General Information of the Protein
Protein ID
PT01250
Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 5
Secondarily
Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 11
ADMP-2
Aggrecanase-2
Gene Name
ADAMTS5
Secondarily
Gene Name
ADAMTS11
ADMP2
Sequence
MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MAM clan
>
Metallo protease M12B subfamily
Function
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
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Uniprot ID
Primary ID:
Q9UNA0

Secondarily ID:
Q52LV4
Q9UKP2
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Ensembl ID
ENSG00000154736
HGNC ID
HGNC:221
Subcellular Location
Secreted
Extracellular space
Extracellular matrix
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0052587
 Compound Info 
(2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzenesulfonyl]-3-hydroxy-3-methyl-piperidine-2-carboxylic acid hydroxyamide
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C20H22ClFN2O6S
  1
1
IC50 = 6.3 nM
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CP0191349
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C29H36N8O2S3
  1
1
IC50 = 30 nM
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CP0191351
 Compound Info 
N-[[(2R)-1-[4-[(1-methylimidazol-4-yl)methylamino]-6-(propylamino)-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C25H37N9O2S
  1
1
IC50 = 30 nM
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CP0191353
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]naphthalene-2-sulfonamide
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C30H32N8O2S3
  1
1
IC50 = 40 nM
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CP0191350
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C27H29F3N8O2S3
  1
1
IC50 = 50 nM
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CP0446326
 Compound Info 
N-[[(2R)-1-[4-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-6-(propylamino)-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C30H38N8O2S2
  1
1
IC50 = 50 nM
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CP0534190
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-methoxybenzenesulfonamide
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C29H34N8O3S2
  1
1
IC50 = 50 nM
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CP0413961
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C29H31F3N8O2S2
  1
1
IC50 = 60 nM
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CP0120704
 Compound Info 
N-[[(2R)-1-[4-(cyclopropylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C30H36N8O2S2
  1
1
IC50 = 70 nM
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CP0110474
 Compound Info 
N-[[(2R)-1-[4-(2-cyanoethylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C30H35N9O2S2
  1
1
IC50 = 90 nM
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CP0449949
 Compound Info 
N-[[(2R)-1-[4-(cyclopropylmethylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C27H29F3N8O2S3
  1
1
IC50 = 110 nM
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CP0408592
 Compound Info 
N-[[(2R)-1-[4-(2-methylpropylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C31H40N8O2S2
  1
1
IC50 = 120 nM
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CP0413962
 Compound Info 
N-[[(2R)-1-[4-(2-methoxyethylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C30H38N8O3S2
  1
1
IC50 = 210 nM
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CP0523351
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]benzenesulfonamide
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C28H32N8O2S2
  1
1
IC50 = 230 nM
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CP0534192
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C27H31F3N8O2S3
  1
1
IC50 = 240 nM
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CP0553415
 Compound Info 
N-[[(2R)-1-[4-(2-hydroxyethylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C29H36N8O3S2
  1
1
IC50 = 260 nM
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CP0413963
 Compound Info 
N-[[(2R)-1-[4-(methylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C24H25F3N8O2S3
  1
1
IC50 = 390 nM
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CP0534191
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(6-methylpyridin-2-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C28H40N8O2S
  1
1
IC50 = 410 nM
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CP0553414
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-methyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C24H29F3N8O2S2
  1
1
IC50 = 430 nM
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CP0523350
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-chlorobenzenesulfonamide
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C26H31ClN8O2S3
  1
1
IC50 = 460 nM
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CP0513291
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-3-chlorobenzenesulfonamide
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C26H31ClN8O2S3
  1
1
IC50 = 700 nM
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CP0553411
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-3,4-dimethylbenzenesulfonamide
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C28H36N8O2S3
  1
1
IC50 = 720 nM
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CP0553413
 Compound Info 
N-[[(2R)-1-[4-(benzylamino)-6-(but-3-enylamino)-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C26H30F3N7O2S
  1
1
IC50 = 870 nM
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CP0396384
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-(thiophen-3-ylmethylamino)-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C26H37N7O2S2
  1
1
IC50 = 1170 nM
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CP0413955
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-phenylbenzenesulfonamide
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C32H36N8O2S3
  1
1
IC50 = 1250 nM
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CP0446323
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-fluorobenzenesulfonamide
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C26H31FN8O2S3
  1
1
IC50 = 1500 nM
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CP0553412
 Compound Info 
N-[[(2S)-1-[4-(but-3-enylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C29H31F3N8O2S2
  1
1
IC50 = 1560 nM
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CP0413954
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-3-hydroxybenzenesulfonamide
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C26H32N8O3S3
  1
1
IC50 = 1600 nM
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CP0446325
 Compound Info 
N-[[(2R)-1-[4-(cyclopentylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C32H40N8O2S2
  1
1
IC50 = 1600 nM
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CP0513290
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-cyanobenzenesulfonamide
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C27H31N9O2S3
  1
1
IC50 = 1800 nM
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CP0523355
 Compound Info 
N-[[(2R)-1-[4-(oxan-4-ylmethylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C33H42N8O3S2
  1
1
IC50 = 2140 nM
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CP0408577
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-hydroxybenzenesulfonamide
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C26H32N8O3S3
  1
1
IC50 = 2600 nM
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CP0515629
 Compound Info 
N-[[(2R)-1-[4-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C23H22F3N7O2S3
  1
1
IC50 = 3500 nM
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CP0523356
 Compound Info 
N-[[(2R)-1-[4-(2-cyclopropylethylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C32H40N8O2S2
  1
1
IC50 = 3800 nM
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CP0396382
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-3-cyanobenzenesulfonamide
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C27H31N9O2S3
  1
1
IC50 = 4100 nM
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CP0413957
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(4-cyanothiophen-2-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C27H36N8O2S2
  1
1
IC50 = 4100 nM
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CP0513898
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-methylsulfonylbenzenesulfonamide
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C27H34N8O4S4
  1
1
IC50 = 5300 nM
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CP0523357
 Compound Info 
N-[[(2R)-1-[2-oxo-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1H-1,3,5-triazin-4-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C23H22F3N7O3S3
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1
IC50 = 5300 nM
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CP0452222
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-(propan-2-ylamino)-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C24H39N7O2S
  1
1
IC50 = 5800 nM
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CP0446324
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-(cyclopropylmethylamino)-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C25H39N7O2S
  1
1
IC50 = 6500 nM
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CP0413956
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-(cyclopentylamino)-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C26H41N7O2S
  1
1
IC50 > 10000 nM
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CP0413959
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(3-phenylphenyl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C32H34F3N7O2S
  1
1
IC50 > 10000 nM
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CP0449935
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-3-(trifluoromethyl)benzenesulfonamide
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C29H31F3N8O2S2
  1
1
IC50 > 10000 nM
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CP0449936
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(4-butylphenyl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C32H47N7O2S
  1
1
IC50 > 10000 nM
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CP0452223
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(4-methylthiophen-2-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C27H39N7O2S2
  1
1
IC50 > 10000 nM
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CP0513292
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-2-(trifluoromethyl)benzenesulfonamide
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C29H31F3N8O2S2
  1
1
IC50 > 10000 nM
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CP0513293
 Compound Info 
3-fluoro-4-methyl-N-[(3R)-1-[4-(2-naphthalen-1-ylethylamino)-6-[[(3S)-2-oxoazepan-3-yl]amino]-1,3,5-triazin-2-yl]pyrrolidin-3-yl]benzenesulfonamide
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C32H37FN8O3S
  1
1
IC50 > 10000 nM
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CP0513846
 Compound Info 
N-[[(2R)-1-[4-[methyl(propyl)amino]-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C31H40N8O2S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0513901
 Compound Info 
N-[(3R)-1-[4-(benzylamino)-6-[[(3S)-2-oxoazepan-3-yl]amino]-1,3,5-triazin-2-yl]pyrrolidin-3-yl]-3-fluoro-4-methylbenzenesulfonamide
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C27H33FN8O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0523352
 Compound Info 
N-[[(3R)-1-[4-(but-3-enylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-3-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C29H31F3N8O2S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0523353
 Compound Info 
N-[[(2R)-1-[4-(butylamino)-6-[(3-methylphenyl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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C29H41N7O2S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0523354
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(4-phenylphenyl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
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C32H34F3N7O2S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545199
 Compound Info 
N-[[(2R)-1-[4-(but-3-enylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]cyclopropanesulfonamide
   Show/Hide
C25H32N8O2S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545200
 Compound Info 
N-[[(3S)-1-[4-(but-3-enylamino)-6-[(2-phenyl-1,3-thiazol-4-yl)methylamino]-1,3,5-triazin-2-yl]pyrrolidin-3-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C29H31F3N8O2S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0052587
 Compound Info 
(2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzenesulfonyl]-3-hydroxy-3-methyl-piperidine-2-carboxylic acid hydroxyamide
   Show/Hide
C20H22ClFN2O6S
  2
1 IC50 = 1 nM
2 IC50 = 18 nM
CP0038344
 Compound Info 
(2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-3-(3-hydroxybenzyl)succinamide
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C24H29N3O5
  1
1 IC50 = 12 nM
CP0132958
 Compound Info 
US9926281, Compound 255
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C20H24F2N4O3
  1
1 IC50 = 19 nM
CP0234042
 Compound Info 
2-[[4-[(2-chloro-4-fluorophenyl)methoxy]phenyl]sulfonylamino]-N-hydroxyacetamide
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C15H14ClFN2O5S
  1
1 Ki = 77 nM
CP0144469
 Compound Info 
N-hydroxy-2-[(4-phenoxyphenyl)sulfonylamino]acetamide
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C14H14N2O5S
  1
1 Ki = 840 nM
CP0109082
 Compound Info 
N-hydroxy-2-[(4-phenylmethoxyphenyl)sulfonylamino]acetamide
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C15H16N2O5S
  1
1 Ki = 21000 nM
Clinical Information about the Protein
Target 1 ( Aggrecanase (ADAMTS5) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Osteoarthritis [ICD-11: FA00-FA05]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 AGG-523
 Drug Info 
Phase 1
Osteoarthritis