General Information of the Cell Line
Cell Line ID
CL000652
Cell Line Name
KM12
Synonyms
KM-12
KM.12
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1331
Tissue Information
Colon
Disease
Colon carcinoma (NCIt: C4910)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00934, High affinity nerve growth factor receptor
Compound ID Compound Name Compound Formula
CP0385508
2-[4-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid
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C27H28FN7O2
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0385511
1-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol
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C26H27FN6O
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0082019
(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
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C22H21NO2S  1
1
GI50 = 5010 nM
   TI
   LI
   LO
   TS
CP0124520
(1S,5S,6R,9S,15E,20R)-5-hydroxy-20-(2-methylsulfanylethyl)-6-propan-2-yl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone
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C22H35N3O6S3  1
1
GI50 = 0.76 nM
   TI
   LI
   LO
   TS
CP0345034
[(2R)-1-(4-tert-butylphenoxy)-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)methylideneamino]benzoate
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C29H28N4O7  2
1
GI50 = 16000 nM
   TI
   LI
   LO
   TS
2
LC50 = 67000 nM
   TI
   LI
   LO
   TS
CP0383276
N-(4-methoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
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C16H17N3O2  1
1
GI50 = 21.1 nM
   TI
   LI
   LO
   TS
CP0419168
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-morpholin-4-ylbenzamide
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C25H27F2N5O2  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0421570
N-(5-methoxynaphthalen-2-yl)-N,2-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
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C20H21N3O  1
1
GI50 < 10 nM
   TI
   LI
   LO
   TS
CP0426689
(2,6-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-(4-methoxyphenyl)-methylazanium;chloride
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C17H22ClN3O  1
1
GI50 < 10 nM
   TI
   LI
   LO
   TS
CP0432230
N-(2,3-dihydro-1-benzofuran-5-yl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
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C17H17N3O2  1
1
GI50 = 40.1 nM
   TI
   LI
   LO
   TS
CP0465282
4-N-(4-methoxyphenyl)-4-N-methyl-9H-pyrimido[4,5-b]indole-2,4-diamine
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C18H17N5O  1
1
GI50 = 13.2 nM
   TI
   LI
   LO
   TS
CP0517983
N-[4-[2-[(2S,3S,5S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1,3-dithian-2-yl]phenyl]-N'-hydroxyoctanediamide
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C34H52N4O7S2Si  1
1
GI50 = 6760.83 nM
   TI
   LI
   LO
   TS
CP0557086
(1S,7S,10S,16E,21R)-7-benzyl-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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C26H34N4O6S2  1
1
GI50 = 740 nM
   TI
   LI
   LO
   TS
CP0558284
(1S,7R,10S,16E,21R)-7-(2-methylpropyl)-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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C23H36N4O6S2  1
1
GI50 = 33 nM
   TI
   LI
   LO
   TS
CP0897293
1-(7-Benzyl-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline hydrochloride
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C24H25ClN4O  1
1
GI50 = 366 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Colon)
Cell Line Name Organism Disease
HT-29 Homo sapiens (Human) Colon adenocarcinoma
SW480 Homo sapiens (Human) Colon adenocarcinoma
Caco-2 Homo sapiens (Human) Colon adenocarcinoma
HCA7 Homo sapiens (Human) Colon adenocarcinoma
LS174T Homo sapiens (Human) Colon adenocarcinoma
LS180 Homo sapiens (Human) Colon adenocarcinoma
SW1116 Homo sapiens (Human) Colon adenocarcinoma
WiDr Homo sapiens (Human) Colon adenocarcinoma
S1-M1-80 Homo sapiens (Human) Colon adenocarcinoma
SW48 Homo sapiens (Human) Colon adenocarcinoma
S1 Homo sapiens (Human) Colon adenocarcinoma
Caco-2/TC-7 Homo sapiens (Human) Colon adenocarcinoma
COLO 320DM Homo sapiens (Human) Colon adenocarcinoma
COLO 320 Homo sapiens (Human) Colon adenocarcinoma
HCT 116 Homo sapiens (Human) Colon carcinoma
RKO Homo sapiens (Human) Colon carcinoma
KM12-Luc Homo sapiens (Human) Colon carcinoma
TC71 Homo sapiens (Human) Colon carcinoma
KM12-L4A Homo sapiens (Human) Colon carcinoma
HCA2 Homo sapiens (Human) Rectosigmoid adenocarcinoma
CT26 Mus musculus (Mouse) Mouse colon adenocarcinoma
51B LiM-1 Mus musculus (Mouse) Mouse colon adenocarcinoma
GLUTag Mus musculus (Mouse) Neuroendocrine cell carcinoma of the mouse intestinal tract
CC531 Rattus norvegicus (Rat) Adenocarcinoma of the rat colon