N3O3
  1
1
IC50 = 7990 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069431
 Compound Info 
US9206139, 5
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C19H22F3N3O3
  1
1
IC50 = 14870 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0118960
 Compound Info 
US9206139, 3
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C20H22F3N3O3
  1
1
IC50 = 50200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069429
 Compound Info 
US9206139, 4
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C20H24F3N3O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0069428
 Compound Info 
US9206139, 1
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C18H20F3N3O3
  1
1 IC50 = 3900 nM
CP0199497
 Compound Info 
US9206139, 2
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C19H22F3N3O3
  1
1 IC50 = 8000 nM
CP0069431
 Compound Info 
US9206139, 5
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C19H22F3N3O3
  1
1 IC50 = 15000 nM
CP0118960
 Compound Info 
US9206139, 3
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C20H22F3N3O3
  1
1 IC50 = 50000 nM
CP0069429
 Compound Info 
US9206139, 4
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C20H24F3N3O3
  1
1 IC50 > 100000 nM
Clinical Information about the Protein
Target 1 ( Matrix metalloproteinase-14 (MMP-14) )
Target Type Clinical trial Target
Disease 2 Target-related Diseases  2
1 Hepatic fibrosis [ICD-11: DB93.0]
2 Corneal ulcer [ICD-11: 9A76]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 Epigallocatechin gallate
 Drug Info 
Phase 3
Hepatic fibrosis
Discontinued Drug(s) 1 Discontinued Drug  1
1 GM6001
 Drug Info 
Discontinued in Phase 2
Corneal ulcer