| Compound ID |
Compound Name |
Compound Formula |
|
CP0561660
|
4-[4-[(S)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-methoxyphenyl]benzonitrile
Show/Hide
|
C26H19N5O2
|
5
|
| 1 |
EC50 = 2.3 nM
|
|
|
| 2 |
EC50 = 6.7 nM
|
|
|
| 3 |
EC50 = 14.8 nM
|
|
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| 4 |
EC50 = 66.9 nM
|
|
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| 5 |
EC50 = 87.7 nM
|
|
|
|
CP0010654
|
4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin-4-ylamino)-3,5-dimethylbenzonitrile
Show/Hide
|
C20H15BrN6O
|
10
|
| 1 |
EC50 = 2.3 nM
|
|
|
| 2 |
EC50 = 3 nM
|
|
|
| 3 |
EC50 = 8 nM
|
|
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| 4 |
EC50 = 9 nM
|
|
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| 5 |
EC50 = 9.2 nM
|
|
|
| 6 |
EC50 = 12.2 nM
|
|
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| 7 |
EC50 = 16.3 nM
|
|
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| 8 |
EC50 = 18 nM
|
|
|
| 9 |
EC50 = 18.4 nM
|
|
|
| 10 |
EC50 = 25 nM
|
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|
|
CP0544070
|
4-[3-chloro-4-[(S)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]phenyl]benzonitrile
Show/Hide
|
C25H16ClN5O
|
5
|
| 1 |
EC50 = 3 nM
|
|
|
| 2 |
EC50 = 3.2 nM
|
|
|
| 3 |
EC50 = 14.4 nM
|
|
|
| 4 |
EC50 = 52.5 nM
|
|
|
| 5 |
EC50 = 127.9 nM
|
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|
CP0552383
|
4-[4-[(S)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3,5-dimethylphenyl]benzonitrile
Show/Hide
|
C27H21N5O
|
4
|
| 1 |
EC50 = 3.9 nM
|
|
|
| 2 |
EC50 = 7.2 nM
|
|
|
| 3 |
EC50 = 7.4 nM
|
|
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| 4 |
EC50 = 19.5 nM
|
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|
|
CP0043833
|
(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one
Show/Hide
|
C14H9ClF3NO2
|
10
|
| 1 |
EC50 = 4.8 nM
|
|
|
| 2 |
EC50 = 5 nM
|
|
|
| 3 |
EC50 = 7 nM
|
|
|
| 4 |
EC50 = 31 nM
|
|
|
| 5 |
EC50 = 47.5 nM
|
|
|
| 6 |
EC50 = 71 nM
|
|
|
| 7 |
EC50 = 76 nM
|
|
|
| 8 |
EC50 = 171.1 nM
|
|
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| 9 |
EC50 = 260 nM
|
|
|
| 10 |
EC50 = 380 nM
|
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|
|
CP0551078
|
4-[4-[(S)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-methylphenyl]benzonitrile
Show/Hide
|
C26H19N5O
|
5
|
| 1 |
EC50 = 5.5 nM
|
|
|
| 2 |
EC50 = 8.6 nM
|
|
|
| 3 |
EC50 = 19.2 nM
|
|
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| 4 |
EC50 = 81.4 nM
|
|
|
| 5 |
EC50 = 263.5 nM
|
|
|
|
CP0425699
|
4-[3-chloro-4-[[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]phenyl]benzonitrile
Show/Hide
|
C25H16ClN5O
|
5
|
| 1 |
EC50 = 5.9 nM
|
|
|
| 2 |
EC50 = 7.3 nM
|
|
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| 3 |
EC50 = 14.2 nM
|
|
|
| 4 |
EC50 = 91.3 nM
|
|
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| 5 |
EC50 = 296.9 nM
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|
CP0422273
|
4-[[4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]thieno[2,3-d]pyrimidin-2-yl]amino]phenyl]methyl]piperazine-1-sulfonamide
Show/Hide
|
C28H29N7O3S2
|
5
|
| 1 |
EC50 = 7 nM
|
|
|
| 2 |
EC50 = 15 nM
|
|
|
| 3 |
EC50 = 25 nM
|
|
|
| 4 |
EC50 = 369 nM
|
|
|
| 5 |
EC50 = 877 nM
|
|
|
|
CP0492297
|
4-[[4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]thieno[3,2-d]pyrimidin-2-yl]amino]phenyl]methyl]piperazine-1-sulfonamide
Show/Hide
|
C28H29N7O3S2
|
5
|
| 1 |
EC50 = 7 nM
|
|
|
| 2 |
EC50 = 26 nM
|
|
|
| 3 |
EC50 = 43 nM
|
|
|
| 4 |
EC50 = 175 nM
|
|
|
| 5 |
EC50 = 544 nM
|
|
|
|
CP0422104
|
4-[4-[[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3,5-dimethylphenyl]benzonitrile
Show/Hide
|
C27H21N5O
|
5
|
| 1 |
EC50 = 7 nM
|
|
|
| 2 |
EC50 = 15.5 nM
|
|
|
| 3 |
EC50 = 23.2 nM
|
|
|
| 4 |
EC50 = 48.7 nM
|
|
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| 5 |
EC50 = 417.1 nM
|
|
|
|
CP0546038
|
4-[4-[[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-methoxyphenyl]benzonitrile
Show/Hide
|
C26H19N5O2
|
4
|
| 1 |
EC50 = 7.4 nM
|
|
|
| 2 |
EC50 = 12.9 nM
|
|
|
| 3 |
EC50 = 32.3 nM
|
|
|
| 4 |
EC50 = 113 nM
|
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|
|
CP0422105
|
4-[4-[(S)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3,5-difluorophenyl]benzonitrile
Show/Hide
|
C25H15F2N5O
|
5
|
| 1 |
EC50 = 8.4 nM
|
|
|
| 2 |
EC50 = 36.4 nM
|
|
|
| 3 |
EC50 = 88.7 nM
|
|
|
| 4 |
EC50 = 341.4 nM
|
|
|
| 5 |
EC50 = 2252.9 nM
|
|
|
|
CP0422051
|
4-[4-[(S)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-(trifluoromethyl)phenyl]benzonitrile
Show/Hide
|
C26H16F3N5O
|
5
|
| 1 |
EC50 = 9.1 nM
|
|
|
| 2 |
EC50 = 14.6 nM
|
|
|
| 3 |
EC50 = 29.7 nM
|
|
|
| 4 |
EC50 = 93.3 nM
|
|
|
| 5 |
EC50 = 318.2 nM
|
|
|
|
CP0486353
|
4-[4-[(S)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-fluorophenyl]benzonitrile
Show/Hide
|
C25H16FN5O
|
5
|
| 1 |
EC50 = 9.3 nM
|
|
|
| 2 |
EC50 = 49.8 nM
|
|
|
| 3 |
EC50 = 78.3 nM
|
|
|
| 4 |
EC50 = 379.7 nM
|
|
|
| 5 |
EC50 >= 2301.6 nM
|
|
|
|
CP0552381
|
4-[4-[[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-methylphenyl]benzonitrile
Show/Hide
|
C26H19N5O
|
5
|
| 1 |
EC50 = 9.8 nM
|
|
|
| 2 |
EC50 = 18.4 nM
|
|
|
| 3 |
EC50 = 31.1 nM
|
|
|
| 4 |
EC50 = 184.4 nM
|
|
|
| 5 |
EC50 = 622.8 nM
|
|
|
|
CP0422053
|
4-[4-[(R)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3,5-dimethylphenyl]benzonitrile
Show/Hide
|
C27H21N5O
|
5
|
| 1 |
EC50 = 18.8 nM
|
|
|
| 2 |
EC50 = 20.6 nM
|
|
|
| 3 |
EC50 = 46.3 nM
|
|
|
| 4 |
EC50 = 164.5 nM
|
|
|
| 5 |
EC50 = 2201.6 nM
|
|
|
|
CP0492296
|
4-[4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]thieno[3,2-d]pyrimidin-2-yl]amino]phenyl]piperazine-1-sulfonamide
Show/Hide
|
C27H27N7O3S2
|
5
|
| 1 |
EC50 = 21 nM
|
|
|
| 2 |
EC50 = 43 nM
|
|
|
| 3 |
EC50 = 203 nM
|
|
|
| 4 |
EC50 = 767 nM
|
|
|
| 5 |
EC50 = 23110 nM
|
|
|
|
CP0552382
|
4-[4-[[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3,5-difluorophenyl]benzonitrile
Show/Hide
|
C25H15F2N5O
|
5
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
EC50 = 61.4 nM
|
|
|
| 3 |
EC50 = 125.2 nM
|
|
|
| 4 |
EC50 = 409.6 nM
|
|
|
| 5 |
EC50 = 3504.5 nM
|
|
|
|
CP0544069
|
4-[4-[[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-(trifluoromethyl)phenyl]benzonitrile
Show/Hide
|
C26H16F3N5O
|
4
|
| 1 |
EC50 = 25.5 nM
|
|
|
| 2 |
EC50 = 59.4 nM
|
|
|
| 3 |
EC50 = 212.1 nM
|
|
|
| 4 |
EC50 = 551.5 nM
|
|
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|
CP0422103
|
4-[4-[[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-fluorophenyl]benzonitrile
Show/Hide
|
C25H16FN5O
|
5
|
| 1 |
EC50 = 28.5 nM
|
|
|
| 2 |
EC50 = 87.8 nM
|
|
|
| 3 |
EC50 = 111.5 nM
|
|
|
| 4 |
EC50 = 901.7 nM
|
|
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| 5 |
EC50 = 4176.2 nM
|
|
|
|
CP0426553
|
4-[4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]thieno[2,3-d]pyrimidin-2-yl]amino]phenyl]piperazine-1-sulfonamide
Show/Hide
|
C27H27N7O3S2
|
5
|
| 1 |
EC50 = 31 nM
|
|
|
| 2 |
EC50 = 50 nM
|
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|
| 3 |
EC50 = 331 nM
|
|
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| 4 |
EC50 = 409 nM
|
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| 5 |
EC50 = 10140 nM
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|
|
CP0533198
|
(E)-3-[3,5-dimethyl-4-[2-[4-[(4-methylsulfonylpiperazin-1-yl)methyl]anilino]thieno[2,3-d]pyrimidin-4-yl]oxyphenyl]prop-2-enenitrile
Show/Hide
|
C29H30N6O3S2
|
5
|
| 1 |
EC50 = 54 nM
|
|
|
| 2 |
EC50 = 162 nM
|
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|
| 3 |
EC50 = 387 nM
|
|
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| 4 |
EC50 = 1638 nM
|
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| 5 |
EC50 = 9414 nM
|
|
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|
CP0422052
|
4-[4-[(R)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3,5-difluorophenyl]benzonitrile
Show/Hide
|
C25H15F2N5O
|
5
|
| 1 |
EC50 = 54.6 nM
|
|
|
| 2 |
EC50 = 364.1 nM
|
|
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| 3 |
EC50 = 432.4 nM
|
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| 4 |
EC50 = 1433.7 nM
|
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| 5 |
EC50 = 5939.5 nM
|
|
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|
CP0465738
|
(E)-3-[3,5-dimethyl-4-[2-[4-(4-methylsulfonylpiperazin-1-yl)anilino]thieno[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enenitrile
Show/Hide
|
C28H28N6O3S2
|
5
|
| 1 |
EC50 = 56 nM
|
|
|
| 2 |
EC50 = 88 nM
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| 3 |
EC50 = 285 nM
|
|
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| 4 |
EC50 = 938 nM
|
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| 5 |
EC50 = 5114 nM
|
|
|
|
CP0561531
|
4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]-2-[4-[3-(sulfamoylamino)piperidin-1-yl]anilino]thieno[3,2-d]pyrimidine
Show/Hide
|
C28H29N7O3S2
|
5
|
| 1 |
EC50 = 102 nM
|
|
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| 2 |
EC50 = 123 nM
|
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| 3 |
EC50 = 381 nM
|
|
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| 4 |
EC50 = 1660 nM
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| 5 |
EC50 = 6754 nM
|
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|
|
CP0422050
|
4-[4-[(R)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-methylphenyl]benzonitrile
Show/Hide
|
C26H19N5O
|
5
|
| 1 |
EC50 = 148.5 nM
|
|
|
| 2 |
EC50 = 479.1 nM
|
|
|
| 3 |
EC50 = 742.6 nM
|
|
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| 4 |
EC50 = 2634.9 nM
|
|
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| 5 |
EC50 >= 9749.2 nM
|
|
|
|
CP0534945
|
4-[4-[(R)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-fluorophenyl]benzonitrile
Show/Hide
|
C25H16FN5O
|
5
|
| 1 |
EC50 = 163.7 nM
|
|
|
| 2 |
EC50 = 735.6 nM
|
|
|
| 3 |
EC50 = 1162.7 nM
|
|
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| 4 |
EC50 = 3630.4 nM
|
|
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| 5 |
EC50 > 29968.7 nM
|
|
|
|
CP0039375
|
11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2 ,3 -e][1,4]diazepin-6-one
Show/Hide
|
C15H14N4O
|
9
|
| 1 |
EC50 = 168 nM
|
|
|
| 2 |
EC50 = 622 nM
|
|
|
| 3 |
EC50 = 1201.7 nM
|
|
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| 4 |
EC50 = 3154.3 nM
|
|
|
| 5 |
EC50 = 3922 nM
|
|
|
| 6 |
EC50 = 4694 nM
|
|
|
| 7 |
EC50 = 6496.4 nM
|
|
|
| 8 |
EC50 = 8041 nM
|
|
|
| 9 |
EC50 = 9074 nM
|
|
|
|
CP0552380
|
4-[4-[(R)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-methoxyphenyl]benzonitrile
Show/Hide
|
C26H19N5O2
|
5
|
| 1 |
EC50 = 196.1 nM
|
|
|
| 2 |
EC50 = 438.3 nM
|
|
|
| 3 |
EC50 = 507.5 nM
|
|
|
| 4 |
EC50 = 1245.8 nM
|
|
|
| 5 |
EC50 = 5813.6 nM
|
|
|
|
CP0558537
|
4-[3-chloro-4-[(R)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]phenyl]benzonitrile
Show/Hide
|
C25H16ClN5O
|
4
|
| 1 |
EC50 = 205.5 nM
|
|
|
| 2 |
EC50 = 251.2 nM
|
|
|
| 3 |
EC50 = 799.3 nM
|
|
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| 4 |
EC50 = 1575.7 nM
|
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|
CP0451047
|
(E)-3-[3,5-dimethyl-4-[2-[4-(4-methylsulfonylpiperazin-1-yl)anilino]thieno[2,3-d]pyrimidin-4-yl]oxyphenyl]prop-2-enenitrile
Show/Hide
|
C28H28N6O3S2
|
5
|
| 1 |
EC50 = 219 nM
|
|
|
| 2 |
EC50 = 405 nM
|
|
|
| 3 |
EC50 = 1952 nM
|
|
|
| 4 |
EC50 = 3322 nM
|
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| 5 |
EC50 = 68430 nM
|
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|
CP0465740
|
(E)-3-[3,5-dimethyl-4-[2-[4-[(4-methylsulfonylpiperazin-1-yl)methyl]anilino]thieno[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enenitrile
Show/Hide
|
C29H30N6O3S2
|
5
|
| 1 |
EC50 = 356 nM
|
|
|
| 2 |
EC50 = 983 nM
|
|
|
| 3 |
EC50 = 1560 nM
|
|
|
| 4 |
EC50 = 2198 nM
|
|
|
| 5 |
EC50 > 20700 nM
|
|
|
|
CP0426555
|
4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]-2-[4-[3-(sulfamoylamino)piperidin-1-yl]anilino]thieno[2,3-d]pyrimidine
Show/Hide
|
C28H29N7O3S2
|
5
|
| 1 |
EC50 = 450 nM
|
|
|
| 2 |
EC50 = 621 nM
|
|
|
| 3 |
EC50 = 2329 nM
|
|
|
| 4 |
EC50 = 3639 nM
|
|
|
| 5 |
EC50 = 88200 nM
|
|
|
|
CP0451046
|
N-[1-[4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]thieno[3,2-d]pyrimidin-2-yl]amino]phenyl]piperidin-3-yl]methanesulfonamide
Show/Hide
|
C29H30N6O3S2
|
4
|
| 1 |
EC50 = 461 nM
|
|
|
| 2 |
EC50 = 1285 nM
|
|
|
| 3 |
EC50 = 6823 nM
|
|
|
| 4 |
EC50 = 16780 nM
|
|
|
|
CP0534946
|
4-[4-[(R)-[2-(4-cyanoanilino)pyrimidin-4-yl]-hydroxymethyl]-3-(trifluoromethyl)phenyl]benzonitrile
Show/Hide
|
C26H16F3N5O
|
5
|
| 1 |
EC50 = 933.3 nM
|
|
|
| 2 |
EC50 = 1739.4 nM
|
|
|
| 3 |
EC50 = 1824.2 nM
|
|
|
| 4 |
EC50 = 1909 nM
|
|
|
| 5 |
EC50 > 24138.8 nM
|
|
|
|
CP0422274
|
N-[1-[4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]thieno[2,3-d]pyrimidin-2-yl]amino]phenyl]piperidin-3-yl]methanesulfonamide
Show/Hide
|
C29H30N6O3S2
|
5
|
| 1 |
EC50 = 1358 nM
|
|
|
| 2 |
EC50 = 4272 nM
|
|
|
| 3 |
EC50 = 8519 nM
|
|
|
| 4 |
EC50 = 13780 nM
|
|
|
| 5 |
EC50 = 16170 nM
|
|
|
