Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one
    Show/Hide
 PubChem ID
CID: 64139
SID: 14850291
Canonical SMILES
FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1
    Show/Hide
Compound Formula C14H9ClF3NO2
Compound Structure
Protein Name
 Protein Info 
Reverse transcriptase
Protein Classification
Enzyme
Uniprot ID
Q9WKE8
Gene Name
REVERSE TRANSCRIPTASE
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4
 Cell Line Info 
Homo sapiens (Human)  10
1
EC50 = 4.8 nM
   TI
   LI
   LO
   TS
2
EC50 = 5 nM
   TI
   LI
   LO
   TS
3
EC50 = 7 nM
   TI
   LI
   LO
   TS
4
EC50 = 31 nM
   TI
   LI
   LO
   TS
5
EC50 = 47.5 nM
   TI
   LI
   LO
   TS
6
EC50 = 71 nM
   TI
   LI
   LO
   TS
7
EC50 = 76 nM
   TI
   LI
   LO
   TS
8
EC50 = 171.1 nM
   TI
   LI
   LO
   TS
9
EC50 = 260 nM
   TI
   LI
   LO
   TS
10
EC50 = 380 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM
2 IC50 = 20 nM
3 IC50 = 100 nM
4 IC50 = 120 nM
5 IC50 = 170 nM