Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin-4-ylamino)-3,5-dimethylbenzonitrile
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 PubChem ID
CID: 193962
SID: 14856802
Canonical SMILES
Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N
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Compound Formula C20H15BrN6O
Compound Structure
Protein Name
 Protein Info 
Reverse transcriptase
Protein Classification
Enzyme
Uniprot ID
Q9WKE8
Gene Name
REVERSE TRANSCRIPTASE
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4
 Cell Line Info 
Homo sapiens (Human)  10
1
EC50 = 2.3 nM
   TI
   LI
   LO
   TS
2
EC50 = 3 nM
   TI
   LI
   LO
   TS
3
EC50 = 8 nM
   TI
   LI
   LO
   TS
4
EC50 = 9 nM
   TI
   LI
   LO
   TS
5
EC50 = 9.2 nM
   TI
   LI
   LO
   TS
6
EC50 = 12.2 nM
   TI
   LI
   LO
   TS
7
EC50 = 16.3 nM
   TI
   LI
   LO
   TS
8
EC50 = 18 nM
   TI
   LI
   LO
   TS
9
EC50 = 18.4 nM
   TI
   LI
   LO
   TS
10
EC50 = 25 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM
2 IC50 = 20 nM
3 IC50 = 40 nM