General Information of the Protein
Protein ID
PT01178
Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 4
Secondarily
Protein Name
ADMP-1
Aggrecanase-1
Gene Name
ADAMTS4
Secondarily
Gene Name
KIAA0688
UNQ769/PRO1563
Sequence
MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MAM clan
>
Metallo protease M12B subfamily
Function
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
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Uniprot ID
Primary ID:
O75173

Secondarily ID:
Q2HYD0
Q5VTW2
Q6P4Q8
Q6UWA8
Q9UN83
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Ensembl ID
ENSG00000158859
HGNC ID
HGNC:220
Subcellular Location
Secreted
Extracellular space
Extracellular matrix
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0038344
 Compound Info 
(2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-3-(3-hydroxybenzyl)succinamide
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C24H29N3O5
  1
1
IC50 = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0234042
 Compound Info 
2-[[4-[(2-chloro-4-fluorophenyl)methoxy]phenyl]sulfonylamino]-N-hydroxyacetamide
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C15H14ClFN2O5S
  1
1
IC50 = 80 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0035896
 Compound Info 
GM6001
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C20H28N4O4
  1
1
IC50 = 480 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0144469
 Compound Info 
N-hydroxy-2-[(4-phenoxyphenyl)sulfonylamino]acetamide
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C14H14N2O5S
  1
1
IC50 = 580 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0127842
 Compound Info 
N-hydroxy-2-[2-methylpropyl-(4-phenylmethoxyphenyl)sulfonylamino]acetamide
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C19H24N2O5S
  1
1
IC50 = 630 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0218336
 Compound Info 
N-hydroxy-3-[(4-phenoxyphenyl)sulfonylamino]propanamide
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C15H16N2O5S
  1
1
IC50 = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0136690
 Compound Info 
2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetamide
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C12H18N2O5S
  1
1
IC50 = 3300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0109082
 Compound Info 
N-hydroxy-2-[(4-phenylmethoxyphenyl)sulfonylamino]acetamide
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C15H16N2O5S
  1
1
IC50 = 3500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0115111
 Compound Info 
N-hydroxy-2-[(6-phenoxypyridin-3-yl)sulfonylamino]acetamide
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C13H13N3O5S
  1
1
IC50 = 5800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0038344
 Compound Info 
(2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-3-(3-hydroxybenzyl)succinamide
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C24H29N3O5
  1
1 IC50 = 3 nM
Clinical Information about the Protein
Target 1 ( Aggrecanase-1 (ADAMTS4) )
Target Type Patented-recorded Target